DK0952853T3 - Konjugat omfattende et aktivt middel, et polypeptid og en polyether - Google Patents

Konjugat omfattende et aktivt middel, et polypeptid og en polyether

Info

Publication number
DK0952853T3
DK0952853T3 DK96946222T DK96946222T DK0952853T3 DK 0952853 T3 DK0952853 T3 DK 0952853T3 DK 96946222 T DK96946222 T DK 96946222T DK 96946222 T DK96946222 T DK 96946222T DK 0952853 T3 DK0952853 T3 DK 0952853T3
Authority
DK
Denmark
Prior art keywords
polyether
polypeptide
conjugate
active agent
conjugates
Prior art date
Application number
DK96946222T
Other languages
English (en)
Inventor
Hannsjoerg Sinn
Wolfgang Maier-Borst
Hans-Hermann Schrenk
Heinz-H Fiebig
Gerd Stehle
Original Assignee
Deutsches Krebsforsch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Krebsforsch filed Critical Deutsches Krebsforsch
Application granted granted Critical
Publication of DK0952853T3 publication Critical patent/DK0952853T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/06Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Polyethers (AREA)
DK96946222T 1995-12-21 1996-12-20 Konjugat omfattende et aktivt middel, et polypeptid og en polyether DK0952853T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19548114A DE19548114C2 (de) 1995-12-21 1995-12-21 Konjugat, umfassend einen Wirkstoff, ein Polypeptid und einen Polyether
PCT/DE1996/002487 WO1997023240A2 (de) 1995-12-21 1996-12-20 Konjugat, umfassend einen wirkstoff, ein polypeptid und einen polyether

Publications (1)

Publication Number Publication Date
DK0952853T3 true DK0952853T3 (da) 2003-07-14

Family

ID=7780997

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96946222T DK0952853T3 (da) 1995-12-21 1996-12-20 Konjugat omfattende et aktivt middel, et polypeptid og en polyether

Country Status (8)

Country Link
US (1) US6395254B1 (da)
EP (1) EP0952853B1 (da)
JP (1) JP2000502109A (da)
AT (1) ATE234636T1 (da)
DE (2) DE19548114C2 (da)
DK (1) DK0952853T3 (da)
ES (1) ES2195040T3 (da)
WO (1) WO1997023240A2 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818626B1 (en) * 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US6852334B1 (en) * 1999-04-20 2005-02-08 The University Of British Columbia Cationic peg-lipids and methods of use
US7189705B2 (en) * 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
CA2563619A1 (en) * 2004-04-20 2005-11-03 Emory University Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof
KR20080074207A (ko) * 2005-12-05 2008-08-12 닛토덴코 가부시키가이샤 폴리글루타메이트-아미노산 콘쥬게이트 및 이의 제조 방법
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
CN101674852A (zh) * 2007-04-10 2010-03-17 日东电工株式会社 多功能聚谷氨酸盐药物载体
EP2155253A2 (en) * 2007-05-09 2010-02-24 Nitto Denko Corporation Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
CN101730549B (zh) * 2007-05-09 2015-12-09 日东电工株式会社 与铂类药物结合的聚合物
US8197828B2 (en) * 2007-05-09 2012-06-12 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
AU2009222230A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
GB201401453D0 (en) * 2014-01-28 2014-03-12 Univ Birmingham Transmucosal and transepithelial drug delivery system
US10945997B2 (en) 2016-01-08 2021-03-16 Nippon Kayaku Kabushiki Kaisha Polymer derivative of macrolide immunosuppressant
EP3654941A1 (en) 2017-07-17 2020-05-27 Keith Roizman Topical delivery of therapeutic agents comprising cell-penetrating peptides for use for the treatment of age-related macular degeneration and other eye diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US5308604A (en) * 1989-04-19 1994-05-03 Deutsches Krebsforschungsinstitut Conjugates for tumor localization and/or tumor therapy
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
DE4017439C2 (de) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyethersubstituierte Tumormittel
JPH08501097A (ja) * 1992-09-04 1996-02-06 ザ ゼネラル ホスピタル コーポレーション 臨床診断及び治療用部分を含む生体適合性ポリマー
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
WO1996000079A1 (en) * 1994-06-27 1996-01-04 The General Hospital Corporation Graft co-polymer adducts of platinum (ii) compounds
US5958372A (en) 1994-06-28 1999-09-28 Nycomed Imaging As Low viscosity chelating polymers for diagnostic imaging

Also Published As

Publication number Publication date
ES2195040T3 (es) 2003-12-01
EP0952853B1 (de) 2003-03-19
WO1997023240A2 (de) 1997-07-03
WO1997023240A3 (de) 1997-10-09
ATE234636T1 (de) 2003-04-15
JP2000502109A (ja) 2000-02-22
US6395254B1 (en) 2002-05-28
EP0952853A2 (de) 1999-11-03
DE59610251D1 (de) 2003-04-24
DE19548114C2 (de) 2000-04-27
DE19548114A1 (de) 1997-06-26

Similar Documents

Publication Publication Date Title
DK0923570T3 (da) Pyridylalken- og pyridylalkynsyreamider som cytostatiske og immunosuppresive midler
DK0952853T3 (da) Konjugat omfattende et aktivt middel, et polypeptid og en polyether
NO20002785L (no) Adamantanderivater
NO20002786D0 (no) Adamantanderivater
FI980862A0 (fi) Kiraalisia metyylifenyylioksatsolidinoneja
AU3262497A (en) Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
NO990789D0 (no) Cytotoksisk aminosukker og beslektede sukker-derivater av indolopyrrolokarbazoler
AU5186799A (en) Peptides of il-2 and derivatives thereof and their use as therapeutic agents
NO972391D0 (no) 2-substituerte 1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og metoder for anvendelse derav
MX9403915A (es) Derivados de n-alquiltio de pliamina como agentes radioprotectores.
GR1001597B (el) Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών.
DK0821593T3 (da) Konjugat af et aktivt middel, et protein og eventuelt et for kroppen ikke som fremmed anset nativt protein
PT80221B (en) Improved process for preparing benzamide derivatives useful as anticonvulsant agents
DK0815141T3 (da) Antistof mod et fusionspolypeptid omfattende en histidinandel
DK0720597T3 (da) Triarylethylenderivater til terapeutisk anvendelse
ES2082212T3 (es) Nuevos inhibidores de alfa-glucosidasa.
DK0782456T3 (da) Konjugat bestående af et virksomt materiale og et nativt, ikke-kropsfremmed protein
DE69807200D1 (de) Inklusionskomplexe in waessriger loesung
DE69627184D1 (de) 3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften
UA42749C2 (uk) N,n-діетил-8,8-дипропіл-2-азаспіро[4,5]декан-2-пропанамін дималеат, фармацевтична композиція, спосіб лікування
ES2191785T3 (es) Proteina de accion antitumoral.
ATE221068T1 (de) Anellierte beta-carboline
UA23119A (uk) Психотропhий засіб
IT1255678B (it) Composizioni farmaceutiche per la somministrazione di paratormone, suoi frammenti biologicamente attivi o peptidi correlati per via rettale.