DK1679072T5 - Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril - Google Patents

Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril

Info

Publication number
DK1679072T5
DK1679072T5 DK05113099T DK05113099T DK1679072T5 DK 1679072 T5 DK1679072 T5 DK 1679072T5 DK 05113099 T DK05113099 T DK 05113099T DK 05113099 T DK05113099 T DK 05113099T DK 1679072 T5 DK1679072 T5 DK 1679072T5
Authority
DK
Denmark
Prior art keywords
perindopril
synthesis
alanyl
octahydro
indole
Prior art date
Application number
DK05113099T
Other languages
English (en)
Other versions
DK1679072T3 (da
Inventor
Ashok Kumar
Satish Rajanikant Soudagar
Arpana Mathur
Sanjay Tukaram Gunjal
Nalinakshya Balaram Panda
Dilip Uttam Jadhav
Original Assignee
Ipca Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Lab Ltd filed Critical Ipca Lab Ltd
Application granted granted Critical
Publication of DK1679072T3 publication Critical patent/DK1679072T3/da
Publication of DK1679072T5 publication Critical patent/DK1679072T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK05113099T 2005-01-06 2005-12-30 Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril DK1679072T5 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN17MU2005 2005-01-06

Publications (2)

Publication Number Publication Date
DK1679072T3 DK1679072T3 (da) 2009-02-09
DK1679072T5 true DK1679072T5 (da) 2009-04-20

Family

ID=36269938

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05113099T DK1679072T5 (da) 2005-01-06 2005-12-30 Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril

Country Status (8)

Country Link
EP (2) EP1679072B9 (da)
AT (1) ATE409036T1 (da)
DE (1) DE602005009918D1 (da)
DK (1) DK1679072T5 (da)
ES (1) ES2314583T4 (da)
PL (1) PL1679072T3 (da)
PT (1) PT1679072E (da)
SI (1) SI1679072T1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1679072T3 (pl) 2005-01-06 2009-03-31 Ipca Laboratories Ltd Sposób syntezy pochodnych kwasu (2S, 3aS, 7aS)-1-(S)-alanylo- oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprilu
EP2906536B1 (en) 2012-10-10 2018-03-14 Piramal Enterprises Limited An improved process for preparation of perindopril intermediate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3177130D1 (de) * 1980-08-30 1990-01-11 Hoechst Ag Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung.
EP0050800B2 (en) * 1980-10-23 1995-06-07 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
IT1292426B1 (it) * 1997-06-27 1999-02-08 Nicox Sa Sali nitrati di ace-inibitori
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
EP1333026B1 (en) 2002-01-30 2007-06-27 Les Laboratoires Servier Process for the preparation of high purity perindopril and intermediates useful in the synthesis
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
DK1367061T3 (da) 2003-06-30 2006-05-15 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
EP1362864B1 (fr) 2003-06-30 2007-04-25 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
DE60301820T2 (de) 2003-08-29 2006-07-13 Les Laboratoires Servier Verfahren zur Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salze
PT1380590E (pt) 2003-08-29 2006-12-29 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis sob o ponto de vista farmacêutico.
ATE310012T1 (de) 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
EP1420029B9 (fr) * 2003-12-10 2008-11-12 Les Laboratoires Servier Procédé de synthèse du perindopril et ses sels pharmaceutiquement acceptables
PL1679072T3 (pl) 2005-01-06 2009-03-31 Ipca Laboratories Ltd Sposób syntezy pochodnych kwasu (2S, 3aS, 7aS)-1-(S)-alanylo- oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprilu

Also Published As

Publication number Publication date
PL1679072T3 (pl) 2009-03-31
ES2314583T3 (es) 2009-03-16
EP1987828A1 (en) 2008-11-05
SI1679072T1 (sl) 2009-02-28
DK1679072T3 (da) 2009-02-09
ATE409036T1 (de) 2008-10-15
PT1679072E (pt) 2008-12-22
EP1679072B9 (en) 2009-09-02
EP1679072B1 (en) 2008-09-24
DE602005009918D1 (de) 2008-11-06
ES2314583T4 (es) 2009-05-18
EP1679072A1 (en) 2006-07-12

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