DK1087973T3 - Imidazotriazolopyrimidines as a drug with adenosine antagonist effect - Google Patents

Imidazotriazolopyrimidines as a drug with adenosine antagonist effect

Info

Publication number
DK1087973T3
DK1087973T3 DK99927950T DK99927950T DK1087973T3 DK 1087973 T3 DK1087973 T3 DK 1087973T3 DK 99927950 T DK99927950 T DK 99927950T DK 99927950 T DK99927950 T DK 99927950T DK 1087973 T3 DK1087973 T3 DK 1087973T3
Authority
DK
Denmark
Prior art keywords
drug
imidazotriazolopyrimidines
antagonist effect
adenosine antagonist
radicals
Prior art date
Application number
DK99927950T
Other languages
Danish (da)
Inventor
Stefan Blech
Adrian Carter
Wolfram Gaida
Matthias Hoffmann
Christopher John Montagu Meade
Gerald Pohl
Ulrike Kuefner-Muehl
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1087973T3 publication Critical patent/DK1087973T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to new imidazotriazolopyrimidine derivatives of general formula (I), to methods for preparing the same and to their use as a drug. In this formula, the interrupted lines between nitrogen atoms represent a double link in one of two possible positions so that the radicals R<4> and R<6> or R<3> and R<2> cannot be present simultaneously, wherein the radicals R<1> to R<6> are such as described in the description and the claims.
DK99927950T 1998-06-16 1999-06-11 Imidazotriazolopyrimidines as a drug with adenosine antagonist effect DK1087973T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19826843A DE19826843A1 (en) 1998-06-16 1998-06-16 Novel imidazotriazolopyrimidines, process for their preparation and their use as medicaments
PCT/EP1999/004017 WO1999065912A1 (en) 1998-06-16 1999-06-11 Imidazotriazolopyrimidines used as a drug having an adenosine antagonist activity

Publications (1)

Publication Number Publication Date
DK1087973T3 true DK1087973T3 (en) 2003-02-24

Family

ID=7871072

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99927950T DK1087973T3 (en) 1998-06-16 1999-06-11 Imidazotriazolopyrimidines as a drug with adenosine antagonist effect

Country Status (9)

Country Link
EP (1) EP1087973B1 (en)
JP (1) JP4567883B2 (en)
AT (1) ATE230748T1 (en)
AU (1) AU4511299A (en)
CA (1) CA2327395C (en)
DE (2) DE19826843A1 (en)
DK (1) DK1087973T3 (en)
ES (1) ES2186369T3 (en)
WO (1) WO1999065912A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858331A1 (en) * 1998-12-17 2000-06-21 Boehringer Ingelheim Pharma Tricyclic nitrogen heterocycles as PDE IV inhibitors
US6417190B1 (en) 1998-12-17 2002-07-09 Boehringer Ingelheim Pharma Kg Tricyclic nitrogen heterocycles as PDE IV inhibitors
AR044041A1 (en) * 2003-04-23 2005-08-24 Schering Corp ANTAGONISTS OF THE A2A RECEIVER OF 2-ALQUINIL- AND 2-ALQUENIL-PIRAZOLO- [4,3-E] -1,2,4-TRIAZOLO- [1,5-C] -PIRIMIDINA ADENOSINA
US7071333B2 (en) 2003-07-30 2006-07-04 Bristol-Myers Squibb Company Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
AU2019205661B2 (en) * 2018-01-04 2022-06-30 Impetis Biosciences Ltd. Tricyclic compounds, compositions and medicinal applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06104666B2 (en) * 1986-09-30 1994-12-21 チバ―ガイギー アクチェンゲゼルシャフト 2-Substituted-e-fused- [1,2,4] triazolo [1,5-c] pyrimidines and pharmaceutical compositions containing the same
DE19629378A1 (en) * 1996-07-20 1998-01-29 Boehringer Ingelheim Kg New triazolopurines, process for their preparation and their use as medicaments

Also Published As

Publication number Publication date
ES2186369T3 (en) 2003-05-01
JP4567883B2 (en) 2010-10-20
AU4511299A (en) 2000-01-05
ATE230748T1 (en) 2003-01-15
JP2002518396A (en) 2002-06-25
WO1999065912A1 (en) 1999-12-23
EP1087973A1 (en) 2001-04-04
CA2327395A1 (en) 1999-12-23
DE19826843A1 (en) 1999-12-23
DE59903977D1 (en) 2003-02-13
EP1087973B1 (en) 2003-01-08
CA2327395C (en) 2008-05-13

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