DK1648882T3 - 3-fluor-piperidiner som NMDA/NR2B-antagonister - Google Patents

3-fluor-piperidiner som NMDA/NR2B-antagonister

Info

Publication number: DK1648882T3
Authority: DK; Denmark
Prior art keywords: nmda; piperidines; fluoro; nr2b antagonists; nr2b
Prior art date: 2003-06-04

Application number

DK04753896T

Other languages

Danish (da)

English (en)

Inventor

Nigel J Liverton

Christopher F Claiborne

David A Claremon

John A Mccauley

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-04

Filing date

2004-05-28

Publication date

2008-11-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511734&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1648882(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-05-28 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2008-11-24 Application granted granted Critical

2008-11-24 Publication of DK1648882T3 publication Critical patent/DK1648882T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Psychiatry (AREA)
Immunology (AREA)
Addiction (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Tropical Medicine & Parasitology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Biotechnology (AREA)

DK04753896T 2003-06-04 2004-05-28 3-fluor-piperidiner som NMDA/NR2B-antagonister DK1648882T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47593803P	2003-06-04	2003-06-04
PCT/US2004/017175 WO2004108705A1 (en)	2003-06-04	2004-05-28	3-fluoro-piperidines as nmda/nr2b antagonists

Publications (1)

Publication Number	Publication Date
DK1648882T3 true DK1648882T3 (da)	2008-11-24

Family

ID=33511734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04753896T DK1648882T3 (da)	2003-06-04	2004-05-28	3-fluor-piperidiner som NMDA/NR2B-antagonister

Country Status (30)

Country	Link
EP (1)	EP1648882B1 (zh)
JP (1)	JP3927228B2 (zh)
KR (1)	KR20060017839A (zh)
CN (1)	CN1798744A (zh)
AR (1)	AR044579A1 (zh)
AT (1)	ATE403651T1 (zh)
AU (1)	AU2004245522B2 (zh)
BR (1)	BRPI0410837A (zh)
CA (1)	CA2527093C (zh)
CL (1)	CL2004001365A1 (zh)
CO (1)	CO5700762A2 (zh)
DE (1)	DE602004015610D1 (zh)
DK (1)	DK1648882T3 (zh)
EC (1)	ECSP056192A (zh)
ES (1)	ES2309540T3 (zh)
HR (1)	HRP20080490T3 (zh)
IS (1)	IS8117A (zh)
MA (1)	MA27781A1 (zh)
MX (1)	MXPA05013151A (zh)
MY (1)	MY138547A (zh)
NO (1)	NO20060020L (zh)
PE (1)	PE20050245A1 (zh)
PL (1)	PL1648882T3 (zh)
PT (1)	PT1648882E (zh)
RU (1)	RU2339630C2 (zh)
SI (1)	SI1648882T1 (zh)
TW (1)	TW200510378A (zh)
UA (1)	UA81319C2 (zh)
WO (1)	WO2004108705A1 (zh)
ZA (1)	ZA200509000B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009535364A (ja) *	2006-05-03	2009-10-01	シーエヌエスバイオピーティーワイリミテッド	炎症性疼痛の治療のための方法および組成物
KR101506156B1 (ko) *	2007-04-23	2015-03-26	얀센 파마슈티카 엔.브이.	속해리성 도파민 2 수용체 길항제로서의 티아(디아)졸
WO2009000038A1 (en) *	2007-06-28	2008-12-31	Cnsbio Pty Ltd	Combination methods and compositions for treatment of neuropathic pain
CN102762554A (zh)	2010-02-16	2012-10-31	辉瑞大药厂	5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇
JP6042968B2 (ja)	2012-04-20	2016-12-14	ユセベファルマソシエテアノニム	パーキンソン病の処置方法
CN103936663B (zh) *	2013-01-23	2016-12-28	艾琪康医药科技（上海）有限公司	一种1-r1-3,3-二氟(或3-氟)-4-r2-4-氨甲基哌啶及其衍生物的制备方法
US9187506B2 (en)	2014-01-09	2015-11-17	Bristol-Myers Squibb Company	(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders
US9221796B2 (en)	2014-01-09	2015-12-29	Bristol-Myers Squibb Company	Selective NR2B antagonists
US10030026B2 (en)	2014-06-04	2018-07-24	Rugen Holdings (Cayman) Limited	Difluoroethylpyridine derivatives as NR2B NMDA receptor antagonists
CN106715435B (zh)	2014-09-15	2019-10-01	卢郡控股(开曼)有限公司	作为nr2b nmda受体拮抗剂的吡咯并嘧啶衍生物
WO2016049048A1 (en) *	2014-09-22	2016-03-31	Rugen Holdings (Cayman) Limited	Treatment of anxiety disorders and autism spectrum disorders
BR112017013593A2 (pt) *	2014-12-23	2018-06-19	Cerecor, Inc.	compostos, composições e métodos
US10221182B2 (en)	2015-02-04	2019-03-05	Rugen Holdings (Cayman) Limited	3,3-difluoro-piperidine derivatives as NR2B NMDA receptor antagonists
JP6876625B2 (ja)	2015-06-01	2021-05-26	リューゲンホールディングス（ケイマン）リミテッド	Ｎｒ２ｂｎｍｄａレセプターアンタゴニストとしての３，３−ジフルオロピペリジンカルバメート複素環式化合物
WO2017066368A1 (en)	2015-10-14	2017-04-20	Bristol-Myers Squibb Company	Selective nr2b antagonists
CN108137543B (zh)	2015-10-14	2021-11-23	百时美施贵宝公司	选择性nr2b拮抗剂
AU2017319080B2 (en)	2016-08-31	2020-12-17	Eisai R&D Management Co., Ltd.	Pyrazolo[1,5-a]pyrimidine compound
EP3544610A1 (en)	2016-11-22	2019-10-02	Rugen Holdings (Cayman) Limited	Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1379520T1 (sl) *	2001-02-23	2006-08-31	Merck & Co Inc	N-substituirani nonaril-heterociklicni NMDA/NR2B antagonisti

2004
- 2004-05-28 SI SI200430845T patent/SI1648882T1/sl unknown
- 2004-05-28 KR KR1020057023218A patent/KR20060017839A/ko not_active Application Discontinuation
- 2004-05-28 RU RU2005137704/04A patent/RU2339630C2/ru not_active IP Right Cessation
- 2004-05-28 JP JP2006515051A patent/JP3927228B2/ja not_active Expired - Lifetime
- 2004-05-28 PT PT04753896T patent/PT1648882E/pt unknown
- 2004-05-28 CN CNA2004800153228A patent/CN1798744A/zh active Pending
- 2004-05-28 DK DK04753896T patent/DK1648882T3/da active
- 2004-05-28 ES ES04753896T patent/ES2309540T3/es not_active Expired - Lifetime
- 2004-05-28 EP EP04753896A patent/EP1648882B1/en not_active Expired - Lifetime
- 2004-05-28 MX MXPA05013151A patent/MXPA05013151A/es active IP Right Grant
- 2004-05-28 PL PL04753896T patent/PL1648882T3/pl unknown
- 2004-05-28 CA CA002527093A patent/CA2527093C/en not_active Expired - Lifetime
- 2004-05-28 AT AT04753896T patent/ATE403651T1/de not_active IP Right Cessation
- 2004-05-28 WO PCT/US2004/017175 patent/WO2004108705A1/en active Application Filing
- 2004-05-28 BR BRPI0410837-0A patent/BRPI0410837A/pt not_active IP Right Cessation
- 2004-05-28 AU AU2004245522A patent/AU2004245522B2/en not_active Expired
- 2004-05-28 DE DE602004015610T patent/DE602004015610D1/de not_active Expired - Lifetime
- 2004-05-28 UA UAA200511411A patent/UA81319C2/uk unknown
- 2004-05-31 AR ARP040101878A patent/AR044579A1/es unknown
- 2004-05-31 MY MYPI20042091A patent/MY138547A/en unknown
- 2004-06-01 PE PE2004000552A patent/PE20050245A1/es not_active Application Discontinuation
- 2004-06-03 CL CL200401365A patent/CL2004001365A1/es unknown
- 2004-06-03 TW TW093115972A patent/TW200510378A/zh unknown
2005
- 2005-11-07 ZA ZA200509000A patent/ZA200509000B/en unknown
- 2005-11-07 IS IS8117A patent/IS8117A/is unknown
- 2005-11-28 MA MA28626A patent/MA27781A1/fr unknown
- 2005-11-29 EC EC2005006192A patent/ECSP056192A/es unknown
- 2005-11-30 CO CO05121658A patent/CO5700762A2/es not_active Application Discontinuation
2006
- 2006-01-03 NO NO20060020A patent/NO20060020L/no not_active Application Discontinuation
2008
- 2008-10-01 HR HR20080490T patent/HRP20080490T3/xx unknown

Also Published As

Publication number	Publication date
WO2004108705A1 (en)	2004-12-16
ES2309540T3 (es)	2008-12-16
MXPA05013151A (es)	2006-03-17
RU2339630C2 (ru)	2008-11-27
JP2006526650A (ja)	2006-11-24
MY138547A (en)	2009-06-30
AU2004245522A1 (en)	2004-12-16
HRP20080490T3 (en)	2008-11-30
AU2004245522B2 (en)	2009-10-29
SI1648882T1 (sl)	2009-02-28
ATE403651T1 (de)	2008-08-15
CN1798744A (zh)	2006-07-05
CL2004001365A1 (es)	2005-05-06
PL1648882T3 (pl)	2008-12-31
CA2527093A1 (en)	2004-12-16
IS8117A (is)	2005-11-07
BRPI0410837A (pt)	2006-06-27
CA2527093C (en)	2009-10-20
PE20050245A1 (es)	2005-04-13
UA81319C2 (en)	2007-12-25
RU2005137704A (ru)	2006-05-27
KR20060017839A (ko)	2006-02-27
DE602004015610D1 (de)	2008-09-18
NO20060020L (no)	2006-03-03
CO5700762A2 (es)	2006-11-30
ZA200509000B (en)	2006-12-27
JP3927228B2 (ja)	2007-06-06
ECSP056192A (es)	2006-04-19
AR044579A1 (es)	2005-09-21
MA27781A1 (fr)	2006-02-01
PT1648882E (pt)	2008-10-20
EP1648882A1 (en)	2006-04-26
EP1648882B1 (en)	2008-08-06
TW200510378A (en)	2005-03-16

Publication	Publication Date	Title
NO20044654L (no)	2004-10-28	Piperidinoylpiperidiner som 5-HTIF-agonister
IS8117A (is)	2005-11-07	3-Flúr-píperidín sem NMDA/NR2B mótlyf
NO20052739D0 (no)	2005-06-07	CCR5-antagonister som medikamenter
ATE481402T1 (de)	2010-10-15	Pyrazolopyridin-derivate
AT500118A2 (de)	2005-10-15	Mehrfach-funkgerät-vereinheitlichungsprotokoll
DK3384931T3 (da)	2019-09-16	Superfin formoterolformulering
NO20054669D0 (no)	2005-10-11	Substituerte kinobenzoxazinanaloger
DE602004022685D1 (de)	2009-10-01	Abgabevorrichtung
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