DK155329C - 7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner - Google Patents

7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner

Info

Publication number
DK155329C
DK155329C DK453687A DK453687A DK155329C DK 155329 C DK155329 C DK 155329C DK 453687 A DK453687 A DK 453687A DK 453687 A DK453687 A DK 453687A DK 155329 C DK155329 C DK 155329C
Authority
DK
Denmark
Prior art keywords
aminocephalosporines
cephalosporines
acylamino
intermediates
preparation
Prior art date
Application number
DK453687A
Other languages
English (en)
Other versions
DK453687D0 (da
DK155329B (da
DK453687A (da
Inventor
Marc Montavon
Roland Reiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK453687D0 publication Critical patent/DK453687D0/da
Publication of DK453687A publication Critical patent/DK453687A/da
Publication of DK155329B publication Critical patent/DK155329B/da
Application granted granted Critical
Publication of DK155329C publication Critical patent/DK155329C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56One oxygen atom and one sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36Methylene radicals, substituted by sulfur atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK453687A 1974-06-21 1987-08-28 7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner DK155329C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives
CH853774 1974-06-21

Publications (4)

Publication Number Publication Date
DK453687D0 DK453687D0 (da) 1987-08-28
DK453687A DK453687A (da) 1987-08-28
DK155329B DK155329B (da) 1989-03-28
DK155329C true DK155329C (da) 1989-08-07

Family

ID=4341690

Family Applications (2)

Application Number Title Priority Date Filing Date
DK271975A DK153155C (da) 1974-06-21 1975-06-17 Analogifremgangsmaade til fremstilling af cephalosporiner
DK453687A DK155329C (da) 1974-06-21 1987-08-28 7-aminocephalosporiner til anvendelse som mellemprodukter ved fremstilling af terapeutisk virksomme 7-acylamino-cephalosporiner

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK271975A DK153155C (da) 1974-06-21 1975-06-17 Analogifremgangsmaade til fremstilling af cephalosporiner

Country Status (25)

Country Link
JP (1) JPS625917B2 (da)
AT (1) AT337897B (da)
AU (1) AU498387B2 (da)
BE (1) BE830455A (da)
BR (1) BR7503782A (da)
CA (1) CA1111021A (da)
CH (1) CH609989A5 (da)
CU (1) CU34293A (da)
DD (1) DD121113A5 (da)
DE (1) DE2527291A1 (da)
DK (2) DK153155C (da)
FI (1) FI751815A (da)
FR (1) FR2275215A1 (da)
GB (1) GB1471804A (da)
HU (1) HU170576B (da)
IE (1) IE41888B1 (da)
IL (1) IL47299A (da)
LU (1) LU72771A1 (da)
NL (1) NL180665C (da)
NO (1) NO752202L (da)
NZ (1) NZ177508A (da)
PH (1) PH13030A (da)
SE (1) SE431755B (da)
SU (2) SU635873A3 (da)
ZA (1) ZA753086B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FR2474030A1 (fr) * 1980-01-17 1981-07-24 Rhone Poulenc Ind Nouvelles dioxotriazines et leur preparation
FR2494278A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine, leurs preparations et les medicaments qui les contiennent
JP2004537985A (ja) * 2001-04-19 2004-12-24 ビオフェルマ ムルシア,エス.アー. セファロスポリン誘導体を製造する方法
US8637522B2 (en) * 2008-03-05 2014-01-28 Merck Patent Gmbh Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) * 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins

Also Published As

Publication number Publication date
PH13030A (en) 1979-11-15
DK271975A (da) 1975-12-22
IE41888B1 (en) 1980-04-23
DE2527291A1 (de) 1976-01-08
AU8191275A (en) 1976-12-09
DK153155B (da) 1988-06-20
AT337897B (de) 1977-07-25
NZ177508A (en) 1978-04-03
CA1111021A (en) 1981-10-20
CU34293A (es) 1979-01-16
NL7507390A (nl) 1975-12-23
CH609989A5 (en) 1979-03-30
DE2527291C2 (da) 1988-01-14
DK453687D0 (da) 1987-08-28
IL47299A0 (en) 1976-10-31
NL180665C (nl) 1987-04-01
ZA753086B (en) 1976-04-28
FI751815A (da) 1975-12-22
DD121113A5 (da) 1976-07-12
SE7506908L (sv) 1975-12-22
SE431755B (sv) 1984-02-27
FR2275215A1 (fr) 1976-01-16
BR7503782A (pt) 1976-07-06
SU589921A3 (ru) 1978-01-25
NO752202L (da) 1975-12-23
DK155329B (da) 1989-03-28
ATA476975A (de) 1976-11-15
DK453687A (da) 1987-08-28
LU72771A1 (da) 1977-03-04
BE830455A (fr) 1975-12-22
NL180665B (nl) 1986-11-03
DK153155C (da) 1988-10-31
HU170576B (da) 1977-07-28
IL47299A (en) 1979-01-31
GB1471804A (en) 1977-04-27
AU498387B2 (en) 1979-03-08
JPS625917B2 (da) 1987-02-07
IE41888L (en) 1975-12-21
JPS5113793A (da) 1976-02-03
SU635873A3 (ru) 1978-11-30
FR2275215B1 (da) 1980-05-16

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