DK1129066T3 - Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler - Google Patents

Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler

Info

Publication number
DK1129066T3
DK1129066T3 DK99971797T DK99971797T DK1129066T3 DK 1129066 T3 DK1129066 T3 DK 1129066T3 DK 99971797 T DK99971797 T DK 99971797T DK 99971797 T DK99971797 T DK 99971797T DK 1129066 T3 DK1129066 T3 DK 1129066T3
Authority
DK
Denmark
Prior art keywords
alkylphenyl
diols
amino
ethyl
propane
Prior art date
Application number
DK99971797T
Other languages
English (en)
Inventor
Stephan Abel
Tetsuro Fujita
Ryoji Hirose
Guido Jordine
Tadashi Mishina
Original Assignee
Novartis Ag
Taito Co
Mitsubishi Pharma Corp
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9824706.7A external-priority patent/GB9824706D0/en
Priority claimed from GBGB9824705.9A external-priority patent/GB9824705D0/en
Application filed by Novartis Ag, Taito Co, Mitsubishi Pharma Corp, Novartis Pharma Gmbh filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1129066T3 publication Critical patent/DK1129066T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/20—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms
    • C07C17/202—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction
    • C07C17/208—Preparation of halogenated hydrocarbons by replacement by halogens of halogen atoms by other halogen atoms two or more compounds being involved in the reaction the other compound being MX
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
    • C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
    • C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK99971797T 1998-11-11 1999-11-09 Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler DK1129066T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9824706.7A GB9824706D0 (en) 1998-11-11 1998-11-11 Organic compounds
GBGB9824705.9A GB9824705D0 (en) 1998-11-11 1998-11-11 Organic compounds
EP99971797A EP1129066B1 (en) 1998-11-11 1999-11-09 Production of 2-amino-2- 2-(4-c 2-20?-alkyl-phenyl)ethyl]propane-1,3-diols

Publications (1)

Publication Number Publication Date
DK1129066T3 true DK1129066T3 (da) 2005-03-29

Family

ID=26314659

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99971797T DK1129066T3 (da) 1998-11-11 1999-11-09 Fremstilling af 2-amino-2-[2-(C2-20alkylphenyl)ethyl]propan-1,3-dioler

Country Status (10)

Country Link
US (3) US6605744B2 (da)
EP (2) EP1129066B1 (da)
JP (1) JP4503184B2 (da)
AT (1) ATE288414T1 (da)
AU (1) AU1161400A (da)
DE (1) DE69923579T2 (da)
DK (1) DK1129066T3 (da)
ES (2) ES2237970T3 (da)
PT (2) PT1129066E (da)
WO (1) WO2000027798A1 (da)

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Publication number Priority date Publication date Assignee Title
AU2001285331B2 (en) 2000-08-31 2006-04-06 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
BR0306811A (pt) * 2002-01-11 2004-10-26 Sankyo Co Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero
CA2557536C (en) 2004-02-24 2010-07-13 Sankyo Company Limited Amino alcohol compound
RU2402324C2 (ru) 2004-07-30 2010-10-27 Новартис Аг Композиции на основе соединений 2-амино-1,3-пропандиола
WO2007022718A1 (en) * 2005-08-25 2007-03-01 Chunde Liu Alkyl aryl alkyl alcohols, their derivations and preparation process thereof
US20090176744A1 (en) * 2007-11-02 2009-07-09 Concert Pharmaceuticals, Inc. Deuterated fingolimod
MX2010009931A (es) 2008-03-19 2010-09-30 Novartis Ag Proceso para la preparacion de 2-amino-2-[2-(4-c3-c21-alquil-fenil )-etil]-propano-1,3-dioles.
RU2015111229A (ru) * 2008-11-11 2015-11-20 Новартис Аг Кристаллические формы гидрохлорида финголимода
EP2358660A2 (en) * 2008-11-11 2011-08-24 Novartis AG Salts of fingolimod
JP5593164B2 (ja) * 2010-06-29 2014-09-17 株式会社クラレ 第１級アルキルハライドの製造方法
WO2012041358A1 (en) 2010-10-01 2012-04-05 Synthon B.V. Process for making fingolimod hydrochloride crystals
CN103313964A (zh) 2010-10-28 2013-09-18 Mapi医药公司 用于制备芬戈莫德的中间化合物和方法
WO2012071524A1 (en) 2010-11-24 2012-05-31 Ratiopharm Gmbh Arylsulfonate salts of fingolimod and processes for preparation thereof
EP2658840B1 (en) 2010-12-28 2019-07-03 Synthon BV Process for making fingolimod hydrochloride crystals
US9216943B2 (en) 2011-04-29 2015-12-22 Dr. Reddy's Laboratories Ltd. Preparation of fingolimod and its salts
CN103539683A (zh) * 2012-07-17 2014-01-29 广东东阳光药业有限公司 治疗硬化病的药物的新晶型及其制备方法
CN102796022B (zh) * 2012-08-27 2015-03-25 南京华威医药科技开发有限公司 制备2-氨基-2-[2-(4-烷基苯基)乙基]-1,3-丙二醇盐酸盐的方法
AU2014206588A1 (en) 2013-01-17 2015-07-23 Shilpa Medicare Limited Process for preparation of Fingolimod and its salts
JP6484567B2 (ja) * 2013-03-05 2019-03-13 バイオコン・リミテッドＢｉｏｃｏｎ Ｌｉｍｉｔｅｄ ２−アミノ−１，３−プロパンジオール化合物およびその塩の製造のための方法
IN2013MU03696A (da) 2013-11-25 2015-07-31 Emcure Pharmaceuticals Ltd
CN115916201A (zh) 2020-06-26 2023-04-04 国立大学法人大阪大学 药剂诱发性心动过缓及心动过缓性心律失常治疗药

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE269856C (da)
JPS5912643B2 (ja) 1975-04-03 1984-03-24 和光純薬工業 （株） フエネチルブロマイド類の製法
JPS52108943A (en) 1976-03-10 1977-09-12 Teikoku Hormone Mfg Co Ltd Alkyl phenyl ketone derivative
JPS5951932B2 (ja) 1980-04-14 1984-12-17 東ソー株式会社 ハロベンゼン類とオレフィン類との付加化合物の製造方法
DD269856A1 (de) * 1988-03-03 1989-07-12 Univ Halle Wittenberg Fluessig-kristalline amphiphile
US5604229A (en) * 1992-10-21 1997-02-18 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
US5508272A (en) 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
IT1265101B1 (it) * 1993-07-23 1996-10-30 Erba Carlo Spa Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
DK0778263T3 (da) 1994-08-22 2002-04-22 Mitsubishi Pharma Corp Benzenforbindelser og farmaceutisk anvendelse af disse
GB9624038D0 (en) 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
WO1999001420A1 (fr) 1997-07-03 1999-01-14 Taito Co., Ltd. Procede de preparation de derives d'acide 2-aminomalonique, et intermediaires utilises dans ce procede
JP4079505B2 (ja) 1998-04-28 2008-04-23 田辺三菱製薬株式会社 ２−アミノ−２−［２−（４−オクチルフェニル）エチル］プロパン−１，３−ジオールの新規な製造法

Also Published As

Publication number Publication date
US7026522B2 (en) 2006-04-11
US20030229251A1 (en) 2003-12-11
EP1129066B1 (en) 2005-02-02
EP1129066A1 (en) 2001-09-05
DE69923579T2 (de) 2006-01-12
JP2002529441A (ja) 2002-09-10
WO2000027798A1 (en) 2000-05-18
ES2237970T3 (es) 2005-08-01
ATE288414T1 (de) 2005-02-15
PT1457478T (pt) 2017-10-26
US20060079715A1 (en) 2006-04-13
US20020072635A1 (en) 2002-06-13
DE69923579D1 (de) 2005-03-10
AU1161400A (en) 2000-05-29
US6605744B2 (en) 2003-08-12
EP1457478B1 (en) 2017-07-19
PT1129066E (pt) 2005-05-31
EP1457478A3 (en) 2004-12-22
ES2644413T3 (es) 2017-11-28
JP4503184B2 (ja) 2010-07-14
EP1457478A2 (en) 2004-09-15

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