DK1587907T3 - Kunitz-domænebibliotek - Google Patents
Kunitz-domænebibliotekInfo
- Publication number
- DK1587907T3 DK1587907T3 DK04700617.6T DK04700617T DK1587907T3 DK 1587907 T3 DK1587907 T3 DK 1587907T3 DK 04700617 T DK04700617 T DK 04700617T DK 1587907 T3 DK1587907 T3 DK 1587907T3
- Authority
- DK
- Denmark
- Prior art keywords
- kunitz domain
- domain library
- libraries
- kunitz
- phage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Gyroscopes (AREA)
- Optical Communication System (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43849103P | 2003-01-07 | 2003-01-07 | |
PCT/US2004/000333 WO2004063337A2 (en) | 2003-01-07 | 2004-01-07 | Kunitz domain library |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1587907T3 true DK1587907T3 (da) | 2011-04-04 |
Family
ID=32713336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04700617.6T DK1587907T3 (da) | 2003-01-07 | 2004-01-07 | Kunitz-domænebibliotek |
Country Status (11)
Country | Link |
---|---|
US (2) | US20040209243A1 (da) |
EP (2) | EP2290107A1 (da) |
JP (2) | JP2007524348A (da) |
AT (1) | ATE500345T1 (da) |
AU (1) | AU2004204095B2 (da) |
CA (1) | CA2512590A1 (da) |
DE (1) | DE602004031589D1 (da) |
DK (1) | DK1587907T3 (da) |
ES (1) | ES2362424T3 (da) |
PT (1) | PT1587907E (da) |
WO (1) | WO2004063337A2 (da) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
EP1489097B1 (en) * | 1994-01-11 | 2011-10-19 | Dyax Corporation | Inhibitors of human plasmin derived from kunitz domains and nucleic acids encoding the same |
US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
DK2311432T3 (da) * | 2002-06-07 | 2015-02-02 | Dyax Corp | Modificerede Kunitz-domæne-polypeptider og deres anvendelse til reduktion af iskæmi eller indtræden af en systemisk inflammatorisk reaktion i forbindelse med en kirurgisk procedure |
US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
JP2008520729A (ja) * | 2004-11-22 | 2008-06-19 | ダイアックス コーポレーション | プラスミン阻害療法 |
CN101273053A (zh) * | 2005-07-13 | 2008-09-24 | 安进芒廷维尤公司 | Il-6结合蛋白 |
AU2008289005A1 (en) * | 2007-08-21 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
CA2747721C (en) | 2008-12-19 | 2021-07-20 | Baxter International Inc. | Tfpi inhibitors and methods of use |
CA2744235A1 (en) | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
LT3459564T (lt) | 2010-01-06 | 2022-03-10 | Takeda Pharmaceutical Company Limited | Plazmos kalikreiną surišantys baltymai |
NZ603028A (en) | 2010-03-19 | 2014-11-28 | Baxter Healthcare Sa | Tfpi inhibitors and methods of use |
BR112013017080A8 (pt) | 2011-01-06 | 2023-05-09 | Dyax Corp | Anticorpo ou fragmento funcional do mesmo que se liga a forma ativa de calicreína do plasma humano, composiçao farmacêutica e método de detecçao de calicreína do plasma em um paciente |
JP2015514070A (ja) | 2012-03-21 | 2015-05-18 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Tfpi阻害剤および使用方法 |
EP2883954B1 (en) | 2012-08-08 | 2020-07-08 | Daiichi Sankyo Company, Limited | Peptide library and use thereof |
EP3122782A4 (en) | 2014-03-27 | 2017-09-13 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
EP3177644B1 (en) | 2014-08-05 | 2020-10-07 | Mabquest SA | Immunological reagents binding to pd-1 |
US9982052B2 (en) | 2014-08-05 | 2018-05-29 | MabQuest, SA | Immunological reagents |
CN116869964A (zh) | 2014-12-24 | 2023-10-13 | 耐克西缪恩有限公司 | 用于免疫疗法的纳米颗粒组合物和方法 |
EP3371311B1 (en) | 2015-11-06 | 2021-07-21 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
CN108883150A (zh) | 2015-11-19 | 2018-11-23 | 阿斯克雷佩西治疗公司 | 具有抗血管生成、抗***生成以及消水肿性质的肽和纳米粒子制剂 |
KR20180094028A (ko) | 2015-12-11 | 2018-08-22 | 다이액스 코포레이션 | 혈장 칼리크레인 저해제 및 유전성 혈관부종 발작을 치료하기 위한 이의 용도 |
US11214617B2 (en) | 2016-01-22 | 2022-01-04 | MabQuest SA | Immunological reagents |
WO2017125815A2 (en) | 2016-01-22 | 2017-07-27 | MabQuest SA | Immunological reagents |
DK3411407T3 (da) | 2016-02-05 | 2024-07-01 | Orionis Biosciences BV | Bispecifikke signaleringsmidler og anvendelser deraf |
EP4276114A3 (en) | 2016-03-07 | 2024-02-21 | Vib Vzw | Cd20 binding single domain antibodies |
JP7105200B2 (ja) | 2016-05-13 | 2022-07-22 | オリオニス バイオサイエンシズ ビーブイ | 標的突然変異体インターフェロン-ベータおよびその使用 |
US11753463B2 (en) | 2016-05-13 | 2023-09-12 | Orionis Biosciences BV | Therapeutic targeting of non-cellular structures |
US20190225670A1 (en) | 2016-10-04 | 2019-07-25 | Asclepix Therapeutics, Llc | Compounds and methods for activating tie2 signaling |
US11084859B2 (en) | 2016-10-24 | 2021-08-10 | Orionis Biosciences BV | Targeted mutant interferon-gamma and uses thereof |
IL268346B1 (en) | 2017-02-06 | 2024-04-01 | Orionis Biosciences BV | Targeted chimeric proteins and their uses |
US10906985B2 (en) | 2017-02-06 | 2021-02-02 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
EP3580230A1 (en) | 2017-02-07 | 2019-12-18 | VIB vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
WO2019028427A1 (en) | 2017-08-03 | 2019-02-07 | Asclepix Therapeutics, Llc. | METHODS OF IDENTIFYING AND PREPARING PHARMACEUTICAL AGENTS TO ACTIVATE TIE2 RECEPTOR |
EP3710034A4 (en) | 2017-11-14 | 2022-01-26 | Arcellx, Inc. | MULTIFUNCTIONAL IMMUNOCELLULAR THERAPIES |
WO2019152979A1 (en) | 2018-02-05 | 2019-08-08 | Orionis Biosciences, Inc. | Fibroblast binding agents and use thereof |
CA3129834A1 (en) | 2019-02-15 | 2020-08-20 | Integral Molecular, Inc. | Claudin 6 antibodies and uses thereof |
JP2022520632A (ja) | 2019-02-15 | 2022-03-31 | インテグラル・モレキュラー・インコーポレイテッド | 共通軽鎖を含む抗体及びその使用 |
US20230000997A1 (en) | 2019-08-06 | 2023-01-05 | L.E.A.F. Holdings Group Llc | Processes of preparing polyglutamated antifolates and uses of their compositions |
GB202004514D0 (en) | 2020-03-27 | 2020-05-13 | Inst De Medicina Molecular Joaeo Lobo Antunes | Treatment of Immunosuppressive Cancer |
WO2024008755A1 (en) | 2022-07-04 | 2024-01-11 | Vib Vzw | Blood-cerebrospinal fluid barrier crossing antibodies |
WO2024077118A2 (en) | 2022-10-06 | 2024-04-11 | Bicara Therapeutics Inc. | Multispecific proteins and related methods |
US12049502B2 (en) | 2022-11-30 | 2024-07-30 | Integral Molecular, Inc. | Antibodies directed to claudin 6, including bispecific formats thereof |
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CA1340288C (en) | 1988-09-02 | 1998-12-29 | Robert Charles Ladner | Generation and selection of novel binding proteins |
DK0401508T3 (da) * | 1989-05-13 | 1995-05-15 | Bayer Ag | Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf |
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EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
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IL104325A (en) * | 1992-01-07 | 2000-10-31 | Novo Nordisk As | Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above |
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CA2170030A1 (en) * | 1993-09-14 | 1995-03-23 | Robert A. Lazarus | Pharmaceutical compositions containing ecotin and homologs thereof |
EP1489097B1 (en) * | 1994-01-11 | 2011-10-19 | Dyax Corporation | Inhibitors of human plasmin derived from kunitz domains and nucleic acids encoding the same |
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
DK0739355T3 (da) * | 1994-01-11 | 2005-01-24 | Dyax Corp | Kallikrein-inhiberende "Kunitz-domæne"-proteiner og analoger deraf |
US5795954A (en) * | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
DE19507166C1 (de) | 1995-03-01 | 1996-04-18 | Deutsches Krebsforsch | Antikörper gegen ein Histidin-Fusionspolypeptid, das einen Histidin-Anteil aufweist |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
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US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
JP3763505B2 (ja) | 1998-09-22 | 2006-04-05 | Tdk株式会社 | 薄膜磁気ヘッドの製造方法 |
US6472147B1 (en) | 1999-05-25 | 2002-10-29 | The Scripps Research Institute | Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries |
IL142025A0 (en) | 1999-07-20 | 2002-03-10 | Morphosys Ag | Novel methods for displaying (poly) peptides/proteins on bacteriophage particles via disulfide bonds |
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AU2002330162B2 (en) | 2001-10-01 | 2008-08-07 | Takeda Pharmaceutical Company Limited | Multi-chain eukaryotic display vectors and uses thereof |
US20030129659A1 (en) | 2001-12-03 | 2003-07-10 | Whelihan E. Fayelle | Library screening |
-
2004
- 2004-01-07 DE DE602004031589T patent/DE602004031589D1/de not_active Expired - Lifetime
- 2004-01-07 EP EP10012620A patent/EP2290107A1/en not_active Withdrawn
- 2004-01-07 AT AT04700617T patent/ATE500345T1/de active
- 2004-01-07 AU AU2004204095A patent/AU2004204095B2/en not_active Ceased
- 2004-01-07 ES ES04700617T patent/ES2362424T3/es not_active Expired - Lifetime
- 2004-01-07 JP JP2006500832A patent/JP2007524348A/ja active Pending
- 2004-01-07 WO PCT/US2004/000333 patent/WO2004063337A2/en active Search and Examination
- 2004-01-07 US US10/753,544 patent/US20040209243A1/en not_active Abandoned
- 2004-01-07 PT PT04700617T patent/PT1587907E/pt unknown
- 2004-01-07 CA CA002512590A patent/CA2512590A1/en not_active Abandoned
- 2004-01-07 EP EP04700617A patent/EP1587907B1/en not_active Expired - Lifetime
- 2004-01-07 DK DK04700617.6T patent/DK1587907T3/da active
-
2007
- 2007-07-09 US US11/774,964 patent/US20080020394A1/en not_active Abandoned
-
2010
- 2010-02-22 JP JP2010036225A patent/JP2010162030A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20040209243A1 (en) | 2004-10-21 |
AU2004204095B2 (en) | 2009-07-30 |
AU2004204095A1 (en) | 2004-07-29 |
US20080020394A1 (en) | 2008-01-24 |
ES2362424T3 (es) | 2011-07-05 |
EP1587907A4 (en) | 2007-11-14 |
EP1587907B1 (en) | 2011-03-02 |
WO2004063337A3 (en) | 2007-01-25 |
JP2010162030A (ja) | 2010-07-29 |
DE602004031589D1 (de) | 2011-04-14 |
PT1587907E (pt) | 2011-04-08 |
EP1587907A2 (en) | 2005-10-26 |
CA2512590A1 (en) | 2004-07-29 |
JP2007524348A (ja) | 2007-08-30 |
EP2290107A1 (en) | 2011-03-02 |
WO2004063337A2 (en) | 2004-07-29 |
ATE500345T1 (de) | 2011-03-15 |
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