DK0494665T3 - Fremgangsmåde til fremstilling af 6,12-dihydro-6-hydroxy-cannabidiol og anvendelse deraf til fremstilling af transdelta-9-tetrahydrocannabinol - Google Patents
Fremgangsmåde til fremstilling af 6,12-dihydro-6-hydroxy-cannabidiol og anvendelse deraf til fremstilling af transdelta-9-tetrahydrocannabinolInfo
- Publication number
- DK0494665T3 DK0494665T3 DK92100258.0T DK92100258T DK0494665T3 DK 0494665 T3 DK0494665 T3 DK 0494665T3 DK 92100258 T DK92100258 T DK 92100258T DK 0494665 T3 DK0494665 T3 DK 0494665T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- cannabidiol
- tetrahydrocannabinol
- dihydro
- delta
- Prior art date
Links
- 229950011318 cannabidiol Drugs 0.000 title abstract 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- IRMPFYJSHJGOPE-UHFFFAOYSA-N olivetol Chemical compound CCCCCC1=CC(O)=CC(O)=C1 IRMPFYJSHJGOPE-UHFFFAOYSA-N 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/14—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon unsaturated bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4100441A DE4100441A1 (de) | 1991-01-09 | 1991-01-09 | Verfahren zur herstellung von 6,12-dihydro-6-hydroxy-cannabidiol und dessen verwendung zur herstellung von trans-delta-9-tetrahydrocannabinol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0494665T3 true DK0494665T3 (da) | 1995-08-28 |
Family
ID=6422735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92100258.0T DK0494665T3 (da) | 1991-01-09 | 1992-01-09 | Fremgangsmåde til fremstilling af 6,12-dihydro-6-hydroxy-cannabidiol og anvendelse deraf til fremstilling af transdelta-9-tetrahydrocannabinol |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5227537A (da) |
| EP (1) | EP0494665B1 (da) |
| JP (1) | JP2637659B2 (da) |
| AT (1) | ATE121066T1 (da) |
| DE (2) | DE4100441A1 (da) |
| DK (1) | DK0494665T3 (da) |
| ES (1) | ES2071351T3 (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5342971A (en) * | 1992-12-29 | 1994-08-30 | The Australian National University | Process for the preparation of dibenzo[b,d]pyrans |
| CA2329626A1 (en) | 1998-04-21 | 1999-10-28 | The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services | Cannabinoids as antioxidants and neuroprotectants |
| US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
| EP1189603A2 (en) | 1999-03-22 | 2002-03-27 | Immugen Pharmaceuticals, Inc. | Treatment of immune diseases like hiv disease and neoplastic disorders |
| US20020137802A1 (en) * | 2000-09-28 | 2002-09-26 | Travis Craig R. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| US6541510B2 (en) * | 2000-09-28 | 2003-04-01 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
| DE10051427C1 (de) * | 2000-10-17 | 2002-06-13 | Adam Mueller | Verfahren zur Herstellung eines Tetrahydrocannabinol- und Cannabidiol-haltigen Extraktes aus Cannabis-Pflanzenmaterial sowie Cannabis-Extrakte |
| AU2008200935B2 (en) * | 2001-02-05 | 2010-02-04 | Thc Pharm The Health Concept Gmbh | Method for the Production of Dronabinol |
| DE10106024B4 (de) * | 2001-02-09 | 2004-10-14 | Thc Pharm Gmbh | Verfahren zur Herstellung von Dronabinol |
| GB0112748D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Uncatalysed addition reactions |
| GB0112752D0 (en) * | 2001-05-25 | 2001-07-18 | Johnson Matthey Plc | Synthesis of cannabinoids |
| AU2002331595A1 (en) * | 2001-08-15 | 2003-03-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Novel vasoconstrictor cannabinoid analogs |
| AU2003214226A1 (en) * | 2002-03-18 | 2003-10-08 | Immugen Pharmaceuticals, Inc. | Topical formulations of resorcinols and cannibinoids and methods of use |
| PT2311475T (pt) * | 2002-08-14 | 2016-09-22 | Gw Pharma Ltd | Extração de canabinoides farmaceuticamente ativos a partir de material vegetal |
| US7344736B2 (en) * | 2002-08-14 | 2008-03-18 | Gw Pharma Limited | Extraction of pharmaceutically active components from plant materials |
| WO2004092101A2 (en) * | 2003-04-10 | 2004-10-28 | Mallinckrodt Inc. | Olivetol-cyclodextrin complexes and regio-selective process for preparing delta 9-tetrahydrocannabinol |
| CN1809552A (zh) * | 2003-05-20 | 2006-07-26 | 田纳西大学研究基金会 | ***素衍生物、其制备方法和用途 |
| US20070287843A1 (en) * | 2004-04-07 | 2007-12-13 | Cabaj John E | Methods and Intermediates for the Synthesis of Delta-9 Tetrahydrocannabinol |
| US7323576B2 (en) | 2004-10-01 | 2008-01-29 | Alphora Research Inc. | Synthetic route to dronabinol |
| TWI369203B (en) | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol |
| TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
| DE102005028937B4 (de) * | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| KR20080063800A (ko) * | 2005-09-29 | 2008-07-07 | 에이엠알 테크놀로지, 인크. | 델타-9-테트라히드로칸나비놀의 제조 방법 |
| US8323211B2 (en) * | 2006-06-01 | 2012-12-04 | Daniel Larkin | Sexually transmitted infection sampling device |
| CA2992923C (en) | 2014-07-21 | 2021-06-29 | Pharmaceutical Productions, Inc. | Solid dosage form composition for buccal and sublingual administration of cannabinoids |
| US10059683B2 (en) | 2015-07-10 | 2018-08-28 | Noramco, Inc. | Process for the production of cannabidiol and delta-9-tetrahydrocannabinol |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| AU2018239671A1 (en) | 2017-03-24 | 2019-10-10 | Trait Biosciences, Inc. | High level In vivo biosynthesis and isolation of water-soluble cannabinoids in plant systems |
| WO2019014395A1 (en) | 2017-07-11 | 2019-01-17 | Trait Biosciences, Inc. | GENERATION OF WATER-SOLUBLE CANNABINOID COMPOUNDS IN PLANT CELL SUSPENSION YEAST AND CROPS AND MATERIAL COMPOSITIONS |
| US10640482B2 (en) | 2017-07-21 | 2020-05-05 | University Of South Florida | Synthesis of cannabinoids |
| WO2019147873A2 (en) | 2018-01-24 | 2019-08-01 | Trait Biosciences, Inc. | Systems and methods for enhancing trichome formation and density in cannabis |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| US20200138772A1 (en) | 2018-07-09 | 2020-05-07 | Volker Berl | Stabilized formulations of cannabinoid compositions |
| WO2020031179A1 (en) | 2018-08-06 | 2020-02-13 | Beetlebung Pharma Ltd. | Methods for synthesis of cannabinoid compounds |
| EP3847148A2 (en) | 2018-09-05 | 2021-07-14 | Purisys LLC | Cannabidiol compositions having modified cannabinoid profiles |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| JP2022507668A (ja) * | 2018-11-14 | 2022-01-18 | エンバイオ リミテッド | カンナビノイドを調製するための方法および化合物 |
| CN111943813B (zh) | 2019-05-17 | 2023-04-14 | 上海特化医药科技有限公司 | ***二酚类化合物的制备方法 |
| WO2021019536A1 (en) | 2019-07-30 | 2021-02-04 | The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) | Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby |
| CN113087599A (zh) * | 2020-01-08 | 2021-07-09 | 成都百裕制药股份有限公司 | ***二酚衍生物及其制备方法和在医药上的应用 |
| EP4243808A1 (en) * | 2020-11-15 | 2023-09-20 | Technion Research & Development Foundation Limited | Cannabinoids, pharmaceutical compositions comprising same and uses thereof |
| US11242328B1 (en) * | 2021-02-25 | 2022-02-08 | Acid Neutral Alkaline Laboratory | Heterogeneous catalyst and method for preparation of aromatic tricyclic pyrans |
| US11352337B1 (en) * | 2021-06-02 | 2022-06-07 | Acid Neutral Alkaline Laboratory | Zeolite catalyst and method for preparation of aromatic tricyclic pyrans |
| EP4124336B1 (en) | 2021-07-30 | 2023-10-25 | Cannamedical Pharma GmbH | Transmucosal patch comprising a cannabinoid and/or an opioid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3656906A (en) * | 1970-04-13 | 1972-04-18 | Little Inc A | Method for detecting and quantitating the presence of cannabinoids and analogs thereof in biological materials and resulting products |
| US4116979A (en) * | 1975-06-23 | 1978-09-26 | Sheehan Institute For Research, Inc. | Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans |
| HU194858B (en) * | 1982-12-03 | 1988-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them |
| US4758597A (en) * | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
-
1991
- 1991-01-09 DE DE4100441A patent/DE4100441A1/de not_active Withdrawn
-
1992
- 1992-01-08 US US07/818,040 patent/US5227537A/en not_active Expired - Fee Related
- 1992-01-09 JP JP4002315A patent/JP2637659B2/ja not_active Expired - Fee Related
- 1992-01-09 EP EP92100258A patent/EP0494665B1/en not_active Expired - Lifetime
- 1992-01-09 ES ES92100258T patent/ES2071351T3/es not_active Expired - Lifetime
- 1992-01-09 DK DK92100258.0T patent/DK0494665T3/da active
- 1992-01-09 AT AT92100258T patent/ATE121066T1/de not_active IP Right Cessation
- 1992-01-09 DE DE69201959T patent/DE69201959T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5227537A (en) | 1993-07-13 |
| JPH06340650A (ja) | 1994-12-13 |
| DE69201959D1 (de) | 1995-05-18 |
| EP0494665A1 (en) | 1992-07-15 |
| ATE121066T1 (de) | 1995-04-15 |
| ES2071351T3 (es) | 1995-06-16 |
| EP0494665B1 (en) | 1995-04-12 |
| JP2637659B2 (ja) | 1997-08-06 |
| DE4100441A1 (de) | 1992-07-16 |
| DE69201959T2 (de) | 1995-08-24 |
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