DK1228027T3 - 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse - Google Patents

3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse

Info

Publication number
DK1228027T3
DK1228027T3 DK00972335T DK00972335T DK1228027T3 DK 1228027 T3 DK1228027 T3 DK 1228027T3 DK 00972335 T DK00972335 T DK 00972335T DK 00972335 T DK00972335 T DK 00972335T DK 1228027 T3 DK1228027 T3 DK 1228027T3
Authority
DK
Denmark
Prior art keywords
hete
methods
heteroatom substituted
carbon homologues
homologues
Prior art date
Application number
DK00972335T
Other languages
English (en)
Inventor
Peter G Klimko
Mark R Hellberg
Gustav Graff
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of DK1228027T3 publication Critical patent/DK1228027T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
DK00972335T 1999-11-09 2000-10-23 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse DK1228027T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16436899P 1999-11-09 1999-11-09
PCT/US2000/029208 WO2001034548A2 (en) 1999-11-09 2000-10-23 3-heteroatom substituted and two carbon homologs of 15-hete and methods of use

Publications (1)

Publication Number Publication Date
DK1228027T3 true DK1228027T3 (da) 2004-07-19

Family

ID=22594175

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00972335T DK1228027T3 (da) 1999-11-09 2000-10-23 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse

Country Status (12)

Country Link
US (2) US6331644B1 (da)
EP (1) EP1228027B1 (da)
JP (1) JP2003513948A (da)
AR (1) AR034398A1 (da)
AT (1) ATE265996T1 (da)
AU (1) AU776146B2 (da)
CA (1) CA2386333A1 (da)
DE (1) DE60010503T2 (da)
DK (1) DK1228027T3 (da)
ES (1) ES2215740T3 (da)
PT (1) PT1228027E (da)
WO (1) WO2001034548A2 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1228027E (pt) * 1999-11-09 2004-08-31 Alcon Inc Derivados de 15-hete com heteroatomo substituinte em posicao 3 e homologos com dois carbonos e metodos de utilizacao
WO2003030894A1 (en) * 2001-10-11 2003-04-17 Alcon, Inc. Methods for treating dry eye
JP2005505592A (ja) * 2001-10-11 2005-02-24 アルコン，インコーポレイテッド 抗炎症性ステロイドとｍｕｃ−１分泌促進薬との組み合わせによる、ドライアイを処置するための方法
US6831186B2 (en) 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
EP1583527A1 (en) * 2002-06-14 2005-10-12 Alcon, Inc. Use of hydroxyeicosatetraenoic acid compounds to treat ophthalmic inflammatory disorders
WO2003105824A1 (en) * 2002-06-14 2003-12-24 Alcon, Inc. Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis
BR0314603A (pt) * 2002-09-20 2005-07-26 Alcon Inc Uso de inibidores da sìntese de citoquina para o tratamento de distúrbios de olhos secos

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991759A (en) 1975-10-28 1976-11-16 Alza Corporation Method and therapeutic system for treating aqueous deficient dry eye
US4131651A (en) 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
AU546872B2 (en) 1982-06-16 1985-09-26 Unilever Plc Skin treatment compositions containing a fatty acid or ester
US4421748A (en) 1982-07-13 1983-12-20 Trager Seymour F Artificial tear aid
GB8319073D0 (en) 1983-07-14 1983-08-17 Efamol Ltd Fatty acid compositions
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
US4744980A (en) 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4883658A (en) 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4818537A (en) 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US4921644A (en) 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
US4906467A (en) 1988-03-24 1990-03-06 New York Medical College Novel, long-duration treatment for glaucoma
US4923700A (en) 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension
US5064655A (en) 1989-02-24 1991-11-12 Liposome Technology, Inc. Liposome gel composition and method
US5075104A (en) 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5174988A (en) 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
AU655919B2 (en) 1990-02-22 1995-01-19 Macnaught Pty Limited Artificial tears
US5041434A (en) 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
ZA912797B (en) 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
ATE132366T1 (de) 1990-05-29 1996-01-15 Boston Ocular Res Zusammensetzung zur behandlung von dry eye erkrankungen
US5102670A (en) 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
DE69212850T2 (de) 1991-01-15 1997-03-06 Alcon Lab Inc Verwendung von Karrageenan in topischen ophthalmologischen Zusammensetzungen
ZA927277B (en) 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
EP0546728A3 (en) 1991-12-13 1993-09-08 Alcon Laboratories Inc Physiological tear compositions and methods for their preparation
CA2133966C (en) 1992-04-21 1997-09-09 David A. Sullivan Ocular androgen therapy in sjogren's syndrome
US5290572A (en) 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5358706A (en) 1992-09-30 1994-10-25 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
US5455265A (en) 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
DE69419601T2 (de) * 1993-03-17 1999-12-02 Kao Corp Aminderivate und sie enthaltende dermatologische zubereitungen
US5389383A (en) 1993-06-18 1995-02-14 Allergan, Inc. Method for treating hypoxia-associated ocular complications
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
CA2276267C (en) 1996-10-15 2009-12-22 The Liposome Company, Inc. Peptide-lipid conjugates, liposomes and liposomal drug delivery
US5800807A (en) 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
US6281192B1 (en) 1999-03-01 2001-08-28 Vista Scientific Llc Mucin containing ophthalmic preparations
PT1228027E (pt) * 1999-11-09 2004-08-31 Alcon Inc Derivados de 15-hete com heteroatomo substituinte em posicao 3 e homologos com dois carbonos e metodos de utilizacao

Also Published As

Publication number Publication date
CA2386333A1 (en) 2001-05-17
JP2003513948A (ja) 2003-04-15
AR034398A1 (es) 2004-02-25
WO2001034548A2 (en) 2001-05-17
US20020082286A1 (en) 2002-06-27
AU1101101A (en) 2001-06-06
WO2001034548A3 (en) 2001-11-01
PT1228027E (pt) 2004-08-31
AU776146B2 (en) 2004-08-26
US6437160B1 (en) 2002-08-20
EP1228027A2 (en) 2002-08-07
US6331644B1 (en) 2001-12-18
ATE265996T1 (de) 2004-05-15
DE60010503T2 (de) 2004-09-23
DE60010503D1 (de) 2004-06-09
ES2215740T3 (es) 2004-10-16
EP1228027B1 (en) 2004-05-06

Similar Documents

Publication Publication Date Title
DK1233964T3 (da) Ny anvendelse og hidtil ukendte N-azabicycloamidderivater
NO991776D0 (no) Aminotiofenkarboksylsyreamider og anvendelse derav som fosfodiesteraseinhibitorer
DK1021410T3 (da) Prostaglandinagonister og deres anvendelse til behandling af knogletilstande
NO20034857D0 (no) Tilknytning til bruk med utvidbare rör
EE200100373A (et) Bensoheterotsüklid ja nende kasutamine MEK inhibiitoritena
NO20010446D0 (no) Substituert anilidforbindelser og metoder
NO20022334L (no) Ny sammensetning og anvendelse
NO20032753D0 (no) Forbindelse og anvendelse derav
IS5928A (is) Aðferðir og samsetningar til að hindra lyfjaþol
IS7726A (is) Pyrazólólpyridín og aðferðir til þess að búa þau til og nota
NO20024355L (no) Nukleosidforbindelser og anvendelser derav
NO20001201D0 (no) FremgangsmÕte og forbindelse for Õ hindre at rør plugges med gasshydrater
NO20033387D0 (no) Modifiserte antistoffer og fremgangsmåter for anvendelse
NO20012688L (no) Benzamidderivater og anvendelse derav som APOB-100 sekresjonsinhibitorer
DK1656370T3 (da) Heterocykliske biarylforbindelser og fremgangsmåder til fremstilling og anvendelse af samme
NO20015274L (no) ACE-2 inhiberende forbindelser og fremgangsmåter for anvendelse derav
DK1170288T3 (da) Diphenylurinstofderivater og deres anvendelse som alfa2/5-HT2c-antagonister
DK1212317T3 (da) Indolderivater og anvendelse deraf til behandling af osteoporose blandt andre anvendelser
NO20041058L (no) Preparater og fremgangsmater relatert til nye benzodiazepinforbindelser og mal derav
DK1260090T3 (da) System og fremgangsmåde til online-monitorering og -fakturering afenergiforbrug
IS6401A (is) Efnafræðilegar aðferðir og milliefni
DK1106607T3 (da) Uracilforbindelser og anvendelse deraf
DK1228027T3 (da) 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse
IS6975A (is) Búnaður til að hreinsa vatn og notkun hans
DK1228026T3 (da) 15-Hydroxyicosatetraensyrerelaterede forbindelser og fremgangsmåde til anvendelse