DK1011679T3 - Use of 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepines for the preparation of a pharmaceutical composition for the treatment of sleep disorders - Google Patents

Use of 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepines for the preparation of a pharmaceutical composition for the treatment of sleep disorders

Info

Publication number
DK1011679T3
DK1011679T3 DK98907896T DK98907896T DK1011679T3 DK 1011679 T3 DK1011679 T3 DK 1011679T3 DK 98907896 T DK98907896 T DK 98907896T DK 98907896 T DK98907896 T DK 98907896T DK 1011679 T3 DK1011679 T3 DK 1011679T3
Authority
DK
Denmark
Prior art keywords
treatment
pharmaceutical composition
bridge
hydrogen
sleep disorders
Prior art date
Application number
DK98907896T
Other languages
Danish (da)
Inventor
Anders Fink-Jensen
Christian Foged
Original Assignee
Addex Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addex Pharmaceuticals Sa filed Critical Addex Pharmaceuticals Sa
Application granted granted Critical
Publication of DK1011679T3 publication Critical patent/DK1011679T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides novel uses of the compounds of general formula (I) wherein R3 is hydrogen, alkyl or cycloalkyl; R4 is hydrogen or R4 together with R10 represents a bridge; R7 is hydroxy or alkoxy; R10, R11, R12 independently repent hydrogen, trifluoromethyl, halogen or alkyl; or R10 together with R11 represents a bridge, or R11 together with R12 represents a bridge the bridge in both cases being chosen among -O-CH2-CH2-, -O-CH2-CH2-CH2-, -O-CH=CH-, -CH2-CH2-CH2-, -CH2-CH=CH- or -CH2-CH2-CH2-CH2-; R13 is hydrogen, halogen or alkyl; and pharmaceutically acceptable salts thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for treatment of sleep disorders and/or sleep disturbances.
DK98907896T 1997-03-12 1998-03-11 Use of 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepines for the preparation of a pharmaceutical composition for the treatment of sleep disorders DK1011679T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK26597 1997-03-12
US4150997P 1997-03-24 1997-03-24
PCT/DK1998/000088 WO1998040072A1 (en) 1997-03-12 1998-03-11 Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders

Publications (1)

Publication Number Publication Date
DK1011679T3 true DK1011679T3 (en) 2003-11-24

Family

ID=26063641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98907896T DK1011679T3 (en) 1997-03-12 1998-03-11 Use of 8-nitro-2,3,4,5-tetrahydro-1H-3-benzazepines for the preparation of a pharmaceutical composition for the treatment of sleep disorders

Country Status (16)

Country Link
US (1) US6211173B1 (en)
EP (1) EP1011679B1 (en)
JP (1) JP2001515484A (en)
AT (1) ATE245986T1 (en)
AU (1) AU742873B2 (en)
BR (1) BR9808234A (en)
CA (1) CA2283083C (en)
CZ (1) CZ296464B6 (en)
DE (1) DE69816832T2 (en)
DK (1) DK1011679T3 (en)
ES (1) ES2203933T3 (en)
IL (1) IL131670A (en)
NO (1) NO324719B1 (en)
PL (1) PL189822B1 (en)
PT (1) PT1011679E (en)
WO (1) WO1998040072A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526021A (en) * 2003-05-22 2006-11-16 シェーリング　コーポレイション 5H-benzo [D] naphtho [2,1-B] azepine derivatives as selective D1 / D5 receptor antagonists to treat obesity and CNS disorders
PL1691811T3 (en) * 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
US20050215521A1 (en) * 2003-12-22 2005-09-29 Karim Lalji Modafinil combination therapy for improving sleep quality
WO2005063297A2 (en) * 2003-12-24 2005-07-14 Sepracor Inc. Melatonin combination therapy for improving sleep quality
DE602005018763D1 (en) * 2004-02-18 2010-02-25 Sepracor Inc DOPAMINE AGONIST COMBINATION THERAPY WITH SEDATIVA TO IMPROVE THE SLEEP QUALITY

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK325188D0 (en) 1988-06-15 1988-06-15 Novo Industri As BENZAZEPINE DERIVATIVES UNKNOWN
US5470850A (en) 1992-02-24 1995-11-28 Novo Nordisk A/S 2,3,4,5-tetrahydro-1H-3-benzazepines
DK26793D0 (en) 1993-03-10 1993-03-10 Novo Nordisk As BENZOFURANYL- OR DIHYDROBENZOFURANYL-SUBSTITUTED TRICYCLIC BENZAZEPINES USING AND PREPARING

Also Published As

Publication number Publication date
CZ317799A3 (en) 2000-03-15
US6211173B1 (en) 2001-04-03
EP1011679A1 (en) 2000-06-28
AU6610098A (en) 1998-09-29
WO1998040072A1 (en) 1998-09-17
EP1011679B1 (en) 2003-07-30
NO994343L (en) 1999-11-11
NO994343D0 (en) 1999-09-07
PT1011679E (en) 2003-12-31
ES2203933T3 (en) 2004-04-16
CA2283083A1 (en) 1998-09-17
NO324719B1 (en) 2007-12-03
IL131670A0 (en) 2001-01-28
AU742873B2 (en) 2002-01-17
JP2001515484A (en) 2001-09-18
PL189822B1 (en) 2005-09-30
CZ296464B6 (en) 2006-03-15
PL335545A1 (en) 2000-04-25
CA2283083C (en) 2007-09-04
IL131670A (en) 2005-07-25
BR9808234A (en) 2000-05-16
DE69816832D1 (en) 2003-09-04
ATE245986T1 (en) 2003-08-15
DE69816832T2 (en) 2004-05-27

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