DK112239B - Process for the preparation of α- (3-indolyl) -acetic acid compounds. - Google Patents

Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Info

Publication number: DK112239B
Authority: DK; Denmark
Prior art keywords: indolyl; preparation; acetic acid; acid compounds; compounds
Prior art date: 1963-02-01

Application number

DK598665A

Other languages

Danish (da)

Inventor

G Gal

M Sletzinger

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1963-02-01

Filing date

1965-11-22

Publication date

1968-11-25

1965-11-22 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1968-11-25 Publication of DK112239B publication Critical patent/DK112239B/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK598665A 1963-02-01 1965-11-22 Process for the preparation of α- (3-indolyl) -acetic acid compounds. DK112239B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US25564263A	1963-02-01	1963-02-01

Publications (1)

Publication Number	Publication Date
DK112239B true DK112239B (en)	1968-11-25

Family

ID=22969254

Family Applications (11)

Application Number	Title	Priority Date	Filing Date
DK598765A DK109334C (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK48964A DK112238B (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598565A DK109514C (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598265A DK109562C (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598965A DK112314B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598365A DK113501B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598865A DK112313B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598465A DK111751B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598665A DK112239B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93366A DK112447B (en)	1963-02-01	1966-02-23	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93266A DK112446B (en)	1963-02-01	1966-02-23	Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Family Applications Before (8)

Application Number	Title	Priority Date	Filing Date
DK598765A DK109334C (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK48964A DK112238B (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598565A DK109514C (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598265A DK109562C (en)	1963-02-01	1964-01-31	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598965A DK112314B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598365A DK113501B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598865A DK112313B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK598465A DK111751B (en)	1963-02-01	1965-11-22	Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK93366A DK112447B (en)	1963-02-01	1966-02-23	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK93266A DK112446B (en)	1963-02-01	1966-02-23	Process for the preparation of α- (3-indolyl) -acetic acid compounds.

Country Status (11)

Country	Link
AT (1)	AT277992B (en)
BE (1)	BE643268A (en)
BR (1)	BR6456479D0 (en)
CH (16)	CH464203A (en)
DE (16)	DE1695492A1 (en)
DK (11)	DK109334C (en)
FI (9)	FI46955C (en)
FR (1)	FR1559559A (en)
GB (13)	GB1050737A (en)
NL (1)	NL6400813A (en)
SE (12)	SE317975B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU163233B (en) *	1970-07-31	1973-07-28
ATE79741T1 (en) *	1988-06-21	1992-09-15	Rauter Vita Zahnfabrik	DISPERSED CERAMIC COMPOUND.
GB9518994D0 (en) *	1995-09-16	1995-11-15	Agrevo Uk Ltd	Fungicides

0
- GB GB1050732D patent/GB1050732A/en active Active
- GB GB1050731D patent/GB1050731A/en active Active
- GB GB1050730D patent/GB1050730A/en active Active
- GB GB1050739D patent/GB1050739A/en active Active
- GB GB1050733D patent/GB1050733A/en active Active
- GB GB1050736D patent/GB1050736A/en active Active
- GB GB1050729D patent/GB1050729A/en active Active
- GB GB1050738D patent/GB1050738A/en active Active
- GB GB1050735D patent/GB1050735A/en active Active
- GB GB1050740D patent/GB1050740A/en active Active
- GB GB1050734D patent/GB1050734A/en active Active
- GB GB1050728D patent/GB1050728A/en active Active
- GB GB1050737D patent/GB1050737A/en active Active
1964
- 1964-01-14 DE DE19641695492 patent/DE1695492A1/en active Pending
- 1964-01-24 DE DE19641470059D patent/DE1470059B1/en active Pending
- 1964-01-24 DE DE19641695490 patent/DE1695490A1/en active Pending
- 1964-01-24 DE DE19641695488 patent/DE1695488A1/en active Pending
- 1964-01-24 DE DE19641695491 patent/DE1695491A1/en active Pending
- 1964-01-24 DE DE19641793561 patent/DE1793561A1/en active Pending
- 1964-01-24 DE DE19641695489 patent/DE1695489A1/en active Pending
- 1964-01-24 DE DE19641770134 patent/DE1770134A1/en active Pending
- 1964-01-24 DE DE19641770132 patent/DE1770132A1/en active Pending
- 1964-01-24 DE DE19641695493 patent/DE1695493A1/en active Pending
- 1964-01-24 DE DE19641695487 patent/DE1695487A1/en active Pending
- 1964-01-24 DE DE19641695486 patent/DE1695486A1/en active Pending
- 1964-01-24 DE DE19641770116 patent/DE1770116A1/en active Pending
- 1964-01-24 DE DE19641770802 patent/DE1770802A1/en active Pending
- 1964-01-24 DE DE19641695484 patent/DE1695484A1/en active Pending
- 1964-01-24 DE DE19641695485 patent/DE1695485A1/en active Pending
- 1964-01-28 AT AT01821/67A patent/AT277992B/en not_active IP Right Cessation
- 1964-01-28 BR BR15647964A patent/BR6456479D0/en unknown
- 1964-01-29 FI FI16964A patent/FI46955C/en active
- 1964-01-31 CH CH236568A patent/CH464203A/en unknown
- 1964-01-31 CH CH1674468A patent/CH466288A/en unknown
- 1964-01-31 DK DK598765A patent/DK109334C/en active
- 1964-01-31 CH CH490368A patent/CH466287A/en unknown
- 1964-01-31 DK DK48964A patent/DK112238B/en unknown
- 1964-01-31 CH CH236468A patent/CH466283A/en unknown
- 1964-01-31 NL NL6400813A patent/NL6400813A/xx unknown
- 1964-01-31 CH CH235868A patent/CH457434A/en unknown
- 1964-01-31 CH CH444166A patent/CH466285A/en unknown
- 1964-01-31 CH CH490268A patent/CH466286A/en unknown
- 1964-01-31 FR FR1559559D patent/FR1559559A/fr not_active Expired
- 1964-01-31 CH CH236368A patent/CH457436A/en unknown
- 1964-01-31 DK DK598565A patent/DK109514C/en active
- 1964-01-31 CH CH419468A patent/CH466284A/en unknown
- 1964-01-31 BE BE643268D patent/BE643268A/xx unknown
- 1964-01-31 SE SE88967A patent/SE317975B/xx unknown
- 1964-01-31 CH CH236668A patent/CH457437A/en unknown
- 1964-01-31 SE SE123764A patent/SE307948B/xx unknown
- 1964-01-31 CH CH236068A patent/CH457435A/en unknown
- 1964-01-31 DK DK598265A patent/DK109562C/en active
- 1964-01-31 SE SE89267A patent/SE302463B/xx unknown
- 1964-01-31 CH CH236268A patent/CH557815A/en not_active IP Right Cessation
- 1964-01-31 CH CH236168A patent/CH464202A/en unknown
- 1964-01-31 CH CH1674568A patent/CH466289A/en unknown
- 1964-01-31 CH CH1674768A patent/CH466290A/en unknown
1965
- 1965-11-22 DK DK598965A patent/DK112314B/en unknown
- 1965-11-22 DK DK598365A patent/DK113501B/en unknown
- 1965-11-22 DK DK598865A patent/DK112313B/en unknown
- 1965-11-22 DK DK598465A patent/DK111751B/en unknown
- 1965-11-22 DK DK598665A patent/DK112239B/en unknown
1966
- 1966-02-23 DK DK93366A patent/DK112447B/en unknown
- 1966-02-23 DK DK93266A patent/DK112446B/en unknown
1967
- 1967-01-20 SE SE89367A patent/SE302133B/en unknown
- 1967-01-20 SE SE895/67A patent/SE320069B/xx unknown
- 1967-01-20 SE SE896/67A patent/SE320666B/xx unknown
- 1967-01-20 SE SE88667A patent/SE302130B/en unknown
- 1967-01-20 SE SE891/67A patent/SE304995B/xx unknown
- 1967-01-20 SE SE890/67A patent/SE307133B/xx unknown
- 1967-01-20 SE SE88867A patent/SE302132B/en unknown
- 1967-01-20 SE SE894/67A patent/SE320367B/xx unknown
- 1967-01-31 SE SE88767A patent/SE302131B/xx unknown
- 1967-02-23 CH CH115364A patent/CH489495A/en not_active IP Right Cessation
1970
- 1970-09-21 FI FI257170A patent/FI47098C/en active
- 1970-09-21 FI FI257370A patent/FI47185C/en active
- 1970-09-21 FI FI257070A patent/FI47097B/fi active
- 1970-09-21 FI FI257270A patent/FI47099C/en active
- 1970-09-21 FI FI257570A patent/FI47101C/en active
- 1970-09-21 FI FI702570A patent/FI47097C/en active
- 1970-09-21 FI FI256870A patent/FI47096C/en active
- 1970-09-21 FI FI257470A patent/FI47100C/en active

Also Published As

Publication number	Publication date
CH466283A (en)	1968-12-15
DE1695486A1 (en)	1971-04-15
DK109514C (en)	1968-05-06
GB1050737A (en)
CH489495A (en)	1970-04-30
CH466286A (en)	1968-12-15
NL6400813A (en)	1964-08-03
GB1050738A (en)
DE1695489A1 (en)	1970-08-13
DK112313B (en)	1968-12-02
GB1050736A (en)
FI46955C (en)	1973-08-10
SE320367B (en)	1970-02-09
GB1050739A (en)
DK109562C (en)	1968-05-13
CH457436A (en)	1968-06-15
CH457434A (en)	1968-06-15
FI47099C (en)	1973-09-10
DE1695484A1 (en)	1971-04-15
FI47096C (en)	1973-09-10
BE643268A (en)	1964-07-31
FI47100B (en)	1973-05-31
DE1695493A1 (en)	1971-04-01
DE1695492A1 (en)	1971-04-01
GB1050740A (en)
DE1695491A1 (en)	1971-04-15
CH466288A (en)	1968-12-15
CH466285A (en)	1968-12-15
FI47100C (en)	1973-09-10
FI47098B (en)	1973-05-31
GB1050733A (en)
GB1050729A (en)
CH457435A (en)	1968-06-15
FI47097B (en)	1973-05-31
SE307133B (en)	1968-12-23
FI47097C (en)	1973-09-10
CH466287A (en)	1968-12-15
CH464202A (en)	1968-10-31
CH466290A (en)	1968-12-15
CH464203A (en)	1968-10-31
SE302463B (en)	1968-07-22
DK112238B (en)	1968-11-25
FI47101C (en)	1973-09-10
DE1770134A1 (en)	1971-09-30
FI47099B (en)	1973-05-31
CH466289A (en)	1968-12-15
SE302130B (en)	1968-07-08
CH557815A (en)	1975-01-15
CH466284A (en)	1968-12-15
SE302133B (en)	1968-07-08
SE307948B (en)	1969-01-27
SE304995B (en)	1968-10-14
DK112314B (en)	1968-12-02
DE1470059B1 (en)	1970-01-29
DK113501B (en)	1969-03-31
DE1695490A1 (en)	1971-04-15
DK112447B (en)	1968-12-16
DE1695487A1 (en)	1970-10-01
SE320666B (en)	1970-02-16
AT277992B (en)	1970-01-12
GB1050732A (en)
FI47098C (en)	1973-09-10
GB1050731A (en)
DE1770132A1 (en)	1971-09-30
DE1770802A1 (en)	1972-02-17
DK111751B (en)	1968-10-07
FI47185B (en)	1973-07-02
GB1050734A (en)
DK112446B (en)	1968-12-16
SE317975B (en)	1969-12-01
DE1770116A1 (en)	1971-10-14
DE1695488A1 (en)	1970-09-17
SE302132B (en)	1968-07-08
GB1050728A (en)
CH457437A (en)	1968-06-15
SE320069B (en)	1970-02-02
SE302131B (en)	1968-07-08
FI47185C (en)	1973-10-10
DE1695485A1 (en)	1971-04-15
FI47096B (en)	1973-05-31
FR1559559A (en)	1969-03-14
DE1793561A1 (en)	1972-01-20
GB1050730A (en)
FI47101B (en)	1973-05-31
DK109334C (en)	1968-04-16
GB1050735A (en)
BR6456479D0 (en)	1973-09-20
FI46955B (en)	1973-05-02

Publication	Publication Date	Title
DK117068B (en)	1970-03-16	Process for the preparation of N-1-aroylindolyl acetic acid compounds.
DK120639B (en)	1971-06-28	Process for the preparation of benzimidazole compounds.
DK120898B (en)	1971-08-02	Process for the preparation of indoleacetic acid compounds.
DK124264B (en)	1972-10-02	Analogous process for the preparation of mitosane compounds.
DK127726B (en)	1973-12-24	Analogous process for the preparation of 1-halobenzoylaminomethyl-2-phenyl-cyclopropane compounds.
DK111113B (en)	1968-06-10	Process for the preparation of 3-methylflavone-8-carboxylic acid.
DK124334B (en)	1972-10-09	Process for the preparation of derivatives of 7-aminocephalosporanic acid.
DK120075B (en)	1971-04-05	Analogous process for the preparation of N-aromatically substituted acid amides.
DK113858B (en)	1969-05-05	Process for the preparation of benzimidazole compounds.
DK113859B (en)	1969-05-05	Process for the preparation of hydroxamic acids.
DK120637B (en)	1971-06-28	Process for the preparation of α- (3-indolyl) -alkane- or -alkene acids.
DK109562C (en)	1968-05-13	Process for the preparation of α- (3-indolyl) -acetic acid compounds.
DK116127B (en)	1969-12-15	Process for purifying alkyl esters of α- (0,0-dimethyldithiophosphoryl) -α-phenylacetic acid.
DK105592C (en)	1966-10-17	Process for the preparation of substituted 5-fluoro-pyrimidines.
DK121022B (en)	1971-08-23	Analogous process for the preparation of γ -resorcylic acid anilides.
DK123764B (en)	1972-07-31	Analogous process for the preparation of acid amides.
DK136644B (en)	1977-11-07	Process for the preparation of 1-p-chlorobenzoyl-2-methyl-3-indolyl-acetic acid compounds.
DK107548C (en)	1967-06-12	Process for the preparation of carboxylic acid nitriles.
DK120542B (en)	1971-06-14	Process for the preparation of α- (2-methyl-3-indolyl) -acetic acids.
DK113149B (en)	1969-02-24	Process for the preparation of sulfamylanthranilic acids.
DK114980B (en)	1969-08-25	Process for the preparation of sulfamylanthranilic acid amides.
DK118240B (en)	1970-07-27	Process for the preparation of 1-p-chlorobenzoyl-2-methyl-5-methoxy- or dimethylamino-3-indolyl-acetic acid.
DK111957B (en)	1968-10-28	Process for the preparation of adamantyl derivatives of αhydroxy-carboxylic acids.
DK114126B (en)	1969-06-02	Process for the preparation of substituted benzamides.
DK123021B (en)	1972-05-08	Analogous process for the preparation of acid addition salts of 2-aminoadamantane.