DK1572169T3 - Påvisning og modulering af Slit- og Robo-medieret angiogenese og anvendelser deraf - Google Patents

Påvisning og modulering af Slit- og Robo-medieret angiogenese og anvendelser deraf

Info

Publication number
DK1572169T3
DK1572169T3 DK03716469.6T DK03716469T DK1572169T3 DK 1572169 T3 DK1572169 T3 DK 1572169T3 DK 03716469 T DK03716469 T DK 03716469T DK 1572169 T3 DK1572169 T3 DK 1572169T3
Authority
DK
Denmark
Prior art keywords
robo
slit
modulation
applications
detection
Prior art date
Application number
DK03716469.6T
Other languages
English (en)
Inventor
Jian-Guo Geng
Original Assignee
Shanghai Inst Biol Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Inst Biol Sciences filed Critical Shanghai Inst Biol Sciences
Application granted granted Critical
Publication of DK1572169T3 publication Critical patent/DK1572169T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Eye Examination Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK03716469.6T 2002-03-08 2003-03-10 Påvisning og modulering af Slit- og Robo-medieret angiogenese og anvendelser deraf DK1572169T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36248502P 2002-03-08 2002-03-08
PCT/US2003/007458 WO2003075860A2 (en) 2002-03-08 2003-03-10 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof

Publications (1)

Publication Number Publication Date
DK1572169T3 true DK1572169T3 (da) 2013-10-21

Family

ID=27805180

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03716469.6T DK1572169T3 (da) 2002-03-08 2003-03-10 Påvisning og modulering af Slit- og Robo-medieret angiogenese og anvendelser deraf

Country Status (8)

Country Link
US (1) US7939497B2 (da)
EP (2) EP2316853A3 (da)
AU (1) AU2003220173A1 (da)
DK (1) DK1572169T3 (da)
ES (1) ES2431040T3 (da)
PT (1) PT1572169E (da)
SI (1) SI1572169T1 (da)
WO (1) WO2003075860A2 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60127986T2 (de) * 2000-11-06 2008-01-17 Cancer Research Technology Ltd. Bildgebende verfahren, diagnose und behandlung von krankheiten
AU2003247828B2 (en) * 2002-06-27 2010-05-20 University Of Utah Research Foundation Methods and compositions for manipulating the guided navigation of endothelial tubes during angiogenesis
AU2003285500B8 (en) * 2002-11-20 2011-02-03 Cancer Research Technology Limited Antibodies binding to human magic roundabout (MR), polypeptides and uses thereof for inhibition of angiogenesis
US20060025335A1 (en) * 2004-01-30 2006-02-02 Kinane Thomas B Netrin compositions and methods of using the same
ATE550661T1 (de) * 2004-03-31 2012-04-15 Hiroyuki Aburatani Krebsdiagnose und behandlung unter verwendung eines anti-robo1-antikörper
US8940488B2 (en) 2004-03-31 2015-01-27 Hiroyuki Aburatani Cancer diagnosis and treatment of cancer using anti-robo 1 antibody
JP2010512327A (ja) 2006-12-11 2010-04-22 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 病的血管形成および脈管透過性の処置用の組成物および方法
AU2008216495A1 (en) * 2007-02-09 2008-08-21 Genentech, Inc. Anti-Robo4 antibodies and uses therefor
CN101687014A (zh) * 2008-04-16 2010-03-31 犹他大学研究基金会 用于治疗病理性血管生成和血管通透的组合物和方法
JP2012514462A (ja) * 2009-01-06 2012-06-28 ファンクショナル・ジェネティクス・インコーポレーテッド 熱非対称インターレース（ｔａｉｌ）ｐｃｒを用いたランダムホモ接合性遺伝子摂動（ｒｈｇｐ）
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
CN102233134A (zh) * 2010-04-30 2011-11-09 中国科学院上海生命科学研究院 Slit-robo介导的***形成及其应用
WO2012042289A1 (en) * 2010-09-28 2012-04-05 Inserm ( Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of bone density related diseases
KR20130132880A (ko) 2010-12-23 2013-12-05 사노피 간암의 치료에 사용하기 위한 ｒｏｂｏ１－ｆｃ 융합 단백질
LT2800578T (lt) * 2012-01-05 2019-02-11 Boston Medical Center Corporation Slit-robo signalo perdavimas, skirtas inkstų ligos diagnozavimui ir gydymui
KR101897322B1 (ko) * 2015-01-21 2018-09-10 재단법인 아산사회복지재단 원발성 갑상선암 전이의 진단방법 및 이를 이용한 진단키트
CN104711279B (zh) * 2015-03-17 2018-03-02 山东一达启航生物科技有限公司 一种血管内皮生长因子检测试剂盒及其原料制备
BR112019024742A2 (pt) 2017-06-02 2020-06-16 Pfizer Inc. Proteínas robo2 recombinantes, composições, métodos e usos das mesmas

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Publication number Priority date Publication date Assignee Title
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE4221256C2 (de) 1992-06-26 1997-07-10 Lancaster Group Ag Galenische Zusammensetzung für die topische Anwendung
US5869305A (en) 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5741511A (en) 1995-04-12 1998-04-21 Sam Yang Co., Ltd. Transdermal drug delivery device for treating erectile dysfunction
US5888767A (en) 1996-11-27 1999-03-30 The Johns Hopkins University School Of Medicine Method of using a conditionally replicating viral vector to express a gene
US5941868A (en) 1995-12-22 1999-08-24 Localmed, Inc. Localized intravascular delivery of growth factors for promotion of angiogenesis
US5736154A (en) 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
SE9703226D0 (sv) 1997-09-08 1997-09-08 Astra Ab New pharmaceutical composition
JP2003517262A (ja) * 1997-10-20 2003-05-27 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 神経誘導に含まれるポリペプチド及び核酸のファミリーであるｒｏｂｏ
US6197801B1 (en) 1998-01-14 2001-03-06 Usa Doctors Products, Inc. Injectable pharmaceutical composition for treatment and reversal of erectile dysfunction
US5962274A (en) 1998-03-13 1999-10-05 Wake Forest University Viral vector directed to predetermined target cells
EP1165591A4 (en) * 1999-03-26 2002-09-25 Human Genome Sciences Inc 47 HUMAN SECRETED PROTEINS
US6811788B2 (en) 2000-01-19 2004-11-02 Baofa Yu Combinations and methods for treating neoplasms
AU2003285500B8 (en) * 2002-11-20 2011-02-03 Cancer Research Technology Limited Antibodies binding to human magic roundabout (MR), polypeptides and uses thereof for inhibition of angiogenesis

Also Published As

Publication number Publication date
EP1572169B1 (en) 2013-07-17
EP2316853A3 (en) 2011-10-05
EP2316853A2 (en) 2011-05-04
ES2431040T3 (es) 2013-11-22
WO2003075860A2 (en) 2003-09-18
EP1572169A2 (en) 2005-09-14
US7939497B2 (en) 2011-05-10
US20030236210A1 (en) 2003-12-25
AU2003220173A1 (en) 2003-09-22
WO2003075860A3 (en) 2006-08-17
PT1572169E (pt) 2013-10-08
AU2003220173A8 (en) 2003-09-22
SI1572169T1 (sl) 2013-12-31
EP1572169A4 (en) 2007-07-25

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