DK147152B - PROCEDURE FOR PREPARING A PREPARATION FOR FEED USE - Google Patents
PROCEDURE FOR PREPARING A PREPARATION FOR FEED USE Download PDFInfo
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- DK147152B DK147152B DK517877AA DK517877A DK147152B DK 147152 B DK147152 B DK 147152B DK 517877A A DK517877A A DK 517877AA DK 517877 A DK517877 A DK 517877A DK 147152 B DK147152 B DK 147152B
- Authority
- DK
- Denmark
- Prior art keywords
- premix
- weight
- lactose
- flour
- feed
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 18
- 238000002360 preparation method Methods 0.000 title description 5
- 239000002245 particle Substances 0.000 description 33
- 239000000203 mixture Substances 0.000 description 31
- 239000004480 active ingredient Substances 0.000 description 30
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 29
- 239000008101 lactose Substances 0.000 description 29
- 235000013312 flour Nutrition 0.000 description 25
- 239000002002 slurry Substances 0.000 description 21
- 239000000843 powder Substances 0.000 description 15
- 239000000243 solution Substances 0.000 description 13
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- 229940126578 oral vaccine Drugs 0.000 description 9
- 239000007921 spray Substances 0.000 description 9
- 239000002253 acid Substances 0.000 description 7
- 239000005862 Whey Substances 0.000 description 6
- 102000007544 Whey Proteins Human genes 0.000 description 6
- 108010046377 Whey Proteins Proteins 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
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- 238000005507 spraying Methods 0.000 description 3
- 238000009827 uniform distribution Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- 230000008901 benefit Effects 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
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- 238000010348 incorporation Methods 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000003921 particle size analysis Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
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- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000392514 Salmonella enterica subsp. enterica serovar Dublin Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 240000000359 Triticum dicoccon Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000001165 anti-coccidial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 235000015155 buttermilk Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910052622 kaolinite Inorganic materials 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000010815 organic waste Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000000700 radioactive tracer Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000011845 white flour Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- General Preparation And Processing Of Foods (AREA)
- Medicinal Preparation (AREA)
- Feed For Specific Animals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
i o 147152in o 147152
Den foreliggende opfindelse angår en fremgangsmåde til fremstilling af en forblanding til foderbrug i form af en fritstrømmende partikelformet sammensætning, ved hvilken en mindre mængde aktiv bestanddel såsom en oral vaccine, et 5 vitamin eller et sporstof dispergeres ensartet gennem et bæremateriale, som udgør hovedmassen af forblandingen.The present invention relates to a process for preparing a premix for feed use in the form of a free-flowing particulate composition in which a minor amount of active ingredient such as an oral vaccine, vitamin or tracer is uniformly dispersed through a carrier which is the main mass of the premix. .
Sådanne forblandinger anvendes for at lette indblandingen af disse mindre mængder aktive bestanddele i foder på homogen måde.Such premixes are used to facilitate the incorporation of these smaller amounts of active ingredients into feed in a homogeneous manner.
10 I det følgende vil betegnelsen "den aktive bestand del" altså dække sådanne vigtige komposanter som en oral vaccine eller en ernæringsmæssig essentiel bestanddel.Hence, the term "active ingredient portion" will cover such important components as an oral vaccine or nutritional essential ingredient.
Sædvanlige forblandinger, som typisk omfatter den aktive bestanddel dispergeret med mekaniske midler i en 15 tør bærer som f.eks. mel eller et andet formalet kornprodukt, er tilbøjelige til at opføre sig utilfredsstillende, fordi det er vanskeligt at opnå en ensartet fordeling af den aktive bestanddel gennem hele bærermassen ved simpel sammenblanding, især i tilfælde, hvor den aktive be-20 standdel er lettest at håndtere som en væske. Gennem nærværende opfindelse tilvejebringes der en fremgangsmåde til fremstilling af forblandinger, som kun omfatter simple trin, og som fører til større ensartethed ved den aktive bestanddels fordeling.Conventional premixes which typically comprise the active ingredient dispersed by mechanical means in a dry carrier such as e.g. flour or other ground cereal products tend to behave unsatisfactorily because it is difficult to achieve a uniform distribution of the active ingredient throughout the carrier mass by simple mixing, especially in cases where the active ingredient is most easily handled. like a liquid. The present invention provides a process for preparing premixes which comprises only simple steps and which leads to greater uniformity in the distribution of the active ingredient.
25 Fremgangsmåden ifølge opfindelsen er ejendommelig ved, at bærematerialet omfatter en tør, partikelformet blanding af et mel og en lactose-kilde, idet lactoseind-holdet i blandingen er fra 20 til 50 vægt%, og at forblandingen dannes ved intens omrøring af bærematerialet og 30 samtidig sprøjtning af det med en vandig opløsning eller opslæmning af den aktive bestanddel, idet opløsningen eller opslæmningen påføres i en mængde fra 1 til 12 vægt% af bærematerialet.The process of the invention is characterized in that the carrier comprises a dry, particulate mixture of a flour and a lactose source, the lactose content of the mixture being from 20 to 50% by weight and the premix being formed by intense stirring of the carrier and 30 simultaneously spraying it with an aqueous solution or slurry of the active ingredient, the solution or slurry being applied in an amount of 1 to 12% by weight of the carrier material.
Fortrinsvis er lactose-indholdet i den tørre par-35 tikelformede blanding mindst 22 vægt%, og ideelt er lactose-indholdet mindst 25 vægt%. Fortrinsvis er lactose-ind- 2 147152 o holdet i den tørre partikelformede blanding ikke større end 45 vægt% og ideelt ikke større end 35 vægt%.Preferably, the lactose content of the dry particulate mixture is at least 22% by weight, and ideally the lactose content is at least 25% by weight. Preferably, the lactose content of the dry particulate mixture is not greater than 45% by weight and ideally not greater than 35% by weight.
Fortrinsvis er den mængde opløsning eller opslæmning, som den tørre partikelformede blanding påføres, 5 mindst 2 vægt%, og fortrinsvis er den ikke større end 10 vægt%, ideelt ikke større end 6 vægt%.Preferably, the amount of solution or slurry to which the dry particulate mixture is applied is at least 2% by weight, and preferably is not greater than 10% by weight, ideally not greater than 6% by weight.
Melet bør sammen med lactosekilden udgøre hovedmassen af den tørre, partikelformede blanding, men andre materialer kan dog være til stede i en samlet mængde, som 10 ikke overskrider f.eks. 15 vægt% af den tørre partikelformede blanding, forudsat at ethvert sådant yderligere materiale ikke utilbørligt påvirker strømningsegenskaberne for den tørre partikelformede blanding eller de ønskede egenskaber for den dannede forblanding.The flour should, together with the source of lactose, constitute the main mass of the dry particulate mixture, however other materials may be present in a total amount not exceeding e.g. 15% by weight of the dry particulate mixture, provided that any such additional material does not unduly affect the flow properties of the dry particulate mixture or the desired properties of the premix formed.
15 Melet er et pulver, som er i hovedsagen lactosefrit, og som kun er lidt opløseligt i vand. Der kan anvendes mange forskellige melsorter, der almindeligvis anvendes som bestanddele i foder, f.eks. malet korn, bønnemel og sojamel, forudsat at der deri ikke findes for mange olieagtige 20 eller vandopløselige komponenter, samt endvidere organiske spildprodukter og fyldstoffer, der anvendes i animalske foderstoffer, f.eks. roepulp, kartoffelpulp og fjermel, samt uorganiske fyldstoffer, såsom kaolin, kaolinit, sili-ca og kridt. Fortrinsvis skal det valgte mel inkorporeres 25 i en mængde på op til mindst 0,5 vægt% i det færdige foder, og ideelt skal det inkorporeres i en mængde på mindst 1,5 vægt%. Ideelle i handelen værende melsorter er f.eks. hvedemel, majsmel, rismel og kartoffelmel. De fleste i handelen værende melsorter indeholder ca. 12 vægt% vand, og 30 disse produkter kan anvendes til fremstilling af acceptable forblandinger ifølge opfindelsen, men det er at foretrække at anvende tørrede melsorter, dvs. mel med et fugtig-hedsindhold på mindre end 10 vægt%, idet der hermed kan fås en længere opbevaringsholdbarhed for forblandingen.The flour is a powder which is essentially lactose-free and which is only slightly soluble in water. Many different types of flour can be used, commonly used as constituents in feed, e.g. ground cereals, bean flour and soy flour, provided there are not too many oily or water-soluble components in them, as well as organic waste products and fillers used in animal feed, e.g. beet pulp, potato pulp and buttermilk, as well as inorganic fillers such as kaolin, kaolinite, silica and chalk. Preferably, the selected flour should be incorporated in an amount of up to at least 0.5% by weight in the finished feed, and ideally it should be incorporated in an amount of at least 1.5% by weight. Ideal commercial flour types are e.g. wheat flour, corn flour, rice flour and potato flour. Most commercial flour types contain approx. 12% by weight of water and these products can be used to prepare acceptable premixtures of the invention, but it is preferable to use dried flour varieties, ie. flour having a moisture content of less than 10% by weight, thereby providing a longer shelf life of the premix.
35 Lactosekilden kan være et hvilket som helst i han delen forekommende lactoseholdigt produkt, som har et tilstrækkeligt højt lactose-indhold og ikke indeholder kende-The source of lactose may be any lactose-containing product present in the portion which has a sufficiently high lactose content and does not contain known
OISLAND
3 147152 lige mængder af nogen anden bestanddel, som kan påvirke dannelse af forblandingen eller dens egenskaber. Et indhold på 50 vægt% lactose kan betragtes som et praktisk minimum i det fleste tilfælde, og et højere indhold vil 5 almindeligvis være at foretrække. Fedt er et eksempel på en bestanddel, der kan være uønsket i lactosekilden eller endda generelt i forblandingen, og derfor bør lactosekil-der med højt fedtindhold undgås. Af denne grund er skummetmælk ikke at anbefale til anvendelse som den egentlige 10 lactosekilde, selv om der i nogle tilfælde kan inkorporeres mindre mængder skummetmælkpulver, forudsat at hovedmassen af lactosen i forblandingen kommer fra en anden kilde. Rent lactosepulver kan anvendes som lactosekilde, men det er forholdsvis dyrt og er derfor kun at foretræk-15 ke, når andre lactosekilder af smagsmæssige grunde ville være uegnede.Equal amounts of any other component which may affect formation of the premix or its properties. A content of 50% by weight of lactose can be considered a practical minimum in most cases, and a higher content would generally be preferred. Fat is an example of an ingredient that may be undesirable in the lactose source or even generally in the premix and therefore high fat lactose sources should be avoided. For this reason, skimmed milk is not recommended for use as the actual source of lactose, although in some cases smaller amounts of skimmed milk powder may be incorporated, provided that the bulk of the lactose in the premix comes from another source. Pure lactose powder can be used as a source of lactose, but it is relatively expensive and is therefore only preferred when other lactose sources for taste reasons would be unsuitable.
Ved en særlig foretrukken udførelsesform for fremgangsmåden ifølge opfindelsen ved fremstilling af forblandinger til foderstoffer er den inkorporerede lactosekil-20 de vallepulver, der typisk indeholder ca. 75 vægt% lactose. Ved denne udførelsesform bør den tørre partikelformede blanding omfatte fra 40 til 70 vægt% mel og fra 60 til 30 vægt% vallepulver. Fortrinsvis udgør melet mindst 50% og ideelt mindst 55 vægt% af den tørre partikelfor-25 mede blanding, og fortrinsvis udgør melet ikke mere end 65 vægt% af den tørre partikelformede blanding. Fortrinsvis udgør vallepulveret mindst. 35 vægt% af denne blanding, og fortrinsvis udgør vallepulveret ikke mere end 50, ideelt ikke mere end 45 vægt% af den tørre partikelfor-30 mede blanding.In a particularly preferred embodiment of the method according to the invention in the preparation of feed premixes, the incorporated lactose-free whey powder, which typically contains approx. 75% by weight of lactose. In this embodiment, the dry particulate mixture should comprise from 40 to 70% by weight of flour and from 60 to 30% by weight of whey powder. Preferably, the flour comprises at least 50% and ideally at least 55% by weight of the dry particle-mixed mixture, and preferably the flour does not constitute more than 65% by weight of the dry particulate mixture. Preferably, the whey powder is the least. 35% by weight of this mixture, and preferably the whey powder does not constitute more than 50, ideally not more than 45% by weight of the dry particle-shaped mixture.
En yderligere udførelsesform for fremgangsmåden ifølge opfindelsen består i, at der i forblandingen inkorporeres en lille mængde af en svag, spiselig syre, og denne kan da fortrinsvis udgøre fra 1 til 10 vægt% af for-35 bladingen. Ideelt udgør syren mindst 2 vægt% og ikke mere end 6 vægt% af forblandingen. Selv om syren almindeligvis kan inkorporeres i den tørre, partikelformede blanding,A further embodiment of the process according to the invention consists in incorporating in the premix a small amount of a weak, edible acid, and this can then preferably comprise from 1 to 10% by weight of the premix. Ideally, the acid represents at least 2% by weight and not more than 6% by weight of the premix. Although the acid can generally be incorporated into the dry, particulate mixture,
OISLAND
4 U71B2 som påføres opløsningen eller opslæmningen, kan det i nogle tilfælde være praktisk og nyttigt at inkorporere noget af eller al syren i opløsningen eller opslæmningen. Citronsyre er at foretrække, men andre spiselige g syrer såsom vinsyre og ascorbinsyre kan også anvendes. Endvidere kan der anvendes spiselige syresalte såsom natrium-di-hydrogenphosphat i tilfælde, hvor tilstedeværelse af natrium ikke vil føre til uønskede problemer med hensyn til saltbalancen hos dyr, der indtager fo-10 deret. Fra in vitro-forsøg kan det sluttes, at tilstedeværelse af den svage, spiselige syre forøger frigørelsen af den aktive bestanddel, når foder indeholdende forblandingen kommer ned i tarmen.4 U71B2 applied to the solution or slurry may in some cases be practical and useful to incorporate some or all of the acid into the solution or slurry. Citric acid is preferred, but other edible acids such as tartaric acid and ascorbic acid may also be used. In addition, edible acid salts such as sodium di-hydrogen phosphate can be used in cases where the presence of sodium will not lead to undesirable problems with respect to the salt balance of animals consuming the feed. From in vitro experiments, it can be concluded that the presence of the weak, edible acid increases the release of the active ingredient when feed containing the premix enters the intestine.
Ved endnu en udførelsesform inkorporeres der et ac-15 ceptabelt farvemiddel i den vandige opløsning eller opslæmning, som påføres den tørre, partikelformede blanding, og fortrinsvis er dette farvemiddel vandopløseligt. Formålet dermed er at sikre, at det bliver tydeligt at se fordelingen af den vandige opløsning eller opslæmning gen-20 nem hele den tørre, parkelformede blanding. Den valgte farve skal derfor være således, at den er tydelig at skelne fra grundfarven for den tørre partikelformede blanding.In yet another embodiment, an acceptable colorant is incorporated into the aqueous solution or slurry applied to the dry, particulate mixture, and preferably this colorant is water soluble. The purpose of this is to ensure that it is clear to see the distribution of the aqueous solution or slurry throughout the dry, parquet-shaped mixture. Therefore, the color chosen must be such that it is clearly distinguishable from the basic color of the dry particulate mixture.
I de fleste tilfælde vil grundfarven for denne blanding være i hovedsagen hvid. Bortset fra dette ønske og ønske-25 ligheden af at anvende et farvemiddel, som er effektivt i forhold til prisen, er valget af farve udelukkende et æstetisk spørgsmål.In most cases, the basic color of this mixture will be substantially white. Apart from this desire and the desirability of using a colorant which is effective in relation to price, the choice of color is purely an aesthetic question.
Ved fremgangsmåden ifølge opfindelsen udnyttes lac-toses evne til at absorbere små mængder vand under dannelse 30 af et glaslignende stof. I en forblanding fremstillet ved fremgangsmåden ifølge opfindelsen er det konstateret, at forblandingen omfatter en mangfoldighed af små hårde partikler, som hver består af mel bundet sammen af lactose--glasset og ensartet fordelt gennem hele massen af tør par-35 tikelformet blanding. Det er endvidere konstateret, at den aktive bestanddel vil være næsten fuldstændig at finde i de lactose-bundne partikler, hvilket fremgår tydeligt, når o 5 147152 der også er inkorporeret et farvestof/ fordi det da ses tydeligt, at farven er koncentreret i de lactosebundne partikler.The process of the invention utilizes the ability of lactose to absorb small amounts of water to form a glass-like substance. In a premix made by the process of the invention, it is found that the premix comprises a plurality of small hard particles, each consisting of flour bonded together by the lactose glass and uniformly distributed throughout the mass of dry particulate mixture. Furthermore, it has been found that the active ingredient will be almost completely found in the lactose-bound particles, which is evident when a dye is also incorporated / because it is then clearly seen that the color is concentrated in the lactose-bound particles. particles.
På grund af den kritiske udvælgelse af mængde-5 forholdene mellem lactosen og melet repræsenterer den forblanding, som fås ved fremgangsmåden ifølge opfindelsen, et produkt med en ensartet fordeling af partikler indeholdende den aktive bestanddel igennem hele den enkelte partikels masse og dog i form af et fritstrømmende, par-10 tikelprodukt, som kun har ringe tilbøjelighed til at sammenklumpe eller segregere. Desuden er det ved hjælp af farvestoffet, når et sådant inkorporeres, muligt at konstatere den ensartede fordeling af partiklerne indeholdende den aktive bestanddel. Den ved fremgangsmåden ifølge 15 opfindelsen fremstillede foderforblanding har den yderligere fordel, at de enkelte partikler indeholdende de aktive bestanddele kan adskilles fysisk fra hovedmassen af melet, der stadig foreligger som pulver, f.eks. med hånden eller ved sigtning, og prøvning af den aktive bestand-20 del kan da let udføres på de fraskilte partikler.Due to the critical selection of the ratio of lactose to flour, the premix obtained by the process of the invention represents a product having a uniform distribution of particles containing the active ingredient throughout the mass of the individual particle, but in the form of a free-flowing, particulate product having little inclination to clump or segregate. In addition, when the dye is incorporated, it is possible to ascertain the uniform distribution of the particles containing the active ingredient. The feed premix made by the process according to the invention has the additional advantage that the individual particles containing the active ingredients can be physically separated from the main mass of the flour still present as powder, e.g. by hand or by sieving, and testing of the active ingredient can then easily be performed on the separated particles.
De ved fremgangsmåden ifølge opfindelsen opnåede forblandinger er anvendelige til mange forskellige aktive bestanddele, men en foretrukken anvendelse af disse forblandinger er til inkorporering af orale vacciner i fodere.The premixtures obtained by the process of the invention are useful for many different active ingredients, but a preferred use of these premixtures is for incorporating oral vaccines into feed.
25 Fremgangsmåden ifølge opfindelsen er således ideelt egnet til fremstilling af forblandinger indeholdende endotoksi-ner stammende fra bakteriestammer, der er impliceret i gastro-intestinale forstyrrelser. Da sådanne endotoksiner er i hovedsagen fri for indhold af levende bakterier, frem-30 bringer de ved oral indgivning en i høj grad effektiv immum-reaktion over for bakterierne. Især gælder det for Escherichia coli, og også andre tarminfektionsbakterier har vist sig modtagelige. Der er til svin udviklet en oral vaccine, hvori endotoksinerne stammer fra en eller flere af 35 E. coli-stammerne 08, 045, 0138, 0139, 0141, 0149 og 0157, og et foder indeholdende en sådan oral vaccine er beskre- 147152Thus, the method of the invention is ideally suited for the preparation of premixes containing endotoxins derived from bacterial strains implicated in gastrointestinal disorders. Since such endotoxins are essentially free of living bacteria, they produce a highly effective immune response to the bacteria by oral administration. This is especially true of Escherichia coli, and other gut infection bacteria have also been found to be susceptible. An oral vaccine has been developed for pigs in which the endotoxins originate from one or more of the 35 E. coli strains 08, 045, 0138, 0139, 0141, 0149 and 0157 and a feed containing such an oral vaccine is described.
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6 vet i britisk patentskrift nr. 1.336.015. En analog oral vaccine til kalve indeholder endotoksiner fra en eller flere af E. coli-stammerne 08, 09, 015, 026, 078, 086, 0114, 0115, 0137 og 0139. Kalvevaccinen kan desuden med fordel 5 indeholde endotoksiner stammende fra Salmonella dublin og/eller Salmonella typhimurium, og et foderstof 'indeholdende en sådan oral vaccine findes beskrevet i britisk patentskrift nr. 1.401.280, medens en lignende oral vaccine til lam indeholdende endotoksiner fra E. coli-10 -stammerne 08, 09, 015, 020, 078, 0114, 0137 og 0139 og en oral vaccine indeholdende disse endotoksiner findes beskrevet i britisk patentskrift nr. 1.462.384.6 knows in British Patent Specification No. 1,336,015. An analogue oral vaccine for calves contains endotoxins from one or more of E. coli strains 08, 09, 015, 026, 078, 086, 0114, 0115, 0137 and 0139. In addition, the calf vaccine may advantageously contain endotoxins derived from Salmonella dublin and / or Salmonella typhimurium, and a feed containing such an oral vaccine are disclosed in British Patent Specification No. 1,401,280, while a similar oral vaccine to lambs containing endotoxins from E. coli-10 strains 08, 09, 015, 020 , 078, 0114, 0137 and 0139 and an oral vaccine containing these endotoxins are disclosed in British Patent Specification No. 1,462,384.
Alternative aktive bestanddele omfatter antibiotika såsom anticoccidiale lægemidler, hormoner, vitami-15 ner såsom A og D og provitaminer såsom β-caroten, samt sporstoffer og mineraler såsom kilder for calcium, phos-phor, jern, mangan, kobber og iod, samt vækstfremmere/ foruden aromastoffer og parfumer. Behovet for, at sådanne aktive bestanddele findes i dyrefoder, er velkendt og vel-20 dokumenteret i den tekniske litteratur, hvilket også gælder arten af sådanne aktive bestanddele og den grad, hvori de kan fås kommercielt.Alternative active ingredients include antibiotics such as anticoccidial drugs, hormones, vitamins such as A and D and provitamins such as β-carotene, as well as trace elements and minerals such as sources of calcium, phosphorus, iron, manganese, copper and iodine, and growth promoters. in addition to flavors and perfumes. The need for such active ingredients to be found in animal feed is well known and well documented in the technical literature, as is the nature of such active ingredients and the degree to which they can be obtained commercially.
Koncentrationen af de aktive bestanddele i den vandige opløsning eller opslæmning er ikke kritisk, bort-25 set fra, at opløsningens eller opslæmningens viskositet skal være således, at opløsningen eller opslæmningen kan udsprøjtes som meget fine dråber på den tørre partikelformede blanding.The concentration of the active ingredients in the aqueous solution or slurry is not critical, except that the viscosity of the solution or slurry must be such that the solution or slurry can be sprayed as very fine droplets on the dry particulate mixture.
Forblandinger indeholdende mere end én aktiv be-30 standdel kan også fremstilles ved fremgangsmåden ifølge opfindelsen, og alle de pågældende aktive bestanddele kan da om ønsket inkorporeres i en enkelt vandig opløsning eller opslæmning. I nogle tilfælde kan dog en ikke--samtidig påføring af særskilte opløsninger eller opslæm-35 ninger af de enkelte aktive bestanddele være praktisk og fordelagtig. Når der anvendes særskilte opløsninger eller opslæmningen kan inkorporering af tydeligt forskelli-Premixtures containing more than one active ingredient can also be prepared by the process of the invention, and all the active ingredients concerned can then be incorporated into a single aqueous solution or slurry if desired. However, in some cases, non-simultaneous application of separate solutions or slurries of the individual active ingredients may be practical and advantageous. When using separate solutions or the slurry, incorporation of distinct
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7 147162 ge farvemidler i hver opløsning eller opslæmning muliggøre, at partikler indeholdende de forskellige aktive bestanddele kan identificeres i den opnåede forblanding, f.eks. til sikkerhed for landmanden, der bruger flere forskel-5 lige typer forblandinger til forskellige dyr.Coloring agents in each solution or slurry enable particles containing the various active ingredients to be identified in the premix obtained, e.g. for the safety of the farmer using several different types of premixes for different animals.
Den fysiske fremstilling af forblandingerne kan ske under anvendelse af et hvilket som helst sædvanligt apparatur, der er i stand til at give intens omrøring af et partikelformet materiale og samtidigt at sprøjte en væ-10 ske fint ud på dette materiale. Der kan anvendes vandrette båndblandere, men der kan også anvendes lodrette spray--blandere såsom "Schugi"-blanderen. Om ønsket kan forblandingen fremstillet i et fluidiseret lag udstyret med et sprøjtehoved for opløsningen eller opslæmningen.The physical preparation of the premixtures may be effected using any conventional apparatus capable of providing intense agitation of a particulate material and at the same time spraying a liquid finely onto this material. Horizontal tape mixers can be used, but vertical spray mixers such as the "Schugi" mixer can also be used. If desired, the premix can be made in a fluidized layer equipped with a spray head for the solution or slurry.
15 Det vil være klart, at partikelstørrelsen af de materialer, der udgør den tørre partikelformede blanding, og også dråbestørrelsen for den derpå sprøjtede opløsning eller opslæmning vil påvirke de partikelstørrelser, der findes i den opnåede forblanding. Ved variation af disse para-20 metre er det muligt at fremstille forblandinger, der har forskellig partikelstørrelsesfordelinger, og hvori den aktive bestanddel findes i et stort antal meget små partikler eller i et mindre antal forholdsvis store partikler. Fremgangsmåden ifølge opfindelsen gør det således muligt 25 at frembringe forblandinger til opfyldelse af forskellige produkt-ønsker. De generelle principper, der bestemmer virkningen, er substratets partikelstørrelse, opløsningens eller opslæmningens viskositet, sprøjtedysens form og sprøjtetrykket, hvilket er velkendt for sagkyndige inden 30 for fødevareteknologien og beslægtede områder, og den teknik, der kræves til den fysiske fremstilling af en forblanding som den her omhandlede, er i sig selv kun standard-teknologi.It will be appreciated that the particle size of the materials constituting the dry particulate mixture and also the droplet size of the solution or slurry then sprayed will affect the particle sizes found in the premix obtained. By varying these parameters, it is possible to prepare premixes having different particle size distributions and wherein the active ingredient is present in a large number of very small particles or in a smaller number of relatively large particles. Thus, the process of the invention makes it possible to produce premixes to fulfill various product desires. The general principles that determine the effect are the particle size of the substrate, the viscosity of the solution or slurry, the shape of the spray nozzle and the spray pressure, which is well known to those skilled in the art of food technology and related fields, and the technique required for the physical preparation of a premix such as the this is in itself only standard technology.
Hvad angår partikelstørrelsen for bestanddelene 35 i den tørre partikelformede blanding, har det vist sig, at i handelen værende standard-bestanddele er ganske o 8 147152 fyldestgørende. Standard-melsorter, hvori f.eks. alle partiklerne undtagen en ganske lille mængde er mindre end 200^u i diameter, er således fuldstændig velegnede, og dette gælder også for i handelen værende vallepulver og lac-5 tosepulver. Generelt kan det angives, at hver bestanddel i den tørre, partikelformede blanding fortrinsvis skal have en sådan partikelstørrelse, at mindst 80 vægt% af bestanddelen vil passere gennem en 500^u-sigte, og ideelt at mindst 90 vægts af hver bestanddel vil passere gennem en 10 sådan sigte.As to the particle size of the constituents 35 of the dry particulate mixture, it has been found that commercially available standard constituents are quite adequate. Standard flour types, in which e.g. all the particles except a very small amount are less than 200 µm in diameter are thus perfectly suitable, and this is also true for commercially available whey powder and lactose powder. In general, it can be stated that each ingredient in the dry particulate mixture should preferably have a particle size such that at least 80% by weight of the component will pass through a 500 µl screen, and ideally at least 90% by weight of each component will pass through such a sieve.
Fortrinsvis skal den mængde opløsning eller opslæmning, der påføres på den tørre partikelformede blanding, og de anvendte sprøjtebetingelser vælges således, at den opnåede forblanding pr. gram indeholder mindst 1000 lactose-15 -bundne partikler med indhold af aktive bestanddele. Ideelt vil en ved fremgangsmåden ifølge opfindelsen opnået forblanding indeholde et endnu højere antal af lactosebundne partikler med indhold af aktive bestanddele, og der bør sigtes efter et indhold på mindst 2000 lactosebundne par-20 tikler indeholdende den aktive bestanddel for hvert gram af forblandingen. I en ideel forblanding vil mindst 95 vægt% af den aktive bestanddel være indeholdt i særskilte lactosebundne partikler, der kan adskilles fra forblandingens hovedmasse.Preferably, the amount of solution or slurry applied to the dry particulate mixture and the spraying conditions used should be selected so that the premix obtained grams contain at least 1000 lactose-15 bound particles containing active ingredients. Ideally, a premix obtained by the process of the invention will contain an even higher number of lactose-bound particles containing active ingredients, and a content of at least 2,000 lactose-bound particles containing the active ingredient should be sought for each gram of the premix. In an ideal premix, at least 95% by weight of the active ingredient will be contained in separate lactose-bound particles separable from the premix of the premix.
25 De ved fremgangsmåden ifølge opfindelsen opnåede forblandinger kan inkorporeres i foderstoffer ved simpel indblanding, idet mængden af forblanding for hver vægtdel af foderet vælges under hensyntagen til koncentrationen af den aktive bestanddel i forblandingen og den koncentration 30 af den aktive bestanddel, der ønskes i foderet. Ved fremstilling af blandede foderstoffer kan forblandingen sættes til næringsstofferne i formalingstrinet.The premixtures obtained by the process of the invention can be incorporated into feedingstuffs by simple mixing, the amount of premixture for each part by weight of the feed being selected taking into account the concentration of the active ingredient in the premix and the concentration of the active ingredient desired in the feed. In preparing mixed feed, the premix can be added to the nutrients in the milling step.
De følgende eksempler skal tjene til nærmere illustrering af fremgangsmåden ifølge opfindelsen.The following examples are intended to further illustrate the process of the invention.
3535
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9 1471529 147152
Eksempel 1Example 1
Der fremstilles 250 kg af en tør, partikelformet foderforblanding ved sammenblanding af følgende bestanddele: 5 Bestanddele Vægt% tørret hvedemel 58 ostevallepulver 38 citronsyre 4250 kg of dry, particulate feed mixture is prepared by mixing the following ingredients: 5 Ingredients Weight% dried wheat flour 58 Cheese whey powder 38 Citric acid 4
Det tørrede hvedemel er et i handelen værende pro-10 dukt indeholdende 4,8 vægt% vand (som fugt), og over 99 vægt% af melet passerer gennem en 195^u-sigte. Ostevalle-pulveret er også et i handelen værende produkt, der indeholder 6,1 vægt% vand (som fugt), og. over 99 vægt% af det passerer gennem en 532^u-sigte og over 68 vægt% gennem en 15 195^u-sigte.The dried wheat flour is a commercially available product containing 4.8% by weight water (as moisture), and over 99% by weight of the flour passes through a 195 µl screen. The Ostevalle powder is also a commercially available product containing 6.1% by weight water (as moisture), and. over 99 wt.% of it passes through a 532 ^ u sieve and over 68 wt.% through a 15 195 ^ u sieve.
Den tørre partikelformede blanding ledes derefter til en Gardner-mixer med vandret bånd og udstyret med seks hulkegle M2-sprøjtedyser. Medens den tørre blanding omrøres intenst i blandeapparatet, sprøjtes den med 12,5 liter (5 2o vægt%'s) af en vandig opslæmning af E. colo-endotoksinma-teriale fremstillet på den i eksempel 3 i britisk patentskrift nr. 1.366.015 beskrevne metode A, og hvori er inkorporeret 125 g af et i handelen værende, rødt azo-farve-stof af fødekvalitet. Opslæmningens aktivitet er 3000 hæ-25 maglutinationsenheder af endotoksiner for hver E. coli- -serotype pr. ml. Sprøjtetiden er 30 minutter. Sammenblandingen fortsættes i flere minutter efter afslutningen af sprøjtningen til sikring af en jævn fordeling af bestanddelene i forblandingen.The dry particulate mixture is then passed to a Gardner horizontal band mixer and equipped with six hollow cone M2 spray nozzles. While the dry mixture is stirred intensely in the mixer, it is sprayed with 12.5 liters (520 wt%) of an aqueous slurry of E. colo endotoxin material prepared on the example of British Patent No. 1,366,015. method A and incorporating 125 g of a commercially available, red azo food grade dye. The activity of the slurry is 3000 high 25 maglutination units of endotoxins for each E. coli serotype per ml. Spray time is 30 minutes. The mixing is continued for several minutes after completion of the spray to ensure an even distribution of the constituents of the premix.
30 Den herved opnåede forblanding består af et frit- strømmende pulver af tilsyneladende meget svag lyserød farve, nemlig et hvidt melpulver, hvorigennem der ensartet dispergeret findes et stort antal af små bitte, hårde, intensivt rødfarvede partikler.The premix thus obtained consists of a free-flowing powder of apparently very faint pink color, namely a white flour powder, through which uniformly dispersed a large number of tiny, hard, intensely red colored particles.
35 De intensivt farvede partikler lader sig let ad skille fra forblandingens hovedmasse, og analyse viser, at over 98% af både farvestoffet og vaccine-aktiviteten fore- 147152 ίο o kommer i de intensivt farvede partikler.35 The intensively colored particles are easily separated from the main mass of the premix, and analysis shows that more than 98% of both the dye and vaccine activity occur in the intensively colored particles.
En partikelstørrelsesanalyse af forblandingen giver følgende resultat.A particle size analysis of the premix yields the following result.
Partikeldiameter (^u) Vægt% af forblandingen 5 > 1999 0,4 800 - 1999 3,4 600 - 799 2,6 350 - 599 4,0 250 - 349 6,4 10 149 - 249 17,0 125 - 148 11,4 74 - 124 38,6 < 74 16,2 15 En partikeltælling udført på en prøve af forblan dingen viser, at der i hvert gram af denne findes ca.Particle diameter (µ u) Weight% of premix 5> 1999 0.4 800 - 1999 3.4 600 - 799 2.6 350 - 599 4.0 250 - 349 6.4 10 149 - 249 17.0 125 - 148 11 , 4 74 - 124 38.6 <74 16.2 15 A particle count carried out on a sample of the blend shows that in each gram of this there are approx.
5000 intensivt farvede, lactosebundne partikler.5000 intensely colored, lactose-bound particles.
Denne forblandingen inkorporeres derefter i mængder på 0,5, 1,0 og 1,5 vægt% i et standardfoder til grise-20 polte, og foderblandingen formales og pelletteres til dannelse af små pellets, nemlig ca. 10 pellets pr. gram foder. Gennemsnitligt må således hver pellet indeholde 2,5 lactosebundne partikler inkorporeret i en mængde på 0,5%.This premix is then incorporated in amounts of 0.5, 1.0 and 1.5% by weight in a standard piglet feed standard feed and the feed mixture is ground and pelleted to form small pellets, i.e. 10 pellets per grams of feed. Thus, on average, each pellet must contain 2.5 lactose-bound particles incorporated in an amount of 0.5%.
Grise fodres med dette foder og accepterer det godt, idet 25 de tillige opnår de profylaktiske fordele, der er beskrevet i britisk patentskrift nr. 1.366.015.Pigs are fed with this feed and accept it well, also obtaining the prophylactic benefits described in British Patent Specification No. 1,366,015.
Eksempel 2 og 3Examples 2 and 3
Fremgangsmåden ifølge eksempel 1 gentages med to 30 yderligere portioner på 250 kg af en tør partikelformet blanding som den i eksempel 1 anvendte, idet dog begge portioner i dette tilfælde sprøjtes med 7 liter (2,8 vægt%) af den vandige opslæmning, og i eksempel 3 erstattes sprøjtedyserne M2 med dyser M6. Sprøjtetiden i ek-35 sempel 2 er 12 minutter, og i eksempel 3 er den 5,5 minutter. Som i eksempel 1 opnås en forblanding bestående af et stort antal meget små, intenst farvede partikler ensartet 11 147152 o fordelt gennem et svagtfarvet pulver. Dysen M6 bevirker dannelse af nogle større partikler, hvilket stemmer med den større dråbestørrelse, som denne dyser giver, men forblandingen ifølge eksempel 3 er på ingen måde ringere end 5 forblandingen ifølge eksempel 2. En partikelstørrelsesanalyse på hver forblanding giver følgende resultat.The procedure of Example 1 is repeated with two additional 250 kg aliquots of a dry particulate mixture as used in Example 1, however both portions are sprayed in this case with 7 liters (2.8% by weight) of the aqueous slurry, and Example 3, the spray nozzles M2 are replaced by nozzles M6. The spray time in Example 2 is 12 minutes and in Example 3 it is 5.5 minutes. As in Example 1, a premix consisting of a large number of very small, intensely colored particles is obtained uniformly distributed through a slightly colored powder. Nozzle M6 causes the formation of some larger particles, which is consistent with the larger droplet size provided by these nozzles, but the premix of Example 3 is by no means inferior to the premix of Example 2. A particle size analysis on each premix yields the following result.
Partikeldiameter (^,u) Vagt% af forblandingenParticle diameter (^, u) Guard% of the premix
Eksempel 2 Eksempel 3 1999 0,2 0,4 10 800 - 1999 0,4 3,6 600 - 799 0,6 3,0 350 - 599 2,2 2,2 250 - 349 6,4 2,6 149 - 249 50,6 29,6 15 125 - 148 11,4 13,4 74 - 124 15,0 29,6 74 13,2 15,4Example 2 Example 3 1999 0.2 0.4 10 800 - 1999 0.4 3.6 600 - 799 0.6 3.0 350 - 599 2.2 2.2 250 - 349 6.4 2.6 149 - 249 50.6 29.6 15 125 - 148 11.4 13.4 74 - 124 15.0 29.6 74 13.2 15.4
Forblandingerne ifølge eksempel 2 og 3 inkorporeres 20 hver for sig i standard-svinefoder og giver fremragende resultater ved fodringsprøver.The premixes of Examples 2 and 3 are individually incorporated into standard pig feed and give excellent results in feeding samples.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GB48808/76A GB1596505A (en) | 1976-11-23 | 1976-11-23 | Food manufacture |
GB4880876 | 1976-11-23 |
Publications (3)
Publication Number | Publication Date |
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DK517877A DK517877A (en) | 1978-05-24 |
DK147152B true DK147152B (en) | 1984-04-30 |
DK147152C DK147152C (en) | 1984-09-17 |
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ID=10449977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DK517877A DK147152C (en) | 1976-11-23 | 1977-11-22 | PROCEDURE FOR PREPARING A PREPARATION FOR FEED USE |
Country Status (21)
Country | Link |
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JP (1) | JPS5379046A (en) |
AT (1) | AT368841B (en) |
AU (1) | AU514767B2 (en) |
BE (1) | BE861026A (en) |
CA (1) | CA1097979A (en) |
CS (1) | CS235066B2 (en) |
DE (1) | DE2751614C2 (en) |
DK (1) | DK147152C (en) |
ES (1) | ES464337A1 (en) |
FR (1) | FR2392675A1 (en) |
GB (1) | GB1596505A (en) |
GR (1) | GR66160B (en) |
IE (1) | IE46093B1 (en) |
IN (1) | IN147365B (en) |
IT (1) | IT1091299B (en) |
LU (1) | LU78570A1 (en) |
NL (1) | NL7712830A (en) |
NO (1) | NO147818C (en) |
SE (1) | SE433033B (en) |
YU (1) | YU43204B (en) |
ZA (1) | ZA776963B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3062867D1 (en) * | 1980-04-01 | 1983-06-01 | Sumitomo Chemical Co | Process for the production of water-soluble biotin-containing preparations and their use as additives to feed supplements |
FR2526273A1 (en) * | 1982-05-04 | 1983-11-10 | Guibert Jacques | Mixing heat sensitive food and medicinal substances - with material that melts above 40 deg. C and is solid below 30 Deg. C. |
HU191244B (en) * | 1984-01-06 | 1987-01-28 | Egyt Gyogyszervegyeszeti Gyar | Dust mixture of high propylene-glycol content and process for producing same |
HU191245B (en) * | 1984-01-06 | 1987-01-28 | Egis Gyogyszergyar,Hu | Process for the production of stbale pharmaceutical preparation against ketosis |
ES2076123B1 (en) * | 1993-10-25 | 1996-05-16 | Alimentacion Menorca S L Alime | AROMATIC BALLOONS FOR THE FORMULATION OF COMPOUND FEED IN ANIMAL FEEDING. |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL300742A (en) * | ||||
DE375668C (en) * | 1921-11-08 | 1923-05-17 | Chem Fab Helfenberg A G | Process for the production of high-percentage, durable and air-resistant glycerine preparations in powder form |
DE728335C (en) * | 1938-02-09 | 1942-11-25 | Dr Erich Thomae | Process for the production of oil preparations in solid form |
US3055804A (en) * | 1961-03-29 | 1962-09-25 | American Cyanamid Co | Mange powders |
DE1517044A1 (en) * | 1962-06-04 | 1969-05-14 | Hoffmann La Roche | Process for the vitaminization of food and feed |
CH433944A (en) * | 1962-12-17 | 1967-04-15 | Hoffmann La Roche | Preparation for adding vitamins to food and animal feed and process for the production thereof |
DE1468498B1 (en) * | 1963-04-15 | 1970-10-01 | Du Pont | Mono- and dialkylated 1-aminoadamantanes and processes for their preparation |
BE658119A (en) * | 1964-11-23 | 1965-04-30 | ||
FR1488271A (en) * | 1966-03-21 | 1967-07-13 | Chimetron Sarl | New anthelmintics imidazothiazole |
US3617302A (en) * | 1968-07-08 | 1971-11-02 | Kraftco Corp | Preparation of a flowable particulate composition |
GB1404583A (en) * | 1971-10-08 | 1975-09-03 | Vymatt Sa | Urea compositions and methods of preparation thereof |
US3919408A (en) * | 1973-03-26 | 1975-11-11 | Gen Foods Corp | Alcohol-containing oral hygiene powders |
GB1462384A (en) * | 1973-04-12 | 1977-01-26 | Unilever Ltd | Rearing of lambs |
BE836977A (en) * | 1975-01-15 | 1976-06-22 | METHOD AND PROCEDURE FOR CONTROLLING SWINE DYSENTERY |
-
1976
- 1976-11-23 GB GB48808/76A patent/GB1596505A/en not_active Expired
-
1977
- 1977-11-17 YU YU2739/77A patent/YU43204B/en unknown
- 1977-11-18 IN IN328/BOM/77A patent/IN147365B/en unknown
- 1977-11-18 GR GR54842A patent/GR66160B/el unknown
- 1977-11-18 IE IE2348/77A patent/IE46093B1/en not_active IP Right Cessation
- 1977-11-18 AU AU30757/77A patent/AU514767B2/en not_active Expired
- 1977-11-18 DE DE2751614A patent/DE2751614C2/en not_active Expired
- 1977-11-21 CA CA291,277A patent/CA1097979A/en not_active Expired
- 1977-11-21 NO NO773979A patent/NO147818C/en unknown
- 1977-11-21 FR FR7734890A patent/FR2392675A1/en active Granted
- 1977-11-21 AT AT0830777A patent/AT368841B/en not_active IP Right Cessation
- 1977-11-21 ES ES464337A patent/ES464337A1/en not_active Expired
- 1977-11-21 BE BE182790A patent/BE861026A/en not_active IP Right Cessation
- 1977-11-22 IT IT69638/77A patent/IT1091299B/en active
- 1977-11-22 SE SE7713188A patent/SE433033B/en not_active IP Right Cessation
- 1977-11-22 DK DK517877A patent/DK147152C/en not_active IP Right Cessation
- 1977-11-22 NL NL7712830A patent/NL7712830A/en not_active Application Discontinuation
- 1977-11-22 ZA ZA00776963A patent/ZA776963B/en unknown
- 1977-11-22 JP JP14058777A patent/JPS5379046A/en active Pending
- 1977-11-23 LU LU78570A patent/LU78570A1/xx unknown
- 1977-11-23 CS CS777746A patent/CS235066B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
CS235066B2 (en) | 1985-04-16 |
BE861026A (en) | 1978-05-22 |
ATA830777A (en) | 1982-04-15 |
ZA776963B (en) | 1979-06-27 |
IE46093L (en) | 1978-05-23 |
IT1091299B (en) | 1985-07-06 |
DE2751614A1 (en) | 1978-05-24 |
GB1596505A (en) | 1981-08-26 |
NO147818B (en) | 1983-03-14 |
FR2392675B1 (en) | 1980-02-29 |
FR2392675A1 (en) | 1978-12-29 |
SE433033B (en) | 1984-05-07 |
AU514767B2 (en) | 1981-02-26 |
AU3075777A (en) | 1979-05-24 |
IN147365B (en) | 1980-02-09 |
LU78570A1 (en) | 1978-07-12 |
NL7712830A (en) | 1978-05-25 |
DK147152C (en) | 1984-09-17 |
JPS5379046A (en) | 1978-07-13 |
SE7713188L (en) | 1978-05-24 |
YU273977A (en) | 1984-02-29 |
CA1097979A (en) | 1981-03-24 |
ES464337A1 (en) | 1978-12-01 |
YU43204B (en) | 1989-06-30 |
GR66160B (en) | 1981-01-20 |
DK517877A (en) | 1978-05-24 |
DE2751614C2 (en) | 1984-03-08 |
AT368841B (en) | 1982-11-10 |
IE46093B1 (en) | 1983-02-23 |
NO773979L (en) | 1978-05-24 |
NO147818C (en) | 1983-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed |