DK1866433T3 - Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2 - Google Patents
Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2Info
- Publication number
- DK1866433T3 DK1866433T3 DK07717962T DK07717962T DK1866433T3 DK 1866433 T3 DK1866433 T3 DK 1866433T3 DK 07717962 T DK07717962 T DK 07717962T DK 07717962 T DK07717962 T DK 07717962T DK 1866433 T3 DK1866433 T3 DK 1866433T3
- Authority
- DK
- Denmark
- Prior art keywords
- lrrk2
- lrrk
- purifying
- identifying
- interacting molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78211906P | 2006-03-14 | 2006-03-14 | |
| PCT/EP2007/052357 WO2007104763A1 (en) | 2006-03-14 | 2007-03-13 | Methods for the identification of lrrk2 interacting molecules and for the purification of lrrk2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1866433T3 true DK1866433T3 (da) | 2009-08-17 |
Family
ID=38093568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07717962T DK1866433T3 (da) | 2006-03-14 | 2007-03-13 | Fremgangsmåde til identifikation af LRRK-2interagerende molekyler og til rensning af LRRK2 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8163511B2 (da) |
| EP (1) | EP1866433B1 (da) |
| JP (1) | JP2009529860A (da) |
| CN (1) | CN101426927B (da) |
| AT (1) | ATE431426T1 (da) |
| AU (1) | AU2007224411B2 (da) |
| CA (1) | CA2645214A1 (da) |
| DE (1) | DE602007001103D1 (da) |
| DK (1) | DK1866433T3 (da) |
| ES (1) | ES2325797T3 (da) |
| WO (1) | WO2007104763A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0706709D0 (en) | 2007-04-05 | 2007-05-16 | Medical Res Council | Methods |
| US8206942B2 (en) | 2007-04-05 | 2012-06-26 | Medical Research Council | Methods of identifying LRRK2 inhibitors |
| ES2348187T3 (es) | 2007-10-05 | 2010-12-01 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Amplificacion proteomica de pequeñas moleculas que se unen a proteinas celulares diana. |
| AU2009211845A1 (en) * | 2008-02-04 | 2009-08-13 | Cellzome Gmbh | Selectivity profiling of PI3K interacting molecules against multiple targets |
| GB2463656B (en) * | 2008-09-18 | 2010-10-13 | Medical Res Council | Substrate of LRRK2 and methods of assessing LRRK2 activity |
| US8367349B2 (en) * | 2010-04-19 | 2013-02-05 | Medical Research Council | Methods for identifying modulators of LRRK2 |
| EP2710041A4 (en) * | 2011-05-18 | 2014-11-05 | Parkinson S Inst | ASSAY FOR DETERMINING LRRK2 ACTIVITY IN MORBUS PARKINSON |
| NZ702571A (en) | 2012-06-29 | 2017-02-24 | Pfizer | 4-(substituted-amino)-7h-pyrrolo[2,3-d]pyrimidines as lrrk2 inhibitors |
| JP6487921B2 (ja) | 2013-12-17 | 2019-03-20 | ファイザー・インク | ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン |
| CN108137586B (zh) | 2015-09-14 | 2021-04-13 | 辉瑞大药厂 | 作为LRRK2抑制剂的新颖咪唑并[4,5-c]喹啉和咪唑并[4,5-c][1,5]萘啶衍生物 |
| WO2019096325A1 (zh) * | 2017-11-20 | 2019-05-23 | 江苏达骏生物科技有限公司 | 一种双酰胺复合物及其制备方法和用途 |
| CN112505328B (zh) * | 2020-11-02 | 2024-02-13 | 武汉金开瑞生物工程有限公司 | 一种同位素标记试剂盒和标记方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002081466A1 (en) * | 2001-04-09 | 2002-10-17 | Sugen, Inc. | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
| AU2003253880A1 (en) * | 2002-07-15 | 2004-02-02 | Sugen, Inc. | Novel kinases |
| WO2006134056A1 (en) * | 2005-06-14 | 2006-12-21 | Cellzome Ag | Process for the identification of novel enzyme interacting compounds |
-
2007
- 2007-03-13 DE DE602007001103T patent/DE602007001103D1/de active Active
- 2007-03-13 JP JP2008558809A patent/JP2009529860A/ja active Pending
- 2007-03-13 CA CA002645214A patent/CA2645214A1/en not_active Abandoned
- 2007-03-13 AU AU2007224411A patent/AU2007224411B2/en not_active Ceased
- 2007-03-13 US US12/282,851 patent/US8163511B2/en not_active Expired - Fee Related
- 2007-03-13 ES ES07717962T patent/ES2325797T3/es active Active
- 2007-03-13 CN CN2007800142956A patent/CN101426927B/zh not_active Expired - Fee Related
- 2007-03-13 EP EP07717962A patent/EP1866433B1/en not_active Not-in-force
- 2007-03-13 WO PCT/EP2007/052357 patent/WO2007104763A1/en active Application Filing
- 2007-03-13 AT AT07717962T patent/ATE431426T1/de active
- 2007-03-13 DK DK07717962T patent/DK1866433T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007224411B2 (en) | 2012-11-01 |
| US20090220992A1 (en) | 2009-09-03 |
| JP2009529860A (ja) | 2009-08-27 |
| WO2007104763A9 (en) | 2007-11-15 |
| EP1866433A1 (en) | 2007-12-19 |
| CA2645214A1 (en) | 2007-09-20 |
| US8163511B2 (en) | 2012-04-24 |
| ES2325797T3 (es) | 2009-09-17 |
| DE602007001103D1 (de) | 2009-06-25 |
| WO2007104763A1 (en) | 2007-09-20 |
| CN101426927A (zh) | 2009-05-06 |
| AU2007224411A1 (en) | 2007-09-20 |
| ATE431426T1 (de) | 2009-05-15 |
| CN101426927B (zh) | 2012-05-23 |
| EP1866433B1 (en) | 2009-05-13 |
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