DK0622376T3 - Amorphous monospheric forms of insulin derivatives - Google Patents

Amorphous monospheric forms of insulin derivatives

Info

Publication number
DK0622376T3
DK0622376T3 DK94106196T DK94106196T DK0622376T3 DK 0622376 T3 DK0622376 T3 DK 0622376T3 DK 94106196 T DK94106196 T DK 94106196T DK 94106196 T DK94106196 T DK 94106196T DK 0622376 T3 DK0622376 T3 DK 0622376T3
Authority
DK
Denmark
Prior art keywords
monospheric
amorphous
forms
insulin derivatives
water
Prior art date
Application number
DK94106196T
Other languages
Danish (da)
Inventor
Walter Sabel
Rainer Dr Obermeier
Peter Deil
Karl Dr Geisen
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0622376T3 publication Critical patent/DK0622376T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Abstract

A process for the preparation of an amorphous monospheric form of insulin derivatives entails the insulin derivative being dissolved in an n-propanol/buffer mixture at a pH of 4.5 to 6.5, adjusting to an n-propanol content of more than 13% based on water, and subsequently diluting the resulting solution with water.
DK94106196T 1993-04-27 1994-04-21 Amorphous monospheric forms of insulin derivatives DK0622376T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4313702 1993-04-27

Publications (1)

Publication Number Publication Date
DK0622376T3 true DK0622376T3 (en) 2001-11-12

Family

ID=6486458

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94106196T DK0622376T3 (en) 1993-04-27 1994-04-21 Amorphous monospheric forms of insulin derivatives

Country Status (8)

Country Link
US (1) US5466666A (en)
EP (1) EP0622376B1 (en)
JP (1) JP3532956B2 (en)
AT (1) ATE203998T1 (en)
DE (1) DE59409816D1 (en)
DK (1) DK0622376T3 (en)
ES (1) ES2161726T3 (en)
GR (1) GR3036840T3 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19903125B4 (en) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Process for drying crystals of insulin or insulin analogues
EP1545460A4 (en) * 2001-12-20 2005-11-16 Lilly Co Eli Insulin molecule having protracted time action
KR20050121748A (en) * 2003-04-29 2005-12-27 일라이 릴리 앤드 캄파니 Insulin analogs having protracted time action
MX2010009033A (en) * 2008-02-19 2010-12-21 Biocon Ltd A method of obtaining purified heterologous insulins expressed in yeast.
PL239062B1 (en) * 2016-01-22 2021-11-02 Inst Biotechnologii I Antybiotykow Method for producing insulin and its derivatives and the hybrid peptide used in this method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333640A1 (en) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt METHOD FOR THE PRODUCTION OF INSULIN DERIVATIVES, THE B-CHAIN C-TERMINAL EXTENDED, NEW BASICALLY MODIFIED INSULIN DERIVATIVES, THE MEANS CONTAINING THEM AND THEIR USE
DE4012818A1 (en) * 1990-04-21 1991-10-24 Hoechst Ag METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES
ES2061797T3 (en) * 1988-06-23 1994-12-16 Hoechst Ag MINI-PROINSULIN, ITS PREPARATION AND EMPLOYMENT.
DE3837825A1 (en) * 1988-11-08 1990-05-10 Hoechst Ag NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
IL95495A (en) * 1989-08-29 1996-10-16 Hoechst Ag Fusion proteins their preparation and use

Also Published As

Publication number Publication date
US5466666A (en) 1995-11-14
JP3532956B2 (en) 2004-05-31
GR3036840T3 (en) 2002-01-31
ES2161726T3 (en) 2001-12-16
EP0622376A1 (en) 1994-11-02
EP0622376B1 (en) 2001-08-08
ATE203998T1 (en) 2001-08-15
JPH06321990A (en) 1994-11-22
DE59409816D1 (en) 2001-09-13

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