DK0536399T3 - Hidtil ukendt arylalkanonylaminderivat og lægemiddel indeholdende samme - Google Patents
Hidtil ukendt arylalkanonylaminderivat og lægemiddel indeholdende sammeInfo
- Publication number
- DK0536399T3 DK0536399T3 DK91910447.1T DK91910447T DK0536399T3 DK 0536399 T3 DK0536399 T3 DK 0536399T3 DK 91910447 T DK91910447 T DK 91910447T DK 0536399 T3 DK0536399 T3 DK 0536399T3
- Authority
- DK
- Denmark
- Prior art keywords
- same
- derivative
- alkanonylamine
- aryl
- drug containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14728190 | 1990-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0536399T3 true DK0536399T3 (da) | 1996-06-03 |
Family
ID=15426662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91910447.1T DK0536399T3 (da) | 1990-06-07 | 1991-06-07 | Hidtil ukendt arylalkanonylaminderivat og lægemiddel indeholdende samme |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5407950A (fr) |
| EP (1) | EP0536399B1 (fr) |
| AT (1) | ATE133407T1 (fr) |
| AU (1) | AU643300B2 (fr) |
| CA (1) | CA2084204A1 (fr) |
| DE (1) | DE69116692T2 (fr) |
| DK (1) | DK0536399T3 (fr) |
| WO (1) | WO1991018877A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012474A1 (fr) | 1992-11-20 | 1994-06-09 | Japan Tobacco Inc. | Compose inhibant la prolyle endopeptidase et utilisation pharmaceutique de ce dernier |
| JP3810097B2 (ja) * | 1993-01-15 | 2006-08-16 | 明治製菓株式会社 | ピロリジン−２−イルカルボニル複素環式化合物誘導体 |
| PL350453A1 (en) * | 1999-03-15 | 2002-12-16 | Axys Pharmaceuticals | N−cyanomethyl amides as protease inhibitors |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| CA2433520A1 (fr) | 2000-12-22 | 2002-07-04 | Axys Pharmaceuticals, Inc. | Composes et compositions en tant qu'inhibiteurs de cathepsine |
| IL160819A0 (en) | 2001-09-14 | 2004-08-31 | Aventis Pharma Inc | Novel compounds and compositions as cathepsin inhibitors |
| BR0214104A (pt) | 2001-11-14 | 2004-09-28 | Aventis Pharma Inc | Oligopeptìdeos e composições contendo os mesmos como inibidores de catepsina |
| FI20030014A0 (fi) * | 2003-01-03 | 2003-01-03 | Orion Corp | Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä |
| ATE462432T1 (de) | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| NZ546887A (en) | 2003-11-03 | 2009-04-30 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| AU2005210004B2 (en) | 2004-02-05 | 2010-10-28 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| CA2599419A1 (fr) * | 2005-04-22 | 2006-11-02 | Alantos Pharmaceuticals Holding, Inc. | Inhibiteurs de la dipeptidyl peptidase iv |
| EP1760076A1 (fr) * | 2005-09-02 | 2007-03-07 | Ferring B.V. | Inhibiteur de FAP |
| EP2089383B1 (fr) | 2006-11-09 | 2015-09-16 | Probiodrug AG | Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies |
| JP5523107B2 (ja) | 2006-11-30 | 2014-06-18 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
| WO2008104580A1 (fr) | 2007-03-01 | 2008-09-04 | Probiodrug Ag | Nouvelle utilisation d'inhibiteurs de la glutaminyl cyclase |
| US9656991B2 (en) | 2007-04-18 | 2017-05-23 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008144748A1 (fr) * | 2007-05-21 | 2008-11-27 | The Uab Research Foundation | Inhibiteurs de la prolyle endopeptidase pour la réduction ou la prévention de l'inflammation neutrophilique |
| ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
| EP2542549B1 (fr) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibiteurs de glutaminyl cyclase |
| EP2545047B9 (fr) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Inhibiteurs hétérocycliques de la glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| WO2012123563A1 (fr) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Dérivés de benzimidazole en tant qu'inhibiteurs de la glutaminyl cyclase |
| DE102016116130A1 (de) * | 2016-08-30 | 2018-03-01 | Universität Bielefeld | Verfahren zur Herstellung chiraler Aminonitrile |
| DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3680578D1 (de) * | 1985-04-16 | 1991-09-05 | Suntory Ltd | Dipeptid-derivate, verfahren zur herstellung, pharmazeutische zusammensetzungen und ihre anwendung. |
| JP2526084B2 (ja) * | 1987-02-23 | 1996-08-21 | 小野薬品工業株式会社 | 新規なチアゾリジン誘導体 |
| DE3712364A1 (de) * | 1987-04-11 | 1988-10-27 | Hoechst Ag | Neue pyrrolidin-2-(1,3-dicarbonyl)-derivate, verfahren zu ihrer herstellung, sie enthaltende mittel sowie deren verwendung |
| US4857524A (en) * | 1987-08-08 | 1989-08-15 | Kissei Pharmaceutical Co., Ltd. | Thiazolidine compounds and therapeutic method |
| JPH0670023B2 (ja) * | 1987-08-08 | 1994-09-07 | キッセイ薬品工業株式会社 | チアゾリジン誘導体 |
| JPH01250370A (ja) * | 1987-12-23 | 1989-10-05 | Zeria Pharmaceut Co Ltd | 新規アミノ酸イミド誘導体、製法ならびに用途 |
| US5212191A (en) * | 1988-04-08 | 1993-05-18 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
| US5053414A (en) * | 1988-04-08 | 1991-10-01 | Ono Pharmaceutical Co., Ltd. | Heterocyclic compounds |
| CA2004028C (fr) * | 1988-12-08 | 1998-09-22 | Motoki Torizuka | Derives condenses de benzene |
| US5118811A (en) * | 1989-04-13 | 1992-06-02 | Japan Tobacco Inc. | Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities |
-
1991
- 1991-06-07 DK DK91910447.1T patent/DK0536399T3/da active
- 1991-06-07 AT AT91910447T patent/ATE133407T1/de not_active IP Right Cessation
- 1991-06-07 US US07/952,499 patent/US5407950A/en not_active Expired - Fee Related
- 1991-06-07 CA CA002084204A patent/CA2084204A1/fr not_active Abandoned
- 1991-06-07 AU AU79866/91A patent/AU643300B2/en not_active Ceased
- 1991-06-07 DE DE69116692T patent/DE69116692T2/de not_active Expired - Fee Related
- 1991-06-07 EP EP91910447A patent/EP0536399B1/fr not_active Expired - Lifetime
- 1991-06-07 WO PCT/JP1991/000771 patent/WO1991018877A1/fr active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2084204A1 (fr) | 1991-12-08 |
| EP0536399A1 (fr) | 1993-04-14 |
| WO1991018877A1 (fr) | 1991-12-12 |
| ATE133407T1 (de) | 1996-02-15 |
| DE69116692T2 (de) | 1996-09-05 |
| AU7986691A (en) | 1991-12-31 |
| US5407950A (en) | 1995-04-18 |
| EP0536399B1 (fr) | 1996-01-24 |
| AU643300B2 (en) | 1993-11-11 |
| DE69116692D1 (de) | 1996-03-07 |
| EP0536399A4 (en) | 1993-04-21 |
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