DK1601776T3 - Ekspressionsvektorer omfattende mCmV-IE2-promotoren - Google Patents

Ekspressionsvektorer omfattende mCmV-IE2-promotoren

Info

Publication number: DK1601776T3
Authority: DK; Denmark
Prior art keywords: mcmv; promoter; expression vectors; gene; expression
Prior art date: 2003-03-11

Application number

DK04718972T

Other languages

English (en)

Inventor

Philippe Chatellard

Markus Imhof

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-11

Filing date

2004-03-10

Publication date

2008-10-13

2004-03-10 Application filed by Serono Lab filed Critical Serono Lab

2008-10-13 Application granted granted Critical

2008-10-13 Publication of DK1601776T3 publication Critical patent/DK1601776T3/da

Links

239000013604 expression vector Substances 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 abstract 3
239000012634 fragment Substances 0.000 abstract 2
239000003623 enhancer Substances 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/03—Herpetoviridae, e.g. pseudorabies virus
- C07K14/04—Varicella-zoster virus
- C07K14/045—Cytomegalovirus
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16141—Use of virus, viral particle or viral elements as a vector
- C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Virology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Cell Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK04718972T 2003-03-11 2004-03-10 Ekspressionsvektorer omfattende mCmV-IE2-promotoren DK1601776T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03100617		2003-03-11
PCT/EP2004/050280 WO2004081167A2 (en)	2003-03-11	2004-03-10	Expression vectors comprising the mcmv ie2 promoter

Publications (1)

Publication Number	Publication Date
DK1601776T3 true DK1601776T3 (da)	2008-10-13

Family

ID=32981915

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04718972T DK1601776T3 (da)	2003-03-11	2004-03-10	Ekspressionsvektorer omfattende mCmV-IE2-promotoren

Country Status (26)

Country	Link
US (3)	US7824907B2 (da)
EP (1)	EP1601776B1 (da)
JP (3)	JP5171033B2 (da)
KR (1)	KR101180139B1 (da)
CN (1)	CN100429315C (da)
AT (1)	ATE399872T1 (da)
AU (1)	AU2004219917B2 (da)
BR (1)	BRPI0408246A (da)
CA (1)	CA2516157C (da)
CY (1)	CY1108344T1 (da)
DE (1)	DE602004014738D1 (da)
DK (1)	DK1601776T3 (da)
EA (1)	EA010096B1 (da)
ES (1)	ES2309508T3 (da)
HK (1)	HK1085766A1 (da)
HR (1)	HRP20050705B1 (da)
IL (1)	IL170754A (da)
MX (1)	MXPA05009608A (da)
NO (1)	NO333818B1 (da)
PL (1)	PL1601776T4 (da)
PT (1)	PT1601776E (da)
RS (1)	RS50488B (da)
SI (1)	SI1601776T1 (da)
UA (1)	UA88138C2 (da)
WO (1)	WO2004081167A2 (da)
ZA (1)	ZA200506400B (da)

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GB0216648D0 (en)	2002-07-18	2002-08-28	Lonza Biologics Plc	Method of expressing recombinant protein in CHO cells
EA010096B1 (ru) *	2003-03-11	2008-06-30	Лаборатуар Сероно Са	Экспрессирующие векторы, содержащие ie2-промотор mcmv
JP5074030B2 (ja) *	2003-05-13	2012-11-14	メルクセローノソシエテアノニム	Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
WO2005040384A1 (en)	2003-10-21	2005-05-06	Applied Research Systems Ars Holding N.V.	Minimal dna sequence acting as a chromatin insulator and its use in protein expression
ME01198B (me)	2003-11-05	2013-03-20	Ares Trading Sa	Prečišćavanje il-18 vezujućeg proteina
ATE375385T1 (de)	2004-03-01	2007-10-15	Ares Trading Sa	Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
WO2006003134A1 (en) *	2004-06-29	2006-01-12	Ares Trading S.A.	Process for the purification of il-18 binding protein
EP1819812B1 (en) *	2004-12-02	2012-05-30	Merck Serono SA	The lupac bifunctional marker and its use in protein production
JP2008536506A (ja)	2005-04-22	2008-09-11	ロンザ・バイオロジクス・ピーエルシー	ｍＣＭＶプロモーターおよびｈＣＭＶ主要最初期遺伝子を含む哺乳類発現ベクター
AU2006247425A1 (en) *	2005-05-16	2006-11-23	Morphotek, Inc.	Regulated vectors for selection of cells exhibiting desired phenotypes
DK2267024T3 (da) *	2005-06-03	2012-06-25	Ares Trading Sa	Fremstilling af rekombinant II-18 bindingsprotein
PL1891088T3 (pl)	2005-06-10	2012-03-30	Ares Trading Sa	Sposób oczyszczania białka wiążącego IL-18
EP1760092A1 (en) *	2005-08-26	2007-03-07	Applied Research Systems ARS Holding N.V.	System for screening cells for high expression of a protein of interest
CN103805633B (zh) *	2007-12-21	2016-09-07	诺华股份有限公司	有机化合物
JP2009276724A (ja) *	2008-05-19	2009-11-26	Nitto Denko Corp	光導波路装置の製造方法
EP2401377B1 (en)	2009-02-27	2016-05-18	Novartis AG	Expression vector system comprising two selection markers
JP5502406B2 (ja) *	2009-09-14	2014-05-28	ロンザ・バイオロジクス・ピーエルシー	Ｃｈｏ細胞において組換えタンパク質を発現する方法
KR101038126B1 (ko) *	2010-11-30	2011-05-31	주식회사 엘지생명과학	새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
US9249785B2 (en) *	2012-01-31	2016-02-02	Brightsource Industries (Isreal) Ltd.	Method and system for operating a solar steam system during reduced-insolation events
DK2711426T3 (da) *	2012-09-24	2015-07-13	Lonza Biologics Plc	Ekspressionsvektorer omfattende kimære cytomegalovirus promoter- og enhancersekvenser
ITFI20120221A1 (it) *	2012-10-22	2014-04-23	Nuovo Pignone Srl	"exhaust gas collector and gas turbine"
WO2014133468A1 (en) *	2013-02-28	2014-09-04	Agency For Science, Technology And Research	Chimeric promoters for high gene expression level and stability in mammalian cells
CN103173480B (zh) *	2013-03-01	2015-06-24	上海中医药大学附属曙光医院	一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法
CN103173481A (zh) *	2013-03-01	2013-06-26	上海中医药大学附属普陀医院	一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途
WO2014141037A1 (en)	2013-03-11	2014-09-18	Novartis Ag	Method of screening cell clones
AU2014297966B2 (en)	2013-07-31	2017-10-26	Novartis Ag	Novel selection vectors and methods of selecting eukaryotic host cells
SG11201604215XA (en)	2013-12-20	2016-07-28	Novartis Ag	Novel eukaryotic cells and methods for recombinantly expressing a product of interest
US11242551B2 (en)	2013-12-20	2022-02-08	Novartis Ag	Eukaryotic cells and methods for recombinantly expressing a product of interest
JP6265020B2 (ja) *	2014-04-16	2018-01-24	Jnc株式会社	エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
PL3137595T3 (pl)	2014-04-29	2019-09-30	Novartis Ag	Nowe komórki kręgowców i sposoby ekspresji rekombinowanej polipeptydu będącego przedmiotem zainteresowania
JP6661549B2 (ja) *	2014-05-19	2020-03-11	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	ポリペプチドの産生の方法
KR20160068558A (ko)	2014-12-05	2016-06-15	삼성바이오에피스 주식회사	마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
MY194040A (en)	2015-03-05	2022-11-09	Ab2 Bio Sa	Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases
PL3283634T3 (pl)	2015-04-14	2019-10-31	Janssen Vaccines & Prevention Bv	Rekombinowany adenowirus eksprymujący dwa transgeny z dwukierunkowym promotorem
WO2017132376A1 (en)	2016-01-27	2017-08-03	Just Biotherapeutics, Inc.	Hybrid promoter and uses thereof
RU2758238C2 (ru)	2016-05-12	2021-10-26	Янссен Вэксинс Энд Превеншн Б.В.	Эффективный и сбалансированный двунаправленный промотор
RU2745500C2 (ru)	2016-06-20	2021-03-25	Янссен Вэксинс Энд Превеншн Б.В.	Эффективный и сбалансированный двунаправленный промотор
KR101864581B1 (ko) *	2016-11-04	2018-07-13	국립암센터	양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도
SG11201906271QA (en)	2017-02-09	2019-08-27	Janssen Vaccines & Prevention Bv	Potent and short promoter for expression of heterologous genes
JP2020536513A (ja)	2017-10-02	2020-12-17	アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａＡｋｔｉｅｂｏｌａｇ	タンパク質産生の増加のための細胞株及び方法
EP3891278A4 (en) *	2018-12-04	2022-08-31	Catalent Pharma Solutions, LLC	PROTEIN MANUFACTURE VECTORS

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US7812148B2 (en) *	2001-04-05	2010-10-12	Millipore Corporation	Vectors comprising CpG islands without position effect varigation and having increased expression
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EA010096B1 (ru) *	2003-03-11	2008-06-30	Лаборатуар Сероно Са	Экспрессирующие векторы, содержащие ie2-промотор mcmv
JP5074030B2 (ja)	2003-05-13	2012-11-14	メルクセローノソシエテアノニム	Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
WO2005040384A1 (en)	2003-10-21	2005-05-06	Applied Research Systems Ars Holding N.V.	Minimal dna sequence acting as a chromatin insulator and its use in protein expression
ME01198B (me)	2003-11-05	2013-03-20	Ares Trading Sa	Prečišćavanje il-18 vezujućeg proteina
ATE375385T1 (de)	2004-03-01	2007-10-15	Ares Trading Sa	Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
WO2006003134A1 (en)	2004-06-29	2006-01-12	Ares Trading S.A.	Process for the purification of il-18 binding protein
EP1819812B1 (en) *	2004-12-02	2012-05-30	Merck Serono SA	The lupac bifunctional marker and its use in protein production
DK2267024T3 (da)	2005-06-03	2012-06-25	Ares Trading Sa	Fremstilling af rekombinant II-18 bindingsprotein
PL1891088T3 (pl)	2005-06-10	2012-03-30	Ares Trading Sa	Sposób oczyszczania białka wiążącego IL-18
BR112013024781B1 (pt) *	2011-04-01	2021-09-08	Chugai Seiyaku Kabushiki Kaisha	Métodos de produção de um anticorpo e de uma composição farmacêutica

2004
- 2004-03-10 EA EA200501444A patent/EA010096B1/ru not_active IP Right Cessation
- 2004-03-10 EP EP04718972A patent/EP1601776B1/en not_active Expired - Lifetime
- 2004-03-10 JP JP2006505456A patent/JP5171033B2/ja not_active Expired - Lifetime
- 2004-03-10 CA CA2516157A patent/CA2516157C/en not_active Expired - Lifetime
- 2004-03-10 DK DK04718972T patent/DK1601776T3/da active
- 2004-03-10 PL PL04718972T patent/PL1601776T4/pl unknown
- 2004-03-10 US US10/548,364 patent/US7824907B2/en active Active
- 2004-03-10 CN CNB2004800067294A patent/CN100429315C/zh not_active Expired - Lifetime
- 2004-03-10 MX MXPA05009608A patent/MXPA05009608A/es active IP Right Grant
- 2004-03-10 AU AU2004219917A patent/AU2004219917B2/en not_active Expired
- 2004-03-10 BR BRPI0408246-0A patent/BRPI0408246A/pt not_active Application Discontinuation
- 2004-03-10 AT AT04718972T patent/ATE399872T1/de active
- 2004-03-10 ES ES04718972T patent/ES2309508T3/es not_active Expired - Lifetime
- 2004-03-10 DE DE602004014738T patent/DE602004014738D1/de not_active Expired - Lifetime
- 2004-03-10 SI SI200430835T patent/SI1601776T1/sl unknown
- 2004-03-10 WO PCT/EP2004/050280 patent/WO2004081167A2/en active IP Right Grant
- 2004-03-10 RS YUP-2005/0687A patent/RS50488B/sr unknown
- 2004-03-10 PT PT04718972T patent/PT1601776E/pt unknown
- 2004-03-10 KR KR1020057015746A patent/KR101180139B1/ko active IP Right Grant
- 2004-10-03 UA UAA200509529A patent/UA88138C2/ru unknown
2005
- 2005-08-09 HR HRP20050705AA patent/HRP20050705B1/hr not_active IP Right Cessation
- 2005-08-11 ZA ZA200506400A patent/ZA200506400B/en unknown
- 2005-09-08 IL IL170754A patent/IL170754A/en unknown
- 2005-10-10 NO NO20054642A patent/NO333818B1/no unknown
2006
- 2006-07-14 HK HK06107903A patent/HK1085766A1/xx not_active IP Right Cessation
2008
- 2008-09-16 CY CY20081100997T patent/CY1108344T1/el unknown
2010
- 2010-08-31 US US12/872,151 patent/US9051582B2/en active Active
2012
- 2012-07-13 JP JP2012157563A patent/JP5848202B2/ja not_active Expired - Lifetime
2015
- 2015-05-20 US US14/716,937 patent/US20150252383A1/en not_active Abandoned
- 2015-06-10 JP JP2015117538A patent/JP2015180222A/ja active Pending

Also Published As

Publication number	Publication date
EP1601776A2 (en)	2005-12-07
SI1601776T1 (sl)	2008-10-31
JP2006520589A (ja)	2006-09-14
ATE399872T1 (de)	2008-07-15
US20070258962A1 (en)	2007-11-08
EP1601776B1 (en)	2008-07-02
WO2004081167A3 (en)	2004-11-04
US20110008839A1 (en)	2011-01-13
RS50488B (sr)	2010-03-02
PL1601776T4 (pl)	2009-05-29
PT1601776E (pt)	2008-09-17
JP2015180222A (ja)	2015-10-15
UA88138C2 (en)	2009-09-25
AU2004219917A1 (en)	2004-09-23
NO20054642L (no)	2005-10-10
JP5171033B2 (ja)	2013-03-27
HRP20050705A2 (en)	2005-12-31
BRPI0408246A (pt)	2006-03-01
HRP20050705B1 (hr)	2013-08-31
EA200501444A1 (ru)	2006-02-24
DE602004014738D1 (de)	2008-08-14
EA010096B1 (ru)	2008-06-30
HK1085766A1 (en)	2006-09-01
CY1108344T1 (el)	2014-02-12
JP2012235787A (ja)	2012-12-06
US20150252383A1 (en)	2015-09-10
MXPA05009608A (es)	2006-03-21
US9051582B2 (en)	2015-06-09
NO333818B1 (no)	2013-09-23
CN1759184A (zh)	2006-04-12
PL1601776T3 (pl)	2008-12-31
WO2004081167A2 (en)	2004-09-23
CA2516157C (en)	2012-09-18
CA2516157A1 (en)	2004-09-23
ZA200506400B (en)	2006-12-27
CN100429315C (zh)	2008-10-29
IL170754A (en)	2010-11-30
ES2309508T3 (es)	2008-12-16
US7824907B2 (en)	2010-11-02
KR101180139B1 (ko)	2012-09-13
JP5848202B2 (ja)	2016-01-27
AU2004219917B2 (en)	2008-01-31
RS20050687A (en)	2007-11-15
KR20050113193A (ko)	2005-12-01

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DK1601776T3 (da)	2008-10-13	Ekspressionsvektorer omfattende mCmV-IE2-promotoren
ITMI20030709A1 (it)	2003-10-13	Miscele di stabilizzanti.
DE602004024107D1 (de)	2009-12-24	Vektoren zur gerichteten klonierung
EP1344827A3 (en)	2003-10-15	Antifreeze proteins from basidiomycetes
WO2004087874A3 (en)	2005-12-22	Novel nucleic acids and polypeptides
WO2003074546A8 (de)	2003-11-20	Streptavidin-bindungspeptid
WO2002068465A3 (en)	2003-04-03	Novel p53-inducible protein
WO2002100895A3 (de)	2003-10-23	Antimikrobiell wirkendes peptid
ATE532861T1 (de)	2011-11-15	Expressionsvektor
SG146640A1 (en)	2008-10-30	Isolated photoprotein mtclytin, and use thereof
WO2004056964A3 (en)	2004-10-14	Vectors for inducible rna interference
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ZA200308303B (en)	2004-10-25	Condensates for the retanning of fe-tanned leather.
WO2003091447A3 (en)	2004-08-26	D1-1 nucleic acids, polypeptides and related methods
GB0520872D0 (en)	2005-11-23	Onion flavour compounds and use
HK1082510A1 (en)	2006-06-09	Promoter to il-18bp, its preparation and use
WO2003093300A3 (en)	2004-09-10	Anti-microbial peptides and compositions
SE0101519D0 (sv)	2001-04-27	Nucleic ACID
TW200617021A (en)	2006-06-01	Isolated photoprotein aequorin y89f, and its use
TW200716177A (en)	2007-05-01	Isolated photoprotein aqdecay, and its use
TW200716666A (en)	2007-05-01	Isolated photoprotein gr-bolinopsin, and its use
ITVR20030001A1 (it)	2004-07-09	Chiodo ad elica.
TH60455B (th)	2018-02-02	โมโนเนกาไวเรลส์ไวรัสเวคเตอร์ชนิดรีคอมบิแนนท์
TH90012A (th)	2008-06-10	โมโนเนกาไวเรลส์ไวรัสเวคเตอร์ชนิดรีคอมบิแนนท์
CY1115280T1 (el)	2017-01-04	Μεθοδος ρυθμισης εκφρασης γονιδιου