DK0880520T3 - Benzo[c]quinolinderivater, deres fremstilling af anvendelse som 5-alfa-reduktaseinhibitorer - Google Patents

Benzo[c]quinolinderivater, deres fremstilling af anvendelse som 5-alfa-reduktaseinhibitorer

Info

Publication number: DK0880520T3
Authority: DK; Denmark
Prior art keywords: benzo; preparation; alpha; reductase inhibitors; quinoline derivatives
Prior art date: 1996-02-09

Application number

DK97903230T

Other languages

English (en)

Inventor

Antonio Guarna

Mario Serio

Original Assignee

Applied Research Systems

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-09

Filing date

1997-02-07

Publication date

2003-08-11

1997-02-07 Application filed by Applied Research Systems filed Critical Applied Research Systems

2003-08-11 Application granted granted Critical

2003-08-11 Publication of DK0880520T3 publication Critical patent/DK0880520T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK97903230T 1996-02-09 1997-02-07 Benzo[c]quinolinderivater, deres fremstilling af anvendelse som 5-alfa-reduktaseinhibitorer DK0880520T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96FI000019A IT1286545B1 (it)	1996-02-09	1996-02-09	Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi
PCT/EP1997/000552 WO1997029107A1 (en)	1996-02-09	1997-02-07	BENZO[C]QUINOLIZINE DERIVATIVES, THEIR PREPARATION AND USE AS 5α-REDUCTASES INHIBITORS

Publications (1)

Publication Number	Publication Date
DK0880520T3 true DK0880520T3 (da)	2003-08-11

Family

ID=11351478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97903230T DK0880520T3 (da)	1996-02-09	1997-02-07	Benzo[c]quinolinderivater, deres fremstilling af anvendelse som 5-alfa-reduktaseinhibitorer

Country Status (26)

Country	Link
US (3)	US6303622B1 (da)
EP (1)	EP0880520B1 (da)
JP (1)	JP2000504680A (da)
KR (1)	KR100480448B1 (da)
CN (1)	CN1116296C (da)
AT (1)	ATE237614T1 (da)
AU (1)	AU711886C (da)
BG (1)	BG64596B1 (da)
CZ (1)	CZ298061B6 (da)
DE (1)	DE69720966T2 (da)
DK (1)	DK0880520T3 (da)
EA (1)	EA000975B1 (da)
EE (1)	EE04058B1 (da)
ES (1)	ES2192263T3 (da)
HK (1)	HK1018783A1 (da)
HU (1)	HUP9900509A3 (da)
IL (2)	IL125628A0 (da)
IT (1)	IT1286545B1 (da)
MX (1)	MX9806229A (da)
NO (2)	NO320155B1 (da)
NZ (1)	NZ331256A (da)
PL (1)	PL187618B1 (da)
PT (1)	PT880520E (da)
SK (1)	SK283299B6 (da)
UA (1)	UA67724C2 (da)
WO (1)	WO1997029107A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITFI970193A1 (it) *	1997-08-01	1999-02-01	Applied Research Systems	Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali
EP0926148A1 (en) *	1997-12-23	1999-06-30	Applied Research Systems Ars Holding N.V.	Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
JP2002522435A (ja)	1998-08-03	2002-07-23	アプライドリサーチシステムズエーアールエスホールディングナームロゼフェンノートシャップ	（１ｈ）−ベンゾ［ｃ］キノリン−３−オン誘導体の合成方法
KR20080023680A (ko)	2005-05-10	2008-03-14	인터뮨, 인크.	스트레스-활성화 단백질 키나제 시스템을 조절하기 위한피리돈 유도체
KR20080087070A (ko) *	2005-05-20	2008-09-30	알란토스 파마슈티컬즈 홀딩, 인코포레이티드	피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제
US20070155738A1 (en)	2005-05-20	2007-07-05	Alantos Pharmaceuticals, Inc.	Heterobicyclic metalloprotease inhibitors
MX2010012848A (es)	2008-06-03	2011-03-01	Intermune Inc	Compuestos y metodos para tratar trastornos inflamatorios y fibroticos.
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
CN106459042B (zh)	2014-04-02	2019-06-28	英特穆恩公司	抗纤维化吡啶酮类
CN105001216B (zh) *	2015-07-08	2017-03-01	中国科学院兰州化学物理研究所	一种喹嗪酮的制备方法
CN107089980B (zh) *	2017-05-11	2019-08-30	合肥工业大学	一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3455929A (en) *	1966-08-15	1969-07-15	Bristol Myers Co	Esters of 1,4-dihydroquinoline-n-carboxylic acids and thione acids
FR1534278A (fr)	1966-08-15	1968-07-26	Bristol Myers Co	Procédé de fabrication de 1, 4-dihydroquinoléine-n-carboxylates d'alcoyle
US3625877A (en) *	1968-01-08	1971-12-07	Eastman Kodak Co	High-modulus polycarbonate compositions
SU1027166A1 (ru)	1981-09-11	1983-07-07	Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко	Способ получени 1,2-полиметиленкетоцианоазагетероциклов
IE57014B1 (en)	1983-03-25	1992-03-11	Wyeth John & Brother Ltd	Benzoquinolizines

1996
- 1996-02-09 IT IT96FI000019A patent/IT1286545B1/it active IP Right Grant
1997
- 1997-02-07 AU AU17672/97A patent/AU711886C/en not_active Ceased
- 1997-02-07 CZ CZ0228998A patent/CZ298061B6/cs not_active IP Right Cessation
- 1997-02-07 HU HU9900509A patent/HUP9900509A3/hu unknown
- 1997-02-07 DK DK97903230T patent/DK0880520T3/da active
- 1997-02-07 JP JP9528158A patent/JP2000504680A/ja not_active Ceased
- 1997-02-07 CN CN97192097A patent/CN1116296C/zh not_active Expired - Fee Related
- 1997-02-07 AT AT97903230T patent/ATE237614T1/de not_active IP Right Cessation
- 1997-02-07 DE DE69720966T patent/DE69720966T2/de not_active Expired - Fee Related
- 1997-02-07 ES ES97903230T patent/ES2192263T3/es not_active Expired - Lifetime
- 1997-02-07 PL PL97328123A patent/PL187618B1/pl not_active IP Right Cessation
- 1997-02-07 WO PCT/EP1997/000552 patent/WO1997029107A1/en active IP Right Grant
- 1997-02-07 KR KR10-1998-0705848A patent/KR100480448B1/ko not_active IP Right Cessation
- 1997-02-07 SK SK1044-98A patent/SK283299B6/sk not_active IP Right Cessation
- 1997-02-07 EP EP97903230A patent/EP0880520B1/en not_active Expired - Lifetime
- 1997-02-07 IL IL12562897A patent/IL125628A0/xx active IP Right Grant
- 1997-02-07 NZ NZ331256A patent/NZ331256A/xx unknown
- 1997-02-07 US US09/117,583 patent/US6303622B1/en not_active Expired - Fee Related
- 1997-02-07 EE EE9800233A patent/EE04058B1/xx not_active IP Right Cessation
- 1997-02-07 EA EA199800701A patent/EA000975B1/ru unknown
- 1997-02-07 PT PT97903230T patent/PT880520E/pt unknown
- 1997-07-02 UA UA98094739A patent/UA67724C2/uk unknown
1998
- 1998-07-24 NO NO19983444A patent/NO320155B1/no not_active IP Right Cessation
- 1998-07-30 BG BG102661A patent/BG64596B1/bg unknown
- 1998-08-03 IL IL125628A patent/IL125628A/en not_active IP Right Cessation
- 1998-08-03 MX MX9806229A patent/MX9806229A/es unknown
1999
- 1999-09-03 HK HK99103821A patent/HK1018783A1/xx not_active IP Right Cessation
2001
- 2001-06-25 US US09/888,952 patent/US6555549B2/en not_active Expired - Fee Related
- 2001-06-25 US US09/891,088 patent/US6552034B2/en not_active Expired - Fee Related
2004
- 2004-11-24 NO NO20045132A patent/NO20045132L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ITFI960019A0 (da)	1996-02-09
EP0880520A1 (en)	1998-12-02
EE9800233A (et)	1998-12-15
HUP9900509A2 (hu)	1999-06-28
US6303622B1 (en)	2001-10-16
DE69720966T2 (de)	2004-05-19
KR19990082126A (ko)	1999-11-15
AU1767297A (en)	1997-08-28
NZ331256A (en)	1999-06-29
UA67724C2 (en)	2004-07-15
ES2192263T3 (es)	2003-10-01
CZ298061B6 (cs)	2007-06-06
ATE237614T1 (de)	2003-05-15
NO983444D0 (no)	1998-07-24
EA000975B1 (ru)	2000-08-28
HK1018783A1 (en)	2000-01-07
AU711886C (en)	2002-10-17
IL125628A (en)	2006-10-31
HUP9900509A3 (en)	1999-11-29
IL125628A0 (en)	1999-04-11
AU711886B2 (en)	1999-10-21
NO20045132L (no)	1998-07-24
MX9806229A (es)	1998-11-30
EP0880520B1 (en)	2003-04-16
JP2000504680A (ja)	2000-04-18
NO983444L (no)	1998-07-24
BG102661A (en)	1999-04-30
IT1286545B1 (it)	1998-07-15
PT880520E (pt)	2003-07-31
SK283299B6 (sk)	2003-05-02
PL187618B1 (pl)	2004-08-31
ITFI960019A1 (it)	1997-08-09
EE04058B1 (et)	2003-06-16
EA199800701A1 (ru)	1999-02-25
KR100480448B1 (ko)	2005-08-31
SK104498A3 (en)	1998-12-02
WO1997029107A1 (en)	1997-08-14
US6555549B2 (en)	2003-04-29
DE69720966D1 (de)	2003-05-22
US20010047098A1 (en)	2001-11-29
US20010044542A1 (en)	2001-11-22
BG64596B1 (bg)	2005-08-31
CN1116296C (zh)	2003-07-30
PL328123A1 (en)	1999-01-18
US6552034B2 (en)	2003-04-22
CZ228998A3 (cs)	1998-10-14
NO320155B1 (no)	2005-11-07
CN1210536A (zh)	1999-03-10

Publication	Publication Date	Title
DK0889877T3 (da)	2001-10-01	Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
HUP0100156A2 (hu)	2001-07-30	Foszfolipáz-A2 inhibitor hatású indolszármazékok és alkalmazásuk gyógyászati készítmények előállítására
DK1106612T3 (da)	2004-05-17	Quinolinderivater, der er nyttige til inhibering af farnesylproteintransferase
NO20044731L (no)	2004-12-30	Kinolin- og isokinolinderivater fremgangsmate for fremstilling derav og anvendelse derav som betennelseshemmere
ATE253545T1 (de)	2003-11-15	Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
BR9812010A (pt)	2000-12-12	Determinados ácidos 5-alquil-2-arilaminofenilacéticos e derivados
WO2003013484A3 (en)	2003-04-17	N-monoacylated derivatives of o-phenylenediamines, their six membered heterocyclic analogues and their use as pharmaceutical agents
HUP0101146A2 (hu)	2001-08-28	Foszfolipáz enzim inhibitor hatású indolszármazékok, valamint a vegyületeket tartalmazó gyógyászati készítmények
DK0894084T3 (da)	2002-10-14	Kanelsyrederivater og deres anvendelse som integrinantagonister
DK0880520T3 (da)	2003-08-11	Benzo[c]quinolinderivater, deres fremstilling af anvendelse som 5-alfa-reduktaseinhibitorer
TR199900732T2 (xx)	1999-08-23	PDE IV inhibe eden 2-siyanoiminoimidazol t�revleri.
ES2171945T3 (es)	2002-09-16	Derivados aromaticos de amidina que sirven de inhibidores selectivos de la trombina.
DK1165544T3 (da)	2003-12-01	Substituerede 1,4-dihydroindeno[1,2-c]pyrazoler som inhibitorer af tyrosinkinase
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
YU6396A (sh)	1999-06-15	Kombinacija inhibitora hiv proteaze sa drugim jedinjenjima za terapiju hiv infekcija
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel
ATE241624T1 (de)	2003-06-15	Benzo(f)naphthyridinderivate, ihre herstellung und sie enthaltende pharmazeutische zusammenstzungen
NO991589L (no)	1999-04-06	Nye 3-,5- og/eller 6-substituerte analoger av swainsonin, fremgangsmÕter for deres fremstilling og deres anvendelse som terapeutiske midler
WO2002018363A3 (en)	2002-06-27	3-phenyl-propanoic acid derivatives as protein tyrosine phosphatase inhibitors
CA2245758A1 (en)	1997-08-14	Benzo[c]quinolizine derivatives, their preparation and use as 5.alpha.-reductases inhibitors
AU1434201A (en)	2001-05-30	Antithrombotic agents
DE69824410D1 (en)	2004-07-15	Antithrombosemittel