DK0832104T3 - Dolastatinderivater, deres fremstilling og anvendelse - Google Patents

Dolastatinderivater, deres fremstilling og anvendelse

Info

Publication number: DK0832104T3
Authority: DK; Denmark
Prior art keywords: preparation; dolastatin derivatives; dolastatin; derivatives
Prior art date: 1995-06-07

Application number

DK96918660T

Other languages

English (en)

Inventor

Andreas Haupt

Franz Emling

Cynthia A Romerdahl

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-03

Publication date

2003-01-06

1996-06-03 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2003-01-06 Application granted granted Critical

2003-01-06 Publication of DK0832104T3 publication Critical patent/DK0832104T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DK96918660T 1995-06-07 1996-06-03 Dolastatinderivater, deres fremstilling og anvendelse DK0832104T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/472,453 US5831002A (en)	1992-05-20	1995-06-07	Antitumor peptides
PCT/EP1996/002392 WO1996040751A1 (en)	1995-06-07	1996-06-03	Novel dolastatin derivatives, their preparation and use

Publications (1)

Publication Number	Publication Date
DK0832104T3 true DK0832104T3 (da)	2003-01-06

Family

ID=23875567

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK96918661T DK0871656T3 (da)	1995-06-07	1996-06-03	Dolastatinderivater, deres fremstilling og anvendelse
DK96918660T DK0832104T3 (da)	1995-06-07	1996-06-03	Dolastatinderivater, deres fremstilling og anvendelse

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK96918661T DK0871656T3 (da)	1995-06-07	1996-06-03	Dolastatinderivater, deres fremstilling og anvendelse

Country Status (33)

Country	Link
US (1)	US5831002A (da)
EP (2)	EP0871656B1 (da)
JP (2)	JP4221062B2 (da)
KR (2)	KR100437986B1 (da)
CN (2)	CN1182154C (da)
AR (2)	AR003136A1 (da)
AT (2)	ATE224910T1 (da)
AU (2)	AU725170B2 (da)
BG (2)	BG102125A (da)
BR (2)	BR9609424A (da)
CA (2)	CA2219819C (da)
CO (2)	CO4700527A1 (da)
CZ (2)	CZ293683B6 (da)
DE (2)	DE69623472T2 (da)
DK (2)	DK0871656T3 (da)
ES (2)	ES2188759T3 (da)
HR (2)	HRP960257A2 (da)
HU (2)	HU228071B1 (da)
IL (2)	IL122215A (da)
MX (2)	MX9709147A (da)
MY (2)	MY119042A (da)
NO (2)	NO317670B1 (da)
NZ (2)	NZ310444A (da)
PL (2)	PL185762B1 (da)
PT (2)	PT871656E (da)
RO (2)	RO118953B1 (da)
SI (2)	SI0832104T1 (da)
SK (1)	SK282466B6 (da)
TR (2)	TR199701545T1 (da)
TW (2)	TW508357B (da)
UA (2)	UA46776C2 (da)
WO (2)	WO1996040751A1 (da)
ZA (2)	ZA964710B (da)

Families Citing this family (30)

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US5807984A (en) *	1995-11-09	1998-09-15	Basf Aktienegesellschaft	Oligopeptides, the preparation and use thereof
TW474946B (en) *	1995-12-15	2002-02-01	Basf Ag	Novel compounds, the preparation and use thereof
US20010009901A1 (en) *	1996-12-11	2001-07-26	Basf Aktiengesellschaft Germany	Antineoplastic peptides
US5965537A (en) *	1997-03-10	1999-10-12	Basf Aktiengesellschaft	Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) *	1997-03-13	2000-08-15	Basf Aktiengesellschaft	Dolastatin-15 derivatives in combination with taxanes
US6143721A (en)	1997-07-18	2000-11-07	Basf Aktiengesellschaft	Dolastatin 15 derivatives
US6015790A (en) *	1997-10-06	2000-01-18	Basf Aktiengesellschaft	Methods and compositions for treating rheumatoid arthritis
US5985837A (en) *	1998-07-08	1999-11-16	Basf Aktiengesellschaft	Dolastatin 15 derivatives
CA2360740A1 (en)	1999-03-02	2000-09-08	Boehringer Ingelheim Pharmaceuticals, Inc.	Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en)	1999-09-13	2002-07-16	Boehringer Ingelheim Pharmaceuticals, Inc.	Compound useful as reversible inhibitors of cysteine proteases
EP2266607A3 (en)	1999-10-01	2011-04-20	Immunogen, Inc.	Immunoconjugates for treating cancer
WO2002088298A1 (en)	2001-04-27	2002-11-07	The Procter & Gamble Company	Compounds, compositions, and methods for controlling biofilms
WO2003051835A2 (en) *	2001-12-18	2003-06-26	Proteologics, Inc.	Methods and compositions for the inhibition of viral release
EP1531846A4 (en) *	2002-02-27	2006-04-19	Us Gov Health & Human Serv	CONJUGATES OF LIGAND, LINK AND CYTOTOXIC AGENS, AND RELATED COMPOSITIONS AND USE PROCESSES
US8568637B2 (en)	2004-08-02	2013-10-29	Ramot At Tel-Aviv University Ltd.	Method of forming a fiber made of peptide nanostructures
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
US20080292616A1 (en) *	2005-08-19	2008-11-27	Government Of The United Of America, Represented By The Secretary, Department Of Health And....	Topical Formulations of Histone Deacetylase Inhibitors and Methods Using the Same
US10004828B2 (en) *	2005-10-11	2018-06-26	Romat at Tel-Aviv University Ltd.	Self-assembled Fmoc-ff hydrogels
CN101535300B (zh)	2006-05-16	2014-05-28	埃格拉医疗公司	Iap bir域结合化合物
EP2049524A2 (en) *	2006-07-24	2009-04-22	Tetralogic Pharmaceuticals Corporation	Iap inhibitors
NZ580271A (en) *	2007-04-12	2011-03-31	Scinopharm Taiwan Ltd	Process for making galantamine
UY32099A (es)	2008-09-11	2010-04-30	Enanta Pharm Inc	Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en)	2009-07-02	2012-10-09	Tetralogic Pharmaceuticals Corp.	2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
WO2011098904A1 (en)	2010-02-12	2011-08-18	Aegera Therapeutics, Inc.	Iap bir domain binding compounds
MX2013007677A (es)	2010-12-30	2013-07-30	Abbvie Inc	Inhibidores macrociclicos de serina proteasa de hepatitis.
AU2011352145A1 (en)	2010-12-30	2013-07-18	Abbvie Inc.	Phenanthridine macrocyclic hepatitis C serine protease inhibitors
US10201584B1 (en)	2011-05-17	2019-02-12	Abbvie Inc.	Compositions and methods for treating HCV
JP6581774B2 (ja) *	2011-05-27	2019-09-25	アンブルックス, インコーポレイテッドAmbrx, Inc.	非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法
EP3089757A1 (en)	2014-01-03	2016-11-09	AbbVie Inc.	Solid antiviral dosage forms
WO2023033129A1 (ja)	2021-09-03	2023-03-09	東レ株式会社	癌の治療及び／又は予防用医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816444A (en) *	1987-07-10	1989-03-28	Arizona Board Of Regents, Arizona State University	Cell growth inhibitory substance
US4879278A (en) *	1989-05-16	1989-11-07	Arizona Board Of Regents	Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DE69230824T2 (de) *	1991-08-09	2000-07-27	Teikoku Hormone Mfg Co Ltd	Neue tetrapeptidderivate
UA45304C2 (uk) *	1992-05-20	2002-04-15	Басф Аг	Похідні пептиду або їх солі, фармацевтична композиція
US5504191A (en) *	1994-08-01	1996-04-02	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory pentapeptide methyl esters
US5530097A (en) *	1994-08-01	1996-06-25	Arizona Board Of Regents Acting On Behalf Of Arizona State University	Human cancer inhibitory peptide amides

1995
- 1995-06-07 US US08/472,453 patent/US5831002A/en not_active Expired - Lifetime
1996
- 1996-06-03 AU AU61242/96A patent/AU725170B2/en not_active Ceased
- 1996-06-03 TR TR97/01545T patent/TR199701545T1/xx unknown
- 1996-06-03 UA UA98010070A patent/UA46776C2/uk unknown
- 1996-06-03 SI SI9630539T patent/SI0832104T1/xx unknown
- 1996-06-03 BR BR9609424-9A patent/BR9609424A/pt not_active Application Discontinuation
- 1996-06-03 WO PCT/EP1996/002392 patent/WO1996040751A1/en active IP Right Grant
- 1996-06-03 PL PL96323723A patent/PL185762B1/pl unknown
- 1996-06-03 RO RO97-02264A patent/RO118953B1/ro unknown
- 1996-06-03 AT AT96918661T patent/ATE224910T1/de active
- 1996-06-03 BR BR9609423A patent/BR9609423A/pt not_active Application Discontinuation
- 1996-06-03 DE DE69623472T patent/DE69623472T2/de not_active Expired - Lifetime
- 1996-06-03 CA CA002219819A patent/CA2219819C/en not_active Expired - Fee Related
- 1996-06-03 JP JP50013297A patent/JP4221062B2/ja not_active Expired - Fee Related
- 1996-06-03 JP JP50013197A patent/JP3957751B2/ja not_active Expired - Fee Related
- 1996-06-03 AT AT96918660T patent/ATE223431T1/de active
- 1996-06-03 CA CA002219818A patent/CA2219818C/en not_active Expired - Fee Related
- 1996-06-03 PT PT96918661T patent/PT871656E/pt unknown
- 1996-06-03 HU HU9801910A patent/HU228071B1/hu not_active IP Right Cessation
- 1996-06-03 HU HU9801817A patent/HU228073B1/hu not_active IP Right Cessation
- 1996-06-03 NZ NZ310444A patent/NZ310444A/xx not_active IP Right Cessation
- 1996-06-03 DK DK96918661T patent/DK0871656T3/da active
- 1996-06-03 MY MYPI96002155A patent/MY119042A/en unknown
- 1996-06-03 NZ NZ310443A patent/NZ310443A/en not_active IP Right Cessation
- 1996-06-03 UA UA98010069A patent/UA46775C2/uk unknown
- 1996-06-03 TR TR97/01544T patent/TR199701544T1/xx unknown
- 1996-06-03 SK SK1653-97A patent/SK282466B6/sk not_active IP Right Cessation
- 1996-06-03 CZ CZ19973765A patent/CZ293683B6/cs not_active IP Right Cessation
- 1996-06-03 RO RO97-02254A patent/RO119783B1/ro unknown
- 1996-06-03 CN CNB961944676A patent/CN1182154C/zh not_active Expired - Fee Related
- 1996-06-03 ES ES96918661T patent/ES2188759T3/es not_active Expired - Lifetime
- 1996-06-03 SI SI9630550T patent/SI0871656T1/xx unknown
- 1996-06-03 ES ES96918660T patent/ES2186783T3/es not_active Expired - Lifetime
- 1996-06-03 KR KR1019970709064A patent/KR100437986B1/ko not_active IP Right Cessation
- 1996-06-03 PT PT96918660T patent/PT832104E/pt unknown
- 1996-06-03 DE DE69623992T patent/DE69623992T2/de not_active Expired - Lifetime
- 1996-06-03 WO PCT/EP1996/002393 patent/WO1996040752A1/en active IP Right Grant
- 1996-06-03 MX MX9709147A patent/MX9709147A/es unknown
- 1996-06-03 IL IL12221596A patent/IL122215A/xx not_active IP Right Cessation
- 1996-06-03 EP EP96918661A patent/EP0871656B1/en not_active Expired - Lifetime
- 1996-06-03 DK DK96918660T patent/DK0832104T3/da active
- 1996-06-03 MX MX9709146A patent/MX9709146A/es unknown
- 1996-06-03 CZ CZ19973763A patent/CZ293682B6/cs not_active IP Right Cessation
- 1996-06-03 EP EP96918660A patent/EP0832104B1/en not_active Expired - Lifetime
- 1996-06-03 PL PL96323726A patent/PL185763B1/pl unknown
- 1996-06-03 KR KR1019970709063A patent/KR100437985B1/ko not_active IP Right Cessation
- 1996-06-03 AU AU61241/96A patent/AU725164B2/en not_active Ceased
- 1996-06-03 CN CNB961944684A patent/CN1182153C/zh not_active Expired - Fee Related
- 1996-06-03 IL IL12221696A patent/IL122216A/en not_active IP Right Cessation
- 1996-06-04 MY MYPI96002170A patent/MY124487A/en unknown
- 1996-06-06 ZA ZA9604710A patent/ZA964710B/xx unknown
- 1996-06-06 HR HR08/472,453A patent/HRP960257A2/hr not_active Application Discontinuation
- 1996-06-06 HR HR08/472,453A patent/HRP960277A2/hr not_active Application Discontinuation
- 1996-06-06 ZA ZA9604711A patent/ZA964711B/xx unknown
- 1996-06-06 AR ARP960102980A patent/AR003136A1/es active IP Right Grant
- 1996-06-06 AR ARP960102981A patent/AR003427A1/es active IP Right Grant
- 1996-06-07 CO CO96029751A patent/CO4700527A1/es unknown
- 1996-06-07 CO CO96029749A patent/CO4700526A1/es unknown
- 1996-06-07 TW TW085106866A patent/TW508357B/zh not_active IP Right Cessation
- 1996-10-02 TW TW085106867A patent/TW424096B/zh not_active IP Right Cessation
1997
- 1997-12-05 NO NO19975711A patent/NO317670B1/no not_active IP Right Cessation
- 1997-12-05 NO NO19975710A patent/NO318384B1/no not_active IP Right Cessation
- 1997-12-18 BG BG102125A patent/BG102125A/xx unknown
- 1997-12-29 BG BG102152A patent/BG102152A/xx unknown

Also Published As

Publication number	Publication date
DE69623472T2 (de)	2003-08-21
NZ310444A (en)	1999-11-29
HRP960257A2 (en)	1998-02-28
AU6124296A (en)	1996-12-30
IL122215A0 (en)	1998-04-05
CA2219818C (en)	2008-05-20
SK282466B6 (sk)	2002-02-05
US5831002A (en)	1998-11-03
ZA964710B (en)	1997-12-08
PL323726A1 (en)	1998-04-14
NO975711L (no)	1998-01-30
AR003136A1 (es)	1998-07-08
CZ293682B6 (cs)	2004-07-14
NO975711D0 (no)	1997-12-05
EP0871656B1 (en)	2002-09-25
ZA964711B (en)	1997-12-08
AU725170B2 (en)	2000-10-05
ATE224910T1 (de)	2002-10-15
CN1182154C (zh)	2004-12-29
CA2219819A1 (en)	1996-12-19
EP0871656A1 (en)	1998-10-21
CA2219819C (en)	2008-05-20
CN1187199A (zh)	1998-07-08
DK0871656T3 (da)	2003-01-27
CA2219818A1 (en)	1996-12-19
PL185763B1 (pl)	2003-07-31
RO119783B1 (ro)	2005-03-30
JPH11504652A (ja)	1999-04-27
WO1996040752A1 (en)	1996-12-19
MY124487A (en)	2006-06-30
CZ376597A3 (cs)	1998-06-17
TW424096B (en)	2001-03-01
EP0832104B1 (en)	2002-09-04
DE69623992T2 (de)	2003-05-22
CZ376397A3 (cs)	1998-06-17
KR19990022583A (ko)	1999-03-25
AR003427A1 (es)	1998-08-05
JPH11504653A (ja)	1999-04-27
EP0832104A1 (en)	1998-04-01
IL122216A (en)	2002-02-10
TW508357B (en)	2002-11-01
KR19990022582A (ko)	1999-03-25
AU6124196A (en)	1996-12-30
UA46775C2 (uk)	2002-06-17
CZ293683B6 (cs)	2004-07-14
HUP9801817A2 (hu)	1998-11-30
NO317670B1 (no)	2004-11-29
NO975710L (no)	1998-02-02
RO118953B1 (ro)	2004-01-30
PL185762B1 (pl)	2003-07-31
MX9709146A (es)	1998-03-31
ATE223431T1 (de)	2002-09-15
UA46776C2 (uk)	2002-06-17
HRP960277A2 (en)	1997-10-31
AU725164B2 (en)	2000-10-05
ES2188759T3 (es)	2003-07-01
CN1187198A (zh)	1998-07-08
BR9609424A (pt)	2000-03-28
PT871656E (pt)	2002-12-31
JP4221062B2 (ja)	2009-02-12
HUP9801910A2 (hu)	1999-01-28
MY119042A (en)	2005-03-31
SI0832104T1 (en)	2003-08-31
MX9709147A (es)	1998-03-31
WO1996040751A1 (en)	1996-12-19
SI0871656T1 (en)	2003-08-31
NO318384B1 (no)	2005-03-14
HUP9801817A3 (en)	1999-06-28
ES2186783T3 (es)	2003-05-16
DE69623472D1 (de)	2002-10-10
SK165397A3 (en)	1998-10-07
HUP9801910A3 (en)	1999-06-28
DE69623992D1 (de)	2002-10-31
HU228073B1 (hu)	2012-09-28
PL323723A1 (en)	1998-04-14
HU228071B1 (hu)	2012-09-28
BG102125A (en)	1998-09-30
BR9609423A (pt)	1999-06-29
CN1182153C (zh)	2004-12-29
TR199701544T1 (xx)	1998-03-21
JP3957751B2 (ja)	2007-08-15
TR199701545T1 (xx)	1998-04-21
CO4700526A1 (es)	1998-12-29
IL122216A0 (en)	1998-04-05
NO975710D0 (no)	1997-12-05
KR100437986B1 (ko)	2004-09-18
CO4700527A1 (es)	1998-12-29
KR100437985B1 (ko)	2004-09-18
IL122215A (en)	2001-08-26
BG102152A (en)	1998-09-30
NZ310443A (en)	1999-10-28
PT832104E (pt)	2002-12-31

Publication	Publication Date	Title
DK0871656T3 (da)	2003-01-27	Dolastatinderivater, deres fremstilling og anvendelse
NO980720D0 (no)	1998-02-20	Pyridazin-3-on-derivater, deres anvendelse og mellomprodukter for deres fremstilling
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DK0869126T3 (da)	2002-11-18	Dithiolanderivater, deres fremstilling og deres terapeutiske virkning
DK1019358T3 (da)	2003-09-01	3,3-diarylpropylaminer, deres anvendelse og fremstilling
NO943682D0 (no)	1994-10-03	Imidazol-4-yl-piperidin-derivater, deres fremstilling og terapeutiske anvendelse
NO961721D0 (no)	1996-04-29	2-oksetanon-limingsmidler, deres fremstilling og bruk
NO981282D0 (no)	1998-03-20	Calcitriolderivater og deres anvendelser
NO975020D0 (no)	1997-10-31	Azacykloalkanderivater, fremstilling derav og deres anvendelse i terapi
NO953673D0 (no)	1995-09-18	[1,2,4ÅTriazolo[4,3-aÅkinoksalinderivater, deres fremstilling og anvendelse
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NO951418D0 (no)	1995-04-11	Peptidderivater, deres fremstilling og anvendelse som terapeutika
DK60893D0 (da)	1993-05-26	Piperidinderivater, deres fremstilling og anvendelse
DK0835254T3 (da)	2000-03-27	Oxazolidinonderivater, deres fremstilling og deres terapeutiske anvendelse
NO954763D0 (no)	1995-11-24	Piperidinderivater, deres fremstilling og anvendelse
NO984921D0 (no)	1998-10-22	Tienopyridinderivater og deres anvendelse
NO973230D0 (no)	1997-07-11	Nye peptider, deres fremstilling og anvendelse
NO980471D0 (no)	1998-02-03	Benzensulfonamidderivater, fremstilling derav og terapautiske anvendelser derav
NO955242D0 (no)	1995-12-22	Piperidinderivater, fremgangsmåte for fremstilling derav og deres terapeutiske anvendelse
NO20000066D0 (no)	2000-01-06	6-pyrrolidin-2-ylpyrindin-derivater, deres fremstilling og deres farmasoeytiske anvendelse
NO972821D0 (no)	1997-06-18	1-C-perfluoralkylglycosider, deres fremstilling og anvendelse
NO981002L (no)	1998-03-09	Karboksylsyrederivater, deres fremstilling og anvendelse
NO982549D0 (no)	1998-06-04	5-naftalen-1-yl-1,3-dioksan-derivater, fremstilling og terapeutisk anvendelse derav