DK1679072T5 - Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril - Google Patents
Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindoprilInfo
- Publication number
- DK1679072T5 DK1679072T5 DK05113099T DK05113099T DK1679072T5 DK 1679072 T5 DK1679072 T5 DK 1679072T5 DK 05113099 T DK05113099 T DK 05113099T DK 05113099 T DK05113099 T DK 05113099T DK 1679072 T5 DK1679072 T5 DK 1679072T5
- Authority
- DK
- Denmark
- Prior art keywords
- perindopril
- synthesis
- alanyl
- octahydro
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN17MU2005 | 2005-01-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1679072T3 DK1679072T3 (da) | 2009-02-09 |
DK1679072T5 true DK1679072T5 (da) | 2009-04-20 |
Family
ID=36269938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05113099T DK1679072T5 (da) | 2005-01-06 | 2005-12-30 | Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP1679072B9 (da) |
AT (1) | ATE409036T1 (da) |
DE (1) | DE602005009918D1 (da) |
DK (1) | DK1679072T5 (da) |
ES (1) | ES2314583T4 (da) |
PL (1) | PL1679072T3 (da) |
PT (1) | PT1679072E (da) |
SI (1) | SI1679072T1 (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL1679072T3 (pl) | 2005-01-06 | 2009-03-31 | Ipca Laboratories Ltd | Sposób syntezy pochodnych kwasu (2S, 3aS, 7aS)-1-(S)-alanylo- oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprilu |
EP2906536B1 (en) | 2012-10-10 | 2018-03-14 | Piramal Enterprises Limited | An improved process for preparation of perindopril intermediate |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
DE3177130D1 (de) * | 1980-08-30 | 1990-01-11 | Hoechst Ag | Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung. |
EP0050800B2 (en) * | 1980-10-23 | 1995-06-07 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
FR2620709B1 (fr) | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
IT1292426B1 (it) * | 1997-06-27 | 1999-02-08 | Nicox Sa | Sali nitrati di ace-inibitori |
FR2807431B1 (fr) | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
EP1333026B1 (en) | 2002-01-30 | 2007-06-27 | Les Laboratoires Servier | Process for the preparation of high purity perindopril and intermediates useful in the synthesis |
FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
DK1367061T3 (da) | 2003-06-30 | 2006-05-15 | Servier Lab | Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf |
EP1362864B1 (fr) | 2003-06-30 | 2007-04-25 | Les Laboratoires Servier | Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables |
DE60301820T2 (de) | 2003-08-29 | 2006-07-13 | Les Laboratoires Servier | Verfahren zur Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salze |
PT1380590E (pt) | 2003-08-29 | 2006-12-29 | Servier Lab | Novo processo de síntese do perindopril e dos seus sais aceitáveis sob o ponto de vista farmacêutico. |
ATE310012T1 (de) | 2003-08-29 | 2005-12-15 | Servier Lab | Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen |
EP1420029B9 (fr) * | 2003-12-10 | 2008-11-12 | Les Laboratoires Servier | Procédé de synthèse du perindopril et ses sels pharmaceutiquement acceptables |
PL1679072T3 (pl) | 2005-01-06 | 2009-03-31 | Ipca Laboratories Ltd | Sposób syntezy pochodnych kwasu (2S, 3aS, 7aS)-1-(S)-alanylo- oktahydro-1H-indolo-2-karboksylowego i zastosowanie w syntezie perindoprilu |
-
2005
- 2005-12-30 PL PL05113099T patent/PL1679072T3/pl unknown
- 2005-12-30 DE DE602005009918T patent/DE602005009918D1/de active Active
- 2005-12-30 EP EP05113099A patent/EP1679072B9/en not_active Not-in-force
- 2005-12-30 AT AT05113099T patent/ATE409036T1/de not_active IP Right Cessation
- 2005-12-30 ES ES05113099T patent/ES2314583T4/es active Active
- 2005-12-30 EP EP08104990A patent/EP1987828A1/en not_active Withdrawn
- 2005-12-30 DK DK05113099T patent/DK1679072T5/da active
- 2005-12-30 PT PT05113099T patent/PT1679072E/pt unknown
- 2005-12-30 SI SI200530509T patent/SI1679072T1/sl unknown
Also Published As
Publication number | Publication date |
---|---|
PL1679072T3 (pl) | 2009-03-31 |
ES2314583T3 (es) | 2009-03-16 |
EP1987828A1 (en) | 2008-11-05 |
SI1679072T1 (sl) | 2009-02-28 |
DK1679072T3 (da) | 2009-02-09 |
ATE409036T1 (de) | 2008-10-15 |
PT1679072E (pt) | 2008-12-22 |
EP1679072B9 (en) | 2009-09-02 |
EP1679072B1 (en) | 2008-09-24 |
DE602005009918D1 (de) | 2008-11-06 |
ES2314583T4 (es) | 2009-05-18 |
EP1679072A1 (en) | 2006-07-12 |
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