DK1469890T3 - Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik - Google Patents

Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik

Info

Publication number
DK1469890T3
DK1469890T3 DK03702538.4T DK03702538T DK1469890T3 DK 1469890 T3 DK1469890 T3 DK 1469890T3 DK 03702538 T DK03702538 T DK 03702538T DK 1469890 T3 DK1469890 T3 DK 1469890T3
Authority
DK
Denmark
Prior art keywords
contrast agent
magnetic resonance
resonance imaging
imaging technique
paramagnetic contrast
Prior art date
Application number
DK03702538.4T
Other languages
English (en)
Inventor
Silvio Aime
Castelli Daniela Delli
Franco Fedeli
Enzo Terreno
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Application granted granted Critical
Publication of DK1469890T3 publication Critical patent/DK1469890T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK03702538.4T 2002-01-29 2003-01-27 Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik DK1469890T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020001178 EP1331012A1 (en) 2002-01-29 2002-01-29 Responsive paramagnetic MRI contrast agents
PCT/EP2003/000796 WO2003063912A1 (en) 2002-01-29 2003-01-27 Responsive paramagnetic mri contrast agents

Publications (1)

Publication Number Publication Date
DK1469890T3 true DK1469890T3 (da) 2011-11-14

Family

ID=8185284

Family Applications (2)

Application Number Title Priority Date Filing Date
DK10176761.4T DK2298362T3 (da) 2002-01-29 2003-01-27 Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik
DK03702538.4T DK1469890T3 (da) 2002-01-29 2003-01-27 Reaktivt paramagnetisk kontrastmiddel til magnetresonansbilledteknik

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK10176761.4T DK2298362T3 (da) 2002-01-29 2003-01-27 Reagerende paramagnetiske kontrastmidler til magnetresonansbilledteknik

Country Status (6)

Country Link
US (2) US7524483B2 (da)
EP (3) EP1331012A1 (da)
JP (3) JP4850391B2 (da)
AT (1) ATE519505T1 (da)
DK (2) DK2298362T3 (da)
WO (1) WO2003063912A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066180A2 (en) * 1999-04-21 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Method for enhancing contrast produced by mri
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents
EP1466629A1 (en) * 2003-04-11 2004-10-13 BRACCO IMAGING S.p.A. Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "CEST" applications
US20070292354A1 (en) * 2004-09-23 2007-12-20 Guerbet Contrast Agents Encapsulating Systems for Cest Imaging
JP5271077B2 (ja) * 2005-04-26 2013-08-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 時間変調されたコントラストの向上を備えた造影剤を伴うｍｒｉ
EP1881852B1 (en) 2005-04-26 2009-08-19 Koninklijke Philips Electronics N.V. Mri contrast agents comprising cest active paramagnetic complex
US7917188B2 (en) 2005-04-26 2011-03-29 Koninklijke Philips Electronics N.V. Method for using CEST contrast agents in MRI
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
US7610077B2 (en) * 2005-12-08 2009-10-27 General Electric Compnay Quantitation of sample properties using contrast enhancement from saturation transfer
WO2007115115A2 (en) * 2006-03-29 2007-10-11 Kereos, Inc. Targeted mr imaging agents
CN101466411B (zh) * 2006-06-09 2014-12-24 皇家飞利浦电子股份有限公司 消除mri中的造影剂浓度依赖性
WO2009042881A1 (en) * 2007-09-26 2009-04-02 The Johns Hopkins University Frequency referencing for chemical exchange saturation transfer (cest) mri
EP2370447B1 (en) 2008-12-02 2016-07-27 The University of Melbourne Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals
US20120330132A1 (en) 2009-12-07 2012-12-27 Paul Sorajja Device for the Delineation of Cardiovascular or Other Anatomical Structures
WO2011083730A1 (ja) 2010-01-06 2011-07-14 株式会社資生堂 Ｎｍｒ用の標準物質、ｎｍｒ用の試料管、ｎｍｒ用のキャピラリー、及び試料のｎｍｒを測定する方法
WO2012006038A2 (en) * 2010-06-28 2012-01-12 The Board Of Regents, The University Of Texas System Agents and compounds for imaging and other applications, and methods of use and synthesis thereof
EP2457594A1 (en) * 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
WO2012155076A2 (en) * 2011-05-11 2012-11-15 The Research Foundation Of State University Of New York Imaging contrast agents and uses thereof
EP4063369A1 (en) 2011-12-06 2022-09-28 Clarity Pharmaceuticals Ltd Cage amine ligands for metallo-radiopharmaceuticals
US10551455B2 (en) 2015-05-04 2020-02-04 Duke University Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses
CN108369266B (zh) * 2015-12-23 2021-08-06 伯拉考成像股份公司 比率计量的脉冲cest成像

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
JP3759765B2 (ja) * 1994-03-28 2006-03-29 第一製薬株式会社 リポソーム
IL113139A0 (en) 1994-03-28 1995-06-29 Nycomed Imaging As Diagnostic compositions comprising imaging agents encapsulated in liposomes
WO2000066180A2 (en) * 1999-04-21 2000-11-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health Method for enhancing contrast produced by mri
WO2002043775A2 (en) 2000-11-20 2002-06-06 GODFREY, Cullen, M. Paramagnetic metal ion-based macrocyclic contrast agents
EP1302465A1 (en) 2001-10-11 2003-04-16 BRACCO IMAGING S.p.A. Enhanced substrate imaging by reversible binding to a paramagnetic complex
EP1331012A1 (en) * 2002-01-29 2003-07-30 BRACCO IMAGING S.p.A. Responsive paramagnetic MRI contrast agents

Also Published As

Publication number Publication date
US7524483B2 (en) 2009-04-28
EP1469890B1 (en) 2011-08-10
JP2010088901A (ja) 2010-04-22
US20050191243A1 (en) 2005-09-01
EP2298362A1 (en) 2011-03-23
ATE519505T1 (de) 2011-08-15
US20090234221A1 (en) 2009-09-17
US8318134B2 (en) 2012-11-27
JP4796643B2 (ja) 2011-10-19
EP1469890A1 (en) 2004-10-27
JP4850391B2 (ja) 2012-01-11
EP1331012A1 (en) 2003-07-30
EP2298362B1 (en) 2013-03-13
DK2298362T3 (da) 2013-06-10
WO2003063912A1 (en) 2003-08-07
JP2011235125A (ja) 2011-11-24
JP2005515842A (ja) 2005-06-02

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