DK0644899T3 - Fremstilling af rekombinant humant lactoferrin - Google Patents

Fremstilling af rekombinant humant lactoferrin

Info

Publication number
DK0644899T3
DK0644899T3 DK93912287T DK93912287T DK0644899T3 DK 0644899 T3 DK0644899 T3 DK 0644899T3 DK 93912287 T DK93912287 T DK 93912287T DK 93912287 T DK93912287 T DK 93912287T DK 0644899 T3 DK0644899 T3 DK 0644899T3
Authority
DK
Denmark
Prior art keywords
human lactoferrin
recombinant human
preparation
lactoferrin protein
production
Prior art date
Application number
DK93912287T
Other languages
Danish (da)
English (en)
Inventor
Denis R Lishin Aghnacur Headon
Bert W O'malley
Orla M Conneely
Gregory S May
Original Assignee
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Application granted granted Critical
Publication of DK0644899T3 publication Critical patent/DK0644899T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK93912287T 1992-04-24 1993-04-16 Fremstilling af rekombinant humant lactoferrin DK0644899T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87330492A 1992-04-24 1992-04-24
PCT/US1993/003614 WO1993022348A1 (en) 1992-04-24 1993-04-16 Production of recombinant human lactoferrin

Publications (1)

Publication Number Publication Date
DK0644899T3 true DK0644899T3 (da) 1999-09-27

Family

ID=25361366

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912287T DK0644899T3 (da) 1992-04-24 1993-04-16 Fremstilling af rekombinant humant lactoferrin

Country Status (19)

Country Link
US (1) US5571896A (ja)
EP (1) EP0644899B1 (ja)
JP (1) JP2824332B2 (ja)
KR (2) KR0184693B1 (ja)
CN (2) CN1047204C (ja)
AT (1) ATE177473T1 (ja)
AU (1) AU681583B2 (ja)
BR (1) BR9306289A (ja)
CA (1) CA2134094C (ja)
DE (1) DE69323879T2 (ja)
DK (1) DK0644899T3 (ja)
ES (1) ES2132232T3 (ja)
GR (1) GR3029942T3 (ja)
HK (1) HK1027360A1 (ja)
IL (1) IL105400A (ja)
NZ (1) NZ252844A (ja)
SG (1) SG47605A1 (ja)
WO (1) WO1993022348A1 (ja)
ZA (1) ZA932568B (ja)

Families Citing this family (49)

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US6066469A (en) * 1990-03-08 2000-05-23 Ferro Dynamics, Inc. Cloning, expression, and uses of human lactoferrin
JP3529423B2 (ja) * 1994-04-01 2004-05-24 森永乳業株式会社 抗菌性ペプチドの製造方法
FR2735983B1 (fr) 1995-06-29 1997-12-05 Centre Nat Rech Scient Peptide permettant de modifier l'activite du systeme immunitaire humain ou animal
DE19540233B4 (de) * 1995-10-19 2005-08-25 Schering Ag Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
WO1998033509A2 (en) * 1997-02-03 1998-08-06 Pharming Intellectual Property Bv Useful properties of human lactoferrin and variants thereof
WO2000004132A1 (en) * 1998-07-15 2000-01-27 Samyang Genex Corporation Mass production method of lactoferrin polypeptide from yeast and useful microorganism thereof
US6423509B1 (en) 1998-07-15 2002-07-23 Samyang Genex Corporation Pichia pastoris strain for producing lactoferrin and methods of use
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
AU7042000A (en) * 1999-10-19 2001-05-14 Easy Bio System, Inc. Recombinant yeast strain for expressing human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin and process for preparation recombinant human lactoferrin, n-lobe lactoferrin, c-lobe lactoferrin using the same
US20080050503A1 (en) * 2000-05-02 2008-02-28 Ning Huang Expression of human milk proteins in transgenic plants
US7417178B2 (en) * 2000-05-02 2008-08-26 Ventria Bioscience Expression of human milk proteins in transgenic plants
US7138150B2 (en) * 2000-05-02 2006-11-21 Ventria Bioscience Method of making an anti-infective composition for treating oral infections
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
US20070031440A1 (en) * 2001-08-30 2007-02-08 Prior Christopher P Modified transferin-antibody fusion proteins
US7176278B2 (en) * 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
EP1427750B1 (en) * 2001-08-30 2010-12-08 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
US20030226155A1 (en) * 2001-08-30 2003-12-04 Biorexis Pharmaceutical Corporation Modified transferrin-antibody fusion proteins
EP1478379A4 (en) * 2001-12-28 2005-12-21 Campina Bv HUMANIZED LACTOFERRIN AND ITS APPLICATIONS
WO2003094952A1 (en) * 2002-05-10 2003-11-20 Agennix Incorporated Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
AU2003233583A1 (en) * 2002-05-24 2003-12-12 Agennix Incorporated Oral lactoferrin in the treatment of respiratory disorders
US20060105387A1 (en) * 2002-08-30 2006-05-18 Prior Christopher P Transferrin fusion proteins libraries
US20060130158A1 (en) * 2002-08-30 2006-06-15 Turner Andrew J Modified transferrin fusion proteins comprising duplicate transferrin amino or carboxy terminal domains
WO2004024180A1 (en) 2002-09-16 2004-03-25 Agennix Incorporated Lactoferrin compositions and methods of wound treatment
AU2003298906A1 (en) * 2002-12-06 2004-06-30 Agennix Incorporated Oral lactoferrin in the treatment of sepsis
AU2003296447A1 (en) * 2002-12-10 2004-06-30 Agennix Incorporated Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
US20070060512A1 (en) * 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
KR100468596B1 (ko) * 2003-04-04 2005-01-27 (주) 디지탈바이오텍 메탄올자화효모인 피치아 패스토리스를 이용하여 인간락토페린을 생산하는 방법, 이 방법에 의해 제조된 인간락토페린 및 피치아 패스토리스 균주
US7379700B2 (en) * 2003-05-06 2008-05-27 Canon Kabushiki Kaisha Image reading apparatus with rotatable internal and external guides
WO2005046571A2 (en) * 2003-06-06 2005-05-26 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20040259770A1 (en) * 2003-06-19 2004-12-23 Rush University Medical Center Method for determining leukocyte activation
US20050075277A1 (en) * 2003-07-10 2005-04-07 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
EP1663278A4 (en) * 2003-08-28 2009-07-29 Biorexis Pharmaceutical Corp EPO MIMETIC PEPTIDES AND FUSION PROTEINS
US20060205037A1 (en) * 2003-08-28 2006-09-14 Homayoun Sadeghi Modified transferrin fusion proteins
GB0329722D0 (en) * 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
US7125963B2 (en) * 2004-03-03 2006-10-24 En N Tech Inc Treatments for contaminant reduction in lactoferrin preparations and lactoferrin containing compositions
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
DK2330200T3 (en) 2004-12-23 2017-07-24 Albumedix As GENE EXPRESSION TECHNIQUE
WO2007150049A2 (en) 2006-06-22 2007-12-27 Agennix Incorporated Lactoferrin as a radioprotective agent
CA2658654A1 (en) 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
NZ583234A (en) 2007-07-10 2012-06-29 Glanbia Nutritionals Method for removing endotoxin from proteins
WO2011104352A1 (en) 2010-02-25 2011-09-01 Agennix Ag Oral lactoferrin in the treatment of severe sepsis
EP2851421B1 (en) 2012-07-03 2018-11-28 Kao Corporation Useful microorganism, and method for producing substance of interest
KR20210091206A (ko) * 2018-11-06 2021-07-21 아르헬 프로젝티랜제 인 인제나이어링 디.오.오. 우유, 초유 및 산 또는 스위트 유청으로부터 고도로 정제된 락토페린 및 락토퍼옥시다제를 제조하는 방법
KR200494603Y1 (ko) 2019-12-09 2021-11-12 한국청소년활동진흥원 타워형 구조를 이루는 기술 융합형 조립 교구

Family Cites Families (10)

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US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
AU619458B2 (en) * 1987-01-30 1992-01-30 Board Of Trustees Of The Leland Stanford Junior University Lymphocyte inhibition by hla peptides
WO1989001969A1 (en) * 1987-09-04 1989-03-09 Novo-Nordisk A/S Process for the production of protein products in aspergillus and promoters for use in aspergillus
IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5155037A (en) * 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
WO1991013982A1 (en) * 1990-03-08 1991-09-19 Ferrodynamics, Inc. Genetically engineered human lactoferrin
JP2818056B2 (ja) * 1990-09-07 1998-10-30 森永乳業株式会社 抗菌性ペプチドおよび抗菌剤

Also Published As

Publication number Publication date
DE69323879T2 (de) 1999-11-04
CN1250055A (zh) 2000-04-12
KR100221404B1 (en) 1999-10-01
AU681583B2 (en) 1997-09-04
JP2824332B2 (ja) 1998-11-11
SG47605A1 (en) 1998-04-17
DE69323879D1 (de) 1999-04-15
WO1993022348A1 (en) 1993-11-11
US5571896A (en) 1996-11-05
ZA932568B (en) 1993-11-12
AU4289293A (en) 1993-11-29
CA2134094C (en) 2004-01-06
NZ252844A (en) 1996-05-28
EP0644899A4 (en) 1996-06-26
JPH08504561A (ja) 1996-05-21
IL105400A (en) 2003-03-12
CN1047204C (zh) 1999-12-08
ATE177473T1 (de) 1999-03-15
CA2134094A1 (en) 1993-11-11
KR0184693B1 (ko) 1999-04-01
KR950701348A (ko) 1995-03-23
EP0644899A1 (en) 1995-03-29
CN1079780A (zh) 1993-12-22
HK1027360A1 (en) 2001-01-12
BR9306289A (pt) 1998-06-30
GR3029942T3 (en) 1999-07-30
EP0644899B1 (en) 1999-03-10
CN1161382C (zh) 2004-08-11
IL105400A0 (en) 1993-08-18
ES2132232T3 (es) 1999-08-16

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