DK0711289T3 - Piperazinforbindelser til anvendelse i terapi - Google Patents
Piperazinforbindelser til anvendelse i terapiInfo
- Publication number
- DK0711289T3 DK0711289T3 DK94921756T DK94921756T DK0711289T3 DK 0711289 T3 DK0711289 T3 DK 0711289T3 DK 94921756 T DK94921756 T DK 94921756T DK 94921756 T DK94921756 T DK 94921756T DK 0711289 T3 DK0711289 T3 DK 0711289T3
- Authority
- DK
- Denmark
- Prior art keywords
- utility
- compounds
- receptors
- piperazine compounds
- depression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Water Treatment By Sorption (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9833393A | 1993-07-30 | 1993-07-30 | |
US16987993A | 1993-12-17 | 1993-12-17 | |
PCT/GB1994/001641 WO1995004051A1 (en) | 1993-07-30 | 1994-07-29 | Piperazine compounds used in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0711289T3 true DK0711289T3 (da) | 2000-11-06 |
Family
ID=26794651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94921756T DK0711289T3 (da) | 1993-07-30 | 1994-07-29 | Piperazinforbindelser til anvendelse i terapi |
Country Status (18)
Country | Link |
---|---|
US (1) | US5552404A (da) |
EP (1) | EP0711289B1 (da) |
JP (1) | JPH09501156A (da) |
CN (1) | CN1054850C (da) |
AT (1) | ATE195733T1 (da) |
AU (1) | AU692788B2 (da) |
CA (1) | CA2168432C (da) |
DE (1) | DE69425662T2 (da) |
DK (1) | DK0711289T3 (da) |
ES (1) | ES2149881T3 (da) |
GR (1) | GR3034695T3 (da) |
HU (1) | HU221726B1 (da) |
IL (1) | IL110512A (da) |
MY (1) | MY111348A (da) |
PT (1) | PT711289E (da) |
RU (1) | RU2133744C1 (da) |
TW (1) | TW386081B (da) |
WO (1) | WO1995004051A1 (da) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
US5985880A (en) * | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US6410537B1 (en) * | 1994-09-09 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
US6046200A (en) * | 1994-09-09 | 2000-04-04 | The United States Of America As Represented By The Secretary Of The Army | Compositions having neuroprotective and analgesic activity |
SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
SE9504662D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
GB9709972D0 (en) * | 1997-05-19 | 1997-07-09 | Pfizer Ltd | Tetrazoles |
GB9804734D0 (en) * | 1998-03-05 | 1998-04-29 | Pfizer Ltd | Compounds |
US6359111B1 (en) | 1998-05-28 | 2002-03-19 | Neorx Corporation | Opioid receptor targeting |
AU4572999A (en) | 1998-06-18 | 2000-01-05 | Sepracor, Inc. | Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors |
SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
SE9904674D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
AU2001239896A1 (en) * | 2000-03-16 | 2001-10-03 | Sepracor, Inc. | Peptidomimetic ligands for cellular receptors and ion channels |
SE0001209D0 (sv) | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
SE0100764D0 (sv) * | 2001-03-07 | 2001-03-07 | Astrazeneca Ab | New assymetric process |
WO2002080918A1 (fr) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Agent therapeutique ou prophylactique en cas de miction frequente ou d'incontinence urinaire |
AU2002305994B2 (en) | 2001-05-18 | 2008-06-26 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for the treatment of pain anxiety or gastrointestinal disorders |
MXPA04004059A (es) * | 2001-10-29 | 2005-03-31 | Ardent Pharmaceuticals Inc | Metodo para tratar la depresion con compuestos agonistas receptores delta. |
PL372096A1 (en) * | 2002-01-02 | 2005-07-11 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
US6881829B2 (en) * | 2002-04-26 | 2005-04-19 | Chimeracom, L.L.C. | Chimeric hybrid analgesics |
US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
WO2003097057A1 (en) * | 2002-05-16 | 2003-11-27 | Akzo Nobel N.V. | Synergistic combination of an opioid analgesic and a nsaid |
CN1202843C (zh) * | 2002-06-21 | 2005-05-25 | 天大药业(深圳)有限公司 | 一种戒毒药物组合物及其制备方法和应用 |
EP1522542A1 (en) * | 2002-07-11 | 2005-04-13 | Toray Industries, Inc. | Therapeutic or preventive agent for nausea/vomiting |
EP1546837B1 (de) * | 2002-09-27 | 2007-02-28 | Continental Teves AG & Co. oHG | Verstellbare pedaleinrichtung |
SE0203302D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
US7314880B2 (en) * | 2003-01-02 | 2008-01-01 | Mount Cook Biosciences, Inc. | Cardioprotective delta opioid receptor agonists and methods of using same |
US20090297611A1 (en) * | 2003-07-31 | 2009-12-03 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
TWI317286B (en) | 2003-12-31 | 2009-11-21 | Targeting delivery system | |
DK1781631T3 (da) | 2004-08-02 | 2012-05-14 | Astrazeneca Ab | Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf |
JP2008546638A (ja) * | 2005-04-14 | 2008-12-25 | マウント クック バイオサイエンシズ,インコーポレイテッド | 新規なオピオイド化合物の組成物およびその使用方法 |
WO2008036858A2 (en) | 2006-09-20 | 2008-03-27 | The Board Of Regents Of The University Of Texas System | Methods for delivering volatile anesthetics for regional anesthesia and/or pain relief |
DK2244737T3 (da) | 2008-01-22 | 2019-07-08 | Univ Texas | Flygtige anæstetiske sammensætninger omfattende ekstraktionsopløsningsmidler til regional anæstesi og/eller smertelindring |
US20090291966A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Method Of Treating Anxious Major Depressive Disorder |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2630435A (en) * | 1948-09-09 | 1953-03-03 | Burroughs Wellcome Co | N-benzohydryl-n-methyl piperazines and process of preparing same |
US4518711A (en) | 1983-05-16 | 1985-05-21 | Gibson-Stephens Institute | Conformationally constrained cyclic enkephalin analogs with delta receptor specificity |
GB8320701D0 (en) | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
IN163948B (da) | 1986-01-17 | 1988-12-10 | Robins Co Inc A H | |
CA1321792C (en) * | 1987-04-16 | 1993-08-31 | Eli Lilly And Company | Piperidine opioid antagonists |
US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
JPH04506072A (ja) * | 1989-06-19 | 1992-10-22 | ザ・ウエルカム・ファウンデーション・リミテッド | 癌治療に有用であり、かつ抗ヒスタミン特性を有する医薬 |
EP0458160A3 (en) | 1990-05-25 | 1992-03-18 | Sociedad Espanola De Especialidades Farmaco-Terapeuticas, S.A. | Substituted diphenylmethane derivatives as analgesic or anti-inflammatory agents |
SE467304B (sv) * | 1990-10-31 | 1992-06-29 | Kamewa Ab | Styr- och reverseringsanordning foer ett marint straaldriftsaggregat |
US5159081A (en) * | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
IE914218A1 (en) * | 1991-09-11 | 1993-03-24 | Mcneilab Inc | Novel 4-arylpiperazines and 4-arylpiperidines |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
-
1994
- 1994-07-29 JP JP7505665A patent/JPH09501156A/ja not_active Ceased
- 1994-07-29 IL IL11051294A patent/IL110512A/en not_active IP Right Cessation
- 1994-07-29 DK DK94921756T patent/DK0711289T3/da active
- 1994-07-29 HU HU9501982A patent/HU221726B1/hu not_active IP Right Cessation
- 1994-07-29 WO PCT/GB1994/001641 patent/WO1995004051A1/en active IP Right Grant
- 1994-07-29 ES ES94921756T patent/ES2149881T3/es not_active Expired - Lifetime
- 1994-07-29 AU AU72351/94A patent/AU692788B2/en not_active Ceased
- 1994-07-29 DE DE69425662T patent/DE69425662T2/de not_active Expired - Fee Related
- 1994-07-29 AT AT94921756T patent/ATE195733T1/de not_active IP Right Cessation
- 1994-07-29 RU RU96104351/04A patent/RU2133744C1/ru not_active IP Right Cessation
- 1994-07-29 CN CN94192949A patent/CN1054850C/zh not_active Expired - Fee Related
- 1994-07-29 MY MYPI94001988A patent/MY111348A/en unknown
- 1994-07-29 EP EP94921756A patent/EP0711289B1/en not_active Expired - Lifetime
- 1994-07-29 PT PT94921756T patent/PT711289E/pt unknown
- 1994-07-29 CA CA002168432A patent/CA2168432C/en not_active Expired - Fee Related
- 1994-08-02 TW TW083107072A patent/TW386081B/zh not_active IP Right Cessation
-
1995
- 1995-04-28 US US08/431,377 patent/US5552404A/en not_active Expired - Lifetime
-
2000
- 2000-10-27 GR GR20000402382T patent/GR3034695T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH09501156A (ja) | 1997-02-04 |
HUT72893A (en) | 1996-06-28 |
IL110512A0 (en) | 1994-10-21 |
EP0711289B1 (en) | 2000-08-23 |
CN1133593A (zh) | 1996-10-16 |
HU221726B1 (hu) | 2002-12-28 |
PT711289E (pt) | 2001-02-28 |
AU7235194A (en) | 1995-02-28 |
DE69425662T2 (de) | 2001-04-12 |
EP0711289A1 (en) | 1996-05-15 |
MY111348A (en) | 1999-11-30 |
CA2168432A1 (en) | 1995-02-09 |
DE69425662D1 (de) | 2000-09-28 |
ES2149881T3 (es) | 2000-11-16 |
GR3034695T3 (en) | 2001-01-31 |
HU9501982D0 (en) | 1995-09-28 |
ATE195733T1 (de) | 2000-09-15 |
CA2168432C (en) | 2004-03-23 |
US5552404A (en) | 1996-09-03 |
WO1995004051A1 (en) | 1995-02-09 |
TW386081B (en) | 2000-04-01 |
CN1054850C (zh) | 2000-07-26 |
IL110512A (en) | 1998-10-30 |
RU2133744C1 (ru) | 1999-07-27 |
AU692788B2 (en) | 1998-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0711289T3 (da) | Piperazinforbindelser til anvendelse i terapi | |
CA2129046A1 (en) | Opioid diarylmethylpiperazines and piperidines | |
ATE222754T1 (de) | Ultrafeines pulver zur inhalation und dessen herstellung | |
ZA955868B (en) | Substituted pyrimidine compounds and the use thereof | |
ATE132852T1 (de) | Tramadol n-oxid, dessen enantiomere und zusammensetzungen davon, und deren verwendung | |
DE69707461T2 (de) | Titandioxidteilchen, ihr herstellungsverfahren und ihre verwendung in kosmetika und lacken | |
TR200000726T2 (tr) | Budesonid ve formoterol'ün yeni kullanımı. | |
GEP20074165B (en) | Imidazolopyridines and methods of making and using the same | |
RS95904A (en) | Tri -substituted heteroaryls and methods for making and using the same | |
ZA951780B (en) | Prodrugs of morpholine tachykinin receptor antagonists | |
ZA200409814B (en) | 3-Z-(1-(4-(N-((4-methyl-piperazin-1-YL)-methylcarbnonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene)-6-methoxycarbonyl-2-indolinone-monoethanesulphonate and the use thereof as a pharmaceutical composition. | |
DE69531038D1 (de) | Adsorptionskörper enthaltend Aktivkohle, aktiviertes Aluminiumoxid und einen anorganischen Binder und Methode zu dessen Herstellung | |
ATE163042T1 (de) | Lactobazillusstämme menschlichen ursprungs, ihre zusammensetzung und deren verwendung | |
MXPA06000716A (es) | Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1. | |
IL139080A0 (en) | Btx inhibitors and methods for their indentification and use | |
DE60202624D1 (de) | Schmierbeständiger, aus nanoverbundmaterial bestehender hartüberzug und methode zu seiner herstellung | |
ATE352300T1 (de) | Zusammensetzung bestehend aus phentolaminmesylat und deren verwendung | |
EP1401960A4 (en) | BRAI OF HARD AND HYDROCARBON TAR MIXTURE, PREPARATION AND USE THEREOF | |
MY128639A (en) | 1,3-disubstituted pyrrolidines as alpha-2-adrenoceptor antagonists | |
ATE322288T1 (de) | Zusammensetzungen zur immunisierung sowie deren verwendung | |
GEP20074125B (en) | Pyrazolopyridines and methods of making and using the same | |
MXPA04004477A (es) | Antagonistas del neuropeptido neuroquinina-1(nk1). | |
DE59907544D1 (de) | Ventil zum dosierten einleiten von verflüchtigtem brennstoff | |
NZ335052A (en) | Piperazino derivatives as neurokinin antagonists | |
DE60324803D1 (de) | Russe und deren verwendung |