DK1100529T3 - Thymosin beta 4 fremmer sårheling - Google Patents

Thymosin beta 4 fremmer sårheling

Info

Publication number
DK1100529T3
DK1100529T3 DK99937654T DK99937654T DK1100529T3 DK 1100529 T3 DK1100529 T3 DK 1100529T3 DK 99937654 T DK99937654 T DK 99937654T DK 99937654 T DK99937654 T DK 99937654T DK 1100529 T3 DK1100529 T3 DK 1100529T3
Authority
DK
Denmark
Prior art keywords
wound healing
promotes wound
thymosin beta
angiogenesis
thymosin
Prior art date
Application number
DK99937654T
Other languages
English (en)
Other versions
DK1100529T4 (da
Inventor
Allan George Washing Goldstein
Katherine M Building R Malinda
Hynda K Building Room Kleinman
Gabriel Sosne
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22246605&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1100529(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of DK1100529T3 publication Critical patent/DK1100529T3/da
Publication of DK1100529T4 publication Critical patent/DK1100529T4/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2292Thymosin; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1841Transforming growth factor [TGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/18Thymus derived hormone or factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Silicon Polymers (AREA)
DK99937654.4T 1998-07-30 1999-07-29 Thymosin beta 4 fremmer sårheling DK1100529T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9469098P 1998-07-30 1998-07-30
PCT/US1999/017282 WO2000006190A1 (en) 1998-07-30 1999-07-29 THYMOSIN β4 PROMOTES WOUND REPAIR

Publications (2)

Publication Number Publication Date
DK1100529T3 true DK1100529T3 (da) 2005-12-19
DK1100529T4 DK1100529T4 (da) 2010-12-20

Family

ID=22246605

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99937654.4T DK1100529T4 (da) 1998-07-30 1999-07-29 Thymosin beta 4 fremmer sårheling

Country Status (12)

Country Link
US (6) US20070111931A9 (da)
EP (3) EP2311485A1 (da)
AT (1) ATE292473T1 (da)
AU (1) AU766826B2 (da)
CA (1) CA2338928A1 (da)
DE (1) DE69924615T3 (da)
DK (1) DK1100529T4 (da)
ES (1) ES2239846T5 (da)
HK (1) HK1038307A1 (da)
MX (1) MXPA01001041A (da)
PT (1) PT1100529E (da)
WO (1) WO2000006190A1 (da)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080096817A1 (en) * 1998-07-30 2008-04-24 Regenerx Biopharmaceuticals, Inc. METHODS OF TREATING DISORDERS OF THE EYE AND SURROUNDING TISSUE WITH THYMOSIN BETA 4 (Tbeta4), ANALOGUES, ISOFORMS AND OTHER DERIVATIVES
US20070191275A1 (en) * 1998-07-30 2007-08-16 Regenerx Biopharmaceuticals, Inc. Method of treating, preventing, inhibiting or reducing damage to cardiac tissue with thymosin beta 4 fragments
WO2002036143A1 (en) 2000-11-02 2002-05-10 Regenerx Biopharmaceuticals, Inc. Inhibition or reversal of skin aging by actin-sequestering peptides
US20070015698A1 (en) * 1998-07-30 2007-01-18 United States Of America As Represented By The Secretary Of Health Treatment of skin, and wound repair, with thymosin beta 4
DE69924615T3 (de) * 1998-07-30 2011-05-05 The Government Of The United States Of America, Represented By The Department Of Health & Human Services, National Institute Of Health, Office Of Technology Transfer Thymosin beta 4 stimuliert wundheilung
US20040170625A1 (en) * 1998-07-30 2004-09-02 Regenerx Biopharmaceuticals, Inc. Methods of treating Epidermolysis Bullosa and associated dermatological indications with thymosin beta 4, analogues, isoforms and other derivatives
US6992170B2 (en) 1999-10-15 2006-01-31 Curagen Corporation Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin
US6855806B1 (en) 1999-10-15 2005-02-15 Curagen Corporation Thymosin beta 10-like proteins and nucleic acids encoding same
DE10030149A1 (de) * 2000-06-20 2002-01-10 Switch Biotech Ag Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankungen oder Wundheilung sowie ihre Verwendung zur Identifizierung von pharmakologisch aktiven Substanzen
EP1176200A3 (de) 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
FR2814076B1 (fr) * 2000-09-21 2002-12-20 Centre Nat Rech Scient Agent angiogenique et ses utilisations
US6855345B2 (en) * 2001-11-02 2005-02-15 Morinda, Inc. Preventative and treatment effects of Morinda citrifolia on diabetes and its related conditions
US20040192761A1 (en) * 2003-03-25 2004-09-30 Palu Afa Kehaati Preventative and treatment effects of morinda citrifolia as an aromatase inhibitor
US7244463B2 (en) * 2005-10-18 2007-07-17 Tahitian Noni International, Inc. Garcinia mangostana L. enhanced animal food product
US20070196527A1 (en) * 2006-02-23 2007-08-23 Jensen Claude J Preventative and treatment effects of Morinda citrifolia on Osteoarthritis and its related conditions
US20110171333A1 (en) * 2000-12-05 2011-07-14 Bryant Wadsworth Morinda Citrifolia Based Antioxidant and Antimicrobial Formulations for Improved Color Stability and Increased Shelf Life of Various Meat Products
US8652546B2 (en) 2007-09-06 2014-02-18 Tahitian Noni International, Inc. Morinda citrifolia based formulations for regulating T cell immunomodulation in neonatal stock animals
US8574642B2 (en) 2000-12-05 2013-11-05 Tahitian Noni International, Inc. Antiviral Morinda citrifolia L. based formulations and methods of administration
US8790727B2 (en) * 2000-12-05 2014-07-29 Tahitian Noni International, Inc. Morinda citrifolia and iridoid based formulations
US20110217394A1 (en) * 2000-12-05 2011-09-08 Brett Justin West Iridoid Based Formulations
CN100360174C (zh) * 2001-03-15 2008-01-09 雷金纳克斯生物制药公司 胸腺素β4(Tβ4)、类似物、异构体及其它衍生物在制备治疗眼睛和周围组织失调的药物中的应用
AU2006233251B2 (en) * 2001-03-15 2008-10-02 Regenerx Biopharmaceuticals, Inc. Methods for Treating Disorders of the Eye and Surrounding Tissue with Thymosin Beta4 (TBeta4), Analogues, Isoforms and Other Derivatives
JP2005511479A (ja) * 2001-04-17 2005-04-28 モリンダ・インコーポレーテッド モリンダシトリフォリア油および果汁の緩和作用
JP2004525988A (ja) * 2001-05-17 2004-08-26 リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド サイモシンβ4を用いる表皮水疱症(EpidermolysisBullosa)の治療
MXPA04001942A (es) 2001-08-29 2004-07-23 Regenerx Biopharmaceuticals Composiciones farmaceuticas a base de timosina ??4(t??4), analogos, isorformas y otros derivados para curar o prevenir la inflamacion, el dano y otros cambios que ocurren antes, despues de, durante o inmediatamente despues de un evento micardico.
US7070813B2 (en) * 2001-11-02 2006-07-04 Morinda, Inc. Preventative and treatment effects of morinda citrifolia as a colon cancer cell growth inhibitor
US20110160057A1 (en) * 2001-11-14 2011-06-30 Bryant Wadsworth Morinda Citrifolia Based Antimicrobial Formulations
US7442395B2 (en) * 2002-11-14 2008-10-28 Tahitian Noni International, Inc. Formulation for treating candidiasis using Morinda citrifolia
GB0130608D0 (en) 2001-12-21 2002-02-06 Psimedica Ltd Medical fibres and fabrics
TWI353849B (en) * 2002-01-25 2011-12-11 Us Gov Health & Human Serv Methods and compositions for the promotion of hair
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
WO2004035008A2 (en) * 2002-02-06 2004-04-29 Regenerx Biopharmaceuticals, Inc. Treatment of infections and other disorders
AU2008201749B2 (en) * 2002-02-06 2010-05-13 Regenerx Biopharmaceuticals, Inc. Treatment of Infections and Other Disorders
AU2003223601A1 (en) * 2002-04-12 2003-10-27 King's College London ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN Beta 4
US6821524B2 (en) * 2002-06-03 2004-11-23 Jan Marini Skin Research, Inc. Cosmetic skin care compositions
WO2004091550A2 (en) * 2003-03-31 2004-10-28 Regenerx Biopharmaceuticals, Inc. Compositions and methods for delivering thymosin beta 4, analogues, isoforms and other derivatives
US20060269630A1 (en) * 2003-04-16 2006-11-30 Palu Afa K Morinda citrifolia as a 5-Lipoxygenase inhibitor
JP4073826B2 (ja) * 2003-06-04 2008-04-09 タヒチアン ノニ インターナショナル インコーポレーテッド ヤエヤマアオキの抽出物を含む農業用活力剤
CN1822850A (zh) * 2003-07-18 2006-08-23 雷根内克斯生物制药有限公司 由放射线照射引起的损伤的治疗或预防
US20070259060A1 (en) * 2003-08-12 2007-11-08 Mian-Ying Wang Formulations and Methods for Treating Breast Cancer with Morinda Citrifolia and Methylsulfonymethane
US20090053194A1 (en) * 2003-12-22 2009-02-26 Regenerx Biopharmaceuticals, Inc. Method of treating or preventing biological or immunological responses to a reactive chemical or biological or toxic agent
KR20070001995A (ko) * 2004-03-05 2007-01-04 리지너크스 바이오 파마소티컬스, 인코포레이티드 세포외 매트릭스 축적의 치료 또는 예방법
US20090214507A1 (en) * 2004-08-20 2009-08-27 Regenerx Biopharmaceuticals, Inc. Method of treating preventing, inhibiting or reducing damage to cardiac tissue
WO2006023879A1 (en) 2004-08-20 2006-03-02 Board Of Regents, The University Of Texas System Screening of agents for activity against ischemic myocardial insults
MX2007008464A (es) * 2005-01-13 2007-09-14 Regenerx Biopharmaceuticals Metodo de tratamiento o prevencion del deterioro, lesion o dano de tejido debido a enfermedad neuro-degenerativa, musculo-degenerativa o neuro-musculo-degenerativa, o para restablecer tejido afectado adversamente por dicha enfermedad.
US20060204601A1 (en) * 2005-03-09 2006-09-14 Palu Afa K Formulations and methods for preventing and treating substance abuse and addiction
US20060280818A1 (en) * 2005-05-26 2006-12-14 Palu Afa K Nicotinic acetylcholine receptor antagonist
US20070122507A1 (en) * 2005-05-26 2007-05-31 Palu Afa K Histone deacetylase and tumor necrosis factor converting enzyme inhibition
KR20080021782A (ko) 2005-06-17 2008-03-07 리지너크스 바이오 파마소티컬스, 인코포레이티드 엘케이케이티이티 및/또는 엘케이케이티엔티 펩티드조성물들 및 그 방법
JP5180074B2 (ja) * 2005-07-15 2013-04-10 ベイジン・ノースランド・バイオテック・カンパニー・リミテッド サイモシンβ4誘導体及びその使用方法
AU2006272612B2 (en) * 2005-07-26 2011-10-06 Regenerx Biopharmaceuticals, Inc. Method of treating or preventing tissue deterioration, injury or damage due to congestive heart failure
US20070166417A1 (en) * 2005-11-29 2007-07-19 Palu Afa K Formulation and Methods for Use of Morinda Citrifolia Seed Oil
US20070154579A1 (en) * 2005-11-29 2007-07-05 Palu Afa K Morinda Citrifolia Based Formulation And Methods For Weight Management
US20070184137A1 (en) * 2005-11-29 2007-08-09 Palu Afa K Morinda Citrifolia L. Based Formulations for Inhibiting Matrix Metalloproteinase Enzymes
ATE534415T1 (de) 2005-12-13 2011-12-15 Harvard College Gerüste zur zelltransplantation
EP1984017B1 (en) * 2006-01-17 2016-07-27 RegeneRx Biopharmaceuticals, Inc. Methods of treating or preventing tissue damage caused by increased blood flow
US20070281903A1 (en) * 2006-05-04 2007-12-06 Palu Afa K Morinda Citrifolia-Based Formulation 5-LOX And 15-LOX
US8025910B2 (en) 2006-05-12 2011-09-27 Tahitian Noni International, Inc. Method and composition for administering bioactive compounds derived from Morinda citrifolia
US8535741B2 (en) 2006-05-12 2013-09-17 Morinda, Inc. Method and composition for administering bioactive compounds derived from Morinda citrifolia
KR20090049605A (ko) * 2006-08-18 2009-05-18 리지너크스 바이오 파마소티컬스, 인코포레이티드 이식용 장기 또는 조직을 보존 및/또는 준비하기 위한 방법과 조성물
EP2076277A4 (en) * 2006-10-06 2011-06-01 Regenerx Biopharmaceuticals A METHOD FOR TREATING OR PREVENTING DETERIORATION, DAMAGE OR TISSUE DAMAGE DUE TO ORAL MUCOSAL DISEASE OR DISORDER AND / OR REGULATING NF-KAPPAB FALL OR REMOVING NF-KAPPAB ASSISTED ACTIONS
KR20100027091A (ko) 2006-11-15 2010-03-10 코다 테라퓨틱스, 인크. 상처 치유를 위한 개선 방법 및 조성물
CA2621452A1 (en) * 2007-02-21 2008-08-21 Innovational Holdings, Llc Stent and method for reducing tissue damage after ischemic injury with thymosin b4
WO2009002401A2 (en) 2007-06-21 2008-12-31 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US20080317890A1 (en) * 2007-06-21 2008-12-25 Claude Jarakae Jensen Method for treating visual impairment through the prophylactic administration of a morinda citrifolia-based naturaceutical
KR20100056524A (ko) * 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 치료제로서의 펩티드 배합물 티모신 베타 4 및 델타 수면 유도 펩티드의 용도
EP2205265A1 (en) * 2007-09-11 2010-07-14 Mondobiotech Laboratories AG Use of the peptide thymosin beta 4 alone or in combination with cecropin a as a therapeutic agent
WO2009033816A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of the combination of thymosin beta 10 and thymosin alpha 1 peptides as a therapeutic agent
CA2710386A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Improved medical devices
US20090196944A1 (en) * 2008-02-01 2009-08-06 Brad Rawson Methods of Manufacture of Morinda Citrifolia Based Compositions for Treatment of Anti-Inflammatory Diseases through Inhibition of Cox-1, Cox-2, Interleukin -1beta, Interleukin-6, TNF-alpha, HLE, and iNOS
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
JP5690143B2 (ja) 2008-02-13 2015-03-25 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 持続的細胞プログラミング装置
US9012399B2 (en) * 2008-05-30 2015-04-21 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
CN101297965B (zh) * 2008-06-16 2011-01-05 浙江省中医药研究院 胸腺肽β4在制备防治支气管哮喘药物中的应用
DK3006459T3 (da) 2008-08-26 2021-12-06 Hope City Fremgangsmåde og sammensætninger til forbedring af t-cellers antitumoreffektorfunktion
US9149509B2 (en) 2009-03-26 2015-10-06 Henry Ford Health System Methods for improving neurological outcome after neural injury and neurodegenerative disease
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
US8230654B2 (en) 2009-06-10 2012-07-31 Comc, Llc Medallion insert for modular flooring assemblies
US8782989B2 (en) 2009-06-11 2014-07-22 Comc, Llc Narrow lined modular flooring assemblies
EP2461828B1 (en) 2009-07-31 2017-06-21 President and Fellows of Harvard College Programming of cells for tolerogenic therapies
GB2476789A (en) * 2009-11-10 2011-07-13 Gl Holdings Inc Bv Use of thymosin for treatment of type 2 diabetes
US20110206786A1 (en) * 2010-02-23 2011-08-25 Brett Justin West Acai and Iridoid Based Formulations
US9610328B2 (en) 2010-03-05 2017-04-04 President And Fellows Of Harvard College Enhancement of skeletal muscle stem cell engraftment by dual delivery of VEGF and IGF-1
KR101297037B1 (ko) * 2010-03-26 2013-08-14 숙명여자대학교산학협력단 혈관신생촉진용 펩타이드 및 이의 용도
EP2585053A4 (en) 2010-06-25 2014-02-26 Harvard College COMMON RELEASE OF STIMULATING AND HEMMING FACTORS FOR THE PRODUCTION OF TEMPORARY STABILIZED AND SPATULARLY LIMITED ZONES
WO2012044783A2 (en) * 2010-09-30 2012-04-05 Regenerx Biopharmaceuticals, Inc. Method of achieving a thymosin beta 4 concentration in a human patient
KR102155383B1 (ko) 2010-10-06 2020-09-11 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 재료에 기초한 세포 치료를 위한 주사 가능한 기공 형성 하이드로겔
US9603894B2 (en) 2010-11-08 2017-03-28 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
WO2012126047A1 (en) * 2011-03-18 2012-09-27 Adistem Ltd Agent and method for treating pain and reducing inflammation
US10647959B2 (en) 2011-04-27 2020-05-12 President And Fellows Of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
ES2685327T3 (es) 2011-04-28 2018-10-08 President And Fellows Of Harvard College Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva
US9486512B2 (en) 2011-06-03 2016-11-08 President And Fellows Of Harvard College In situ antigen-generating cancer vaccine
US20130022687A1 (en) * 2011-07-19 2013-01-24 Fitzgerald Jr John James Topical transdermal method for delivering nutrients through the skin for expedited wound healing
US8632827B2 (en) * 2011-12-13 2014-01-21 Avon Products, Inc Modulation of thymosin beta-4 in skin
AU2012358361B2 (en) 2011-12-23 2017-09-28 Henry Ford Health System Methods, systems, and compositions for promoting recovery of peripheral neuropathy
US9937249B2 (en) 2012-04-16 2018-04-10 President And Fellows Of Harvard College Mesoporous silica compositions for modulating immune responses
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US9808654B2 (en) 2013-02-11 2017-11-07 Jan Marini Skin Research Post procedure skin care gel and methods of use thereof
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
DE102013017203A1 (de) * 2013-10-16 2015-04-16 Isa Atay Thymustherapie
CN107073090A (zh) 2014-04-30 2017-08-18 哈佛学院董事会 结合的疫苗装置和杀死癌细胞的方法
EA201790434A1 (ru) 2014-08-22 2017-07-31 Окленд Юнисервисиз Лимитед Модуляторы каналов
KR101530278B1 (ko) * 2014-09-04 2015-06-24 부산대학교 산학협력단 심근전환유전자 및 심혈관재생유전자를 포함하는 아데노부속바이러스를 유효성분으로 포함하는, 허혈성 심장질환 예방 또는 치료용 조성물
BR112017005631A2 (pt) 2014-09-19 2018-06-26 City Of Hope células t com receptor de antígeno coestimulador quimérico direcionadas à il13ra2
EP3210614A4 (en) * 2014-10-22 2018-06-13 G-Treebnt Co., Ltd. Composition containing thymosin beta 4, and pharmaceutical formulation comprising same
EP3242677A4 (en) * 2015-01-06 2018-09-26 CardioVascular BioTherapeutics, Inc. Therapeutic angiogenesis for wound healing
AU2016205336A1 (en) 2015-01-06 2017-08-03 Venturis Therapeutics, Inc. Angiogenic treatment of ischemic heart disease
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
EP3259012A4 (en) 2015-02-16 2018-09-19 CardioVascular BioTherapeutics, Inc. Therapeutic angiogenesis for treating erectile conditions
US11150242B2 (en) 2015-04-10 2021-10-19 President And Fellows Of Harvard College Immune cell trapping devices and methods for making and using the same
US10781595B2 (en) 2015-09-10 2020-09-22 Comc, Llc Modular flooring assemblies
JP6996713B2 (ja) 2015-10-06 2022-02-04 エイチエルビー・セラピューティクス・カンパニー・リミテッド チモシンベータ4を含む眼科用製剤の製造方法
CN115531609A (zh) 2016-02-06 2022-12-30 哈佛学院校长同事会 重塑造血巢以重建免疫
MX2018013546A (es) * 2016-05-06 2019-04-22 Phasebio Pharmaceuticals Inc Proteinas de fusion de elp para liberacion controlada y sostenida.
MA45738A (fr) 2016-07-13 2019-05-22 Harvard College Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser
KR102340750B1 (ko) 2017-03-03 2021-12-21 에이치엘비테라퓨틱스 주식회사 티모신 베타 4를 유효성분으로 포함하는 안정화된 외용 제제
CN110585055B (zh) * 2019-08-26 2023-06-13 武汉贝缇安卡医疗健康投资有限公司 AcSDKP在增加成纤维细胞分泌Ⅲ型胶原蛋白含量的应用
CN111249534B (zh) * 2020-01-16 2021-06-15 中国人民解放军总医院 可用于促进创面组织同步修复再生的生物活性支架及其制备方法
AU2021251785A1 (en) * 2020-04-07 2022-11-03 Combangio, Inc. Lyophilized mesenchymal stem cell derived secretome and uses thereof
CN111888462B (zh) * 2020-08-10 2022-08-26 中国人民解放军军事科学院军事医学研究院 胸腺素β4在制备微生态平衡调节剂中的应用

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261982A (en) * 1977-11-09 1981-04-14 The Procter & Gamble Company Therapeutic composition
US4297276A (en) * 1979-03-23 1981-10-27 Hoffman-La Roche Inc. Thymosin beta 3 and beta 4
US4444757A (en) 1981-11-16 1984-04-24 Research Corporation Use of thymosin as an anti-diabetes and anti-hypertensive disease agent
US4389343A (en) * 1981-12-24 1983-06-21 Hoffmann-La Roche Inc. Immunopotentiating peptides from thymus
US4388234A (en) * 1981-12-28 1983-06-14 Hoffmann-La Roche Inc. Peptide isolation
FR2530466A1 (fr) 1982-07-21 1984-01-27 Hecmati Michel Gel anti-ride, produit et procede
JPS61500431A (ja) 1982-12-09 1986-03-13 ビルトン,ジエラルド エル. 傷治癒に有用な活性化され、安定化された酵素
WO1984003437A1 (en) 1983-03-01 1984-09-13 Rudolf Trensch Method and product for the treatment or hair
US4543340A (en) * 1983-04-07 1985-09-24 George Washington University Radioimmunoassay of thymosin β4
GB8330969D0 (en) * 1983-11-21 1983-12-29 Wellcome Found Promoting healing
JPS60142908A (ja) 1983-12-29 1985-07-29 Kanebo Ltd 養毛化粧料
GB8517402D0 (en) * 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
US4713394A (en) 1986-01-17 1987-12-15 Thornfeldt Carl R Treatment of nonacne inflammatory and infectious dermatoses and hair loss
JPS62252711A (ja) 1986-04-24 1987-11-04 Hideharu Tamaki 養毛剤
US4983581A (en) * 1988-05-20 1991-01-08 Institute Of Molecular Biology, Inc. Wound healing composition of IGF-I and TGF-β
US5055447A (en) * 1988-07-28 1991-10-08 Genentech, Inc. Method and compositions for the treatment and prevention of septic shock
JPH02101019A (ja) * 1988-10-05 1990-04-12 Genichiro Soma 抗エイズ剤
JPH02142717A (ja) 1988-11-22 1990-05-31 Kanebo Ltd 養毛化粧料
US5654267A (en) * 1988-12-20 1997-08-05 La Jolla Cancer Research Center Cooperative combinations of ligands contained within a matrix
EP0410348A1 (en) 1989-07-26 1991-01-30 G.D. Searle & Co. Topical spironolactone composition
US5068315A (en) 1990-04-12 1991-11-26 University Of Dundee Composition for the regulation of hair growth
GB9014221D0 (en) 1990-06-26 1990-08-15 Janssen Pharmaceutica Nv Method of treating alopecia
JPH04234325A (ja) * 1990-12-27 1992-08-24 Hoechst Japan Ltd 脳および神経障害治療予防剤
CN1701814A (zh) * 1992-11-13 2005-11-30 马克斯普朗克科学促进协会 作为血管内皮生长因子受体的f1k-1
US6124259A (en) 1993-01-28 2000-09-26 Celtrix Pharmaceuticals, Inc. Method for treating ophthalmic disorders with IGFBP
WO1994018988A2 (en) * 1993-02-22 1994-09-01 Von Arnim Ulrich Christoph Use of heparins for the treatment of inflammatory or immunological diseases
AU6771594A (en) * 1993-04-22 1994-11-08 George Washington University, The Method of decreasing the toxicity of therapeutic compositions using thymosin beta 4
US5358703A (en) * 1993-09-27 1994-10-25 Mcw Research Foundation, Inc. Method for the detection of nitric oxide
US5578570A (en) * 1993-10-07 1996-11-26 The George Washington University Medical Center Method of treating septic shock using thymosin β4
AU7879294A (en) * 1993-10-07 1995-05-01 George Washington University Medical Center, The Method of treating septic shock using thymosin beta 4
US5593964A (en) * 1993-10-07 1997-01-14 The George Washington University Medical Center Method of treating septic shock by preventing actin polymerization
FR2711060B1 (fr) 1993-10-13 1995-11-17 Oreal Procédé pour modifier la pousse des poils et/ou des cheveux et compositions utilisables à cet effet.
US5591716A (en) * 1993-11-19 1997-01-07 New York University Beneficial wound healing applications of calreticulin and other hyaluronan-associated proteins
CA2139385C (en) * 1994-02-04 2001-12-25 Gottfried Alber Products containing g-csf and tnf binding protein
US5652209A (en) 1994-04-29 1997-07-29 University Of Miami Use of secretory products of human lacrimal gland acinar epithelia for tear replacement therapy
FR2719481B1 (fr) * 1994-05-05 1996-05-31 Oreal Composition à base de composés antifongiques et de composés antibactériens halogènes pour diminuer la chute des cheveux.
JPH07316022A (ja) 1994-05-24 1995-12-05 Kyowa Hakko Kogyo Co Ltd 育毛剤
JP3202135B2 (ja) 1994-08-10 2001-08-27 カネボウ株式会社 頭髪化粧料
DE19509354A1 (de) * 1994-12-08 1996-06-13 Klett Loch Lore M Kombinationspräparat zur Förderung des Haarwachstums und ggf. des Haut- und Nagelwachstums sowie zur Verhinderung bzw. zur Beseitigung von Haarausfall
FR2741076B1 (fr) * 1995-11-15 1998-01-30 Rech De Pathologie Appliquee S Conjugues peptidiques derives des hormones thymiques, leur utilisation a titre de medicament et compositions les contenant
DE19622422A1 (de) * 1996-06-04 1997-12-11 Sanorell Pharma Gmbh & Co Lagerungsstabile pharmazeutische Zusammensetzung mit immun - modulierenden und antiinflammatorischen Eigenschaften sowie ein Verfahren zu dessen Herstellung
US5663071A (en) * 1996-06-17 1997-09-02 Children's Medical Center Corporation Human thymosin β 15 gene, protein and uses thereof
JP3128203B2 (ja) 1997-02-10 2001-01-29 一男 坪田 分泌腺細胞とリンパ球との接着阻害剤
DE19711939A1 (de) * 1997-03-21 1998-09-24 Bosch Gmbh Robert Vorrichtung zur Erfassung des Drucks und der Temperatur im Saugrohr einer Brennkraftmaschine
DE19731420A1 (de) * 1997-07-22 1999-01-28 Bosch Gmbh Robert Vorrichtung zur Erfassung des Drucks und der Temperatur im Saugrohr einer Brennkraftmaschine und Verfahren zu ihrer Herstellung
US6030948A (en) 1997-12-19 2000-02-29 Mann; Morris A. Hair regeneration compositions for treatment of alopecia and methods of application related thereto
GB9806632D0 (en) 1998-03-28 1998-05-27 Stevenson Robert Peptide factor
US20040067227A1 (en) * 2001-11-02 2004-04-08 Goldstein Allan L. Inhibition or reversal of skin aging by actin-sequestering peptides
DE69924615T3 (de) * 1998-07-30 2011-05-05 The Government Of The United States Of America, Represented By The Department Of Health & Human Services, National Institute Of Health, Office Of Technology Transfer Thymosin beta 4 stimuliert wundheilung
WO2002036143A1 (en) 2000-11-02 2002-05-10 Regenerx Biopharmaceuticals, Inc. Inhibition or reversal of skin aging by actin-sequestering peptides
US6586403B1 (en) * 2000-07-20 2003-07-01 Salpep Biotechnology, Inc. Treating allergic reactions and inflammatory responses with tri-and dipeptides
US7560280B2 (en) * 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
US6821524B2 (en) * 2002-06-03 2004-11-23 Jan Marini Skin Research, Inc. Cosmetic skin care compositions
JP3870918B2 (ja) * 2002-10-23 2007-01-24 株式会社デンソー 温度センサ一体型圧力センサ装置
RU2295963C1 (ru) 2005-10-18 2007-03-27 Закрытое акционерное общество Научно-производственное предприятие "Тринита" Способ получения иммуностимулятора

Also Published As

Publication number Publication date
HK1038307A1 (en) 2002-03-15
AU766826B2 (en) 2003-10-23
DE69924615T3 (de) 2011-05-05
EP2311485A1 (en) 2011-04-20
MXPA01001041A (es) 2002-06-04
DK1100529T4 (da) 2010-12-20
US20110124550A1 (en) 2011-05-26
US20090023663A1 (en) 2009-01-22
PT1100529E (pt) 2005-10-31
AU5244399A (en) 2000-02-21
EP1100529A1 (en) 2001-05-23
DE69924615T2 (de) 2006-02-02
EP1100529B2 (en) 2010-08-25
DE69924615D1 (de) 2005-05-12
ATE292473T1 (de) 2005-04-15
US8143218B2 (en) 2012-03-27
EP1591128A1 (en) 2005-11-02
US7268118B2 (en) 2007-09-11
ES2239846T5 (es) 2011-03-04
US20070111931A9 (en) 2007-05-17
US20040220111A1 (en) 2004-11-04
EP1100529B1 (en) 2005-04-06
US20030060405A1 (en) 2003-03-27
ES2239846T3 (es) 2005-10-01
WO2000006190A1 (en) 2000-02-10
CA2338928A1 (en) 2000-02-10
US20170326207A1 (en) 2017-11-16
US20070009469A1 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
DK1100529T4 (da) Thymosin beta 4 fremmer sårheling
ATE395928T1 (de) Expressionsvektoren und zellinien zur expression von vaskulärem wachstumsfaktor d, sowie verfahren zur behandlung von melanomen
DE69827001D1 (de) Gewebedezellularization
DE69829858D1 (de) System zum verankern von gewebe an knochen
NO963742L (no) Fremgangsmåte til å stimulere hematopoese med hemaglobin
ATE84420T1 (de) Verfahren zur stimulierung von melanozyten durch lokales anbringen von alpha-msh-analogen, sowie zusammensetzungen.
ATE96033T1 (de) Mittel zur behandlung von arthrosen.
DE69728057D1 (de) Iontophoretische auslösbare lieferungsvorrichtung zur verminderung von elektrischen empfindungen
ATE252639T1 (de) Modifizierter, das dorsalgewebe beeinflussender faktor
DE3781263D1 (de) Peptid-derivate und deren verwendung in der therapie.
DE69837114D1 (de) Oestronsulfamat-Inhibitoren von Oestronsulfatase, pharmazeutischen Zusammensetzungen und Methoden zu ihrer Verwendung
EE9700225A (et) Meetod diabetes mellituse raviks, kasutades KKF
DE3578611D1 (de) Instrumente zur behandlung von verformten naegeln bei menschlichen patienten.
DE69534180D1 (de) Promotor der tie rezeptor protein kinase
DK0572688T3 (da) Peptider, med organ-beskyttende aktivitet, fremgangsmåde til deres fremstilling og deres anvendelse ved terapi
ATE374618T1 (de) Verwendung von rekombinanten menschlichen uteroglobin zur behandlung von fibrotischen krankheitszuständen
DK403384D0 (da) Enteralt effektivt, biologisk aktivt peptid- eller proteinmiddel ogfremgangsmaader til fremstilling deraf
DE69732789D1 (de) Von humanem lipase-ähnlichem gen kodierte polypeptide, sowie zusammensetzungen und methoden
ATE221123T1 (de) Glykoprotein-hormonrezeptor-moleküle
NO985573L (no) Veksthormonkomponent og ben-antiresorpsjonsmiddel ved syklisk (koherens-) behandling av osteoporose
DE69734349D1 (de) Behandlung von knochenleiden mit adrenomedullin
DE69825307D1 (de) Verwendung von protein h als zytostattischer wirkstoff
DK467286D0 (da) Protese til implantation i knoglevaev
IT1286183B1 (it) Uso della relaxina come agente farmacologico per la produzione di farmaci per la cura delle gestosi gravidiche
IT1286182B1 (it) Impiego della relaxina o relassina, come nuovo agente farmacologico antistaminico per bloccare il rilascio di istamina nei tessuti in