DK1121594T3 - Fremgangsmåder til identifikation af hot-spot remanenser af bindende proteiner og små forbindelser som binder til samme - Google Patents

Fremgangsmåder til identifikation af hot-spot remanenser af bindende proteiner og små forbindelser som binder til samme

Info

Publication number
DK1121594T3
DK1121594T3 DK99946946T DK99946946T DK1121594T3 DK 1121594 T3 DK1121594 T3 DK 1121594T3 DK 99946946 T DK99946946 T DK 99946946T DK 99946946 T DK99946946 T DK 99946946T DK 1121594 T3 DK1121594 T3 DK 1121594T3
Authority
DK
Denmark
Prior art keywords
methods
bind
same
binding proteins
spot residues
Prior art date
Application number
DK99946946T
Other languages
English (en)
Inventor
Virgil L Woods Jr
Original Assignee
Exsar Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exsar Corp filed Critical Exsar Corp
Application granted granted Critical
Publication of DK1121594T3 publication Critical patent/DK1121594T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/22—Hydrogen, per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK99946946T 1998-09-11 1999-09-13 Fremgangsmåder til identifikation af hot-spot remanenser af bindende proteiner og små forbindelser som binder til samme DK1121594T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9984798P 1998-09-11 1998-09-11
PCT/US1999/021177 WO2000016100A1 (en) 1998-09-11 1999-09-13 Methods for identifying hot-spot residues of binding proteins and small compounds that bind to the same

Publications (1)

Publication Number Publication Date
DK1121594T3 true DK1121594T3 (da) 2003-10-27

Family

ID=22276893

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99946946T DK1121594T3 (da) 1998-09-11 1999-09-13 Fremgangsmåder til identifikation af hot-spot remanenser af bindende proteiner og små forbindelser som binder til samme

Country Status (8)

Country Link
US (2) US6599707B1 (da)
EP (1) EP1121594B1 (da)
AT (1) ATE244405T1 (da)
AU (1) AU5924699A (da)
CA (1) CA2347419A1 (da)
DE (1) DE69909312T2 (da)
DK (1) DK1121594T3 (da)
WO (1) WO2000016100A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE393910T1 (de) * 2000-04-28 2008-05-15 Univ Duke Quantitatives screening-verfahren mit hohem durchsatz für die proteinstabilität
US6734023B1 (en) 2000-04-28 2004-05-11 Duke University Quantitative, high-throughput screening method for protein stability
WO2005044087A2 (en) * 2003-11-05 2005-05-19 The Regents Of The University Of California Methods for the determination of protein three-dimensional structure employing hydrogen exchange analysis to refine computational structure prediction
US7363171B2 (en) * 2003-11-26 2008-04-22 The Regents Of The University Of California Enhanced methods for crystallographic structure determination employing hydrogen exchange analysis
US20070087448A1 (en) * 2004-02-16 2007-04-19 Nelsestuen Gary L Biological profiles and methods of use
US20080274959A1 (en) * 2004-12-17 2008-11-06 Wyeth Actinomadura Chromoprotein, Apoprotein and Gene Cluster
JP5664667B2 (ja) * 2011-01-11 2015-02-04 株式会社島津製作所 質量分析データ解析方法、質量分析データ解析装置、及び質量分析データ解析用プログラム
WO2012166056A1 (en) * 2011-06-02 2012-12-06 National University Of Singapore Fragment-based approach for inhibitor design by amide hydrogen/deuterium exchange mass spectrometry

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5101059A (en) 1989-12-05 1992-03-31 Research Corporation Technologies, Inc. Amino acid protecting groups
US5273886A (en) 1990-08-24 1993-12-28 The Reagents Of The University Of California Determination of isoaspartate in proteins
US5521097A (en) 1991-08-28 1996-05-28 Seiko Instruments Inc. Method of determining amino acid sequence of protein or peptide from carboxy-terminal
US5254730A (en) 1992-01-14 1993-10-19 Kilgore James L Production of amino acids and amino acid derivatives bearing isotopic hydrogen labels
US5470753A (en) 1992-09-03 1995-11-28 Selectide Corporation Peptide sequencing using mass spectrometry
US5658739A (en) 1994-05-10 1997-08-19 The Regents Of The University Of California Method for characterization of the fine structure of protein binding sites
US6291189B1 (en) 1994-05-10 2001-09-18 Carta Proteomics, Inc. Methods for the high-resolution identification of solvent-accessible amide hydrogens in polypeptides or proteins and for characterization of the fine structure of protein binding sites
US5786218A (en) 1996-08-16 1998-07-28 Zeneca Limited Method for monitoring solid phase reactions

Also Published As

Publication number Publication date
EP1121594A4 (en) 2001-09-12
CA2347419A1 (en) 2000-03-23
US6599707B1 (en) 2003-07-29
EP1121594A1 (en) 2001-08-08
ATE244405T1 (de) 2003-07-15
DE69909312T2 (de) 2004-04-22
US20020197650A1 (en) 2002-12-26
DE69909312D1 (de) 2003-08-07
AU5924699A (en) 2000-04-03
EP1121594B1 (en) 2003-07-02
WO2000016100A1 (en) 2000-03-23

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