DK0707579T3 - Piperidinylsubstituerede methanoanthracener som D1/D2-antagonister og 5 HT2-serotanin-antagonister - Google Patents

Piperidinylsubstituerede methanoanthracener som D1/D2-antagonister og 5 HT2-serotanin-antagonister

Info

Publication number
DK0707579T3
DK0707579T3 DK94919752T DK94919752T DK0707579T3 DK 0707579 T3 DK0707579 T3 DK 0707579T3 DK 94919752 T DK94919752 T DK 94919752T DK 94919752 T DK94919752 T DK 94919752T DK 0707579 T3 DK0707579 T3 DK 0707579T3
Authority
DK
Denmark
Prior art keywords
antagonists
serotanin
methanoanthracenes
piperidinyl
substituted
Prior art date
Application number
DK94919752T
Other languages
English (en)
Inventor
Michael Thaddeus Klimas
Marc Ornal Terpko
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DK0707579T3 publication Critical patent/DK0707579T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • C07D211/52Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK94919752T 1993-07-09 1994-07-04 Piperidinylsubstituerede methanoanthracener som D1/D2-antagonister og 5 HT2-serotanin-antagonister DK0707579T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939314250A GB9314250D0 (en) 1993-07-09 1993-07-09 Piperidinyl compounds
PCT/GB1994/001439 WO1995001974A1 (en) 1993-07-09 1994-07-04 Piperidinyl substituted methanoanthracenes as d1/d2-antagonists and 5ht2-serotanin-antagonists

Publications (1)

Publication Number Publication Date
DK0707579T3 true DK0707579T3 (da) 1999-09-13

Family

ID=10738563

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94919752T DK0707579T3 (da) 1993-07-09 1994-07-04 Piperidinylsubstituerede methanoanthracener som D1/D2-antagonister og 5 HT2-serotanin-antagonister

Country Status (26)

Country Link
EP (1) EP0707579B1 (da)
JP (1) JP3031634B2 (da)
AP (1) AP521A (da)
AT (1) ATE175963T1 (da)
AU (1) AU687414B2 (da)
CA (1) CA2163994A1 (da)
CZ (1) CZ4496A3 (da)
DE (1) DE69416131T2 (da)
DK (1) DK0707579T3 (da)
DZ (1) DZ1796A1 (da)
ES (1) ES2128567T3 (da)
FI (1) FI960084A0 (da)
GB (2) GB9314250D0 (da)
HR (1) HRP940394A2 (da)
HU (1) HU219239B (da)
IL (1) IL110222A (da)
MY (1) MY111604A (da)
NO (1) NO960080L (da)
NZ (1) NZ268048A (da)
PL (1) PL312498A1 (da)
RU (1) RU2128178C1 (da)
SG (1) SG45425A1 (da)
SI (1) SI9400281A (da)
SK (1) SK2996A3 (da)
WO (1) WO1995001974A1 (da)
ZA (1) ZA944930B (da)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9117639D0 (en) * 1991-08-15 1991-10-02 Ici Plc Therapeutic compounds

Also Published As

Publication number Publication date
NZ268048A (en) 1997-10-24
HUT75116A (en) 1997-04-28
SK2996A3 (en) 1997-02-05
CZ4496A3 (en) 1996-06-12
IL110222A (en) 1999-09-22
EP0707579B1 (en) 1999-01-20
GB9314250D0 (en) 1993-08-18
WO1995001974A1 (en) 1995-01-19
GB9413235D0 (en) 1994-08-24
AP521A (en) 1996-08-05
AU687414B2 (en) 1998-02-26
FI960084A (fi) 1996-01-08
JPH08512308A (ja) 1996-12-24
SG45425A1 (en) 1998-01-16
IL110222A0 (en) 1994-10-21
CA2163994A1 (en) 1995-01-19
AU7077994A (en) 1995-02-06
NO960080D0 (no) 1996-01-08
PL312498A1 (en) 1996-04-29
ES2128567T3 (es) 1999-05-16
JP3031634B2 (ja) 2000-04-10
AP9400652A0 (en) 1994-07-31
FI960084A0 (fi) 1996-01-08
EP0707579A1 (en) 1996-04-24
ATE175963T1 (de) 1999-02-15
DZ1796A1 (fr) 2002-02-17
MY111604A (en) 2000-09-27
DE69416131T2 (de) 1999-06-10
HRP940394A2 (en) 1996-12-31
DE69416131D1 (de) 1999-03-04
ZA944930B (en) 1995-01-16
HU9503554D0 (en) 1996-02-28
SI9400281A (en) 1995-02-28
NO960080L (no) 1996-01-08
RU2128178C1 (ru) 1999-03-27
HU219239B (en) 2001-03-28

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