DK1524272T3 - Væksthormonsekretionsfremmere - Google Patents

Væksthormonsekretionsfremmere

Info

Publication number: DK1524272T3
Authority: DK; Denmark
Prior art keywords: growth hormone; hormone; growth
Prior art date: 2000-06-13

Application number

DK05075086T

Other languages

English (en)

Inventor

Jean Martinez

Vincent Guerlavais

Jean-Alain Fehrentz

Original Assignee

Zentaris Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-13

Filing date

2001-06-13

Publication date

2007-09-03

2001-06-13 Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh

2007-09-03 Application granted granted Critical

2007-09-03 Publication of DK1524272T3 publication Critical patent/DK1524272T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DK05075086T 2000-06-13 2001-06-13 Væksthormonsekretionsfremmere DK1524272T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US21132600P	2000-06-13	2000-06-13
US23492800P	2000-09-26	2000-09-26
PCT/EP2001/006717 WO2001096300A1 (en)	2000-06-13	2001-06-13	Growth hormone secretagogues

Publications (1)

Publication Number	Publication Date
DK1524272T3 true DK1524272T3 (da)	2007-09-03

Family

ID=26906052

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK03075950T DK1344773T3 (da)	2000-06-13	2001-06-13	Væksthormonsekretionsfremmere
DK01943504T DK1289951T3 (da)	2000-06-13	2001-06-13	Væksthormon sekretionsfremmere
DK05075086T DK1524272T3 (da)	2000-06-13	2001-06-13	Væksthormonsekretionsfremmere

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DK03075950T DK1344773T3 (da)	2000-06-13	2001-06-13	Væksthormonsekretionsfremmere
DK01943504T DK1289951T3 (da)	2000-06-13	2001-06-13	Væksthormon sekretionsfremmere

Country Status (30)

Country	Link
US (2)	US6861409B2 (da)
EP (1)	EP1289951B1 (da)
JP (2)	JP3522265B2 (da)
KR (1)	KR100825109B1 (da)
CN (1)	CN1232507C (da)
AR (1)	AR029941A1 (da)
AT (3)	ATE370119T1 (da)
AU (2)	AU6606601A (da)
BG (3)	BG66130B1 (da)
BR (1)	BRPI0111591B8 (da)
CA (1)	CA2407659C (da)
CY (2)	CY1107710T1 (da)
CZ (2)	CZ305279B6 (da)
DE (3)	DE60130025T2 (da)
DK (3)	DK1344773T3 (da)
ES (3)	ES2250416T3 (da)
FR (1)	FR19C1044I2 (da)
HK (1)	HK1054224A1 (da)
HU (1)	HU229233B1 (da)
IL (2)	IL153067A0 (da)
MX (1)	MXPA02011899A (da)
NL (1)	NL300999I2 (da)
NO (1)	NO323873B1 (da)
NZ (1)	NZ522280A (da)
PL (1)	PL216676B1 (da)
PT (2)	PT1524272E (da)
RU (1)	RU2270198C2 (da)
SK (1)	SK287169B6 (da)
TW (2)	TW200831076A (da)
WO (1)	WO2001096300A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK287169B6 (sk) *	2000-06-13	2010-02-08	Zentaris Ag	Zlúčeniny zvyšujúce sekréciu rastového hormónu, farmaceutický prostriedok s ich obsahom a ich použitie
CU23157A1 (es) *	2001-01-03	2006-07-18	Ct Ingenieria Genetica Biotech	COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL
US7476653B2 (en)	2003-06-18	2009-01-13	Tranzyme Pharma, Inc.	Macrocyclic modulators of the ghrelin receptor
US7034050B2 (en) *	2004-04-28	2006-04-25	Romano Deghenghi	Pseudopeptides growth hormone secretagogues
WO2007014258A2 (en) *	2005-07-22	2007-02-01	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Growth hormone secretagogues
EP1757290A1 (en)	2005-08-16	2007-02-28	Zentaris GmbH	Novel triazole derivatives as ghrelin analogue ligands of growth hormone secretagogue receptors
GB0603295D0 (en) *	2006-02-18	2006-03-29	Ardana Bioscience Ltd	Methods and kits
CU23558A1 (es)	2006-02-28	2010-07-20	Ct Ingenieria Genetica Biotech	Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
US7763707B2 (en) *	2006-03-13	2010-07-27	Liat Mintz	Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation
JP2010518090A (ja)	2007-02-09	2010-05-27	トランザイム・ファーマ，インコーポレイテッド	大環状グレリン受容体修飾因子およびその使用方法
EP2103602A1 (en)	2008-03-17	2009-09-23	AEterna Zentaris GmbH	Novel 1,2,4-triazole derivatives and process of manufacturing thereof
US8431642B2 (en) *	2008-06-09	2013-04-30	Exxonmobil Chemical Patents Inc.	Polyolefin adhesive compositions and articles made therefrom
EP2431035A1 (en)	2010-09-16	2012-03-21	Æterna Zentaris GmbH	Novel Triazole Derivatives with Improved Receptor Activity and Bioavailability Properties as Ghrelin Antagonists of Growth Hormone Secretagogue Receptors
US10300101B2 (en)	2012-09-19	2019-05-28	Quality IP Holdings, LLC	Methods and compositions for enhancing or maintaining fertility
US8747922B2 (en)	2012-09-19	2014-06-10	Quality Ip Holdings, Inc.	Methods and compositions for increasing sex steroids and growth hormones
US9198889B2 (en)	2012-09-19	2015-12-01	Quality IP Holdings, LLC	Methods for treating post-traumatic stress disorder
US8747921B2 (en)	2012-09-19	2014-06-10	Quality Ip Holdings, Inc.	Methods for improving health in humans
US9066953B2 (en)	2012-09-20	2015-06-30	Quality IP Holdings, LLC	Methods for increasing endurance and fat metabolism in humans
US8715752B2 (en)	2012-09-20	2014-05-06	Quality Ip Holdings, Inc.	Compositions for increasing human growth hormone levels
US10292957B2 (en)	2012-09-20	2019-05-21	Quality IP Holdings, LLC	Compositions and methods for treating fibromyalgia
US8747923B2 (en)	2012-09-20	2014-06-10	Quality Ip Holdings, Inc.	Methods for improving health in canines
CN104853778A (zh)	2012-10-24	2015-08-19	第一三共株式会社	用于肌萎缩性侧索硬化的治疗剂
CN105330720A (zh) *	2014-06-06	2016-02-17	深圳翰宇药业股份有限公司	一种制备马昔瑞林的方法
SG10201902424TA (en)	2015-09-21	2019-04-29	Lumos Pharma Inc	Detecting and treating growth hormone deficiency
US10894072B2 (en)	2017-02-13	2021-01-19	IP Quality Holdings, LLC	Compositions and methods for treating fibromyalgia
US10288629B1 (en)	2017-12-19	2019-05-14	Aeterna Zentaris, Inc.	Method of assessing growth hormone deficiency in humans by a macimorelin containing composition
JP2023535000A (ja)	2020-07-22	2023-08-15	エテルナツェンタリスゲゼルシャフトミットベシュレンクテルハフツング	マシモレリンを使用することにより小児科患者における成長ホルモン分泌不全症を診断するためのスクリーニング方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0400051B1 (en) *	1988-01-28	1995-05-10	Polygen Holding Corporation	Polypeptide compounds having growth hormone releasing activity
US5536814A (en) *	1993-09-27	1996-07-16	La Jolla Cancer Research Foundation	Integrin-binding peptides
CA2176140A1 (en) *	1993-11-24	1995-06-01	Meng Hsin Chen	Indolyl group containing compounds and the use thereof to promote the release of growth hormone(s)
US5798337A (en) *	1994-11-16	1998-08-25	Genentech, Inc.	Low molecular weight peptidomimetic growth hormone secretagogues
US6025471A (en) *	1998-06-03	2000-02-15	Deghenghi; Romano	Diazaspiro, azepino and azabicyclo therapeutic peptides
SK287169B6 (sk) *	2000-06-13	2010-02-08	Zentaris Ag	Zlúčeniny zvyšujúce sekréciu rastového hormónu, farmaceutický prostriedok s ich obsahom a ich použitie

2001
- 2001-06-13 SK SK1756-2002A patent/SK287169B6/sk not_active IP Right Cessation
- 2001-06-13 EP EP01943504A patent/EP1289951B1/en not_active Expired - Lifetime
- 2001-06-13 US US09/880,498 patent/US6861409B2/en not_active Expired - Lifetime
- 2001-06-13 KR KR1020027016614A patent/KR100825109B1/ko active IP Right Grant
- 2001-06-13 CZ CZ2011-585A patent/CZ305279B6/cs not_active IP Right Cessation
- 2001-06-13 ES ES01943504T patent/ES2250416T3/es not_active Expired - Lifetime
- 2001-06-13 PT PT05075086T patent/PT1524272E/pt unknown
- 2001-06-13 WO PCT/EP2001/006717 patent/WO2001096300A1/en active IP Right Grant
- 2001-06-13 AR ARP010102827A patent/AR029941A1/es active IP Right Grant
- 2001-06-13 PL PL363081A patent/PL216676B1/pl unknown
- 2001-06-13 CZ CZ20024095A patent/CZ303173B6/cs not_active IP Right Cessation
- 2001-06-13 DE DE60130025T patent/DE60130025T2/de not_active Expired - Lifetime
- 2001-06-13 JP JP2002510444A patent/JP3522265B2/ja not_active Expired - Lifetime
- 2001-06-13 AT AT03075950T patent/ATE370119T1/de active
- 2001-06-13 DE DE60112753T patent/DE60112753T2/de not_active Expired - Lifetime
- 2001-06-13 DK DK03075950T patent/DK1344773T3/da active
- 2001-06-13 AT AT05075086T patent/ATE362472T1/de active
- 2001-06-13 AT AT01943504T patent/ATE302181T1/de active
- 2001-06-13 DE DE60128494T patent/DE60128494T2/de not_active Expired - Lifetime
- 2001-06-13 ES ES05075086T patent/ES2288724T3/es not_active Expired - Lifetime
- 2001-06-13 RU RU2002135312/04A patent/RU2270198C2/ru not_active IP Right Cessation
- 2001-06-13 ES ES03075950T patent/ES2292900T3/es not_active Expired - Lifetime
- 2001-06-13 BR BRPI0111591A patent/BRPI0111591B8/pt not_active IP Right Cessation
- 2001-06-13 IL IL15306701A patent/IL153067A0/xx unknown
- 2001-06-13 MX MXPA02011899A patent/MXPA02011899A/es active IP Right Grant
- 2001-06-13 AU AU6606601A patent/AU6606601A/xx active Pending
- 2001-06-13 AU AU2001266066A patent/AU2001266066B2/en not_active Expired
- 2001-06-13 CN CNB018104916A patent/CN1232507C/zh not_active Expired - Lifetime
- 2001-06-13 PT PT03075950T patent/PT1344773E/pt unknown
- 2001-06-13 DK DK01943504T patent/DK1289951T3/da active
- 2001-06-13 NZ NZ522280A patent/NZ522280A/en not_active IP Right Cessation
- 2001-06-13 HU HU0302026A patent/HU229233B1/hu active IP Right Revival
- 2001-06-13 DK DK05075086T patent/DK1524272T3/da active
- 2001-06-13 CA CA2407659A patent/CA2407659C/en not_active Expired - Lifetime
- 2001-08-01 TW TW097111056A patent/TW200831076A/zh unknown
- 2001-08-01 TW TW090114317A patent/TWI305529B/zh not_active IP Right Cessation
2002
- 2002-11-24 IL IL153067A patent/IL153067A/en active IP Right Grant
- 2002-12-09 NO NO20025893A patent/NO323873B1/no not_active IP Right Cessation
- 2002-12-12 BG BG107379A patent/BG66130B1/bg unknown
2003
- 2003-06-02 JP JP2003156884A patent/JP4932132B2/ja not_active Expired - Lifetime
- 2003-08-27 HK HK03106131A patent/HK1054224A1/xx not_active IP Right Cessation
2004
- 2004-05-04 US US10/837,620 patent/US7297681B2/en not_active Expired - Lifetime
2007
- 2007-08-07 CY CY20071101051T patent/CY1107710T1/el unknown
- 2007-11-08 CY CY20071101443T patent/CY1107793T1/el unknown
2010
- 2010-07-21 BG BG10110708A patent/BG66216B1/bg unknown
- 2010-10-18 BG BG10110771A patent/BG66217B1/bg unknown
2019
- 2019-07-05 NL NL300999C patent/NL300999I2/nl unknown
- 2019-07-08 FR FR19C1044C patent/FR19C1044I2/fr active Active

Also Published As

Publication number	Publication date
HK1054224A1 (en)	2003-11-21
US20020165343A1 (en)	2002-11-07
FR19C1044I2 (fr)	2020-07-24
BG66216B1 (bg)	2012-05-31
PT1524272E (pt)	2007-07-25
ES2250416T3 (es)	2006-04-16
BG110708A (en)	2010-12-30
PT1344773E (pt)	2007-11-27
TWI305529B (en)	2009-01-21
JP2003335752A (ja)	2003-11-28
TW200831076A (en)	2008-08-01
CN1431998A (zh)	2003-07-23
PL216676B1 (pl)	2014-05-30
ATE370119T1 (de)	2007-09-15
CZ303173B6 (cs)	2012-05-16
FR19C1044I1 (da)	2019-09-08
BG110771A (bg)	2011-03-31
HUP0302026A2 (hu)	2003-09-29
ATE302181T1 (de)	2005-09-15
BRPI0111591B8 (pt)	2021-05-25
AU2001266066B2 (en)	2005-06-30
NL300999I2 (nl)	2019-08-28
ES2288724T3 (es)	2008-01-16
US6861409B2 (en)	2005-03-01
CY1107793T1 (el)	2013-06-19
WO2001096300A1 (en)	2001-12-20
ATE362472T1 (de)	2007-06-15
JP2004503536A (ja)	2004-02-05
KR20030007889A (ko)	2003-01-23
DE60128494D1 (de)	2007-06-28
DE60130025T2 (de)	2008-05-15
CZ305279B6 (cs)	2015-07-15
IL153067A0 (en)	2003-06-24
AU6606601A (en)	2001-12-24
CA2407659A1 (en)	2001-12-20
BG66217B1 (bg)	2012-05-31
NZ522280A (en)	2004-09-24
US20040229823A1 (en)	2004-11-18
DE60128494T2 (de)	2008-01-17
BG66130B1 (bg)	2011-06-30
BG107379A (bg)	2003-09-30
NL300999I1 (nl)	2019-07-17
KR100825109B1 (ko)	2008-04-25
MXPA02011899A (es)	2003-04-22
NO323873B1 (no)	2007-07-16
CA2407659C (en)	2010-11-09
DE60112753T2 (de)	2006-06-29
JP3522265B2 (ja)	2004-04-26
IL153067A (en)	2010-05-31
DK1344773T3 (da)	2007-12-27
PL363081A1 (en)	2004-11-15
CZ20024095A3 (cs)	2003-05-14
AR029941A1 (es)	2003-07-23
SK287169B6 (sk)	2010-02-08
JP4932132B2 (ja)	2012-05-16
CN1232507C (zh)	2005-12-21
US7297681B2 (en)	2007-11-20
DE60130025D1 (de)	2007-09-27
NO20025893L (no)	2003-02-10
HUP0302026A3 (en)	2009-01-28
RU2270198C2 (ru)	2006-02-20
DK1289951T3 (da)	2005-12-19
BR0111591A (pt)	2003-05-06
ES2292900T3 (es)	2008-03-16
DE60112753D1 (de)	2005-09-22
NO20025893D0 (no)	2002-12-09
EP1289951A1 (en)	2003-03-12
CY1107710T1 (el)	2013-04-18
BR0111591B1 (pt)	2014-02-04
SK17562002A3 (sk)	2003-05-02
EP1289951B1 (en)	2005-08-17
HU229233B1 (en)	2013-09-30

Publication	Publication Date	Title
DK1344773T3 (da)	2007-12-27	Væksthormonsekretionsfremmere
NO20042182L (no)	2004-08-11	Kjemisk-modifiserte veksthormonkonjugater
ATE310728T1 (de)	2005-12-15	Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga
DE60108654D1 (de)	2005-03-03	Mähdrescher
DE60118469D1 (de)	2006-05-18	Keramisches tragwerk
DE60128599D1 (de)	2007-07-05	Arbeitsgerät
DK1292733T3 (da)	2008-08-11	Kunstplæne
DK1333853T3 (da)	2012-11-05	Vækstfaktorkompleks
NO20024890D0 (no)	2002-10-10	Implantat
EE05197B1 (et)	2009-08-17	Linesoliid - kristallivorm II
EE200300269A (et)	2003-10-15	Fibroblasti kasvufaktorid
DE60131102D1 (de)	2007-12-06	Monofilamentband
AR028336A1 (es)	2003-05-07	4-hidroxi-tetrahidropiridonas fenilsubstituidas
DE60030011D1 (de)	2006-09-21	Umpflanzungsmaschine
FR2806309B1 (fr)	2004-04-16	Implant
AR028061A1 (es)	2003-04-23	2-enamino-cetonitrilos fenil-substituidos
AR027931A1 (es)	2003-04-16	Antitranspirantes
CU23064A3 (es)	2005-07-19	Conjunto implante dental-transportador
AR027982A1 (es)	2003-04-23	Aril- y heteroarilsulfonatos
DE50104376D1 (de)	2004-12-09	Düngerstreuer
AT3550U3 (de)	2000-10-25	Futterautomat
FR2817889B1 (fr)	2003-08-15	Coffrage
ATA12252000A (de)	2002-01-15	Regensinkkasten
SE9900592D0 (sv)	1999-01-26	Gallium
SE9902459D0 (sv)	1999-03-09	Gallium