DK1576091T3 - Human adult olefaktorisk stamcelle - Google Patents

Human adult olefaktorisk stamcelle

Info

Publication number
DK1576091T3
DK1576091T3 DK03719290.3T DK03719290T DK1576091T3 DK 1576091 T3 DK1576091 T3 DK 1576091T3 DK 03719290 T DK03719290 T DK 03719290T DK 1576091 T3 DK1576091 T3 DK 1576091T3
Authority
DK
Denmark
Prior art keywords
olefactory
stem cells
human adult
adult
human
Prior art date
Application number
DK03719290.3T
Other languages
English (en)
Inventor
Fred J Roisen
Kathleen M Klueber
Chengliang Lu
Original Assignee
Univ Louisville Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisville Res Found filed Critical Univ Louisville Res Found
Application granted granted Critical
Publication of DK1576091T3 publication Critical patent/DK1576091T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK03719290.3T 2002-01-28 2003-01-24 Human adult olefaktorisk stamcelle DK1576091T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35290602P 2002-01-28 2002-01-28
US10/112,658 US7838292B1 (en) 2001-03-29 2002-03-29 Methods for obtaining adult human olfactory progenitor cells
PCT/US2003/002292 WO2003064601A2 (en) 2002-01-28 2003-01-24 Adult human olfactory stem cell

Publications (1)

Publication Number Publication Date
DK1576091T3 true DK1576091T3 (da) 2012-11-19

Family

ID=27667948

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03719290.3T DK1576091T3 (da) 2002-01-28 2003-01-24 Human adult olefaktorisk stamcelle

Country Status (9)

Country Link
US (2) US7838292B1 (da)
EP (2) EP1576091B1 (da)
AU (1) AU2003223162B8 (da)
CA (1) CA2473353C (da)
DK (1) DK1576091T3 (da)
ES (1) ES2392163T3 (da)
IL (2) IL163128A (da)
PT (1) PT1576091E (da)
WO (1) WO2003064601A2 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8703121B2 (en) 2003-06-27 2014-04-22 DePuy Synthes Products, LLC Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
US7875272B2 (en) 2003-06-27 2011-01-25 Ethicon, Incorporated Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
AU2005322133B2 (en) 2004-12-23 2011-06-30 Ethicon Incorporated Treatment of Parkinson's disease and related disorders using postpartum derived cells
WO2007020611A2 (en) * 2005-08-19 2007-02-22 ECBIO - Investigação e Desenvolvimento em Biotecnologia, S.A. Adult human neural stem/progenitor cells from the olfactory epithelium and olfactory lamina propria, isolation method, proliferation and differentiation in serum free culture medium and utilization for transplantation
PL212052B1 (pl) * 2005-12-14 2012-08-31 Akademia Medyczna Im Piastow Śląskich We Wrocławiu Sposób pozyskiwania glejowych komórek węchowych i ich zastosowania
PL1971681T3 (pl) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
US8329166B2 (en) * 2005-12-16 2012-12-11 Academia Sinica Pluripotent olfactory stem cells
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
US20100068187A1 (en) * 2006-08-31 2010-03-18 Roisen Fred J Transcription factors for differentiation of adult human olfactory progenitor cells
US20100129327A1 (en) * 2006-10-11 2010-05-27 Sharon Oleskevich Method of treating hearing loss
DE102008008558A1 (de) * 2008-02-08 2009-08-13 Phenion Gmbh & Co. Kg Verfahren zur Gewinnung olfaktorischer Epithelzellen aus nicht-menschlichen embryonalen Stammzellen
WO2010051531A1 (en) 2008-10-31 2010-05-06 University Of Louisville Reserch Foundation, Inc. Olfactory epithelial-derived stem cells and methods of use therefor
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
ES2665883T3 (es) 2008-12-19 2018-04-30 DePuy Synthes Products, Inc. Tratamiento de enfermedades y trastornos pulmonares y pulmonares
WO2010111663A1 (en) 2009-03-26 2010-09-30 Ethicon, Inc. Human umbilical cord tissue cells as therapy for alzheimer' s disease
WO2012103109A2 (en) * 2011-01-24 2012-08-02 California Stem Cell, Inc. Neural cell purification for transplantation
WO2012164137A1 (es) 2011-05-30 2012-12-06 Fundación Investigación En Regeneración Del Sistema Nervioso Células madre y células de la estirpe neural derivadas de la glía envolvente olfatoria, y sus aplicaciones
AU2012328582A1 (en) * 2011-10-26 2014-05-01 University Of Louisville Research Foundation, Inc. Methods and compositions for treating diabetes and other degenerative neuroendocrine diseases or disorders
RU2636220C2 (ru) 2011-12-23 2017-11-21 Депуи Синтез Продактс, Инк. Обнаружение клеток, полученных из ткани пуповины человека
US9861663B2 (en) * 2012-02-23 2018-01-09 Technion Research & Development Foundation Ltd. Ex-vivo vascularized implant composition comprising poly-l-lactic acid, polylactic-co-glycolic-acid and olfactory bulb cells

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863899A (en) 1983-05-09 1989-09-05 Todaro George J Biologically active polypeptides
US5240912A (en) 1983-05-09 1993-08-31 Todaro George J Transforming growth factor (TGF) peptides
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5459039A (en) 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
US5411883A (en) * 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
WO1991009936A1 (en) 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
US5869266A (en) * 1990-03-06 1999-02-09 The United States Of America As Represented By The Department Of Health And Human Services Human olfactory neuron cultures to diagnose Alzheimer's disease
US5196315A (en) 1990-05-01 1993-03-23 The Johns Hopkins University Human neuronal cell line
US5618531A (en) 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
US5217893A (en) 1990-12-31 1993-06-08 The Johns Hopkins University Primary culture of olfactory neurons
US6497872B1 (en) 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
US5980885A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US6399369B1 (en) 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US7361505B1 (en) 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US7166277B1 (en) 1991-07-08 2007-01-23 Neurospheres Holdings Ltd. Remyelination of neurons using multipotent neural stem cell progeny
US5308763A (en) 1991-10-01 1994-05-03 The Johns Hopkins University Method of making primary culture of olfactory neurons
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
US6001654A (en) 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
NZ294906A (en) 1994-11-08 2000-03-27 Cellfactors Plc Producing large population of neural cells and cell lines, typically human that are pleiotropic but will differentiate following specific treatment
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5830651A (en) 1995-06-01 1998-11-03 Signal Pharmaceuticals, Inc. Human oligodendroglial progenitor cell line
US5753505A (en) 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
CA2213780C (en) 1996-08-26 2012-02-21 Freda Miller Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
US6787355B1 (en) 1996-08-26 2004-09-07 Mcgill University Multipotent neural stem cells from peripheral tissues and uses thereof
US6969608B1 (en) 1996-08-26 2005-11-29 Mcgill University Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
CA2216439A1 (en) 1996-09-25 1998-03-25 Derek Van Der Kooy Pharmaceuticals containing retinal stem cells
WO1998030678A1 (en) 1997-01-07 1998-07-16 Steindler Dennis A Isolated mammalian neural stem cells, methods of making such cells, and methods of using such cells
US6162428A (en) 1997-02-12 2000-12-19 Layton Bioscience, Inc. hNT-neuron human neuronal cells to replace ganglion cells
US6235527B1 (en) 1997-11-29 2001-05-22 University Of Utah Research Foundation Lineage restricted glial precursors from the central nervous system
US20020016002A1 (en) 2000-01-24 2002-02-07 Jean Toma Multipotent neural stem cells from peripheral tissues and uses thereof
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
US6638501B1 (en) 1997-09-29 2003-10-28 Neurospheres Holdings Ltd. Use of multipotent neural stem cell progeny to augment non-neural tissues
US6165783A (en) 1997-10-24 2000-12-26 Neuro Spheres Holdings Ltd. Erythropoietin-mediated neurogenesis
US6129911A (en) 1998-07-10 2000-10-10 Rhode Island Hospital, A Lifespan Partner Liver stem cell
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US6284539B1 (en) 1998-10-09 2001-09-04 Neuralstem Biopharmaceuticals, Ltd. Method for generating dopaminergic cells derived from neural precursors
US6468794B1 (en) 1999-02-12 2002-10-22 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US6238922B1 (en) 1999-02-26 2001-05-29 Stemcells, Inc. Use of collagenase in the preparation of neural stem cell cultures
US20020099008A1 (en) 1999-04-26 2002-07-25 Daniel R. Twardzik Method for stimulating hematopoiesis using tgf-alpha
ATE364315T1 (de) 1999-04-26 2007-07-15 Applied Protein Sciences Llc Tgf-alpha polypeptide, funktionelle fragmente und verfahren zu ihrer anwendung
JP2003508018A (ja) 1999-05-06 2003-03-04 ステム・セル・サイエンシイズ・ピーティーワイ・リミテッド 異核共存体の作成を介した細胞のリプログラミング法
WO2001005940A2 (en) 1999-07-16 2001-01-25 Neurotrophic Bioscience, Inc. Methods for producing and preparing cells for cell therapy
US6815418B2 (en) 1999-08-19 2004-11-09 Kaleidos Pharma, Inc. TGF-α polypeptides, functional fragments and methods of use therefor
US20020193301A1 (en) 1999-08-19 2002-12-19 Stem Cell Pharmaceuticals, Inc. TGF-alpha polypeptides, functional fragments and methods of use therefor
US6677307B2 (en) 1999-08-19 2004-01-13 Kaleidos Pharma, Inc. TGF-α polypeptides, functional fragments and methods of use therefor
US6878543B1 (en) 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
AUPQ369599A0 (en) 1999-10-27 1999-11-18 Griffith University A method of preparing olfactory cells for transplantation
US7544509B2 (en) 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
US20020169102A1 (en) 2001-04-03 2002-11-14 Frey William H. Intranasal delivery of agents for regulating development of implanted cells in the CNS
WO2002083877A1 (en) 2001-04-11 2002-10-24 Stem Cell Therapeutics Inc. Production of tyrosine hydroxylase positive neurons
AU2002315337A1 (en) 2001-06-18 2003-01-02 Psychiatric Genomics, Inc. Method for neural stem cell differentiation using valproate
EP1406998B1 (en) 2001-06-22 2007-08-22 StemCells, Inc. Liver engrafting cells, assays, and uses thereof
CA2364095C (en) 2001-07-20 2011-07-12 Neurostasis, Inc Production of radial glial cells
JP3993560B2 (ja) 2001-08-30 2007-10-17 ステム セル セラピューティクス インコーポレイテッド 神経幹細胞の分化およびその治療用途
AU2002325711C1 (en) 2001-09-14 2008-05-29 Stem Cell Therapeutics Inc. Prolactin induced increase in neutral stem cell numbers and therapeutical use thereof
WO2003063585A1 (en) 2002-01-31 2003-08-07 Griffith University Animal model
EP2095823A1 (en) 2002-07-30 2009-09-02 Stem Cell Therapeutics Inc. GM-CSF for treating demyelination
CA2492442A1 (en) 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
WO2004053071A2 (en) 2002-12-09 2004-06-24 Judith Kelleher-Andersson Method for discovering neurogenic agents
JP4676442B2 (ja) 2003-12-02 2011-04-27 セラヴィー バイオサイエンシズ エルエルシー 神経前駆細胞を増殖させるための組成物および方法
WO2006055685A2 (en) 2004-11-17 2006-05-26 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
AU2005312302A1 (en) 2004-12-01 2006-06-08 Stem Cell Therapeutics Corp. Platelet-derived growth factor-responsive neural precursor cells and progeny thereof
WO2007036033A1 (en) 2005-09-27 2007-04-05 Stem Cell Therapeutics Corp. Oligodendrocyte precursor cell proliferation regulated by prolactin

Also Published As

Publication number Publication date
CA2473353C (en) 2016-01-19
IL163128A (en) 2010-12-30
PT1576091E (pt) 2012-12-04
US20110014695A1 (en) 2011-01-20
IL208130A0 (en) 2011-07-31
EP1576091B1 (en) 2012-09-12
WO2003064601A2 (en) 2003-08-07
US7838292B1 (en) 2010-11-23
WO2003064601A8 (en) 2004-04-29
EP2308962A1 (en) 2011-04-13
AU2003223162B8 (en) 2010-01-07
ES2392163T3 (es) 2012-12-05
AU2003223162A1 (en) 2003-09-18
AU2003223162B2 (en) 2009-06-04
CA2473353A1 (en) 2003-08-07
EP1576091A4 (en) 2008-07-02
WO2003064601A3 (en) 2007-11-22
EP1576091A2 (en) 2005-09-21

Similar Documents

Publication Publication Date Title
DK1576091T3 (da) Human adult olefaktorisk stamcelle
DE60319848D1 (de) Medikament mit mesenchym-stammzellen
DE10393673D2 (de) Wirbelkörperplatzhalter
DE10393091D2 (de) Wirbelkörperplatzhalter
ATE409447T1 (de) Bequem windel
DE60312054D1 (de) Prothese
ATE390898T1 (de) Zwischenwirbelimplantat
ATE394087T1 (de) Zwischenwirbelimplantat
ATE394086T1 (de) Zwischenwirbelimplantat
IS7663A (is) Starfrænar hjartavöðvafrumur úr mannafósturstofnfrumum
ES1054821Y (es) Peonza de juguete
DE60327986D1 (de) Sitzstruktur
DE60314931D1 (de) Sitzstruktur
GB2407821B (en) Stem Cells
AU2003247514A8 (en) Meningeal-derived stem cells
DE50308359D1 (de) Armlehne
DE50308343D1 (de) Armlehne
EP1637589A4 (en) NEW STEM CELL DERIVED FROM ADULT FABRIC AND THEIR USE
FR2837877B1 (fr) Modele de superstatoreacteur
DE60313015D1 (de) Künstlicher satellit
AU2003217037A8 (en) Stem cell therapy
DE10392685D2 (de) Sitzmöbel
NO20022747L (no) Behandlingsstol
FI20021353A (fi) Istuin
FR2846209B1 (fr) Structure de couchage