DK1499607T3 - 4-(piperidyl- og pyrrolidyl-alkyl-ureido)-quinoliner som urotensin II-receptorantagonister - Google Patents

4-(piperidyl- og pyrrolidyl-alkyl-ureido)-quinoliner som urotensin II-receptorantagonister

Info

Publication number
DK1499607T3
DK1499607T3 DK02791749T DK02791749T DK1499607T3 DK 1499607 T3 DK1499607 T3 DK 1499607T3 DK 02791749 T DK02791749 T DK 02791749T DK 02791749 T DK02791749 T DK 02791749T DK 1499607 T3 DK1499607 T3 DK 1499607T3
Authority
DK
Denmark
Prior art keywords
urotensin
quinolines
pyrrolidyl
ureido
piperidyl
Prior art date
Application number
DK02791749T
Other languages
English (en)
Inventor
Christoph Binkert
Martine Clozel
Boris Mathys
Claus Mueller
Thomas Weller
Scherz Michael Dr
Joerg Velker
Aissaoui Hamed Dr
Oliver Nayler
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK1499607T3 publication Critical patent/DK1499607T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK02791749T 2001-12-04 2002-12-02 4-(piperidyl- og pyrrolidyl-alkyl-ureido)-quinoliner som urotensin II-receptorantagonister DK1499607T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP0114195 2001-12-04

Publications (1)

Publication Number Publication Date
DK1499607T3 true DK1499607T3 (da) 2006-04-18

Family

ID=8164711

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02791749T DK1499607T3 (da) 2001-12-04 2002-12-02 4-(piperidyl- og pyrrolidyl-alkyl-ureido)-quinoliner som urotensin II-receptorantagonister

Country Status (18)

Country Link
US (1) US7375227B2 (da)
EP (1) EP1499607B1 (da)
CN (1) CN100424082C (da)
AT (1) ATE312090T1 (da)
AU (1) AU2002358071B2 (da)
CA (1) CA2473892C (da)
CY (1) CY1104993T1 (da)
DE (1) DE60207894T2 (da)
DK (1) DK1499607T3 (da)
ES (1) ES2254772T3 (da)
HU (1) HUP0402184A2 (da)
IL (1) IL162851A0 (da)
MX (1) MXPA04006599A (da)
NO (1) NO20042844L (da)
NZ (1) NZ534046A (da)
SI (1) SI1499607T1 (da)
WO (1) WO2003048154A1 (da)
ZA (1) ZA200405348B (da)

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WO2004026836A2 (en) * 2002-09-17 2004-04-01 Actelion Pharmaceuticals Ltd 1-pyridin-4-yl-urea derivatives
US20060211707A1 (en) * 2003-05-07 2006-09-21 Hamed Aissaoui Piperazine-alkyl-ureido derivatives
CN1784394A (zh) * 2003-05-08 2006-06-07 埃科特莱茵药品有限公司 新型哌啶衍生物
EP1670470B1 (en) * 2003-09-26 2009-04-08 Actelion Pharmaceuticals Ltd. Pyridine derivatives and use thereof as urotensin ii antagonists
DE10358539A1 (de) * 2003-12-15 2005-07-07 Merck Patent Gmbh Carbonsäureamidderivate
EP1786814B1 (en) 2004-08-25 2010-03-31 Actelion Pharmaceuticals Ltd. Bicyclononene derivatives as renin inhibitors
RU2397978C2 (ru) 2004-10-12 2010-08-27 Актелион Фармасьютиклз Лтд 1-[2-(4-бензил-4-гидроксипиперидин-1-ил)-этил]-3-(2-метилхинолин-4-ил)-мочевина в виде кристаллического сульфата
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
WO2006135694A2 (en) * 2005-06-10 2006-12-21 Acadia Pharmaceuticals Inc. Uii-modulating compounds and their use
CA2640807A1 (en) 2006-02-17 2007-08-23 F. Hoffmann-La Roche Ag Benzoyl-piperidine derivatives as 5ht2/d3 modulators
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
TW200812963A (en) * 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
JP5087631B2 (ja) 2006-10-31 2012-12-05 エフ．ホフマン−ラ ロシュ アーゲー ５−ｈｔ２ａ及びｄ３受容体のデュアルモジュレーターのエーテル誘導体
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
JP2010527367A (ja) * 2007-05-15 2010-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウロテンシンｉｉ受容体アンタゴニスト
CL2008001503A1 (es) * 2007-05-24 2008-07-04 Wyeth Corp Compuestos derivados de azaciclilbenzamidas, antagonistas de histamina-3; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para tratar un trastorno neurodegenerativo, como alzheimer, parkinso
PT2170860T (pt) 2007-06-29 2017-01-04 Pfizer Derivados de benzimidazol
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20090186567A1 (en) * 2008-01-17 2009-07-23 Xavier Orlhac Abrasive Tool With Mosaic Grinding Face
CN102757447B (zh) * 2011-07-05 2014-12-31 北京大学 一种尿素通道蛋白抑制剂及其制备方法与应用
KR101468207B1 (ko) 2013-02-14 2014-12-01 한국화학연구원 신규한 싸이에노[3,2-b]피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-Ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
KR101508214B1 (ko) * 2013-03-07 2015-04-07 한국화학연구원 신규한 아졸-접합 피리딜 우레아 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 유로텐신-ⅱ 수용체 활성 관련 질환의 예방 또는 치료용 약학적 조성물
FR3008619B1 (fr) * 2013-07-16 2018-04-20 Centre Hospitalier Universitaire De Rouen Antagonistes, agonistes partiels et agonistes inverses du recepteur de l'urotensine ii pour leur utilisation dans la prevention des deficits neurologiques consecutifs a une hemorragie sous-arachnoidienne
WO2016116900A1 (en) * 2015-01-23 2016-07-28 Gvk Biosciences Private Limited Inhibitors of trka kinase
JP2018521090A (ja) * 2015-07-29 2018-08-02 ラボラトリオス・デル・デエレ・エステベ・エセ・ア 疼痛に対する多様な活性を有するアミド誘導体
CN109306151B (zh) * 2018-08-31 2020-08-14 大连理工大学 一种不含醚氧键型聚合物阴离子交换膜及其制备方法
CN112830897B (zh) * 2019-11-22 2022-09-09 石家庄以岭药业股份有限公司 含脲基苯并咪唑类衍生物及其制备方法和应用
CN116139140A (zh) * 2021-11-19 2023-05-23 中国医学科学院药物研究所 一种化合物在治疗糖皮质激素不良反应中的用途
CN115677551A (zh) * 2021-12-28 2023-02-03 武汉市振邦生物科技有限公司 一种2-氧代吡咯烷-3-甲酸乙酯的制备工艺

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IE903957A1 (en) 1989-11-06 1991-05-08 Sanofi Sa Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
AUPP003197A0 (en) 1997-09-03 1997-11-20 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
ATE321751T1 (de) 1999-07-28 2006-04-15 Kirin Brewery Harnstoffderivate als ccr-3 rezeptor-inhibitoren
ES2225297T3 (es) * 1999-12-21 2005-03-16 Smithkline Beecham Corporation Antagonistas del receptor de urotensina ii.
ES2207566T3 (es) 1999-12-21 2004-06-01 Smithkline Beecham Corporation Derivados carboxamida de pirrolidina y piperidina como antagonistas del receptor de urotensina-ii.
CA2394603A1 (en) 1999-12-21 2001-06-28 Dashyant Dhanak Urotensin-ii receptor antagonists
EP1262195A4 (en) 2000-03-07 2003-05-21 Takeda Chemical Industries Ltd VASOACTIVE AGENTS
WO2002002530A1 (fr) 2000-07-04 2002-01-10 Takeda Chemical Industries, Ltd. Antagoniste de gpr14
US20040039017A1 (en) 2000-12-11 2004-02-26 Dashyant Dhanak Urotensin-II receptor antagonists
EP1359915A4 (en) 2001-01-26 2004-07-21 Smithkline Beecham UROTENSIN-II RECEPTOR ANTAGONISTS
US20040152692A1 (en) 2001-03-29 2004-08-05 Dashyant Dhanak Pyrrolidine sulfonamides
JP2004525156A (ja) 2001-03-29 2004-08-19 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
JP2004524355A (ja) 2001-03-29 2004-08-12 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド
JP2004529134A (ja) 2001-03-29 2004-09-24 スミスクライン・ビーチャム・コーポレイション ピロリジンスルホンアミド

Also Published As

Publication number Publication date
NO20042844L (no) 2004-08-23
CN100424082C (zh) 2008-10-08
HUP0402184A2 (hu) 2005-02-28
US20050043535A1 (en) 2005-02-24
AU2002358071A1 (en) 2003-06-17
WO2003048154A1 (en) 2003-06-12
DE60207894T2 (de) 2006-07-20
ZA200405348B (en) 2005-12-28
ATE312090T1 (de) 2005-12-15
MXPA04006599A (es) 2004-12-07
DE60207894D1 (en) 2006-01-12
CA2473892C (en) 2010-09-21
IL162851A0 (en) 2005-11-20
CA2473892A1 (en) 2003-06-12
NZ534046A (en) 2006-02-24
SI1499607T1 (sl) 2006-06-30
US7375227B2 (en) 2008-05-20
EP1499607A1 (en) 2005-01-26
AU2002358071B2 (en) 2008-06-12
ES2254772T3 (es) 2006-06-16
CN1617869A (zh) 2005-05-18
EP1499607B1 (en) 2005-12-07
CY1104993T1 (el) 2010-03-03

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