DK153836C - Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser ud fra en blanding af 1 alfa-hydroxy-vitamin d forbindelser og deres tilsvarende 1 alfa-hydroxy-5,6-trans-vitamin d-isomere - Google Patents
Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser ud fra en blanding af 1 alfa-hydroxy-vitamin d forbindelser og deres tilsvarende 1 alfa-hydroxy-5,6-trans-vitamin d-isomereInfo
- Publication number
- DK153836C DK153836C DK302086A DK302086A DK153836C DK 153836 C DK153836 C DK 153836C DK 302086 A DK302086 A DK 302086A DK 302086 A DK302086 A DK 302086A DK 153836 C DK153836 C DK 153836C
- Authority
- DK
- Denmark
- Prior art keywords
- alfa
- vitamin
- hydroxy
- compounds
- hydroxyvitamin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Nutrition Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66729584 | 1984-11-01 | ||
US06/667,295 US4554106A (en) | 1984-11-01 | 1984-11-01 | Method for preparing 1α-hydroxyvitamin D compounds |
US8501980 | 1985-10-15 | ||
PCT/US1985/001980 WO1986002648A1 (en) | 1984-11-01 | 1985-10-15 | METHOD FOR PREPARING 1alpha-HYDROXYVITAMIN D COMPOUNDS |
Publications (4)
Publication Number | Publication Date |
---|---|
DK302086A DK302086A (da) | 1986-06-26 |
DK302086D0 DK302086D0 (da) | 1986-06-26 |
DK153836B DK153836B (da) | 1988-09-12 |
DK153836C true DK153836C (da) | 1989-01-23 |
Family
ID=24677641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK302086A DK153836C (da) | 1984-11-01 | 1986-06-26 | Fremgangsmaade til fremstilling af 1 alfa-hydroxyvitamin-d-forbindelser ud fra en blanding af 1 alfa-hydroxy-vitamin d forbindelser og deres tilsvarende 1 alfa-hydroxy-5,6-trans-vitamin d-isomere |
Country Status (12)
Country | Link |
---|---|
US (1) | US4554106A (da) |
EP (1) | EP0198901B1 (da) |
JP (1) | JPS62500718A (da) |
KR (1) | KR930003496B1 (da) |
AU (1) | AU596085B2 (da) |
CA (1) | CA1233188A (da) |
DE (1) | DE3585687D1 (da) |
DK (1) | DK153836C (da) |
IE (1) | IE58163B1 (da) |
IL (1) | IL76753A (da) |
NZ (1) | NZ213845A (da) |
WO (1) | WO1986002648A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4555364A (en) * | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
CH669706GA3 (en) * | 1987-04-01 | 1989-04-14 | Bracelet and surround for watch - has pair of rings with channels fitting over projecting ribs around watch casing | |
US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
US5030772A (en) * | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
US5756783A (en) * | 1990-09-21 | 1998-05-26 | Bone Care International, Inc. | 1α-Hydroxy-24-EPI-vitamin D4 |
US6538037B2 (en) | 1991-01-08 | 2003-03-25 | Bone Care International, Inc. | Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2 |
US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
US5763429A (en) | 1993-09-10 | 1998-06-09 | Bone Care International, Inc. | Method of treating prostatic diseases using active vitamin D analogues |
US5869472A (en) * | 1994-07-18 | 1999-02-09 | Bone Care International, Inc. | Synthesis of 1α-hydroxy vitamin D |
US5939268A (en) * | 1994-07-26 | 1999-08-17 | The Scripps Research Institute | Combinatorial libraries of molecules and methods for producing same |
US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US6242434B1 (en) | 1997-08-08 | 2001-06-05 | Bone Care International, Inc. | 24-hydroxyvitamin D, analogs and uses thereof |
US6376479B1 (en) | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
US6566353B2 (en) | 1996-12-30 | 2003-05-20 | Bone Care International, Inc. | Method of treating malignancy associated hypercalcemia using active vitamin D analogues |
US6573256B2 (en) | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6503893B2 (en) | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
US20030129194A1 (en) * | 1997-02-13 | 2003-07-10 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
AU750451B2 (en) * | 1997-02-13 | 2002-07-18 | Bone Care International, Inc. | Targeted therapeutic delivery of vitamin D compounds |
JPH1175863A (ja) * | 1997-07-10 | 1999-03-23 | Kyowa Hakko Kogyo Co Ltd | 25−ヒドロキシビタミンD3−1α−水酸化酵素および該酵素をコードするDNA |
US6096876A (en) * | 1997-08-06 | 2000-08-01 | Shriners Hospitals For Children | 1-α-hydroxylase materials and methods |
US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
US6359012B1 (en) | 1999-12-22 | 2002-03-19 | Bone Care International, Inc. | Method for making 24(S)-hydroxyvitamin D2 |
JP2004504295A (ja) * | 2000-07-18 | 2004-02-12 | ボーン ケア インターナショナル インコーポレイテッド | 安定化1α−ヒドロキシビタミンD |
US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
US20040053895A1 (en) * | 2002-09-18 | 2004-03-18 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
US20050239756A1 (en) * | 2004-04-23 | 2005-10-27 | Bone Care International, Inc. | Methods of treating various vitamin D metabolism conditions with 1alpha-hydroxyvitamin D2 |
US7094775B2 (en) | 2004-06-30 | 2006-08-22 | Bone Care International, Llc | Method of treating breast cancer using a combination of vitamin D analogues and other agents |
CA2787900C (en) * | 2010-01-25 | 2018-10-02 | Dh Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
CA2698160C (en) * | 2010-03-30 | 2017-07-25 | Alphora Research Inc. | Stabilized doxercalciferol and process for manufacturing the same |
CN103073469A (zh) * | 2013-01-16 | 2013-05-01 | 青岛正大海尔制药有限公司 | 一种阿法骨化醇的制备方法 |
CN111072540A (zh) * | 2019-12-26 | 2020-04-28 | 山东华铂凯盛生物科技有限公司 | 一种阿法骨化醇改进的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4022768A (en) * | 1976-02-12 | 1977-05-10 | Wisconsin Alumni Research Foundation | Process for preparation of 1α,25-dihydroxycholecalciferol |
US4202829A (en) * | 1978-01-05 | 1980-05-13 | Wisconsin Alumni Research Foundation | Process for preparing 1α-hydroxylated compounds |
US4287129A (en) * | 1980-07-28 | 1981-09-01 | Diamond Shamrock Corp. | Synthesis of 1α-hydroxy-7-dehydrosteroids |
US4338250A (en) * | 1981-04-27 | 1982-07-06 | Wisconsin Alumni Research Foundation | 1-Hydroxylation process |
-
1984
- 1984-11-01 US US06/667,295 patent/US4554106A/en not_active Expired - Lifetime
-
1985
- 1985-10-15 WO PCT/US1985/001980 patent/WO1986002648A1/en active IP Right Grant
- 1985-10-15 KR KR1019860700401A patent/KR930003496B1/ko not_active IP Right Cessation
- 1985-10-15 AU AU50647/85A patent/AU596085B2/en not_active Expired
- 1985-10-15 JP JP60504803A patent/JPS62500718A/ja active Granted
- 1985-10-15 DE DE8585905456T patent/DE3585687D1/de not_active Expired - Lifetime
- 1985-10-15 EP EP85905456A patent/EP0198901B1/en not_active Expired - Lifetime
- 1985-10-16 NZ NZ213845A patent/NZ213845A/xx unknown
- 1985-10-18 IL IL76753A patent/IL76753A/xx not_active IP Right Cessation
- 1985-10-18 CA CA000493352A patent/CA1233188A/en not_active Expired
- 1985-11-01 IE IE270585A patent/IE58163B1/en not_active IP Right Cessation
-
1986
- 1986-06-26 DK DK302086A patent/DK153836C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA1233188A (en) | 1988-02-23 |
IL76753A0 (en) | 1986-02-28 |
IL76753A (en) | 1989-10-31 |
DK153836B (da) | 1988-09-12 |
NZ213845A (en) | 1989-08-29 |
IE852705L (en) | 1986-05-01 |
IE58163B1 (en) | 1993-07-28 |
DK302086A (da) | 1986-06-26 |
DE3585687D1 (de) | 1992-04-23 |
AU596085B2 (en) | 1990-04-26 |
EP0198901A1 (en) | 1986-10-29 |
DK302086D0 (da) | 1986-06-26 |
US4554106A (en) | 1985-11-19 |
EP0198901B1 (en) | 1992-03-18 |
JPS62500718A (ja) | 1987-03-26 |
KR860700354A (ko) | 1986-10-06 |
KR930003496B1 (ko) | 1993-05-01 |
JPH0437075B2 (da) | 1992-06-18 |
AU5064785A (en) | 1986-05-15 |
EP0198901A4 (en) | 1987-03-09 |
WO1986002648A1 (en) | 1986-05-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |