DK1068192T3 - Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanol - Google Patents
Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanolInfo
- Publication number
- DK1068192T3 DK1068192T3 DK99900383T DK99900383T DK1068192T3 DK 1068192 T3 DK1068192 T3 DK 1068192T3 DK 99900383 T DK99900383 T DK 99900383T DK 99900383 T DK99900383 T DK 99900383T DK 1068192 T3 DK1068192 T3 DK 1068192T3
- Authority
- DK
- Denmark
- Prior art keywords
- methylimidazole
- imidazole
- isopropanol
- baccatin iii
- new crystalline
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title abstract 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title abstract 4
- LXBGSDVWAMZHDD-UHFFFAOYSA-N 2-methyl-1h-imidazole Chemical compound CC1=NC=CN1 LXBGSDVWAMZHDD-UHFFFAOYSA-N 0.000 title abstract 2
- 150000004200 baccatin III derivatives Chemical class 0.000 title 1
- OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 4
- 229930014667 baccatin III Natural products 0.000 abstract 2
- 229930190007 Baccatin Natural products 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 239000000419 plant extract Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7132598P | 1998-01-14 | 1998-01-14 | |
| PCT/US1999/000245 WO1999036413A1 (en) | 1998-01-14 | 1999-01-06 | Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1068192T3 true DK1068192T3 (da) | 2002-10-14 |
Family
ID=22100619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99900383T DK1068192T3 (da) | 1998-01-14 | 1999-01-06 | Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6215000B1 (da) |
| EP (1) | EP1068192B1 (da) |
| JP (1) | JP2002509142A (da) |
| AT (1) | ATE219070T1 (da) |
| AU (1) | AU741143B2 (da) |
| CA (1) | CA2317728A1 (da) |
| DE (1) | DE69901819T2 (da) |
| DK (1) | DK1068192T3 (da) |
| ES (1) | ES2178369T3 (da) |
| PT (1) | PT1068192E (da) |
| WO (1) | WO1999036413A1 (da) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| US5475120A (en) * | 1990-11-02 | 1995-12-12 | University Of Florida | Method for the isolation and purification of taxol and its natural analogues |
| ATE180477T1 (de) * | 1991-04-19 | 1999-06-15 | Univ Mississippi | Verfahren und zubereitungen zur isolierung von taxanen |
| FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
| US5399726A (en) * | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US5274124A (en) | 1991-09-23 | 1993-12-28 | Florida State University | Metal alkoxides |
| US5407816A (en) | 1992-02-20 | 1995-04-18 | Phyton Catalytic, Inc. | Enhanced production of taxol and taxanes by cell cultures of taxus species |
| IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
| US5202448A (en) * | 1992-08-14 | 1993-04-13 | Napro Biotherapeutics, Inc. | Processes of converting taxanes into baccatin III |
| FR2696462B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| WO1994013827A1 (en) * | 1992-12-07 | 1994-06-23 | Michigan State University | PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp |
| FR2698871B1 (fr) * | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5973160A (en) | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| CA2153986C (en) | 1993-11-15 | 2002-12-31 | Yukihito Yukimune | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate |
-
1999
- 1999-01-06 EP EP99900383A patent/EP1068192B1/en not_active Expired - Lifetime
- 1999-01-06 PT PT99900383T patent/PT1068192E/pt unknown
- 1999-01-06 AT AT99900383T patent/ATE219070T1/de not_active IP Right Cessation
- 1999-01-06 WO PCT/US1999/000245 patent/WO1999036413A1/en active IP Right Grant
- 1999-01-06 DK DK99900383T patent/DK1068192T3/da active
- 1999-01-06 CA CA002317728A patent/CA2317728A1/en not_active Abandoned
- 1999-01-06 AU AU19515/99A patent/AU741143B2/en not_active Ceased
- 1999-01-06 JP JP2000540129A patent/JP2002509142A/ja active Pending
- 1999-01-06 ES ES99900383T patent/ES2178369T3/es not_active Expired - Lifetime
- 1999-01-06 DE DE69901819T patent/DE69901819T2/de not_active Expired - Fee Related
-
2000
- 2000-03-28 US US09/537,193 patent/US6215000B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69901819T2 (de) | 2003-01-30 |
| ES2178369T3 (es) | 2002-12-16 |
| EP1068192B1 (en) | 2002-06-12 |
| WO1999036413A1 (en) | 1999-07-22 |
| AU1951599A (en) | 1999-08-02 |
| PT1068192E (pt) | 2002-11-29 |
| EP1068192A4 (en) | 2001-04-11 |
| DE69901819D1 (de) | 2002-07-18 |
| AU741143B2 (en) | 2001-11-22 |
| CA2317728A1 (en) | 1999-07-22 |
| JP2002509142A (ja) | 2002-03-26 |
| US6215000B1 (en) | 2001-04-10 |
| EP1068192A1 (en) | 2001-01-17 |
| ATE219070T1 (de) | 2002-06-15 |
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