DK171530B1 - Fremgangsmåde til fremstilling og oprensning af ioderede kontrastmidler - Google Patents

Fremgangsmåde til fremstilling og oprensning af ioderede kontrastmidler Download PDF

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Publication number
DK171530B1
DK171530B1 DK021795A DK21795A DK171530B1 DK 171530 B1 DK171530 B1 DK 171530B1 DK 021795 A DK021795 A DK 021795A DK 21795 A DK21795 A DK 21795A DK 171530 B1 DK171530 B1 DK 171530B1
Authority
DK
Denmark
Prior art keywords
resin
purification
iopamidol
process according
anionic resin
Prior art date
Application number
DK021795A
Other languages
Danish (da)
English (en)
Other versions
DK21795A (da
Inventor
Vincenzo Cannata
Valeriano Merli
Claudio Dal Santo
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of DK21795A publication Critical patent/DK21795A/da
Application granted granted Critical
Publication of DK171530B1 publication Critical patent/DK171530B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DK021795A 1994-03-03 1995-03-02 Fremgangsmåde til fremstilling og oprensning af ioderede kontrastmidler DK171530B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI940378A IT1274027B (it) 1994-03-03 1994-03-03 Processo per la preparazione e purificazione di mezzi di contrasto iodurati
ITMI940378 1994-03-03

Publications (2)

Publication Number Publication Date
DK21795A DK21795A (da) 1995-09-04
DK171530B1 true DK171530B1 (da) 1996-12-23

Family

ID=11368040

Family Applications (1)

Application Number Title Priority Date Filing Date
DK021795A DK171530B1 (da) 1994-03-03 1995-03-02 Fremgangsmåde til fremstilling og oprensning af ioderede kontrastmidler

Country Status (22)

Country Link
US (1) US5550287A (de)
JP (1) JP4143136B2 (de)
AT (1) AT405052B (de)
BE (1) BE1007938A3 (de)
CA (1) CA2143805C (de)
CH (1) CH689296A5 (de)
CZ (1) CZ287640B6 (de)
DE (1) DE19507294B4 (de)
DK (1) DK171530B1 (de)
ES (1) ES2105961B1 (de)
FI (1) FI950977A (de)
FR (1) FR2716881B1 (de)
GB (1) GB2287024B (de)
HU (1) HU216330B (de)
IE (1) IE950154A1 (de)
IL (1) IL112718A (de)
IT (1) IT1274027B (de)
NL (1) NL194332C (de)
NO (1) NO304112B1 (de)
PT (1) PT101665B (de)
SE (1) SE510124C2 (de)
ZA (1) ZA951748B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2929236A (en) * 1955-03-29 1960-03-22 Steward Construction Company Building wall construction
CZ290363B6 (cs) * 1995-05-23 2002-07-17 Bracco Imaging S. P. A. Způsob výroby dichloridu kyseliny S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-trijod-1,3-benzendikarboxylové, jeho vyčiątění a izolace
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
EP0863782B1 (de) * 1995-12-01 2001-08-16 Mallinckrodt Medical Imaging-Ireland Verfahren zur umkehrphasen-chromatographie
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289519B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1292127B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la dissalazione di sostanze instabili a ph acidi
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
TWI288654B (en) * 2001-05-17 2007-10-21 Ind Tech Res Inst Process for the purification of water-soluble non-ionic contrast agents
US20110017673A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Endotoxin removal in contrast media
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
CA3001399C (en) 2013-11-05 2020-06-30 Bracco Imaging Spa Process for the preparation of iopamidol
CN115403481A (zh) * 2022-04-13 2022-11-29 江苏宇田医药有限公司 一种通过离子交换树脂纯化碘海醇的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4956989A (de) * 1972-10-09 1974-06-03
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
NZ224743A (en) * 1987-05-22 1991-07-26 Bracco Ind Chimica Spa 5-acylamino-2,4,6-tribromo- or triiodo-benzoic acid derivatives and intermediate compounds used in their preparation
JPH03244380A (ja) * 1990-02-23 1991-10-31 Asahi Chem Ind Co Ltd 精製酵素およびその製造方法
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IT1254991B (it) * 1992-06-24 1995-10-11 Chemi Spa Procedimento per la preparazione di glicerofosfolipidi
DE10204861B4 (de) * 2002-02-06 2004-01-29 Wacker Construction Equipment Ag Luftfederschlagwerk mit elektrodynamisch bewegtem Antriebskolben

Also Published As

Publication number Publication date
SE9500752L (sv) 1995-09-04
FI950977A (fi) 1995-09-04
NL9500415A (nl) 1995-10-02
IE950154A1 (en) 1995-09-06
NL194332B (nl) 2001-09-03
CA2143805C (en) 2004-12-28
GB2287024B (en) 1998-07-08
GB9503893D0 (en) 1995-04-19
FI950977A0 (fi) 1995-03-02
HUT70401A (en) 1995-10-30
NO304112B1 (no) 1998-10-26
NO950814D0 (no) 1995-03-02
HU9500645D0 (en) 1995-04-28
ES2105961A1 (es) 1997-10-16
HU216330B (hu) 1999-06-28
PT101665A (pt) 1995-09-12
DE19507294B4 (de) 2005-12-15
BE1007938A3 (fr) 1995-11-21
DE19507294A1 (de) 1995-09-07
DK21795A (da) 1995-09-04
NL194332C (nl) 2002-01-04
US5550287A (en) 1996-08-27
CZ287640B6 (en) 2001-01-17
GB2287024A (en) 1995-09-06
PT101665B (pt) 1999-01-29
SE9500752D0 (sv) 1995-03-02
JP4143136B2 (ja) 2008-09-03
ES2105961B1 (es) 1998-07-01
FR2716881B1 (fr) 1996-08-02
FR2716881A1 (fr) 1995-09-08
IL112718A0 (en) 1995-05-26
IL112718A (en) 1999-05-09
IT1274027B (it) 1997-07-14
ITMI940378A1 (it) 1995-09-04
ATA36995A (de) 1998-09-15
NO950814L (no) 1995-09-04
CA2143805A1 (en) 1995-09-04
ZA951748B (en) 1995-12-08
JPH07278081A (ja) 1995-10-24
CZ56295A3 (en) 1995-11-15
ITMI940378A0 (it) 1994-03-03
SE510124C2 (sv) 1999-04-19
CH689296A5 (it) 1999-02-15
AT405052B (de) 1999-05-25

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired

Expiry date: 20150302