EP0873341B1
(de)
|
1995-11-17 |
2003-09-10 |
Gesellschaft für biotechnologische Forschung mbH (GBF) |
Epothilonderivate, herstellung und verwendung
|
US5969145A
(en)
*
|
1996-08-30 |
1999-10-19 |
Novartis Ag |
Process for the production of epothilones and intermediate products within the process
|
AU716610B2
(en)
*
|
1996-08-30 |
2000-03-02 |
Novartis Ag |
Method for producing epothilones, and intermediate products obtained during the production process
|
JP4274583B2
(ja)
*
|
1996-11-18 |
2009-06-10 |
ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング(ゲー・ベー・エフ) |
エポチロンc,d,e及びf、製造と薬剤
|
US6867305B2
(en)
|
1996-12-03 |
2005-03-15 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
DE69734362T2
(de)
*
|
1996-12-03 |
2006-07-20 |
Sloan-Kettering Institute For Cancer Research |
Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
|
US20050043376A1
(en)
*
|
1996-12-03 |
2005-02-24 |
Danishefsky Samuel J. |
Synthesis of epothilones, intermediates thereto, analogues and uses thereof
|
US6204388B1
(en)
|
1996-12-03 |
2001-03-20 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
US6441186B1
(en)
|
1996-12-13 |
2002-08-27 |
The Scripps Research Institute |
Epothilone analogs
|
US6380394B1
(en)
|
1996-12-13 |
2002-04-30 |
The Scripps Research Institute |
Epothilone analogs
|
US6660758B1
(en)
*
|
1996-12-13 |
2003-12-09 |
The Scripps Research Institute |
Epothilone analogs
|
DE19880193D2
(de)
*
|
1997-02-25 |
2000-08-24 |
Biotechnolog Forschung Gmbh |
Seitenkettenmodifizierte Epothilone
|
US6605599B1
(en)
|
1997-07-08 |
2003-08-12 |
Bristol-Myers Squibb Company |
Epothilone derivatives
|
CA2299608A1
(en)
*
|
1997-08-09 |
1999-02-18 |
Schering Aktiengesellschaft |
New epothilone derivatives, method for producing same and their pharmaceutical use
|
US6365749B1
(en)
|
1997-12-04 |
2002-04-02 |
Bristol-Myers Squibb Company |
Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
|
HUP0100582A3
(en)
*
|
1997-12-04 |
2003-03-28 |
Bristol Myers Squibb Co |
A process for the reduction of oxiranyl epothilones to olefinic epothilones
|
US6320045B1
(en)
*
|
1997-12-04 |
2001-11-20 |
Bristol-Myers Squibb Company |
Process for the reduction of oxiranyl epothilones to olefinic epothilones
|
CA2320182C
(en)
*
|
1998-02-05 |
2008-11-25 |
Novartis Ag |
Compositions containing organic compounds
|
GB9802451D0
(en)
*
|
1998-02-05 |
1998-04-01 |
Ciba Geigy Ag |
Organic compounds
|
US6683100B2
(en)
|
1999-01-19 |
2004-01-27 |
Novartis Ag |
Organic compounds
|
US6194181B1
(en)
|
1998-02-19 |
2001-02-27 |
Novartis Ag |
Fermentative preparation process for and crystal forms of cytostatics
|
FR2775187B1
(fr)
*
|
1998-02-25 |
2003-02-21 |
Novartis Ag |
Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
|
US6302838B1
(en)
|
1998-02-25 |
2001-10-16 |
Novartis Ag |
Cancer treatment with epothilones
|
NZ506742A
(en)
*
|
1998-02-25 |
2003-09-26 |
Sloan Kettering Inst Cancer |
Synthesis of desoxyepothilones and hydroxy acid derivative intermediates
|
US6498257B1
(en)
*
|
1998-04-21 |
2002-12-24 |
Bristol-Myers Squibb Company |
2,3-olefinic epothilone derivatives
|
US6380395B1
(en)
*
|
1998-04-21 |
2002-04-30 |
Bristol-Myers Squibb Company |
12, 13-cyclopropane epothilone derivatives
|
DE19820599A1
(de)
|
1998-05-08 |
1999-11-11 |
Biotechnolog Forschung Gmbh |
Epothilonderivate, Verfahren zu deren Herstellung und deren Verwendung
|
GB9810659D0
(en)
|
1998-05-18 |
1998-07-15 |
Ciba Geigy Ag |
Organic compounds
|
DE19826988A1
(de)
*
|
1998-06-18 |
1999-12-23 |
Biotechnolog Forschung Gmbh |
Epothilon-Nebenkomponenten
|
AU5036999A
(en)
*
|
1998-06-30 |
2000-01-17 |
Schering Aktiengesellschaft |
Epothilon derivatives, their preparation process, intermediate products and their pharmaceutical use
|
DE19848306A1
(de)
*
|
1998-10-14 |
2000-04-20 |
Schering Ag |
Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren
|
US6410301B1
(en)
|
1998-11-20 |
2002-06-25 |
Kosan Biosciences, Inc. |
Myxococcus host cells for the production of epothilones
|
US6303342B1
(en)
|
1998-11-20 |
2001-10-16 |
Kason Biosciences, Inc. |
Recombinant methods and materials for producing epothilones C and D
|
US6780620B1
(en)
|
1998-12-23 |
2004-08-24 |
Bristol-Myers Squibb Company |
Microbial transformation method for the preparation of an epothilone
|
US6596875B2
(en)
|
2000-02-07 |
2003-07-22 |
James David White |
Method for synthesizing epothilones and epothilone analogs
|
CN1340053A
(zh)
|
1999-02-11 |
2002-03-13 |
舍林股份公司 |
依泊昔酮衍生物、其制备方法及药物用途
|
DE19908760A1
(de)
*
|
1999-02-18 |
2000-08-24 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
US6262094B1
(en)
|
1999-02-22 |
2001-07-17 |
Bristol-Myers Squibb Company |
C-21 modified epothilones
|
US20020058286A1
(en)
*
|
1999-02-24 |
2002-05-16 |
Danishefsky Samuel J. |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
AU4017400A
(en)
*
|
1999-03-29 |
2000-10-16 |
Bristol-Myers Squibb Company |
A process for the preparation of aziridinyl epothilones from oxiranyl epothilones
|
US6291684B1
(en)
|
1999-03-29 |
2001-09-18 |
Bristol-Myers Squibb Company |
Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
|
US7125875B2
(en)
|
1999-04-15 |
2006-10-24 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
EP2308833A3
(en)
|
1999-04-15 |
2011-09-28 |
Bristol-Myers Squibb Company |
Cyclic protein tyrosine kinase inhibitors
|
AU772750C
(en)
|
1999-04-30 |
2005-02-24 |
Schering Aktiengesellschaft |
6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
|
WO2001007439A2
(en)
*
|
1999-07-22 |
2001-02-01 |
Schering Aktiengesellschaft |
Process for the production of epothiolone b and derivatives as well as intermediate products for this process
|
WO2001024763A2
(en)
|
1999-10-01 |
2001-04-12 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
US6518421B1
(en)
*
|
2000-03-20 |
2003-02-11 |
Bristol-Myers Squibb Company |
Process for the preparation of epothilone analogs
|
US6593115B2
(en)
*
|
2000-03-24 |
2003-07-15 |
Bristol-Myers Squibb Co. |
Preparation of epothilone intermediates
|
DE10020517A1
(de)
*
|
2000-04-19 |
2001-10-25 |
Schering Ag |
Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
|
US6589968B2
(en)
|
2001-02-13 |
2003-07-08 |
Kosan Biosciences, Inc. |
Epothilone compounds and methods for making and using the same
|
UA75365C2
(en)
*
|
2000-08-16 |
2006-04-17 |
Bristol Myers Squibb Co |
Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
|
CN1190440C
(zh)
*
|
2000-09-22 |
2005-02-23 |
生物技术研究有限公司(Gbf) |
***并一依泊昔酮
|
EP1353667A1
(en)
|
2001-01-25 |
2003-10-22 |
Bristol-Myers Squibb Company |
Parenteral formulations containing epothilone analogs
|
KR100851719B1
(ko)
|
2001-01-25 |
2008-08-11 |
브리스톨-마이어스스퀴브컴파니 |
암 치료용 에포틸론 유사체의 투여 방법
|
NZ526871A
(en)
|
2001-01-25 |
2006-01-27 |
Bristol Myers Squibb Co |
Pharmaceutical dosage forms of epothilones for oral administration
|
US6893859B2
(en)
|
2001-02-13 |
2005-05-17 |
Kosan Biosciences, Inc. |
Epothilone derivatives and methods for making and using the same
|
EP1385529A4
(en)
|
2001-02-20 |
2007-05-09 |
Bristol Myers Squibb Co |
TREATMENT OF REFRACTORY TUMORS USING EPOTHILONE DERIVATIVES
|
RU2003128312A
(ru)
|
2001-02-20 |
2005-02-10 |
Бристол-Маерс Сквибб Компани (Us) |
Производные эпотилона, используемые для лечения резистентных опухлей
|
MXPA03007466A
(es)
|
2001-02-27 |
2003-12-08 |
Gbf Ges F R Biotechnologische |
Degradacion de epotilonas y epotilonas substituidas con etileno.
|
US7312237B2
(en)
|
2001-03-14 |
2007-12-25 |
Bristol-Myers Squibb Co. |
Combination of epothilone analogs and chemotherapeutic agents for the treatment of prolilferative diseases
|
JP2004532888A
(ja)
|
2001-06-01 |
2004-10-28 |
ブリストル−マイヤーズ スクイブ カンパニー |
エポチロン誘導体
|
TWI315982B
(en)
*
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
TW200303202A
(en)
|
2002-02-15 |
2003-09-01 |
Bristol Myers Squibb Co |
Method of preparation of 21-amino epothilone derivatives
|
WO2003074521A1
(en)
*
|
2002-03-01 |
2003-09-12 |
University Of Notre Dame |
Derivatives of epothilone b and d and synthesis thereof
|
AU2003218107A1
(en)
|
2002-03-12 |
2003-09-29 |
Bristol-Myers Squibb Company |
C12-cyano epothilone derivatives
|
AU2003218110A1
(en)
|
2002-03-12 |
2003-09-29 |
Bristol-Myers Squibb Company |
C3-cyano epothilone derivatives
|
TW200403994A
(en)
|
2002-04-04 |
2004-03-16 |
Bristol Myers Squibb Co |
Oral administration of EPOTHILONES
|
TW200400191A
(en)
|
2002-05-15 |
2004-01-01 |
Bristol Myers Squibb Co |
Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
|
US7405234B2
(en)
|
2002-05-17 |
2008-07-29 |
Bristol-Myers Squibb Company |
Bicyclic modulators of androgen receptor function
|
WO2003105828A1
(en)
|
2002-06-14 |
2003-12-24 |
Bristol-Myers Squibb Company |
Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
|
DE10232094A1
(de)
*
|
2002-07-15 |
2004-02-05 |
GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) |
5-Thiaepothilone und 15-disubstituierte Epothilone
|
US7649006B2
(en)
*
|
2002-08-23 |
2010-01-19 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
DE60330407D1
(de)
|
2002-08-23 |
2010-01-14 |
Sloan Kettering Inst Cancer |
Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
|
US6921769B2
(en)
|
2002-08-23 |
2005-07-26 |
Sloan-Kettering Institute For Cancer Research |
Synthesis of epothilones, intermediates thereto and analogues thereof
|
EP2287168B1
(en)
|
2002-09-23 |
2013-02-13 |
Bristol-Myers Squibb Company |
Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B
|
AU2003302084A1
(en)
|
2002-11-15 |
2004-06-15 |
Bristol-Myers Squibb Company |
Open chain prolyl urea-related modulators of androgen receptor function
|
CN1780846A
(zh)
*
|
2003-03-05 |
2006-05-31 |
Rib-X医药品有限公司 |
双官能杂环化合物及其制备和使用方法
|
US20050171167A1
(en)
*
|
2003-11-04 |
2005-08-04 |
Haby Thomas A. |
Process and formulation containing epothilones and analogs thereof
|
US7820702B2
(en)
|
2004-02-04 |
2010-10-26 |
Bristol-Myers Squibb Company |
Sulfonylpyrrolidine modulators of androgen receptor function and method
|
US7378426B2
(en)
|
2004-03-01 |
2008-05-27 |
Bristol-Myers Squibb Company |
Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
|
US7696241B2
(en)
|
2004-03-04 |
2010-04-13 |
Bristol-Myers Squibb Company |
Bicyclic compounds as modulators of androgen receptor function and method
|
US7625923B2
(en)
|
2004-03-04 |
2009-12-01 |
Bristol-Myers Squibb Company |
Bicyclic modulators of androgen receptor function
|
GB0405898D0
(en)
|
2004-03-16 |
2004-04-21 |
Novartis Ag |
Organic compounds
|
US20090004277A1
(en)
*
|
2004-05-18 |
2009-01-01 |
Franchini Miriam K |
Nanoparticle dispersion containing lactam compound
|
US10675326B2
(en)
|
2004-10-07 |
2020-06-09 |
The Board Of Trustees Of The University Of Illinois |
Compositions comprising cupredoxins for treating cancer
|
EP1824458A1
(en)
*
|
2004-11-18 |
2007-08-29 |
Bristol-Myers Squibb Company |
Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof
|
TW200631609A
(en)
*
|
2004-11-18 |
2006-09-16 |
Bristol Myers Squibb Co |
Enteric coated bead comprising ixabepilone, and preparation and administration thereof
|
ATE550019T1
(de)
|
2005-05-17 |
2012-04-15 |
Merck Sharp & Dohme |
Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
|
PE20070427A1
(es)
*
|
2005-08-30 |
2007-04-21 |
Novartis Ag |
Compuestos derivados de benzimidazoles sustituidos como inhibidores de tirosina quinasas
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
KR101464385B1
(ko)
|
2006-04-19 |
2014-11-21 |
노파르티스 아게 |
6-o-치환된 벤즈옥사졸 및 벤조티아졸 화합물, 및 csf-1r 신호전달의 억제 방법
|
CA2664113C
(en)
|
2006-09-22 |
2013-05-28 |
Merck & Co., Inc. |
Use of platencin and platensimycin as fatty acid synthesis inhibitors to treat obesity, diabetes and cancer
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
WO2008070672A2
(en)
|
2006-12-04 |
2008-06-12 |
The Board Of Trustees Of The University Of Illinois |
Compositions and methods to treat cancer with cupredoxins and cpg rich dna
|
DK2805945T3
(da)
|
2007-01-10 |
2019-07-15 |
Msd Italia Srl |
Amid-substituerede indazoler som poly(adp-ribose)polymerase- (parp) hæmmere
|
AU2008212788A1
(en)
|
2007-02-08 |
2008-08-14 |
The Board Of Trustees Of The University Of Illinois |
Compositions and methods to prevent cancer with cupredoxins
|
MX2009009304A
(es)
|
2007-03-01 |
2009-11-18 |
Novartis Ag |
Inhibidores de cinasa pim y metodos para su uso.
|
WO2008144062A1
(en)
|
2007-05-21 |
2008-11-27 |
Novartis Ag |
Csf-1r inhibitors, compositions, and methods of use
|
EP2170076B1
(en)
|
2007-06-27 |
2016-05-18 |
Merck Sharp & Dohme Corp. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
EP2065054A1
(en)
|
2007-11-29 |
2009-06-03 |
Bayer Schering Pharma Aktiengesellschaft |
Combinations comprising a prostaglandin and uses thereof
|
DE102007059752A1
(de)
|
2007-12-10 |
2009-06-18 |
Bayer Schering Pharma Aktiengesellschaft |
Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
|
EP2070521A1
(en)
|
2007-12-10 |
2009-06-17 |
Bayer Schering Pharma Aktiengesellschaft |
Surface-modified nanoparticles
|
CN104116736A
(zh)
|
2008-04-24 |
2014-10-29 |
百时美施贵宝公司 |
埃坡霉素D在治疗包括阿尔茨海默病的τ相关疾病中的用途
|
EP2210584A1
(en)
|
2009-01-27 |
2010-07-28 |
Bayer Schering Pharma Aktiengesellschaft |
Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
|
US8691825B2
(en)
|
2009-04-01 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of AKT activity
|
UA109417C2
(uk)
|
2009-10-14 |
2015-08-25 |
Мерк Шарп Енд Доме Корп. |
ЗАМІЩЕНІ ПІПЕРИДИНИ, ЯКІ ПІДВИЩУЮТЬ АКТИВНІСТЬ p53, І ЇХ ЗАСТОСУВАННЯ
|
SG181803A1
(en)
|
2009-12-17 |
2012-07-30 |
Merck Sharp & Dohme |
Aminopyrimidines as syk inhibitors
|
US20110300150A1
(en)
|
2010-05-18 |
2011-12-08 |
Scott Eliasof |
Compositions and methods for treatment of autoimmune and other disease
|
US8597462B2
(en)
|
2010-05-21 |
2013-12-03 |
Lam Research Corporation |
Movable chamber liner plasma confinement screen combination for plasma processing apparatuses
|
EP2584903B1
(en)
|
2010-06-24 |
2018-10-24 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
EP3330377A1
(en)
|
2010-08-02 |
2018-06-06 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
|
KR102072631B1
(ko)
|
2010-08-17 |
2020-02-03 |
시르나 쎄러퓨틱스 인코퍼레이티드 |
짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
EP2613782B1
(en)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
US9242981B2
(en)
|
2010-09-16 |
2016-01-26 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel ERK inhibitors
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
US8618146B2
(en)
|
2011-01-03 |
2013-12-31 |
Dr. Reddy's Laboratories Limited |
Epothilone compound formulations
|
CN102134246A
(zh)
*
|
2011-01-06 |
2011-07-27 |
王文怡 |
一种埃博霉素衍生物及其制备和药物应用
|
EP2665493B1
(en)
|
2011-01-20 |
2018-03-21 |
Board Of Regents, The University Of Texas System |
Mri markers, delivery and extraction systems, and methods of manufacture and use thereof
|
CN103732592A
(zh)
|
2011-04-21 |
2014-04-16 |
默沙东公司 |
***-1受体抑制剂
|
US20140221314A1
(en)
|
2011-05-31 |
2014-08-07 |
Newgen Therapeutics, Inc. |
Tricyclic inhibitors of poly(adp-ribose)polymerase
|
CN103747804B
(zh)
|
2011-06-10 |
2016-08-17 |
梅尔莎纳医疗公司 |
蛋白质-聚合物-药物共轭物
|
CN102863474A
(zh)
|
2011-07-09 |
2013-01-09 |
陈小平 |
一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
|
EP2548877A1
(en)
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
CN102993239A
(zh)
|
2011-09-19 |
2013-03-27 |
陈小平 |
离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
EP3358013B1
(en)
|
2012-05-02 |
2020-06-24 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
EP2863916B1
(en)
|
2012-06-22 |
2018-07-18 |
Merck Sharp & Dohme Corp. |
Substituted pyridine spleen tyrosine kinase (syk) inhibitors
|
US9416111B2
(en)
|
2012-06-22 |
2016-08-16 |
Merck Sharp & Dohme Corp. |
Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
|
US9233979B2
(en)
|
2012-09-28 |
2016-01-12 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
WO2014075391A1
(zh)
|
2012-11-17 |
2014-05-22 |
北京市***维康技术开发有限责任公司 |
离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物
|
CA2892361A1
(en)
|
2012-11-28 |
2014-06-05 |
Merck Sharp & Dohme Corp. |
Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels
|
WO2014093394A1
(en)
|
2012-12-10 |
2014-06-19 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
US9872918B2
(en)
|
2012-12-12 |
2018-01-23 |
Mersana Therapeutics, Inc. |
Hydroxyl-polymer-drug-protein conjugates
|
WO2014100065A1
(en)
|
2012-12-20 |
2014-06-26 |
Merck Sharp & Dohme Corp. |
Substituted imidazopyridines as hdm2 inhibitors
|
WO2014113942A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
US20140206681A1
(en)
|
2013-01-23 |
2014-07-24 |
Ronald M. Kim |
Btk inhibitors
|
US9540377B2
(en)
|
2013-01-30 |
2017-01-10 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as HDM2 inhibitors
|
WO2014176216A1
(en)
|
2013-04-26 |
2014-10-30 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
|
CN105283178A
(zh)
|
2013-06-11 |
2016-01-27 |
拜耳制药股份公司 |
用于治疗癌症的包含mps-1激酶抑制剂和有丝***抑制剂的组合
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
KR102355745B1
(ko)
|
2013-10-11 |
2022-01-26 |
아사나 바이오사이언시스 엘엘씨 |
단백질-폴리머-약물 접합체
|
EP3054991B1
(en)
|
2013-10-11 |
2019-04-03 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
WO2015095444A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
|
US9834554B2
(en)
|
2013-12-20 |
2017-12-05 |
Merck Sharp & Dohme Corp. |
BTK inhibitors
|
US9637486B2
(en)
|
2013-12-20 |
2017-05-02 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
JO3589B1
(ar)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
مثبطات كيناز البروتين c وطرق استخداماتها
|
WO2016106628A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106629A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106623A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Benzamide imidazopyrazine btk inhibitors
|
WO2016106624A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
WO2016106626A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Imidazopyrazine analogs with 3-tertiary carbon substitutions as btk inhibitors
|
WO2017222951A1
(en)
|
2016-06-23 |
2017-12-28 |
Merck Sharp & Dohme Corp. |
3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
|
WO2018004338A1
(en)
|
2016-06-27 |
2018-01-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
JOP20190055A1
(ar)
|
2016-09-26 |
2019-03-24 |
Merck Sharp & Dohme |
أجسام مضادة ضد cd27
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
KR20190140454A
(ko)
|
2017-04-13 |
2019-12-19 |
아두로 바이오테크 홀딩스, 유럽 비.브이. |
항-sirp 알파 항체
|
CN111315414A
(zh)
|
2017-06-22 |
2020-06-19 |
梅尔莎纳医疗公司 |
产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法
|
EP3706742B1
(en)
|
2017-11-08 |
2023-03-15 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
WO2019148412A1
(en)
|
2018-02-01 |
2019-08-08 |
Merck Sharp & Dohme Corp. |
Anti-pd-1/lag3 bispecific antibodies
|
AU2019262521B2
(en)
|
2018-05-04 |
2024-04-18 |
Tagworks Pharmaceuticals B.V. |
Compounds comprising a linker for increasing transcyclooctene stability
|
CA3099419A1
(en)
|
2018-05-04 |
2019-11-07 |
Tagworks Pharmaceuticals B.V. |
Tetrazines for high click conjugation yield in vivo and high click release yield
|
CN110194772B
(zh)
|
2018-07-02 |
2022-04-05 |
深圳市塔吉瑞生物医药有限公司 |
用于抑制蛋白激酶活性的炔基(杂)芳环类化合物
|
US11746110B2
(en)
|
2018-07-17 |
2023-09-05 |
Shenzhen Targetrx, Inc. |
Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
|
EP3833668A4
(en)
|
2018-08-07 |
2022-05-11 |
Merck Sharp & Dohme Corp. |
PRMT5 INHIBITORS
|
US20210309688A1
(en)
|
2018-08-07 |
2021-10-07 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
MX2021004906A
(es)
|
2018-10-29 |
2021-09-10 |
Mersana Therapeutics Inc |
Conjugados de anticuerpo modificado con cisteína-fármaco con enlazadores que contienen péptidos.
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
JP2022537543A
(ja)
|
2019-06-17 |
2022-08-26 |
タグワークス ファーマシューティカルス ビー.ブイ. |
高速で且つ効率的なクリック放出の為の化合物
|
BR112022012032A2
(pt)
|
2019-12-17 |
2022-09-06 |
Merck Sharp & Dohme Llc |
Inibidores de prmt5
|
WO2023031445A2
(en)
|
2021-09-06 |
2023-03-09 |
Veraxa Biotech Gmbh |
Novel aminoacyl-trna synthetase variants for genetic code expansion in eukaryotes
|
WO2023094525A1
(en)
|
2021-11-25 |
2023-06-01 |
Veraxa Biotech Gmbh |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
EP4186529A1
(en)
|
2021-11-25 |
2023-05-31 |
Veraxa Biotech GmbH |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
WO2023104941A1
(en)
|
2021-12-08 |
2023-06-15 |
European Molecular Biology Laboratory |
Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
|
EP4314031B1
(en)
|
2022-02-15 |
2024-03-13 |
Tagworks Pharmaceuticals B.V. |
Masked il12 protein
|
WO2024013723A1
(en)
|
2022-07-15 |
2024-01-18 |
Pheon Therapeutics Ltd |
Antibody drug conjugates that bind cdcp1 and uses thereof
|