DK0724433T3 - Fremgangsmåde til fremstilling af mikrosfærer med et tørringstrin i fluidiseret leje - Google Patents
Fremgangsmåde til fremstilling af mikrosfærer med et tørringstrin i fluidiseret lejeInfo
- Publication number
- DK0724433T3 DK0724433T3 DK94931369T DK94931369T DK0724433T3 DK 0724433 T3 DK0724433 T3 DK 0724433T3 DK 94931369 T DK94931369 T DK 94931369T DK 94931369 T DK94931369 T DK 94931369T DK 0724433 T3 DK0724433 T3 DK 0724433T3
- Authority
- DK
- Denmark
- Prior art keywords
- fluidized bed
- drying step
- bed drying
- preparing microspheres
- microspheres
- Prior art date
Links
- 239000004005 microsphere Substances 0.000 title abstract 3
- 238000001035 drying Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14225793A | 1993-10-22 | 1993-10-22 | |
| US14331393A | 1993-10-25 | 1993-10-25 | |
| PCT/US1994/011678 WO1995011009A1 (en) | 1993-10-22 | 1994-10-13 | Method for preparing microspheres comprising a fluidized bed drying step |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0724433T3 true DK0724433T3 (da) | 1999-08-30 |
Family
ID=26839915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94931369T DK0724433T3 (da) | 1993-10-22 | 1994-10-13 | Fremgangsmåde til fremstilling af mikrosfærer med et tørringstrin i fluidiseret leje |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0724433B1 (da) |
| JP (1) | JP3841309B2 (da) |
| AT (1) | ATE175110T1 (da) |
| AU (1) | AU8017494A (da) |
| CA (1) | CA2172508C (da) |
| DE (1) | DE69415684T2 (da) |
| DK (1) | DK0724433T3 (da) |
| UY (1) | UY23846A1 (da) |
| WO (1) | WO1995011009A1 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE197550T1 (de) * | 1993-02-23 | 2000-12-15 | Genentech Inc | Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff |
| ATE288270T1 (de) | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| EP0765660A3 (en) * | 1995-09-28 | 1998-09-23 | Takeda Chemical Industries, Ltd. | Microcapsules comprising 2-piperazinone-1-acetic acid compounds |
| US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
| ATE192334T1 (de) | 1995-11-09 | 2000-05-15 | Microbiological Res Authority | Mikroverkapselte dna zur impfung und gentherapie |
| DE19545257A1 (de) * | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
| GB2310801A (en) * | 1996-03-04 | 1997-09-10 | Merck & Co Inc | Process for removing an organic solvent from lactide-glycoside copolymer microspheres |
| AU2043297A (en) | 1996-03-28 | 1997-10-17 | Takeda Chemical Industries Ltd. | Sustained-release preparation and its production |
| SI0904063T1 (en) * | 1996-05-07 | 2003-02-28 | Alkermes Controlled Therapeutics Inc. Ii | Process for the preparation of microparticles |
| EP1009429B1 (en) * | 1997-08-29 | 2009-07-08 | Antigenics Inc. | Compositions comprising the adjuvant qs-21 and polysorbate or cyclodextrin as excipient |
| WO1999024061A1 (en) * | 1997-11-07 | 1999-05-20 | Chiron Corporation | Method for producing igf-1 sustained-release formulations |
| SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| GB9810236D0 (en) | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
| WO2001030320A1 (en) * | 1999-10-22 | 2001-05-03 | Amgen Inc. | Biodegradable microparticles with novel erythropoietin stimulating protein |
| WO2006123359A2 (en) * | 2005-03-01 | 2006-11-23 | Sun Pharmaceutical Industries Limited | A process of making microspheres |
| WO2015161139A1 (en) | 2014-04-16 | 2015-10-22 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| CA2784287C (en) * | 2009-12-22 | 2017-07-18 | Evonik Degussa Corporation | Emulsion-based process for preparing microparticles and workhead assembly for use with same |
| UA111162C2 (uk) | 2010-08-04 | 2016-04-11 | Флекшен Терап'Ютікс, Інк. | Ін'єкційна композиція ацетоніду триамцинолону для лікування болю |
| EP3281631A1 (en) * | 2011-08-04 | 2018-02-14 | Flexion Therapeutics, Inc. | Corticosteroids for the treatment of joint pain |
| CA3206208A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| JPWO2023277051A1 (da) * | 2021-06-30 | 2023-01-05 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IT1214629B (it) * | 1985-08-29 | 1990-01-18 | Formenti Farmaceutici Spa | Procedimento di microincapsulazione di un medicamento,medicamento cosi'preparato,e composizioni farmaceutiche che lo comprendono |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| EP0279688B1 (en) * | 1987-02-20 | 1997-04-16 | Genentech, Inc. | Methods and compositions for the use of HIV env polypeptides and antibodies thereto |
| JP2813630B2 (ja) * | 1987-02-20 | 1998-10-22 | ジェネンテク，インコーポレイテッド | ヒト免疫不全ウイルスのエンベロープポリペプチドおよびその抗体 |
| NO176278C (no) * | 1988-08-24 | 1995-03-08 | Allied Colloids Ltd | Fremgangsmåte for fremstilling av en partikkelformig blanding av aktiv bestanddel i et polymert materiale |
| US5008116A (en) * | 1988-11-14 | 1991-04-16 | Frederick Cahn | Immunostimulatory microsphere |
| US4990336A (en) * | 1989-02-08 | 1991-02-05 | Biosearch, Inc. | Sustained release dosage form |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| FR2658432B1 (fr) * | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
| AU8303691A (en) * | 1991-04-24 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Army, The | Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5429822A (en) * | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
| FR2703927B1 (fr) * | 1993-04-13 | 1995-07-13 | Coletica | Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées. |
| EP0724431B1 (en) * | 1993-10-22 | 2002-09-11 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
| JPH09504027A (ja) * | 1993-10-22 | 1997-04-22 | ジェネンテク，インコーポレイテッド | ワクチンとしての使用のための抗原のマイクロカプセル化のための方法および組成物 |
-
1994
- 1994-10-13 JP JP51207695A patent/JP3841309B2/ja not_active Expired - Lifetime
- 1994-10-13 DE DE69415684T patent/DE69415684T2/de not_active Expired - Lifetime
- 1994-10-13 AU AU80174/94A patent/AU8017494A/en not_active Abandoned
- 1994-10-13 CA CA002172508A patent/CA2172508C/en not_active Expired - Lifetime
- 1994-10-13 WO PCT/US1994/011678 patent/WO1995011009A1/en active IP Right Grant
- 1994-10-13 DK DK94931369T patent/DK0724433T3/da active
- 1994-10-13 AT AT94931369T patent/ATE175110T1/de active
- 1994-10-13 EP EP94931369A patent/EP0724433B1/en not_active Expired - Lifetime
- 1994-10-21 UY UY23846A patent/UY23846A1/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3841309B2 (ja) | 2006-11-01 |
| JPH09504026A (ja) | 1997-04-22 |
| EP0724433B1 (en) | 1998-12-30 |
| WO1995011009A1 (en) | 1995-04-27 |
| DE69415684D1 (de) | 1999-02-11 |
| CA2172508C (en) | 2005-08-23 |
| AU8017494A (en) | 1995-05-08 |
| EP0724433A1 (en) | 1996-08-07 |
| UY23846A1 (es) | 1995-03-28 |
| DE69415684T2 (de) | 1999-06-10 |
| CA2172508A1 (en) | 1995-04-27 |
| ATE175110T1 (de) | 1999-01-15 |
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