DK0646596T3 - Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostik - Google Patents
Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostikInfo
- Publication number
- DK0646596T3 DK0646596T3 DK94113573T DK94113573T DK0646596T3 DK 0646596 T3 DK0646596 T3 DK 0646596T3 DK 94113573 T DK94113573 T DK 94113573T DK 94113573 T DK94113573 T DK 94113573T DK 0646596 T3 DK0646596 T3 DK 0646596T3
- Authority
- DK
- Denmark
- Prior art keywords
- branching
- nucleic acid
- diagnostics
- therapy
- binding oligomers
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4331011A DE4331011A1 (de) | 1993-09-13 | 1993-09-13 | Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0646596T3 true DK0646596T3 (da) | 1999-11-29 |
Family
ID=6497575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94113573T DK0646596T3 (da) | 1993-09-13 | 1994-08-31 | Nucleinsyre-bindende oligomerer med C-forgrening til terapi og diagnostik |
Country Status (11)
Country | Link |
---|---|
US (1) | US5849893A (da) |
EP (1) | EP0646596B1 (da) |
JP (1) | JPH07112969A (da) |
AT (1) | ATE180494T1 (da) |
AU (1) | AU7161994A (da) |
CA (1) | CA2131760A1 (da) |
DE (2) | DE4331011A1 (da) |
DK (1) | DK0646596T3 (da) |
ES (1) | ES2131612T3 (da) |
GR (1) | GR3030708T3 (da) |
SI (1) | SI0646596T1 (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7825215B1 (en) * | 1993-04-26 | 2010-11-02 | Peter E. Nielsen | Substituted nucleic acid mimics |
DE4331012A1 (de) * | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
US6133444A (en) | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
WO1996015143A1 (en) * | 1994-11-14 | 1996-05-23 | Chiron Corporation | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH |
JP2001518054A (ja) | 1995-06-07 | 2001-10-09 | パーセプティブ バイオシステムズ,インコーポレーテッド | Pna−dnaキメラと、このキメラ合成用のpnaシントン |
GB9621367D0 (en) | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
US6054568A (en) * | 1998-01-16 | 2000-04-25 | The Perkin-Elmer Corporation | Nucleobase oligomers |
US6030997A (en) * | 1998-01-21 | 2000-02-29 | Eilat; Eran | Acid labile prodrugs |
EP1171435A2 (de) * | 1999-04-13 | 2002-01-16 | Basf Aktiengesellschaft | Pyrimidin-2-on derivate als integrinrezeptorliganden |
HUP9902217A3 (en) * | 1999-06-29 | 2002-07-29 | Szegoe Peter | Polycation based bioconjugates and process for producing thereof |
US6716961B2 (en) | 2001-10-30 | 2004-04-06 | Isis Innovation Limited | Chiral peptide nucleic acids with a N-aminoethyl-d-proline backbone |
ES2316776T3 (es) * | 2002-02-04 | 2009-04-16 | Isis Innovation Limited | Acidos nucleicos de peptidos de pirrolidinilo. |
WO2004022578A2 (en) * | 2002-09-08 | 2004-03-18 | Applera Corporation | Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis |
WO2008070525A1 (en) * | 2006-12-04 | 2008-06-12 | Luminex Corporation | Oxocarbonamide peptide nucleic acids and methods of using same |
CA2953747A1 (en) | 2013-06-28 | 2014-12-31 | Auckland Uniservices Limited | Amino acid and peptide conjugates and conjugation process |
WO2016103192A1 (en) | 2014-12-23 | 2016-06-30 | Margaret Anne Brimble | Amino acid and peptide conjugates and uses thereof |
EA201891639A1 (ru) | 2016-02-26 | 2019-06-28 | Окленд Юнисервисес Лимитед | Аминокислотные и пептидные конъюгаты и способ конъюгации |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3650349T2 (de) * | 1985-03-15 | 1995-12-14 | Antivirals Inc | Immunotestmittel für polynukleotid und verfahren. |
US4994368A (en) * | 1987-07-23 | 1991-02-19 | Syntex (U.S.A.) Inc. | Amplification method for polynucleotide assays |
US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
DK51092D0 (da) * | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
JPH07500820A (ja) * | 1991-09-05 | 1995-01-26 | ユニバーシティ オブ コネティカット | ポリヌクレオチド又はオリゴヌクレオチドの細胞への標的を定めた送達 |
-
1993
- 1993-09-13 DE DE4331011A patent/DE4331011A1/de not_active Withdrawn
-
1994
- 1994-08-31 ES ES94113573T patent/ES2131612T3/es not_active Expired - Lifetime
- 1994-08-31 DE DE59408308T patent/DE59408308D1/de not_active Expired - Fee Related
- 1994-08-31 EP EP94113573A patent/EP0646596B1/de not_active Expired - Lifetime
- 1994-08-31 DK DK94113573T patent/DK0646596T3/da active
- 1994-08-31 SI SI9430250T patent/SI0646596T1/xx unknown
- 1994-08-31 AT AT94113573T patent/ATE180494T1/de active
- 1994-09-01 AU AU71619/94A patent/AU7161994A/en not_active Abandoned
- 1994-09-07 JP JP6238619A patent/JPH07112969A/ja active Pending
- 1994-09-09 CA CA002131760A patent/CA2131760A1/en not_active Abandoned
-
1996
- 1996-09-24 US US08/719,048 patent/US5849893A/en not_active Expired - Fee Related
-
1999
- 1999-07-07 GR GR990401791T patent/GR3030708T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0646596A1 (de) | 1995-04-05 |
US5849893A (en) | 1998-12-15 |
EP0646596B1 (de) | 1999-05-26 |
DE4331011A1 (de) | 1995-03-16 |
CA2131760A1 (en) | 1995-03-14 |
DE59408308D1 (de) | 1999-07-01 |
AU7161994A (en) | 1995-03-23 |
ATE180494T1 (de) | 1999-06-15 |
GR3030708T3 (en) | 1999-11-30 |
ES2131612T3 (es) | 1999-08-01 |
JPH07112969A (ja) | 1995-05-02 |
SI0646596T1 (en) | 1999-08-31 |
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