DK0702696T3 - Trifunktionelle antithrombin- og antiblodpladepeptider - Google Patents

Trifunktionelle antithrombin- og antiblodpladepeptider

Info

Publication number
DK0702696T3
DK0702696T3 DK94920004T DK94920004T DK0702696T3 DK 0702696 T3 DK0702696 T3 DK 0702696T3 DK 94920004 T DK94920004 T DK 94920004T DK 94920004 T DK94920004 T DK 94920004T DK 0702696 T3 DK0702696 T3 DK 0702696T3
Authority
DK
Denmark
Prior art keywords
trifunctional
antithrombin
platelet
peptides
platelet peptides
Prior art date
Application number
DK94920004T
Other languages
Danish (da)
English (en)
Inventor
Robert J Broersma Jr
Thomas J Owen
John L Krstenansky
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0702696T3 publication Critical patent/DK0702696T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK94920004T 1993-06-11 1994-05-13 Trifunktionelle antithrombin- og antiblodpladepeptider DK0702696T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7606693A 1993-06-11 1993-06-11
PCT/US1994/005355 WO1994029349A1 (en) 1993-06-11 1994-05-13 Trifunctional antithrombin and antiplatelet peptides

Publications (1)

Publication Number Publication Date
DK0702696T3 true DK0702696T3 (da) 2003-11-17

Family

ID=22129739

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94920004T DK0702696T3 (da) 1993-06-11 1994-05-13 Trifunktionelle antithrombin- og antiblodpladepeptider

Country Status (20)

Country Link
US (1) US5681925A (zh)
EP (1) EP0702696B1 (zh)
JP (1) JP3532920B2 (zh)
KR (1) KR100330465B1 (zh)
CN (1) CN1124964A (zh)
AT (1) ATE246203T1 (zh)
AU (1) AU685470B2 (zh)
CA (1) CA2164712C (zh)
DE (1) DE69432983T2 (zh)
DK (1) DK0702696T3 (zh)
ES (1) ES2199963T3 (zh)
FI (1) FI955905A0 (zh)
HU (1) HUT73187A (zh)
IL (1) IL109931A0 (zh)
NO (1) NO954991L (zh)
NZ (1) NZ268159A (zh)
PT (1) PT702696E (zh)
TW (1) TW295590B (zh)
WO (1) WO1994029349A1 (zh)
ZA (1) ZA943958B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235877B1 (en) 1999-08-04 2001-05-22 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
DE602005023429D1 (de) 2004-10-19 2010-10-21 Lonza Ag Verfahren zur festphasen-peptidsynthese
US9073974B2 (en) * 2009-12-21 2015-07-07 The Regents Of The University Of California RGD-containing cyclic peptides
WO2020036987A1 (en) 2018-08-13 2020-02-20 Signablok, Inc. Peptides and compositions for targeted treatment and imaging
CN117143194B (zh) * 2023-11-01 2024-02-06 北京大学第一医院 抗血小板聚集多肽、其制备方法及应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
AU3098289A (en) * 1988-03-04 1989-09-07 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
HUT57060A (en) * 1988-12-05 1991-11-28 Biogen Inc Process for producing compositions for inhibiting blood platelet aggregation
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides
CA2026376C (en) * 1989-10-03 2002-01-01 John L. Krstenansky Anticoagulant peptides
WO1991011458A1 (en) * 1990-02-02 1991-08-08 Genentech, Inc. CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
ES2111567T3 (es) * 1990-06-15 1998-03-16 Ca Nat Research Council Inhibidores de la trombina basados en la secuencia de aminoacidos de la hirudina.
IT1243358B (it) * 1990-07-23 1994-06-10 Iketon Farmaceutici Srl Composizioni farmaceutiche per la somministrazione orale di irudina
ZA915658B (en) * 1990-07-24 1992-05-27 Merrell Dow Pharma Analogs of hirudin having antiplatelet activity
US5118790A (en) * 1990-07-24 1992-06-02 Sri International Analogs of hirudin
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation

Also Published As

Publication number Publication date
EP0702696A1 (en) 1996-03-27
JP3532920B2 (ja) 2004-05-31
PT702696E (pt) 2003-12-31
CA2164712A1 (en) 1994-12-22
TW295590B (zh) 1997-01-11
JPH08511518A (ja) 1996-12-03
ZA943958B (en) 1995-02-22
WO1994029349A1 (en) 1994-12-22
ATE246203T1 (de) 2003-08-15
FI955905A (fi) 1995-12-08
EP0702696B1 (en) 2003-07-30
US5681925A (en) 1997-10-28
HU9503530D0 (en) 1996-02-28
IL109931A0 (en) 1994-10-07
FI955905A0 (fi) 1995-12-08
DE69432983T2 (de) 2004-04-29
AU7093894A (en) 1995-01-03
AU685470B2 (en) 1998-01-22
CN1124964A (zh) 1996-06-19
ES2199963T3 (es) 2004-03-01
KR100330465B1 (ko) 2002-11-23
CA2164712C (en) 2000-03-28
HUT73187A (en) 1996-06-28
NO954991L (no) 1996-02-15
DE69432983D1 (de) 2003-09-04
NZ268159A (en) 1997-03-24
NO954991D0 (no) 1995-12-08

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