DK1077072T3 - In vitro method of producing a homologous cardiac or vascular prosthesis - Google Patents

In vitro method of producing a homologous cardiac or vascular prosthesis

Info

Publication number
DK1077072T3
DK1077072T3 DK00108986T DK00108986T DK1077072T3 DK 1077072 T3 DK1077072 T3 DK 1077072T3 DK 00108986 T DK00108986 T DK 00108986T DK 00108986 T DK00108986 T DK 00108986T DK 1077072 T3 DK1077072 T3 DK 1077072T3
Authority
DK
Denmark
Prior art keywords
homologous
matrix
cardiac
producing
vitro method
Prior art date
Application number
DK00108986T
Other languages
Danish (da)
Inventor
Simon Philipp Hoerstrup
Gregor Zuend
Original Assignee
Symetis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symetis Ag filed Critical Symetis Ag
Application granted granted Critical
Publication of DK1077072T3 publication Critical patent/DK1077072T3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/12—Pulsatile flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Prostheses (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Surgical Instruments (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

In vitro production of a homologous heart valve involves: (i) colonizing a biodegradable carrier with homologous fibroblasts and/or myofibroblasts so as to give a connective tissue matrix; (ii) colonizing the matrix with endothelial cells; (iii) introducing the matrix into a pulsating flow chamber (e.g. in a bioreactor) where it is subjected to a (dis)continuous flow rate. An Independent claim is also included for a homologous heart valve with a connective tissue inner core covered with a layer of endothelial cells, the core having a collagen density of 43-55%, based on the matrix.
DK00108986T 1999-04-29 2000-04-27 In vitro method of producing a homologous cardiac or vascular prosthesis DK1077072T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19919625A DE19919625C2 (en) 1999-04-29 1999-04-29 In vitro method for producing a homologous heart valve and valve that can be produced by this method

Publications (1)

Publication Number Publication Date
DK1077072T3 true DK1077072T3 (en) 2004-03-22

Family

ID=7906358

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00108986T DK1077072T3 (en) 1999-04-29 2000-04-27 In vitro method of producing a homologous cardiac or vascular prosthesis

Country Status (6)

Country Link
EP (1) EP1077072B8 (en)
AT (1) ATE253948T1 (en)
DE (2) DE19919625C2 (en)
DK (1) DK1077072T3 (en)
ES (1) ES2209715T3 (en)
PT (1) PT1077072E (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4057781B2 (en) 1997-10-31 2008-03-05 チルドレンズ メディカル センター コーポレーション Bladder reconstruction
DE10058240A1 (en) * 2000-11-17 2002-05-29 Auto Tissue Gmbh Method and device for the production of biological prostheses
DE10164898B4 (en) * 2001-04-30 2010-09-23 Berlin Heart Gmbh Method for controlling a support pump for pulsatile pressure fluid delivery systems
AU2002340463A1 (en) * 2001-11-16 2003-06-10 Children's Medical Center Corporation Augmentation of organ function
DE10235237A1 (en) * 2002-08-01 2004-02-12 Symetis Ag In vitro preparation of homologous heart valves, useful for replacement of diseased valves, by inoculating biodegradable carrier with fibroblasts and attachment to a non-degradable stent
EP1452189A1 (en) * 2003-02-28 2004-09-01 Eidgenössische Technische Hochschule (ETH) Implant body having a multiblock copolymer coating
EP1452190A1 (en) * 2003-02-28 2004-09-01 Eidgenössische Technische Hochschule (ETH) Implant body having a coating of multi block copolymer and polylysine
DE10322024A1 (en) 2003-05-16 2004-12-02 Symetis Ag Bioreactor for manufacturing a tissue prosthesis, in particular a heart valve
DE10327904B3 (en) * 2003-06-20 2004-07-29 Universitätsklinikum Schleswig-Holstein Production of a heart valve prosthesis comprises pulsing a nutrient solution through a section of vein containing a valve in a bioreactor
DE10350287A1 (en) * 2003-10-24 2005-05-25 Deutsche Institute für Textil- und Faserforschung Stuttgart - Stiftung des öffentlichen Rechts Cardiovascular implant, for use as a vascular or heart valve replacement, comprises a non-resorbable polymer formed as a microfiber fleece that allows colonization by a cells
GB0410177D0 (en) * 2004-05-07 2004-06-09 Univ Wales Medicine Engineered tubular tissue structures
EP1693025A1 (en) 2005-02-17 2006-08-23 Universität Zürich Method of manufacturing a tissue-engineered prosthesis
WO2006099332A2 (en) 2005-03-11 2006-09-21 Wake Forest University Health Sciences Production of tissue engineered digits and limbs
US20060204539A1 (en) 2005-03-11 2006-09-14 Anthony Atala Electrospun cell matrices
CA2602050C (en) 2005-03-11 2013-12-03 Wake Forest University Health Sciences Production of tissue engineered heart valves
EP1863547B1 (en) 2005-03-11 2016-05-11 Wake Forest University Health Sciences Tissue engineered blood vessels
US7531503B2 (en) 2005-03-11 2009-05-12 Wake Forest University Health Sciences Cell scaffold matrices with incorporated therapeutic agents
DE102005049905A1 (en) * 2005-10-17 2007-04-19 Medizinische Hochschule Hannover Method and device for producing a joint replacement
EP2267114B1 (en) 2005-10-28 2014-03-12 Universität Zürich Tissue engineering using pure populations of isolated non-embryoblastic fetal cells
CA2688265C (en) 2007-06-08 2021-02-16 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
EP2130905A1 (en) 2008-06-04 2009-12-09 Pharmacell B.V. Method for culturing eukaryotic cells
WO2010057015A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Kidney structures and methods of forming the same
WO2011098367A2 (en) 2010-02-12 2011-08-18 Universität Zürich Method for in-vitro production of tissue engineered auto- and allografts suitable for guarded cryopreservation
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
EP2399986A1 (en) 2010-06-22 2011-12-28 Ludwig-Maximilians-Universität München Bioreactor and method for creating and/or conditioning biological tissues
DE102010026369B4 (en) 2010-07-07 2015-07-30 Zellwerk Gmbh Process and pressurized rotary bed bioreactor for the dynamic expansion and / or differentiation of stem cells or primary cells of human and animal origin
EP2468846A1 (en) 2010-12-22 2012-06-27 Ludwig-Maximilians-Universität München A method of examining tissue growth and conditioning of cells on a scaffold and a perfusion bioreactor
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
CZ2012376A3 (en) * 2012-06-05 2013-12-18 Institut Klinické A Experimentální Medicíny Process for preparing pericardial prosthesis of cardiac valve, cardiac valve pericardial prosthesis produced in such a manner, device for conditioning and modification of autologous pericardial tissue for pericardial prosthesis of heart valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10092679B2 (en) 2013-10-18 2018-10-09 Wake Forest University Health Sciences Laminous vascular constructs combining cell sheet engineering and electrospinning technologies
DE102015111126A1 (en) * 2015-07-09 2017-01-12 Medizinische Hochschule Hannover A method for producing a bioartificial, primary acellular fibrin-based construct and this construct itself
EP3407835A4 (en) 2016-01-29 2019-06-26 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US20180140419A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
CN111263622A (en) 2017-08-25 2020-06-09 内奥瓦斯克迪亚拉公司 Sequentially deployed transcatheter mitral valve prosthesis
CN113271890A (en) 2018-11-08 2021-08-17 内奥瓦斯克迪亚拉公司 Ventricular deployment of transcatheter mitral valve prosthesis
US20220235309A1 (en) * 2019-01-16 2022-07-28 University Of Florida Research Foundation, Inc. Bioreactor chamber and systems thereof
CA3127232A1 (en) * 2019-02-04 2020-08-13 Edwards Lifesciences Corporation Reinforced regenerative heart valves
JP7430732B2 (en) 2019-03-08 2024-02-13 ニオバスク ティアラ インコーポレイテッド Retrievable prosthesis delivery system
CN113811265A (en) 2019-04-01 2021-12-17 内奥瓦斯克迪亚拉公司 Prosthetic valve deployable in a controlled manner
EP3952792A4 (en) 2019-04-10 2023-01-04 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
AU2020279750B2 (en) 2019-05-20 2023-07-13 Neovasc Tiara Inc. Introducer with hemostasis mechanism
JP2022537559A (en) 2019-06-20 2022-08-26 ニオバスク ティアラ インコーポレイテッド Thin artificial prosthetic mitral valve

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025584A1 (en) * 1993-04-28 1994-11-10 Johns Hopkins University School Of Medicine Chronic endothelial cell culture under flow
DE69532976T2 (en) * 1994-03-14 2005-05-04 Cryolife, Inc. METHOD OF MANUFACTURING TISSUE FOR IMPLANTATION
US5792603A (en) * 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
AU5990696A (en) * 1995-06-07 1996-12-30 St. Jude Medical Inc. Method for spatially positioning cells within a three-dimens ional matrix
DE59803925D1 (en) * 1997-06-27 2002-05-29 Augustinus Bader BIOARTIFICIAL TRANSPLANT AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
EP1077072A2 (en) 2001-02-21
EP1077072A3 (en) 2001-06-27
DE19919625A1 (en) 2000-11-30
PT1077072E (en) 2004-04-30
ES2209715T3 (en) 2004-07-01
DE50004406D1 (en) 2003-12-18
EP1077072B1 (en) 2003-11-12
EP1077072B8 (en) 2004-04-14
DE19919625C2 (en) 2002-10-31
ATE253948T1 (en) 2003-11-15

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