DK1485358T3 - Substitueret benzimidazol-sulfonamid som bred-sprektrum HIV-protease-inhibitorer - Google Patents

Substitueret benzimidazol-sulfonamid som bred-sprektrum HIV-protease-inhibitorer

Info

Publication number: DK1485358T3
Authority: DK; Denmark
Prior art keywords: broad; protease inhibitors; hiv protease; substituted benzimidazole; spectrum hiv
Prior art date: 2002-03-12

Application number

DK03714954.9T

Other languages

English (en)

Inventor

Bernhard Joanna Bernard Vergouwen

Dominique Louis Nestor Ghislain Surleraux

Piet Tom Bert Paul Wigerinck

Marieke Christiane Johanna Voets

Kock Herman Augustinus De

Sandrine Marie Helene Vendeville

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-12

Filing date

2003-03-12

Publication date

2011-05-09

2003-03-12 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2011-05-09 Application granted granted Critical

2011-05-09 Publication of DK1485358T3 publication Critical patent/DK1485358T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

DK03714954.9T 2002-03-12 2003-03-12 Substitueret benzimidazol-sulfonamid som bred-sprektrum HIV-protease-inhibitorer DK1485358T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02075999		2002-03-12
PCT/EP2003/050057 WO2003076413A1 (en)	2002-03-12	2003-03-12	Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number	Publication Date
DK1485358T3 true DK1485358T3 (da)	2011-05-09

Family

ID=27798870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03714954.9T DK1485358T3 (da)	2002-03-12	2003-03-12	Substitueret benzimidazol-sulfonamid som bred-sprektrum HIV-protease-inhibitorer

Country Status (26)

Country	Link
US (2)	US20050171175A1 (da)
EP (1)	EP1485358B1 (da)
JP (1)	JP4557552B2 (da)
KR (3)	KR20120136411A (da)
CN (2)	CN101935303B (da)
AP (1)	AP2111A (da)
AR (1)	AR038928A1 (da)
AT (1)	ATE497494T1 (da)
AU (1)	AU2003219159B2 (da)
BR (1)	BR0303373A (da)
CA (1)	CA2479012C (da)
DE (1)	DE60335939D1 (da)
DK (1)	DK1485358T3 (da)
EA (1)	EA011946B1 (da)
HK (1)	HK1072053A1 (da)
HR (1)	HRP20040936B1 (da)
IL (1)	IL163960A0 (da)
MX (1)	MXPA04008929A (da)
MY (1)	MY142238A (da)
NO (1)	NO326702B1 (da)
NZ (1)	NZ535439A (da)
PL (1)	PL213645B1 (da)
SI (1)	SI1485358T1 (da)
TW (1)	TWI329639B (da)
WO (1)	WO2003076413A1 (da)
ZA (1)	ZA200407242B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1860107B (zh) *	2003-09-30	2013-08-21	泰博特克药品有限公司	苯并*唑磺酰胺化合物的制备方法及其中间体
JP5073480B2 (ja) *	2004-05-07	2012-11-14	セコイア、ファーマシューティカルズ、インコーポレイテッド	耐性防止レトロウイルスプロテアーゼ阻害薬
WO2006089942A1 (en)	2005-02-25	2006-08-31	Tibotec Pharmaceuticals Ltd.	Protease inhibitor precursor synthesis
UA103013C2 (uk) *	2007-12-06	2013-09-10	Тиботек Фармасьютикелз	Амідні сполуки як активатори противірусних препаратів
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
WO2013011485A1 (en) *	2011-07-20	2013-01-24	Ranbaxy Laboratories Limited	Process for the preparation of sulfonamides useful as retroviral protease inhibitors

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US5843946A (en) *	1992-08-25	1998-12-01	G.D. Searle & Co.	α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
ES2127938T3 (es)	1993-08-24	1999-05-01	Searle & Co	Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
PT721331E (pt)	1993-10-01	2002-05-31	Astrazeneca Ab	Processo i
ES2303337T3 (es) *	1995-01-20	2008-08-01	G.D. Searle Llc	Inhibidores de la proteasa retroviral de bis-hidroxietilamino sulfonamida.
US6140505A (en) *	1995-03-10	2000-10-31	G. D. Searle & Co.	Synthesis of benzo fused heterocyclic sulfonyl chlorides
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
CZ297676B6 (cs) *	1995-03-10	2007-03-07	G. D. Searle & Co.	Deriváty hydroxyethylaminosulfonamidu jako inhibitory retrovirové proteázy, farmaceutická kompozice
US6150556A (en) *	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) *	1995-03-10	1998-07-07	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
AU7722296A (en)	1995-11-15	1997-06-05	G.D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CA2240161C (en)	1996-05-20	2005-05-24	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
ID21477A (id)	1997-03-26	1999-06-17	Janssen Pharmaceutica Nv	Pelet-pelet yang mempunyai inti yang dilapisi dengan suatu anti jamur dan suatu polimer
CA2297070A1 (en) *	1997-08-01	1999-02-11	Morphosys Ag	Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
WO1999033792A2 (en)	1997-12-24	1999-07-08	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
EP1042280A2 (en)	1997-12-24	2000-10-11	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
WO1999065870A2 (en) *	1998-06-19	1999-12-23	Vertex Pharmaceuticals Incorporated	Sulfonamide inhibitors of aspartyl protease
AU4828199A (en) *	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion

2003
- 2003-03-10 MY MYPI20030825A patent/MY142238A/en unknown
- 2003-03-11 AR ARP030100829A patent/AR038928A1/es not_active Application Discontinuation
- 2003-03-11 TW TW092105142A patent/TWI329639B/zh not_active IP Right Cessation
- 2003-03-12 PL PL374152A patent/PL213645B1/pl unknown
- 2003-03-12 BR BR0303373-2A patent/BR0303373A/pt not_active IP Right Cessation
- 2003-03-12 AT AT03714954T patent/ATE497494T1/de not_active IP Right Cessation
- 2003-03-12 DK DK03714954.9T patent/DK1485358T3/da active
- 2003-03-12 KR KR1020127028481A patent/KR20120136411A/ko not_active Application Discontinuation
- 2003-03-12 MX MXPA04008929A patent/MXPA04008929A/es active IP Right Grant
- 2003-03-12 IL IL16396003A patent/IL163960A0/xx unknown
- 2003-03-12 SI SI200331984T patent/SI1485358T1/sl unknown
- 2003-03-12 KR KR10-2004-7014171A patent/KR20040093119A/ko not_active Application Discontinuation
- 2003-03-12 KR KR1020107018927A patent/KR101302421B1/ko not_active IP Right Cessation
- 2003-03-12 WO PCT/EP2003/050057 patent/WO2003076413A1/en active Application Filing
- 2003-03-12 AU AU2003219159A patent/AU2003219159B2/en not_active Ceased
- 2003-03-12 EA EA200401188A patent/EA011946B1/ru not_active IP Right Cessation
- 2003-03-12 NZ NZ535439A patent/NZ535439A/en not_active IP Right Cessation
- 2003-03-12 JP JP2003574633A patent/JP4557552B2/ja not_active Expired - Fee Related
- 2003-03-12 AP APAP/P/2004/003151A patent/AP2111A/en active
- 2003-03-12 CN CN201010251011.9A patent/CN101935303B/zh not_active Expired - Fee Related
- 2003-03-12 EP EP03714954A patent/EP1485358B1/en not_active Expired - Lifetime
- 2003-03-12 US US10/508,561 patent/US20050171175A1/en not_active Abandoned
- 2003-03-12 CN CNA038104725A patent/CN1653053A/zh active Pending
- 2003-03-12 DE DE60335939T patent/DE60335939D1/de not_active Expired - Lifetime
- 2003-03-12 CA CA2479012A patent/CA2479012C/en not_active Expired - Fee Related
- 2003-11-12 NO NO20035023A patent/NO326702B1/no not_active IP Right Cessation
2004
- 2004-09-09 ZA ZA2004/07242A patent/ZA200407242B/en unknown
- 2004-10-07 HR HRP20040936AA patent/HRP20040936B1/xx not_active IP Right Cessation
2005
- 2005-06-10 HK HK05104907.9A patent/HK1072053A1/xx not_active IP Right Cessation
2009
- 2009-04-27 US US12/430,547 patent/US8143421B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL374152A1 (en)	2005-10-03
AU2003219159A1 (en)	2003-09-22
ATE497494T1 (de)	2011-02-15
NO326702B1 (no)	2009-02-02
WO2003076413A1 (en)	2003-09-18
AP2111A (en)	2010-03-03
NO20035023D0 (no)	2003-11-12
KR20120136411A (ko)	2012-12-18
JP2005519952A (ja)	2005-07-07
HK1072053A1 (en)	2005-08-12
EA200401188A1 (ru)	2005-04-28
IL163960A0 (en)	2005-12-18
BR0303373A (pt)	2004-03-23
AU2003219159B2 (en)	2009-09-03
KR20040093119A (ko)	2004-11-04
EP1485358A1 (en)	2004-12-15
CA2479012C (en)	2011-11-01
KR101302421B1 (ko)	2013-09-02
DE60335939D1 (de)	2011-03-17
CN1653053A (zh)	2005-08-10
EA011946B1 (ru)	2009-06-30
CN101935303A (zh)	2011-01-05
TW200400945A (en)	2004-01-16
US8143421B2 (en)	2012-03-27
MXPA04008929A (es)	2004-11-26
US20090203743A1 (en)	2009-08-13
AP2004003151A0 (en)	2004-12-31
SI1485358T1 (sl)	2011-05-31
CN101935303B (zh)	2014-03-12
AR038928A1 (es)	2005-02-02
US20050171175A1 (en)	2005-08-04
HRP20040936B1 (en)	2012-09-30
KR20100102742A (ko)	2010-09-24
PL213645B1 (pl)	2013-04-30
NZ535439A (en)	2009-09-25
JP4557552B2 (ja)	2010-10-06
MY142238A (en)	2010-11-15
TWI329639B (en)	2010-09-01
ZA200407242B (en)	2005-12-28
EP1485358B1 (en)	2011-02-02
HRP20040936A2 (en)	2005-10-31
CA2479012A1 (en)	2003-09-18

Publication	Publication Date	Title
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DK2279737T3 (da)	2013-02-11	Heterocycliske forbindelser, der er aktive som beta-lactamaseinhibitorer
NO20050665L (no)	2005-04-18	Pyrrolidonderivater som MAOE inhibitoere
NO20051236L (no)	2005-04-08	Heterobiarylderivater som matriksmetalloproteinaseinhibitorer
ATE308544T1 (de)	2005-11-15	N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren
NO20041887L (no)	2004-05-07	Benzomidazoler anvendelige som proteinkinase-inhibitorer
DK1499316T3 (da)	2008-07-21	(1-4-piperidinyl)benzimidazolderivater anvendelige som histamin-H3-antagonister
NO20033618D0 (no)	2003-08-14	Ftalayinon-piperidino-derivater som PDE-4-inhibitorer
ATE304015T1 (de)	2005-09-15	Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren
IL166257A0 (en)	2006-01-15	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
NO20043794L (no)	2004-09-10	Benzensulfonamidderivater som antipsykotiske midler
HK1076099A1 (en)	2006-01-06	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
DK1556377T3 (da)	2006-10-23	Cyclopropylthienylcarboxamider som fungicider
ATE429431T1 (de)	2009-05-15	2-amino-benzoxazol-suphonamide als breitspektrum- hiv-protease-inhibitoren
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NO20043114L (no)	2004-09-20	Bredspektrede heterocyklisk substituerte fenylinneholdende sulfonamid-HIV-proteaseinhibitorer
PL375307A1 (en)	2005-11-28	Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
NO20043610L (no)	2004-10-05	Fenylpyrimidinaminer som IgE inhibitorer
ZA200500926B (en)	2006-03-29	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors