DK1165564T3 - Fremgangsmåde til fremstilling af inhibitorer af nukleosidmetabolisme - Google Patents

Fremgangsmåde til fremstilling af inhibitorer af nukleosidmetabolisme

Info

Publication number
DK1165564T3
DK1165564T3 DK00917509T DK00917509T DK1165564T3 DK 1165564 T3 DK1165564 T3 DK 1165564T3 DK 00917509 T DK00917509 T DK 00917509T DK 00917509 T DK00917509 T DK 00917509T DK 1165564 T3 DK1165564 T3 DK 1165564T3
Authority
DK
Denmark
Prior art keywords
compound
preparation
pyrrolo
pyrimidin
amino
Prior art date
Application number
DK00917509T
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Ind Res Ltd
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Res Ltd, Einstein Coll Med filed Critical Ind Res Ltd
Application granted granted Critical
Publication of DK1165564T3 publication Critical patent/DK1165564T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
DK00917509T 1999-04-08 2000-04-07 Fremgangsmåde til fremstilling af inhibitorer af nukleosidmetabolisme DK1165564T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ33509099 1999-04-08
NZ33616899 1999-06-08
PCT/NZ2000/000048 WO2000061783A2 (en) 1999-04-08 2000-04-07 Process for preparing inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
DK1165564T3 true DK1165564T3 (da) 2009-06-08

Family

ID=26652045

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09150953.9T DK2077268T5 (da) 1999-04-08 2000-04-07 Fremgangsmåde til fremstilling af hæmmere af nukleosidmetabolisme
DK00917509T DK1165564T3 (da) 1999-04-08 2000-04-07 Fremgangsmåde til fremstilling af inhibitorer af nukleosidmetabolisme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK09150953.9T DK2077268T5 (da) 1999-04-08 2000-04-07 Fremgangsmåde til fremstilling af hæmmere af nukleosidmetabolisme

Country Status (18)

Country Link
US (4) US6693193B1 (da)
EP (2) EP2077268B1 (da)
JP (2) JP4430247B2 (da)
KR (1) KR100755110B1 (da)
CN (2) CN101062928B (da)
AT (1) ATE425165T1 (da)
AU (1) AU776540C (da)
CA (3) CA2368095C (da)
CY (2) CY1109103T1 (da)
DE (1) DE60041757D1 (da)
DK (2) DK2077268T5 (da)
ES (2) ES2625636T3 (da)
HK (2) HK1088310A1 (da)
LT (1) LT2077268T (da)
NZ (1) NZ514660A (da)
PT (2) PT1165564E (da)
SI (2) SI2077268T1 (da)
WO (1) WO2000061783A2 (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
DE60041757D1 (de) * 1999-04-08 2009-04-23 Ind Res Ltd Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus
US7109331B2 (en) * 2000-08-29 2006-09-19 Industrial Research Limited 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
BRPI0313664B8 (pt) * 2002-08-21 2021-05-25 Albert Einstein College Medicine Yeshiva Univ compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
US6972331B2 (en) 2003-04-23 2005-12-06 Biocryst Pharmaceuticals, Inc. Carboxy pyrrole, process of preparing and use as precursor
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
CA2615549A1 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8394950B2 (en) * 2006-02-22 2013-03-12 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
JP2009528996A (ja) * 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
JP2009527550A (ja) * 2006-02-24 2009-07-30 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 癌を処置する方法
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通***中的计费方法
SI2057165T1 (sl) 2006-09-07 2011-07-29 Ind Res Ltd Gracefield Res Ct Acikliäśni aminski zaviralci nukleozidnih fosforilaz in hidrolaz
AU2007293773B2 (en) 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
PT2114925E (pt) * 2006-12-22 2012-05-29 Einstein Coll Med Análogos de azetidina de inibidores de nucleosidase e fosforilase
CA2721927C (en) 2008-04-21 2014-01-28 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
CA2768291C (en) 2009-07-17 2018-03-27 Albert Einstein College Of Medicine Of Yeshiva University 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
US9290501B2 (en) 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
JP2014505705A (ja) 2011-02-02 2014-03-06 ザ トラスティーズ オブ プリンストン ユニヴァシティ ウイルス生成モジュレーターとしてのサーチュインモジュレーター
US9682093B2 (en) 2012-03-30 2017-06-20 Charles R. Drew University Of Medicine And Science Compositions and methods for treating or preventing metabolic syndrome disorders
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
EP3478269A4 (en) 2016-06-29 2020-04-08 Otonomy, Inc. OTIC FORMULATIONS BASED ON TRIGLYCERIDES AND THEIR USES
US11114184B2 (en) 2017-02-21 2021-09-07 Albert Einstein College Of Medicine DNA methyltransferase 1 transition state structure and uses thereof
CN110590786B (zh) * 2019-09-29 2021-12-03 上海大学 9-去氮鸟嘌呤合成工艺的改进方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59307270D1 (de) * 1992-11-06 1997-10-09 Ulrich Rindlisbacher Vorrichtung zum befestigen an einem gestell eines zweiradfahrzeugs
IL107616A0 (en) 1992-11-18 1994-02-27 Univ Johns Hopkins Formation of triple helix complexes of single stranded nucleic acids using nucleoside oligomers which comprise pyrimidine analogs
AU1739097A (en) * 1996-02-23 1997-09-10 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US6187777B1 (en) * 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
DE60041757D1 (de) * 1999-04-08 2009-04-23 Ind Res Ltd Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
US7109331B2 (en) * 2000-08-29 2006-09-19 Industrial Research Limited 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
BRPI0313664B8 (pt) 2002-08-21 2021-05-25 Albert Einstein College Medicine Yeshiva Univ compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
AU2005269541A1 (en) 2004-07-27 2006-02-09 Biocryst Pharmaceuticals, Inc. Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
JP2009528996A (ja) 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
JP2009527550A (ja) 2006-02-24 2009-07-30 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 癌を処置する方法

Also Published As

Publication number Publication date
CA2696826C (en) 2013-01-08
US7405297B2 (en) 2008-07-29
EP2077268B1 (en) 2017-03-01
CY1119099T1 (el) 2018-02-14
US7211677B2 (en) 2007-05-01
DK2077268T3 (da) 2017-06-06
PT2077268T (pt) 2017-06-12
AU776540B2 (en) 2004-09-16
SI1165564T1 (sl) 2009-08-31
AU3846900A (en) 2000-11-14
US6693193B1 (en) 2004-02-17
HK1116472A1 (en) 2008-12-24
CN101062928B (zh) 2010-10-06
ES2324016T3 (es) 2009-07-29
CA2696826A1 (en) 2000-10-19
KR100755110B1 (ko) 2007-09-04
EP1165564B1 (en) 2009-03-11
ATE425165T1 (de) 2009-03-15
US20040181063A1 (en) 2004-09-16
DK2077268T5 (da) 2017-08-28
US20060089498A1 (en) 2006-04-27
WO2000061783A2 (en) 2000-10-19
CA2368095C (en) 2009-10-06
KR20020018658A (ko) 2002-03-08
ES2625636T3 (es) 2017-07-20
CA2368095A1 (en) 2000-10-19
SI2077268T1 (sl) 2017-07-31
JP2009173673A (ja) 2009-08-06
JP2002542170A (ja) 2002-12-10
CN1196704C (zh) 2005-04-13
HK1088310A1 (en) 2006-11-03
LT2077268T (lt) 2017-08-10
WO2000061783A3 (en) 2001-02-08
EP1165564A2 (en) 2002-01-02
EP1165564A4 (en) 2003-01-22
NZ514660A (en) 2004-03-26
PT1165564E (pt) 2009-04-16
US20070161667A1 (en) 2007-07-12
DE60041757D1 (de) 2009-04-23
CN1370171A (zh) 2002-09-18
CN101062928A (zh) 2007-10-31
AU776540C (en) 2006-01-05
CY1109103T1 (el) 2014-07-02
CA2634299A1 (en) 2000-10-19
US7022852B2 (en) 2006-04-04
EP2077268A1 (en) 2009-07-08
CA2634299C (en) 2011-05-31
JP4430247B2 (ja) 2010-03-10
JP5070237B2 (ja) 2012-11-07

Similar Documents

Publication Publication Date Title
CY1119099T1 (el) Διαδικασια για την παρασκευη αναστολεων του μεταβολισμου των νουκλεοζιτων
CA2264824A1 (en) A process for preparing 2-amino malonic acid derivatives and 2-amino-1,3-propanediol derivatives, and intermediates for preparing the same
NZ511311A (en) Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives useful as agricultural, horticultural bactericides
UA74370C2 (uk) Піроло(2,3-d)піримідинові сполуки як імуносупресори
ATE255110T1 (de) Fungizide 7-alkyl-triazolopyrimidine
EP1167367A4 (en) THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF
EP1690861A3 (en) A process for preparing duloxetine and intermediates for use therein
PT1038875E (pt) Derivados de imidazopiridina e processo para os preparar
MXPA05008183A (es) Proceso para preparar pirrolotriazina como inhibidores de cinasa.
ES2159488A1 (es) Procedimiento para la preparacion de derivados de pirimidona con actividad antifugica.
UA93860C2 (ru) Способ получения пиразолов, способ региоселективного алкилирования и применение фосфата или фосфоната b способе
PL360499A1 (en) Method of manufacture of donepezyl
DK0841326T3 (da) Fremgangsmåde til fremstilling af pyrimidinderivater
BR0009453B1 (pt) processo para a preparação de um composto.
BR9810685B1 (pt) processo para a prepraração de um composto.
PT1230252E (pt) Derivados de beta-d-5-tioxilose processo de preparacao e utilizacao em terapeutica
GB9906328D0 (en) 2-Substituted RNA preparation
IL172697A (en) 8- (3-Pentylamino) -Methyl-3 (2-chloro-4-methoxyfenil) -7, 6-dihydro-5h-cyclopenta [d] pyrazole [5,1a- [pyrimidine methanesulfonate, crystal and method for its preparation
DK0798297T3 (da) Fremgangsmåde til fremstilling af 2-alkoxy-6-(trifluormethyl)-pyrimidin-4-ol
ES2138535A1 (es) Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir.
BR9810687B1 (pt) processo para a preparação de um composto derivado de 2-alquiltiobenzonitrila.
MXPA96001370A (es) Herbicidas de n-piridinil[1,2,4]triazol[1,5-c]pirimidina-2-sulfonamida.
ZA99614B (en) Process for the preparation of S-alkylcysteines.
ATE388942T1 (de) Verfahren zur herstellung von 1-(pyrimidin-2- yl)propan-2-one derivaten
MXPA03011011A (es) Procedimiento para la preparacion del derivado del acido 3-aril-2-hidroxipropionico.