DK1143928T3 - Fremgangsmåde til formaling ved fremstilling af fint formalede medicinalstoffer - Google Patents

Fremgangsmåde til formaling ved fremstilling af fint formalede medicinalstoffer

Info

Publication number
DK1143928T3
DK1143928T3 DK99972915T DK99972915T DK1143928T3 DK 1143928 T3 DK1143928 T3 DK 1143928T3 DK 99972915 T DK99972915 T DK 99972915T DK 99972915 T DK99972915 T DK 99972915T DK 1143928 T3 DK1143928 T3 DK 1143928T3
Authority
DK
Denmark
Prior art keywords
milling
pharmaceuticals
grinding
manufacture
finely ground
Prior art date
Application number
DK99972915T
Other languages
English (en)
Inventor
N Murti Vemuri
Andrew B Brown
Jean-Rene Authelin
Patrick Hosek
Original Assignee
Aventis Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Ltd filed Critical Aventis Pharma Ltd
Application granted granted Critical
Publication of DK1143928T3 publication Critical patent/DK1143928T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C19/00—Other disintegrating devices or methods
    • B02C19/06—Jet mills

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Disintegrating Or Milling (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
DK99972915T 1998-12-01 1999-12-01 Fremgangsmåde til formaling ved fremstilling af fint formalede medicinalstoffer DK1143928T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9826284.3A GB9826284D0 (en) 1998-12-01 1998-12-01 Process
PCT/GB1999/004041 WO2000032165A1 (en) 1998-12-01 1999-12-01 Milling process for the production of finely milled medicinal substances

Publications (1)

Publication Number Publication Date
DK1143928T3 true DK1143928T3 (da) 2003-09-22

Family

ID=10843360

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99972915T DK1143928T3 (da) 1998-12-01 1999-12-01 Fremgangsmåde til formaling ved fremstilling af fint formalede medicinalstoffer

Country Status (24)

Country Link
US (1) US6641063B2 (da)
EP (1) EP1143928B1 (da)
JP (1) JP4680389B2 (da)
KR (1) KR100606319B1 (da)
CN (1) CN1198583C (da)
AT (1) ATE241958T1 (da)
AU (1) AU763352B2 (da)
BR (1) BR9916153B1 (da)
CA (1) CA2352796C (da)
CZ (1) CZ301914B6 (da)
DE (1) DE69908650T2 (da)
DK (1) DK1143928T3 (da)
ES (1) ES2201842T3 (da)
GB (1) GB9826284D0 (da)
HK (1) HK1037525A1 (da)
HU (1) HU224615B1 (da)
IL (2) IL143344A0 (da)
MX (1) MXPA01005472A (da)
NO (1) NO20012677L (da)
NZ (1) NZ512089A (da)
PL (1) PL193800B1 (da)
PT (1) PT1143928E (da)
RU (1) RU2219908C2 (da)
WO (1) WO2000032165A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10204470C1 (de) * 2002-02-05 2003-08-14 Degussa Verfahren und Vorrichtung zur Herstellung von Dispersionen
DE10317461A1 (de) * 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
GB0409703D0 (en) * 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
US20070185066A1 (en) * 2005-12-20 2007-08-09 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070249572A1 (en) * 2005-12-20 2007-10-25 Verus Pharmaceuticals, Inc. Systems and methods for the delivery of corticosteroids
US20070197486A1 (en) * 2005-12-20 2007-08-23 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids
US20070160542A1 (en) * 2005-12-20 2007-07-12 Verus Pharmaceuticals, Inc. Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile
JP2009526858A (ja) * 2006-02-15 2009-07-23 ティカ レーケメデル アーベー コルチコステロイド溶液を製造する方法
DE102006030166A1 (de) * 2006-06-29 2008-01-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tempern
WO2009016133A1 (en) * 2007-07-27 2009-02-05 Cargill, Incorporated Micronization of polyols
CN101618019B (zh) * 2008-07-01 2011-08-03 上海通用药业股份有限公司 一种醋酸曲安奈德微粒及其制备方法和药物组合物
ES2774391T3 (es) 2009-05-29 2020-07-20 Pearl Therapeutics Inc Composiciones, métodos y sistemas para la administración respiratoria de dos o más agentes activos
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
JO3510B1 (ar) 2011-03-04 2020-07-05 Heptares Therapeutics Ltd استخدام جلايكوبيرولات لعلاج عدم انتظام دقات القلب
DE102011102614A1 (de) 2011-05-27 2012-11-29 Roland Nied Verfahren zum Betrieb einer Strahlmühle sowie Strahlmühle
DE102013000426A1 (de) * 2013-01-14 2014-07-17 Roland Nied Verfahren zur Strahlmahlung sowie Strahlmühle dafür
RU2696582C2 (ru) 2013-03-15 2019-08-05 Перл Терапьютикс, Инк. Способы и системы кондиционирования дисперсных кристаллических материалов
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
TN2017000077A1 (en) 2014-09-09 2018-07-04 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
DK3346990T3 (da) 2015-09-09 2020-06-02 Vectura Ltd Fremgangsmåde til stråleformaling
CN106111304B (zh) * 2016-06-28 2018-05-22 山东大学齐鲁医院 营养补剂研磨加温装置
US11219602B2 (en) 2017-03-15 2022-01-11 Vectura Limited Method for making a micronized dry powder formulation of glycopyrrolate and magnesium stearate

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3937405A (en) * 1973-12-18 1976-02-10 Fluid Energy Processing And Equipment Company Apparatus for mixing pulverizing and grinding black powder
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
US4767612A (en) * 1987-01-23 1988-08-30 Rorer Pharmaceutical Corporation Triamcinolone acetonide for the treatment of allergic rhinitis
SE9302777D0 (sv) * 1993-08-27 1993-08-27 Astra Ab Process for conditioning substances
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
GB9226993D0 (en) * 1992-12-24 1993-02-17 Tioxide Group Services Ltd Method of simultaneous milling and drying
AUPM411494A0 (en) * 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
US5747002A (en) * 1995-04-05 1998-05-05 Genentech, Inc. Preparation of sodium chloride aerosol formulations
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US5730795A (en) * 1996-09-24 1998-03-24 E. I. Du Pont De Nemours And Company Process for manufacturing titanium dioxide pigment having a hydrous oxide coating using a media mill
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
GB9808470D0 (en) * 1998-04-22 1998-06-17 Smithkline Beecham Plc Novel process and apparatus

Also Published As

Publication number Publication date
CZ301914B6 (cs) 2010-07-28
DE69908650D1 (de) 2003-07-10
IL143344A0 (en) 2002-04-21
PT1143928E (pt) 2003-10-31
IL143344A (en) 2006-06-11
GB9826284D0 (en) 1999-01-20
EP1143928B1 (en) 2003-06-04
HUP0104478A2 (hu) 2002-03-28
PL193800B1 (pl) 2007-03-30
US6641063B2 (en) 2003-11-04
HUP0104478A3 (en) 2002-12-28
HU224615B1 (hu) 2005-11-28
BR9916153B1 (pt) 2010-07-13
CA2352796C (en) 2009-06-09
AU763352B2 (en) 2003-07-17
ATE241958T1 (de) 2003-06-15
CN1354652A (zh) 2002-06-19
ES2201842T3 (es) 2004-03-16
JP2002531390A (ja) 2002-09-24
AU1401100A (en) 2000-06-19
CA2352796A1 (en) 2000-06-08
EP1143928A1 (en) 2001-10-17
NZ512089A (en) 2002-09-27
DE69908650T2 (de) 2004-05-13
CZ20011804A3 (cs) 2002-06-12
NO20012677D0 (no) 2001-05-31
BR9916153A (pt) 2001-09-04
RU2219908C2 (ru) 2003-12-27
US20020109025A1 (en) 2002-08-15
CN1198583C (zh) 2005-04-27
KR20010093129A (ko) 2001-10-27
KR100606319B1 (ko) 2006-07-28
JP4680389B2 (ja) 2011-05-11
NO20012677L (no) 2001-05-31
WO2000032165A1 (en) 2000-06-08
MXPA01005472A (es) 2003-03-27
HK1037525A1 (en) 2002-02-15
PL348614A1 (en) 2002-06-03

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