DK163032C - Lyofiliseret antibakterielt praeparat indeholdende 7beta-difluormethylthioacetamido-7alfa-methoxy-3-oe1-(2-hydroxyalkyl)-1h-tetrazol-5-ylaa-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylsyrealkalimetalsalt samt fremgangsmaade til fremstilling af praeparatet - Google Patents

Lyofiliseret antibakterielt praeparat indeholdende 7beta-difluormethylthioacetamido-7alfa-methoxy-3-oe1-(2-hydroxyalkyl)-1h-tetrazol-5-ylaa-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylsyrealkalimetalsalt samt fremgangsmaade til fremstilling af praeparatet

Info

Publication number
DK163032C
DK163032C DK399684A DK399684A DK163032C DK 163032 C DK163032 C DK 163032C DK 399684 A DK399684 A DK 399684A DK 399684 A DK399684 A DK 399684A DK 163032 C DK163032 C DK 163032C
Authority
DK
Denmark
Prior art keywords
preparation
difluormethylthioacetamido
carboxylsyrealkalimetalsalt
ylä
7alfa
Prior art date
Application number
DK399684A
Other languages
English (en)
Other versions
DK399684D0 (da
DK399684A (da
DK163032B (da
Inventor
Kazuhiro Shima
Masayoshi Inoue
Takayuki Tsukada
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of DK399684D0 publication Critical patent/DK399684D0/da
Publication of DK399684A publication Critical patent/DK399684A/da
Publication of DK163032B publication Critical patent/DK163032B/da
Application granted granted Critical
Publication of DK163032C publication Critical patent/DK163032C/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK399684A 1983-08-22 1984-08-21 Lyofiliseret antibakterielt praeparat indeholdende 7beta-difluormethylthioacetamido-7alfa-methoxy-3-oe1-(2-hydroxyalkyl)-1h-tetrazol-5-ylaa-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylsyrealkalimetalsalt samt fremgangsmaade til fremstilling af praeparatet DK163032C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15393883 1983-08-22
JP58153938A JPS6045514A (ja) 1983-08-22 1983-08-22 安定な抗菌性凍結乾燥製剤

Publications (4)

Publication Number Publication Date
DK399684D0 DK399684D0 (da) 1984-08-21
DK399684A DK399684A (da) 1985-02-23
DK163032B DK163032B (da) 1992-01-13
DK163032C true DK163032C (da) 1992-06-15

Family

ID=15573358

Family Applications (1)

Application Number Title Priority Date Filing Date
DK399684A DK163032C (da) 1983-08-22 1984-08-21 Lyofiliseret antibakterielt praeparat indeholdende 7beta-difluormethylthioacetamido-7alfa-methoxy-3-oe1-(2-hydroxyalkyl)-1h-tetrazol-5-ylaa-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylsyrealkalimetalsalt samt fremgangsmaade til fremstilling af praeparatet

Country Status (20)

Country Link
US (1) US4616083A (da)
EP (1) EP0134568B1 (da)
JP (1) JPS6045514A (da)
KR (1) KR910004575B1 (da)
AR (1) AR242390A1 (da)
AT (1) ATE38774T1 (da)
CA (1) CA1231896A (da)
DE (2) DE3475268D1 (da)
DK (1) DK163032C (da)
ES (1) ES535654A0 (da)
FI (1) FI83476C (da)
GB (1) GB2145333B (da)
GR (1) GR80147B (da)
IE (1) IE57587B1 (da)
IL (1) IL72731A (da)
NO (1) NO165223C (da)
NZ (1) NZ209111A (da)
PT (1) PT79093B (da)
SU (1) SU1433390A3 (da)
ZA (1) ZA846104B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61130223A (ja) * 1984-11-28 1986-06-18 Shionogi & Co Ltd 抗菌性凍結乾燥製剤
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
DE3801179A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten
KR0154343B1 (ko) * 1990-11-06 1998-11-16 아만 히데아키 동결 건조 제제 및 이의 제조방법
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
WO2004000323A1 (ja) * 2002-06-21 2003-12-31 Shionogi & Co., Ltd. セフェム化合物の注射用医薬組成物
KR101314500B1 (ko) 2012-12-28 2013-10-07 제일약품주식회사 안정성이 개선된 옥사세펨 제제 및 그 제조방법
US20140274996A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Tazobactam and ceftolozane antibiotic compositions
US20140274994A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Stabilizing ceftolozane
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US9949982B2 (en) 2014-09-04 2018-04-24 Shionogi & Co., Ltd. Preparation containing cephalosporin having a catechol moiety

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA919593A (en) * 1969-03-31 1973-01-23 Nippon Kayaku Kabushiki Kaisha Process for manufacturing a preparation containing finely divided chloramphenicol palmitate
US3993753A (en) * 1974-08-26 1976-11-23 American Home Products Corporation Anhydrous ampicillin stabilization and resultant compositions
US4180571A (en) * 1976-03-25 1979-12-25 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam
JPS5762284A (en) * 1980-10-01 1982-04-15 Sumitomo Chem Co Ltd Stabilizing method
JPS59139385A (ja) * 1982-12-23 1984-08-10 Shionogi & Co Ltd フルオロメチルチオオキサセフアロスポリン

Also Published As

Publication number Publication date
AR242390A1 (es) 1993-03-31
NO165223B (no) 1990-10-08
PT79093B (en) 1986-08-14
EP0134568A1 (en) 1985-03-20
FI843261A0 (fi) 1984-08-17
NO843313L (no) 1985-02-25
DK399684D0 (da) 1984-08-21
ATE38774T1 (de) 1988-12-15
JPS6045514A (ja) 1985-03-12
KR910004575B1 (ko) 1991-07-06
GR80147B (en) 1984-12-18
JPH0370688B2 (da) 1991-11-08
CA1231896A (en) 1988-01-26
DK399684A (da) 1985-02-23
EP0134568B1 (en) 1988-11-23
GB2145333B (en) 1987-01-07
DE134568T1 (de) 1985-08-29
ES8505815A1 (es) 1985-06-16
ZA846104B (en) 1985-03-27
NZ209111A (en) 1987-02-20
GB2145333A (en) 1985-03-27
PT79093A (en) 1984-09-01
DE3475268D1 (en) 1988-12-29
FI83476C (fi) 1991-07-25
ES535654A0 (es) 1985-06-16
FI843261A (fi) 1985-02-23
IL72731A (en) 1988-04-29
SU1433390A3 (ru) 1988-10-23
NO165223C (no) 1991-01-30
DK163032B (da) 1992-01-13
IL72731A0 (en) 1984-11-30
GB8420296D0 (en) 1984-09-12
IE57587B1 (en) 1993-01-13
IE842072L (en) 1985-02-22
KR850001687A (ko) 1985-04-01
US4616083A (en) 1986-10-07
FI83476B (fi) 1991-04-15

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