DK0823476T3 - Fremgangsmåde til aktivering af prothrombin til thrombin - Google Patents

Fremgangsmåde til aktivering af prothrombin til thrombin

Info

Publication number
DK0823476T3
DK0823476T3 DK97113588T DK97113588T DK0823476T3 DK 0823476 T3 DK0823476 T3 DK 0823476T3 DK 97113588 T DK97113588 T DK 97113588T DK 97113588 T DK97113588 T DK 97113588T DK 0823476 T3 DK0823476 T3 DK 0823476T3
Authority
DK
Denmark
Prior art keywords
thrombin
prothrombin
absence
activating
activating prothrombin
Prior art date
Application number
DK97113588T
Other languages
English (en)
Inventor
Hiroshi Kaetsu
Jun Mizuguchi
Takayoshi Hamamoto
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of DK0823476T3 publication Critical patent/DK0823476T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DK97113588T 1996-08-09 1997-08-06 Fremgangsmåde til aktivering af prothrombin til thrombin DK0823476T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22769596A JP3944267B2 (ja) 1996-08-09 1996-08-09 プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法

Publications (1)

Publication Number Publication Date
DK0823476T3 true DK0823476T3 (da) 2004-06-14

Family

ID=16864906

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97113588T DK0823476T3 (da) 1996-08-09 1997-08-06 Fremgangsmåde til aktivering af prothrombin til thrombin

Country Status (6)

Country Link
US (1) US5811279A (da)
EP (1) EP0823476B1 (da)
JP (1) JP3944267B2 (da)
AT (1) ATE260336T1 (da)
DE (1) DE69727736T2 (da)
DK (1) DK0823476T3 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274090B1 (en) * 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) * 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU6214200A (en) * 1999-07-14 2001-02-05 Research Foundation Of The State University Of New York, The Assay of the activation state of platelets
EP1585386A4 (en) * 2002-02-20 2009-09-02 American Integrated Biolog Inc GENE PRODUCTION IN SALIVA
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
RU2457248C2 (ru) * 2010-06-09 2012-07-27 Общество с ограниченной ответственностью фирма "Технология-Стандарт" Способ промышленного получения тромбина
EA028016B1 (ru) * 2013-06-06 2017-09-29 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Набор для измерения параметров системы гемостаза в образце крови или ее компонентов
RU2698206C1 (ru) * 2018-07-02 2019-08-23 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Набор реагентов для диагностики степени нейровоспаления
GB2579630A (en) * 2018-12-07 2020-07-01 Biotherapy Services Ltd Methods and compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560475A (en) * 1969-06-19 1971-02-02 Baxter Laboratories Inc Prothrombin complex prepared by precipitation with polyethylene glycol
US3682881A (en) * 1970-10-02 1972-08-08 Baxter Laboratories Inc Fractionation of plasma using glycine and polyethylene glycol
US5138034A (en) * 1989-07-12 1992-08-11 The Green Cross Corporation Method of fractionating plasma proteins
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
JPH04365481A (ja) * 1991-06-11 1992-12-17 Green Cross Corp:The トロンビンの製造法
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
JPH0733799A (ja) * 1993-07-20 1995-02-03 Green Cross Corp:The 高比活性トロンビンおよびその製造方法
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
US5677162A (en) * 1995-05-01 1997-10-14 New York Blood Center, Inc. Method for activating prothrombin to thrombin

Also Published As

Publication number Publication date
ATE260336T1 (de) 2004-03-15
EP0823476B1 (en) 2004-02-25
JPH1052267A (ja) 1998-02-24
DE69727736D1 (de) 2004-04-01
US5811279A (en) 1998-09-22
DE69727736T2 (de) 2004-11-25
EP0823476A3 (en) 1999-09-01
JP3944267B2 (ja) 2007-07-11
EP0823476A2 (en) 1998-02-11

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