DK154869B - INHALATION DEVICE FOR ADMINISTRATING MEDICINES - Google Patents
INHALATION DEVICE FOR ADMINISTRATING MEDICINES Download PDFInfo
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- DK154869B DK154869B DK47078A DK47078A DK154869B DK 154869 B DK154869 B DK 154869B DK 47078 A DK47078 A DK 47078A DK 47078 A DK47078 A DK 47078A DK 154869 B DK154869 B DK 154869B
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, DK 154869 B, DK 154869 B
Opfindelsen angår et inhalationsapparat til dispensering af medikamenter indeholdt i kapsler af den art, der har et kapsellegeme forsynet med en kapselhætte, eller i lignende beholdere, der i det følgende vil blive betegnet som "kapsler".The invention relates to an inhalation apparatus for dispensing medicaments contained in capsules of the type having a capsule body provided with a capsule cap, or in similar containers which will hereinafter be referred to as "capsules".
5 Inhalationsapparatet ifølge opfindelsen er af den art, der har et skålformet legeme med et indre kammer, mindst én luftindløbsåbning, der fører ind i kammeret, en udløbstud, gennem hvilken der kan suges luft fra kammeret, og organer til åbning af kapslen således, at det pulverformede medikament kan komme ud af den åbnede kapsel og 10 blive medført af den luft, der strømmer gennem kammeret, når luften indsuges gennem tuden.The inhalation apparatus according to the invention is of the type having a bowl-shaped body with an inner chamber, at least one air inlet opening leading into the chamber, an outlet nozzle through which air can be drawn from the chamber, and means for opening the capsule such that the powdered drug may come out of the opened capsule and be entrained by the air flowing through the chamber as the air is sucked in through the spout.
Det er velkendt at markedsføre medikamenter af forskellig art i gelatinekapsler med cylinder- eller torpedoform. Mange af disse kapsler er fremstillet i to dele, af hvilke den ene (der kaldes kapsellegemet) er 15 delvis indesluttet i den anden (der kaldes kapselhætten). Kapslerne indeholder et medikament i pulverform. Det er almindeligt at anvende sådanne kapsler med medikamenter til en patient, som skal inhalere pulveret gennem munden. Til dette formål er det velkendt at anvende dispensere, der har et mundstykke, gennem hvilket patienten kan 20 inhalere, og et kammer, gennem hvilket luft, der inhaleres af patienten eller tilføres patienten, kan passere og således medføre medikamentet fra en kapsel, der er blevet gennembrudt eller perforeret, så at medikamentet kan passere ud af kapslen og ind i kammeret.It is well known to market drugs of various kinds in gelatin capsules with cylinder or torpedo form. Many of these capsules are made in two parts, one of which (called the capsule body) is partially enclosed in the other (called the capsule cap). The capsules contain a powdered drug. It is common to use such capsules with medications for a patient who is to inhale the powder through the mouth. For this purpose, it is well known to use dispensers having a nozzle through which the patient can inhale and a chamber through which air inhaled by the patient or supplied to the patient can pass, thus carrying the drug from a capsule which is been pierced or perforated so that the drug can pass out of the capsule and into the chamber.
Fra dansk patentansøgning nr. 2493/74 kendes et inhalationsapparat, 25 hvor medikamentkapslen åbnes ved hjælp af et fremspring, der gennemborer kapslens ene ende og danner et lille hul i denne. Fra dansk patentansøgning nr. 4884/74 kendes et inhalationsapparat, hvor kapslen åbnes ved hjælp af et par knive, der frembringer indsnit i begge ender af kapslen. Ved begge disse kendte inhalationsapparater åbnes 30 kapslen altså ved en eller anden form for skæreoperation.From Danish Patent Application No. 2493/74 an inhalation apparatus 25 is known in which the drug capsule is opened by means of a projection which pierces one end of the capsule and forms a small hole therein. From Danish Patent Application No. 4884/74 an inhalation apparatus is known in which the capsule is opened by means of a pair of knives which produce incisions at both ends of the capsule. Thus, in both of these known inhalers, the capsule is opened by some form of cutting operation.
Kapsler fremstilles normalt af gelatine, der er et materiale, hvis egenskaber varierer i afhængighed af fugtindhold. Hvis gelatinen tørrer ud, bliver den skør, og den skærevirkning, der anvendes ved de 2Capsules are usually made of gelatin, a material whose properties vary depending on moisture content. If the gelatin dries out, it becomes brittle and the cutting effect used in the 2
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kendte inhalationsapparater, kan medføre dannelsen af små gelatinesplinter. Sådanne gelatinesplinter er naturligvis meget uheldige i et inhalationsapparat, idet de kan blive suget ned i patientens lunger sammen med medikamentet. Hvis gelatinen derimod indeholder megen 5 fugt, kan kapslen være vanskelig at skære i, hvilket bl.a. bevirker, at det fremspring, der anvendes ved et af de ovennævnte kendte apparater til frembringelse af et hul i kapslen, kan blive hængende fast i kapslen uden at kunne trækkes tilbage under indvirkning af kraften fra fremspringets returfjeder, så at der ikke i kapslen vil 10 blive dannet noget hul, gennem hvilket pulveret kan blive suget ud af kapslen.known inhalers may cause the formation of small gelatin splinters. Of course, such gelatin splinters are very unfortunate in an inhalation device as they can be sucked into the patient's lungs along with the drug. If, on the other hand, the gelatin contains a lot of 5 moisture, the capsule can be difficult to cut, which means causes the protrusion used in one of the aforementioned known apparatus to create a hole in the capsule may be stuck in the capsule without being retractable under the action of the return spring of the protrusion so that the some hole is formed through which the powder can be sucked out of the capsule.
Ved inhalationsapparatet ifølge opfindelsen søges disse ulemper ved de kendte inhalationsapparater imødegået, og ved opfindelsen er der blevet tilvejebragt et inhalationsapparat af den indledningsvis nævnte 15 art, der er ejendommeligt ved en inde i kammeret anbragt kapselholder, der er således indrettet, at en af de nævnte dele af kapslen kan fastholdes deri, at de kapselåbnende organer er indrettet til at indgribe med den anden del af den kapsel, der er fastholdt i kapselholderen, og at kapselholderen og de kapselåbnende organer er bevæge-20 lige i forhold til hinanden for adskillelse af de to kapseldele fra hinanden. I apparatet ifølge opfindelsen er der således ikke tale om, at kapslen udsættes for en skære- eller stikkeoperation, men kapslen åbnes ved, at de to dele, af hvilke kapslen er dannet, adskilles fra hinanden. Ved anvendelse af inhalationsapparatet ifølge opfindelsen er 25 der således ikke risiko for dannelse af gelatinesplinter eller lignende dele som dem, der kan dannes ved skære- eller stikkeoperationer.In the apparatus of the invention, these disadvantages are sought to be overcome by the known inhalers, and the invention has provided an inhalation apparatus of the kind mentioned initially, which is characterized by a capsule holder arranged inside the chamber, so arranged that one of the aforementioned portions of the capsule may be retained in that the capsule opening means is adapted to engage with the second portion of the capsule held in the capsule holder and the capsule holder and the capsule opening means are movable relative to each other for separation of the capsule. two capsule parts apart. Thus, in the apparatus of the invention, the capsule is not subjected to a cutting or stitching operation, but the capsule is opened by separating the two parts from which the capsule is formed. Thus, when using the inhalation apparatus of the invention, there is no risk of forming gelatin splinters or similar parts to those which can be formed by cutting or stitching operations.
Ved en udførelsesform for apparatet ifølge opfindelsen har det skålformede legeme to dele, af hvilke den ene kan glide ind i den anden, så at det skålformede legeme kan trækkes ud eller skydes sammen I 30 sin akseretning, medens der inde i og bevæget sammen med hver af de to dele er anbragt en trugformet del, idet de to trugformede dele er koaksiale i forhold til hinanden og anbragt således, at de ligger med ende mod ende, når de to dele af legemet er skudt sammen, og adskilt, når de to dele er trukket ud.In one embodiment of the apparatus according to the invention, the cup-shaped body has two parts, one of which can slide into the other, so that the cup-shaped body can be pulled out or pushed together in its axial direction, while inside and moving together with each other. of the two portions is a trough-shaped portion, the two trough-shaped portions being coaxial to each other and disposed so that they lie end to end when the two portions of the body are pushed together and separated when the two portions is pulled out.
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Ved en anden udførelsesform er kapselholderen en trugformet del, der er bevægelig inde i kammeret og tjener til at optage og fastholde kapsellegemet, medens kapselåbneorganerne er en notformet del, der er fastgjort til indersiden af kammeret i en sådan stilling, at den trugformede del kan bevæges aksialt i kammeret forbi den notformede del og således, at den notformede del under bevægelse af den trugformede del i én retning kan gå i indgreb med hætten på en kapsel, der fastholdes i den trugformede del, og skubbe den af kapsellegemet, ligesom der findes organer til at kaste kapsellegemet ud fra kapselholderen, efter at kapslens hætte er blevet fjernet, samt organer til at hindre kapselhætten og kapsellegemet i at passere gennem dysen, når der suges luft igennem denne.In another embodiment, the capsule holder is a trough-shaped portion which is movable within the chamber and serves to receive and retain the capsule body, while the capsule opening means is a groove-shaped portion attached to the inside of the chamber in such a position that the trough-shaped portion can be moved. axially in the chamber past the groove member and so that the groove member, in movement of the chute member, may engage in one direction with the cap of a capsule held in the chute member and push it by the capsule body, as are organs. for ejecting the capsule body from the capsule holder after the cap of the capsule has been removed, as well as means for preventing the capsule cap and capsule body from passing through the nozzle as air is drawn through it.
Ved en anden udførelsesform er en arbejdende del roterbar i forhold til det skålformede legeme og forbundet med et inde i dette værende magasin, der har en kapselholder, der strækker sig på langs af det skålformede legeme, men ligger forskudt fra dettes akse, og som er indrettet til at optage legemet af en kapsel, hvis resterende del rager ud fra holderen, medens der inde i kammeret er fastgjort et kapselåbneorgan indrettet til at indgribe med den udragende del af en i holderen anbragt kapsel, når den roterbare del og magasinet bringes til at rotere, hvorved den udragende del af kapslen adskilles fra den i holderen fastholdte del, ligesom der findes organer til at udkaste den fastholdte kapseldel fra holderen samt organer til at hindre de to kapseldele i at passere gennem dysen, når der suges luft gennem denne.In another embodiment, a working portion is rotatable relative to the cup-shaped body and connected to an inside magazine which has a capsule holder extending longitudinally of the cup-shaped body but displaced from its axis and which is arranged to receive the body of a capsule, the remainder of which protrudes from the holder, while inside the chamber is secured a capsule opening means adapted to engage with the protruding portion of a capsule when the rotatable member and magazine are brought into position. rotate, thereby separating the protruding portion of the capsule from the portion retained in the holder, as well as means for ejecting the retained capsule portion from the holder, and means for preventing the two capsule portions from passing through the nozzle as air is drawn through it.
Ved alle disse udførelsesformer har udløbet eller dysen fortrinsvis form af et mundstykke, men den kan også have en form, der gør det muligt at indsætte den i en patients næsebor.In all of these embodiments, the outlet or nozzle preferably takes the form of a mouthpiece, but it may also have a form which allows it to be inserted into a patient's nostril.
I det følgende vil udførelsesformer for inhalationsapparatet ifølge opfindelsen blive nærmere beskrevet under henvisning til tegningen, på hvilken fig. 1 viser et længdesnit i et inhalationsapparat, fig. 2 apparatet set fra enden, fig. 3 det samme som fig. 2, men med apparatets låg i åben stilling, fig. 4 et snit som det i fig. 1 viste, men med apparatets dele i en anden stilling, fig. 5 apparatet set i perspektiv med låget i åben stilling,In the following, embodiments of the inhaler according to the invention will be described in greater detail with reference to the drawing, in which 1 is a longitudinal sectional view of an inhaler; FIG. 2 shows the device from the end, FIG. 3 the same as FIG. 2, but with the lid of the apparatus in the open position; FIG. 4 is a sectional view similar to that of FIG. 1, but with the parts of the apparatus in a different position; 5 shows the device in perspective with the lid in the open position,
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fig. 7 og 8 længdesnit i det i fig. 6 viste apparat med apparatets dele i forskellige stillinger, fig. 9 en tredje udførelsesform for apparatet ifølge opfindelsen set i perspektiv og med delene adskilt, fig. 10 et længdesnit i det i fig. 9 viste apparat, fig. 11 og 12 det i fig. 9 og 10 viste apparat set fra enden og med mundstykket fjernet, men med apparatets dele vist i to forskellige stillinger, og fig. 13 et snit som det i fig. 10 viste, men med apparatets dele i en anden stilling.FIG. 7 and 8 are longitudinal sections in the embodiment of FIG. 6 with the parts of the apparatus in different positions; FIG. Fig. 9 is a perspective view of a third embodiment of the apparatus according to the invention and with the parts separated; 10 is a longitudinal section in the embodiment of FIG. 9; FIG. 11 and 12 the FIG. 9 and 10 are viewed from the end and with the nozzle removed, but with the parts of the apparatus shown in two different positions; 13 is a sectional view similar to that of FIG. 10 but with the parts of the apparatus in a different position.
Fig. 1-5 viser en udførelsesform for inhalationsapparatet ifølge opfindelsen, ved hjælp af hvilket medikamenter kan indføres i munden af en patient, og apparatet har et legeme med et i hovedsagen elliptisk ydre tværsnit, men med i hovedsagen cylindrisk indre form. Apparatets legeme består af to dele 1 og 2, af hvilke den ene del kan glide eller er forskydelig inde i den anden, så at legemet kan trækkes ud eller skubbes sammen i længderetningen. De to deles cylindriske inderflader danner et indre kammer 3. Den ene ende af den inderste eller mindste del 2 udrager fra den ene ende af den yderste eller største del 1, selv når den inderste del 2 er blevet skudt mest muligt ind i den yderste del 1. Delen 1 har en åben ende, der tjener som et mundstykke 4, der kan indføres i en patients mund. For at lette beskrivelsen vil legemets mundstykke 4 i det følgende blive anset for at være legemets forreste ende.FIG. 1-5 show an embodiment of the inhalation apparatus according to the invention, by means of which medicaments can be introduced into the mouth of a patient, and the apparatus has a body having a generally elliptical outer cross-section but with a generally cylindrical inner shape. The body of the apparatus consists of two parts 1 and 2, one of which can slide or is slidable within the other, so that the body can be pulled out or pushed lengthwise. The cylindrical inner surfaces of the two parts form an inner chamber 3. One end of the inner or smallest part 2 protrudes from one end of the outer or largest part 1, even when the inner part 2 has been pushed into the outer part as much as possible. 1. The portion 1 has an open end which serves as a mouthpiece 4 which can be inserted into a patient's mouth. For ease of description, the mouthpiece 4 of the body will hereinafter be considered to be the front end of the body.
Inde i delen 1 er der anbragt en aksialt rettet trugformet eller ’ kapseloptagende del 5, på hvilken den ene ende af en kapsel C kan fastholdes. Denne trugformede del 5 understøttes af arme 6 og har en tand 7, der indgriber med en kapsel C, der indsættes i den trugformede del 5. Der strømmer luft omkring og hen over kapslen. En lignende trugformet del eller et kapselåbneorgan 8 strækker sig aksialt inde i den bageste eller inderste del 2 af legemet og er beliggende koaksialt med den forreste trugformede del 5, så at den kan optage den anden ende af kapslen C. Den trugformede del 8 har et endestop 8a, der hindrer kapslens hætte i at bevæge sig i retning mod mundstykket 4. Den ydre cylinder 1 er opdelt på langs over en del af sin længde således, at der dannes et låg 9, der er hængslet til hoveddelen af cylinderen 1. Dette gør det muligt at indsætte eller fjerne en kapsel C fra de trugformede deleInside the portion 1 is provided an axially directed trough-shaped or capsule-receiving portion 5 on which one end of a capsule C may be secured. This trough-shaped portion 5 is supported by arms 6 and has a tooth 7 which engages with a capsule C inserted into the trough-shaped portion 5. Air flows around and over the capsule. A similar trough-shaped portion or capsule opening member 8 extends axially within the rear or inner portion 2 of the body and is located coaxially with the front trough-shaped portion 5 so that it can accommodate the other end of the capsule C. The trough-shaped portion 8 has a end stop 8a which prevents the cap of the capsule from moving in the direction of the nozzle 4. The outer cylinder 1 is divided longitudinally over a portion of its length to form a lid 9 which is hinged to the main part of the cylinder 1. This makes it possible to insert or remove a capsule C from the trough-shaped parts
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Låget 9 har en spændedel 10, der har en tand 7a og ligger over for den trugformede del 5, og som, når låget 9 lukkes, bevæges mod en kapsel i den trugformede del 5, så at denne kapsel gribes og fastklemmes. De trugformede dele 5 og 8 i apparatlegemet bevæges aksialt, når legemet trækkes ud (fig. 4), idet de så vil blive bevæget bort fra hinanden, hvorved kapslen vil blive delt i to dele, så at medikamentet i kapslen kan frigøres fra denne.The lid 9 has a clamping portion 10 which has a tooth 7a and faces the trough-shaped portion 5 and which, when the lid 9 is closed, is moved against a capsule in the trough-shaped portion 5 so that this capsule is gripped and clamped. The trough-shaped parts 5 and 8 of the apparatus body move axially as the body is pulled out (Fig. 4), then they will be moved away from each other, whereby the capsule will be divided into two parts so that the drug in the capsule can be released from it.
Et radialt luftindløb 12 strækker sig gennem låget 9 og ind i kammeret 3. I låget 9 findes der i nærheden af luftindløbet 12 trykorganer 13, der er indrettet til at ligge an mod den del af kapslen C, der understøttes af den bageste trugformede del 8.A radial air inlet 12 extends through the lid 9 and into the chamber 3. In the lid 9 there are in the vicinity of the air inlet 12 pressure means 13 arranged to abut the part of the capsule C supported by the rear trough-shaped part 8 .
Når apparatet skal anvendes, åbnes låget 9, og der indsættes en kapsel C i de trugformede dele 5 og 8, som så er skudt sammen. Kapselhætten anbringes i den trugformede del 8. Låget 9 lukkes så, og apparatlegemets dele 1 og 2 trækkes fra hinanden. Patienten fører derefter mundstykket 4 ind i munden og inhalerer gennem dette. Derved frembringes omkring kapsellegemet i den trugformede del 5 en turbulent luftstrøm, der er tilstrækkelig til at udtage pulver fra kapsellegemet. Det udtagne pulver medslæbes af og dispergeres i luften, der bringes til at strømme gennem apparatlegemet som følge af, at patienten inhalerer, og medikamentet føres derfor ind i patientens mund. De trugformede dele 5 og 8 kan om ønsket farvekodes eller på anden måde mærkes for at gøre det lettere for patienten at anbringe en tilsvarende mærket kapsel i den foretrukne stilling i de trugformede dele, dvs. med kapselhætten i den trugformede del 8 og med kapsellegemet i den trugformede del 5.When the apparatus is to be used, the lid 9 is opened and a capsule C is inserted into the trough-shaped parts 5 and 8, which are then pushed together. The capsule cap is placed in the trough-shaped part 8. The lid 9 is then closed and the parts 1 and 2 of the apparatus body are pulled apart. The patient then guides the mouthpiece 4 into the mouth and inhales through it. Thereby, in the trough-shaped portion 5, around the capsule body, a turbulent air flow is produced which is sufficient to extract powder from the capsule body. The withdrawn powder is entrained and dispersed in the air which is caused to flow through the device body as a result of the patient inhaling, and therefore the drug is introduced into the patient's mouth. The trough-shaped portions 5 and 8 may be color-coded or otherwise labeled if desired to facilitate the patient to place a correspondingly labeled capsule in the preferred position in the trough-shaped portions, i.e. with the capsule cap in the trough-shaped portion 8 and with the capsule body in the trough-shaped portion 5.
Den i fig. 6, 7 og 8 viste udførelsesform for inhalationsapparatet ifølge opfindelsen har et hult cylindrisk legeme 14, der i sit indre danner et kammer 15, som i det følgende vil blive kaldt et dispergeringskammer. Legemet 14 er lukket ved sin ene ende ved hjælp af en endevæg 16. En tud 17 passer ind over den anden (eller forreste) ende af legemet. Denne tud har fortrinsvis form af et mundstykke, der kan indføres i munden af en patient, men tuden kan om ønsket have en sådan størrelse og form, at den kan indsættes i en patients næsebor. Tuden vil i det følgende blive omtalt som et mundstykke.The FIG. 6, 7 and 8, the embodiment of the inhalation apparatus according to the invention has a hollow cylindrical body 14 which in its interior forms a chamber 15, which will in the following be called a dispersing chamber. The body 14 is closed at one end by an end wall 16. A spout 17 fits over the other (or front) end of the body. This spout preferably takes the form of a mouthpiece which can be inserted into the mouth of a patient, but if desired, the spout may be of such size and shape that it can be inserted into a patient's nostril. The spout will hereinafter be referred to as a mouthpiece.
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Dispergeringskammeret 15 indeholder en kapselholder eller en trugformet del 20 og en kapselåbnende not 25, der vil blive beskrevet i det følgende. Mundstykket 17 er forsynet med et beskyttelsesorgan 18, der kan have form af en perforeret skærm af plastmateriale eller af et net eller gaze, der hindrer dele af en åbnet kapsel C, men tillader medikament fra kapslen i at blive inhaleret gennem mundstykket 17.The dispersing chamber 15 contains a capsule holder or a trough-shaped portion 20 and a capsule-opening groove 25, which will be described below. The mouthpiece 17 is provided with a protective means 18 which may be in the form of a perforated screen of plastic material or of a mesh or gauze which obstructs portions of an opened capsule C but allows drug from the capsule to be inhaled through the mouthpiece 17.
Legemet 14 er forsynet med et antal luftindløbsspalter 19, der fører ind i dispergeringskammeret 15. Spalterne 19 danner en vinkel i jbrhold til den diametrale retning.The body 14 is provided with a plurality of air inlet slots 19 leading into the dispersing chamber 15. The slots 19 form an angle relative to the diametrical direction.
Kapselholderen eller den trugformede del 20 er anbragt på en aksial aksel 21 inde i dispergeringskammeret 15. Denne aksel 21 strækker sig gennem kammeret 15 og ud af den bageste endevæg 16, hvor den er forbundet med en betjeningsbøsning 22, der omslutter den bageste del af legemet 14. Bøsningen 22 og dermed også akselen 21 og den trugformede del 20 kan bevæges aksialt ind mod og bort fra den forreste ende af dispergeringskammeret.The capsule holder or trough-shaped portion 20 is disposed on an axial shaft 21 within the dispersing chamber 15. This shaft 21 extends through the chamber 15 and out of the rear end wall 16, where it is connected to an operating sleeve 22 which encloses the rear portion of the body. 14. The bushing 22 and thus also the shaft 21 and the trough-shaped portion 20 can be moved axially towards and away from the front end of the dispersing chamber.
Den trugformede del 20 er en holder, der i princippet har en cylindrisk form og en sådan størrelse, at den kan optage en kapsel C1s kapsellegeme, der kan indsættes manuelt. Kapslens hættedel rager så fremefter fra den trugformede del 20 (se fig. 7).The trough-shaped portion 20 is a holder which, in principle, has a cylindrical shape and size such that it can accommodate a capsule body C1 which can be inserted manually. The cap portion of the capsule then protrudes from the trough-shaped portion 20 (see Fig. 7).
Det indre af den trugformede del 20 er indrettet til at gribe tæt omkring kapsellegemet. Den trugformede del kan have en sådan størrelse, at et standardkapsellegeme passer tæt ind i den trugformede del, eller denne kan være forsynet med passende ribber eller andre friktionsorganer, der kan frembringe et fast greb. Den trugformede del har en spalte eller en åbning 23, der strækker sig i denne .dels fulde længde, som det tydeligt fremgår af fig. 6.The interior of the trough-shaped portion 20 is arranged to engage tightly around the capsule body. The trough-shaped portion may be of such size that a standard capsule body fits snugly into the trough-shaped portion, or it may be provided with suitable ribs or other friction means capable of providing a firm grip. The trough-shaped portion has a slot or aperture 23 which extends to the full length of this portion, as is clearly seen in FIG. 6th
Inde i dispergeringskammeret 15 er der fast anbragt et kapselåbnende organ 24, der hensigtsmæssigt har form af en indre finne eller ribbe med en vinkelformet ende 25, der bedst er vist i fig. 6. Det kapselåbnende organ 24 er anbragt således, at det, når det bevæges fremefter sammen med dispergeringskammeret 15, føres ind i denInside the dispersing chamber 15, a capsule opening means 24 is provided, which is conveniently in the form of an inner fin or rib with an angular end 25 best shown in FIG. 6. The capsule opening means 24 is positioned so that, when moved forward with the dispersion chamber 15, it is inserted into the
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langsgående åbning 23 i den trugformede del 20.longitudinal opening 23 in the trough-shaped portion 20.
Det kapselåbnende organ har fortrinsvis en sådan form, at det bringes i berøring med det størst mulige overfladeareal af den kapsel C, der er anbragt i den trugformede del.The capsule opening means is preferably such that it is brought into contact with the widest possible surface area of the capsule C disposed in the trough-shaped portion.
Når apparatet, der befinder sig i sin i fig. 7 viste lukkede stilling, skal bruges, fjernes mundstykket 17 fra den forreste ende af legemet 14, og patienten anbringer en kapsel C i den trugformede del 20. Patienten anbringer kapslen således, at kapsellegemet indsættes i den trugformede del med kapselhætten ragende ud fra denne. Mundstykket anbringes så igen på plads, og den trugformede kapseloptagende del 20 bevæges bagud inde i kammeret. Under denne bevægelse føres det kapselåbnende organ 24 hen over kapselen C. Derved bringes den til at indgribe med enden af kapselhætten og skubber denne af kapsellegemet. Det kapselåbnende organ 24 har hensigtsmæssigt en del 26 med en sådan størrelse og form, at den, efter at kapselhætten er blevet fjernet, indgriber med enden af kapsellegemet og fører dette ind i dispergeringskammeret.When the apparatus which is in its in FIG. 7, the nozzle 17 is removed from the front end of the body 14 and the patient places a capsule C in the trough-shaped portion 20. The patient places the capsule such that the capsule body is inserted into the trough-shaped portion with the capsule cap protruding therefrom. The nozzle is then reattached and the trough-shaped casing receiving portion 20 is moved backward within the chamber. During this movement, the capsule-opening member 24 is passed over the capsule C. This causes it to engage with the end of the capsule cap and push it off of the capsule body. Conveniently, the capsule opening member 24 has a portion 26 of such size and shape that, after removing the capsule cap, it engages with the end of the capsule body and enters it into the dispersion chamber.
Medens den åbnede kapsel befinder sig i dispergeringskammeret, inhalerer patienten gennem mundstykket. Efter at inhalationen er blevet afsluttet, fjerner patienten mundstykket og hælder den brugte kapsel ud. Mundstykket anbringes derefter igen på plads, eventuelt efter at den trugformede del igen er blevet forsynet med en kapsel, så at apparatet er klart til endnu en inhalationsoperation.While the opened capsule is in the dispersion chamber, the patient inhales through the mouthpiece. After the inhalation is completed, the patient removes the mouthpiece and pours out the used capsule. The nozzle is then reattached, possibly after the trough-shaped portion is again provided with a capsule so that the apparatus is ready for yet another inhalation operation.
Den i fig. 9-13 viste udførelsesform for inhalationsapparatet ifølge opfindelsen har et cylindrisk legeme 27, hvis indre danner et kapseloptagende kammer 28. Legemet 27 er ved sin ene ende lukket ved hjælp af en endevæg 29, medens det er åbent ved sin anden eller forreste ende. Et mundstykket 30 i form af et aftageligt mundstykke er skruet eller på anden måde fastgjort til den forreste ende af legemet 27. Der findes et gitter eller et beskyttelsesorgan 31, der tjener til at hindre kapseldelene, men ikke det pulverformede medikament, i at blive suget gennem mundstykket 30, når patienten inhalerer. Dette gitter 31 er hensigtsmæssigt anbragt ved den bageste ende af mundstykket 30. Kapseldelene har tilbøjelighed til at rotereThe FIG. 9-13, the embodiment of the inhalation apparatus according to the invention has a cylindrical body 27, the interior of which forms a capsule receiving chamber 28. The body 27 is closed at one end by an end wall 29, while it is open at its other or front end. A nozzle 30 in the form of a removable nozzle is screwed or otherwise attached to the front end of the body 27. There is a grating or protective member 31 which serves to prevent the capsule parts but not the powdered drug from being sucked through the mouthpiece 30 as the patient inhales. This grid 31 is conveniently located at the rear end of the nozzle 30. The capsule members tend to rotate.
8 DK 154869B8 DK 154869B
på gitteret eller beskyttelsesorganet 31, når patienten inhalerer.on the lattice or guard 31 as the patient inhales.
Den centrale del af legemet 27 har et antal luftindløbsspalter 32, der strækker sig på langs af legemet 27 som ved den tidligere beskrevne udførelsesform. Disse spalter 32 står i forbindelse med kammeret 28 og danner en vinkel i forhold til den diametrale retning i kammeret.The central portion of the body 27 has a plurality of air inlet slots 32 extending longitudinally of the body 27 as in the previously described embodiment. These slots 32 communicate with the chamber 28 and form an angle with respect to the diametrical direction of the chamber.
En betjeningsbøsning 33 kan teleskopisk skydes ind over den bageste endedel af legemet 27 og kan også drejes på dette. Bøsningen 33 er således forbundet med et inde i legemet anbragt magasin 34, at bøsningen 33 og magasinet 34 sammen kan forskydes og drejes som en enhed. Magasinet har en kapseloptagende holder 35, der strækker sig i magasinets og legemets længderetning, men som ligger forskudt fra legemets og magasinets akse. Denne holder 35 er åben fortil.An operating sleeve 33 can be telescoped in over the rear end portion of the body 27 and can also be rotated thereon. The sleeve 33 is so connected to a magazine 34 disposed within the body that the sleeve 33 and the magazine 34 can be displaced together and rotated as a unit. The magazine has a capsule receiving holder 35 which extends longitudinally of the magazine and body, but which is offset from the axis of the body and magazine. This holder 35 is open at the front.
En kapsel C, der indeholder et pulverformet medikament, der skal inhaleres, kan indføres i den åbne ende af kapselholderen, efter at mundstykket 30 er blevet fjernet. Når kapslen er blevet indsat i holderen 35, vil kapslens forreste endedel rage ud fra den forreste ende af holderen 35 (se fig. 10). Når kapslen C er blevet indført i holderen 35, anbringes mundstykket 30 igen på plads.A capsule C containing a powdered drug to be inhaled may be inserted into the open end of the capsule holder after the nozzle 30 has been removed. Once the capsule has been inserted into the holder 35, the front end portion of the capsule will protrude from the front end of the holder 35 (see Fig. 10). Once the capsule C has been inserted into the holder 35, the nozzle 30 is reattached.
Et kileformet kapselåbnende organ 36 er monteret inde i legemet i en monteringsring 37. Monteringsringen 37 er forskydeligt anbragt inde i legemet 27 og har en not 38, der indgriber med en inde i legemet 27 udformet notgang 39. Ringen 37 kan derfor forskydes i forhold til legemet 27's inderside, men ikke drejes. Ringen 37 er forbundet med den forreste ende af magasinet 34 på en sådan måde, at ringen kan drejes i forhold til magasinet, men ringen og magasinet forskydes sammen.A wedge-shaped capsule opening member 36 is mounted inside the body of a mounting ring 37. The mounting ring 37 is slidably disposed within the body 27 and has a groove 38 which engages a groove 39 formed within the body 27. The ring 37 can therefore be displaced relative to the inside of the body 27 but not turned. The ring 37 is connected to the front end of the magazine 34 in such a way that the ring can be rotated relative to the magazine, but the ring and magazine are displaced together.
En kapseludkasterribbe 40 er fastgjort i legemet 27 bag· ved magasinet 34 i en sådan vinkelstilling, at den, når bøsningen 33 og derfor magasinet 34 bevæges til den åbne eller operative stilling, ligger ud for kapselholderen 35 (se fig. 11) og vil blive ført ind i denne og derved udkaste kapslen fra holderen 35's åbne forreste ende.A capsule ejector rib 40 is secured in the body 27 behind the magazine 34 in such an angular position that when the sleeve 33, and therefore the magazine 34, is moved to the open or operative position, is adjacent the capsule holder 35 (see FIG. 11). inserted into this, thereby ejecting the capsule from the open front end of the holder 35.
9 DK 154869 B9 DK 154869 B
Når apparatet skal anvendes og befinder sig i sin lukkede stilling (se fig. 10), anbringes en kapsel, der indeholder et medikament, som skal inhaleres, i magasinet 34's kapselholder 35, og mundstykket 30 fastgøres derefter til legemet. Bøsningen 33 drejes så omtrent en halv omdrejning. En sådan drejningsbevægelse af bøsningen 33 vil også bevirke drejning af magasinet 34 og af kapslen C, der er anbragt i magasinets holder 35, og det kapselåbnende organ 36 og holderen 35 er anbragt således i forhold til hinanden, at en sådan drejning vil bringe den udragende del af kapslen i indgreb med åbneorganets forreste kant. Fortsat drejning vil forårsage, at det kapselåbnende organ udøver en kilevirkning på den udragende del af kapslen. Den udragende del vil så blive adskilt fra den resterende del af kapslen som følge af det tryk, der frembringes ved denne kilevirkning. Bøsningen 33 og magasinet 34 drejes derefter i modsat retning tilbage til den oprindelige stilling, og den yderligere kilevirkning, som organet 36 vil udøve under en sådan drejning, vil hjælpe til med at adskille kapsellegemet og hætten. En sådan drejning vil også forårsage, at kapselholderen 35, der er åben ved begge ender, bringes til at ligge ud for kapseludkaster-ribben 40. Når bøsningen 33 er korrekt placeret, forskydes den til sin åbne eller operative stilling, og under denne bevægelse vil ribben 40 blive ført ind i magasinet 34's kapselholder 35 og derved presse mod enden af kapselen c1s legeme og skubbe dette ud af holderens forreste ende og ind i kammeret 28. Patienten kan så inhalere gennem mundstykket 30, hvorved det pulverformede medikament inhaleres. Når inhaleringen er afsluttet, kan patienten fjerne mundstykket og fjerne den forbrugte kapsel, hvorefter en anden kapsel kan bringes i kapselholderen, så at apparatet igen gøres klart til inhalering.When the apparatus is to be used and is in its closed position (see Fig. 10), a capsule containing a medicament to be inhaled is placed in the capsule holder 35 of the magazine 34, and the mouthpiece 30 is then secured to the body. The sleeve 33 is then rotated about a half turn. Such a rotational movement of the sleeve 33 will also cause rotation of the magazine 34 and of the capsule C disposed in the magazine holder 35, and the capsule opening means 36 and the holder 35 arranged so as to be relative to one another part of the capsule engaging the front edge of the open member. Continued rotation will cause the capsule-opening member to exert a wedge effect on the protruding portion of the capsule. The protruding portion will then be separated from the remaining portion of the capsule due to the pressure produced by this wedge action. The bushing 33 and the magazine 34 are then rotated in the opposite direction back to the original position, and the additional wedge action that the member 36 will exert during such rotation will help to separate the capsule body and the cap. Such a rotation will also cause the capsule holder 35 open at both ends to be aligned with the capsule ejector rib 40. When the bushing 33 is properly positioned, it is displaced to its open or operative position, and during this movement, the rib 40 is inserted into the capsule holder 35 of the magazine 34, thereby pressing against the end of the body of the capsule c1 and pushing it out of the front end of the holder and into the chamber 28. The patient can then inhale through the mouthpiece 30, thereby inhaling the powdered drug. When the inhalation is completed, the patient can remove the mouthpiece and remove the consumed capsule, after which another capsule can be brought into the capsule holder so that the device is again ready for inhalation.
Der findes organer til positivt at begrænse den relative drejning mellem bøsningen og magasinet på den ene side og legemet på den anden. Således kan der eksempelvis på legemet 27 findes et stop 41 (fig. 9), der kan glide i en reces 42 inde i bøsningen 33. Enderne af recessen danner anslag, med hvilke stoppet kan indgribe og dermed begrænse drejningen af bøsningen i forhold til legemet. Denne konstruktion sikrer, at ribben kan anbringes korrekt for at kunne udstøde en kapseldel.There are means for positively limiting the relative rotation between the bushing and the magazine on one side and the body on the other. Thus, for example, on the body 27 there may be a stop 41 (Fig. 9) which can slide in a recess 42 inside the sleeve 33. The ends of the recess form stops with which the stop can engage and thus limit the rotation of the sleeve relative to the body. . This construction ensures that the ribs can be correctly positioned to eject a capsule member.
Claims (11)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB546877 | 1977-02-10 | ||
| GB548977 | 1977-02-10 | ||
| GB546877 | 1977-02-10 | ||
| GB548977 | 1977-02-10 | ||
| GB1805877 | 1977-04-29 | ||
| GB5486/77A GB1598081A (en) | 1977-02-10 | 1977-04-29 | Inhaler device for dispensing medicaments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK47078A DK47078A (en) | 1978-08-11 |
| DK154869B true DK154869B (en) | 1989-01-02 |
| DK154869C DK154869C (en) | 1989-05-16 |
Family
ID=27254632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK47078A DK154869C (en) | 1977-02-10 | 1978-02-01 | INHALATION DEVICE FOR ADMINISTRATING MEDICINES |
Country Status (1)
| Country | Link |
|---|---|
| DK (1) | DK154869C (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK488474A (en) * | 1973-09-18 | 1975-05-26 | Ritzau Pari Werk Kg Paul |
-
1978
- 1978-02-01 DK DK47078A patent/DK154869C/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK488474A (en) * | 1973-09-18 | 1975-05-26 | Ritzau Pari Werk Kg Paul |
Also Published As
| Publication number | Publication date |
|---|---|
| DK47078A (en) | 1978-08-11 |
| DK154869C (en) | 1989-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |