DK0488470T3 - Fremgangsmåde til fremstilling af antistoffer - Google Patents

Fremgangsmåde til fremstilling af antistoffer

Info

Publication number
DK0488470T3
DK0488470T3 DK91203080.6T DK91203080T DK0488470T3 DK 0488470 T3 DK0488470 T3 DK 0488470T3 DK 91203080 T DK91203080 T DK 91203080T DK 0488470 T3 DK0488470 T3 DK 0488470T3
Authority
DK
Denmark
Prior art keywords
lymphocytes
producing antibodies
antibodies
immortalized
preceded
Prior art date
Application number
DK91203080.6T
Other languages
English (en)
Inventor
Petrus Gerardus A Steenbakkers
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of DK0488470T3 publication Critical patent/DK0488470T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/089—Cytomegalovirus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
DK91203080.6T 1990-11-26 1991-11-25 Fremgangsmåde til fremstilling af antistoffer DK0488470T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90203124 1990-11-26

Publications (1)

Publication Number Publication Date
DK0488470T3 true DK0488470T3 (da) 1997-12-22

Family

ID=8205174

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91203080.6T DK0488470T3 (da) 1990-11-26 1991-11-25 Fremgangsmåde til fremstilling af antistoffer

Country Status (12)

Country Link
EP (1) EP0488470B1 (da)
JP (1) JP3392883B2 (da)
KR (1) KR100223381B1 (da)
AT (1) ATE153695T1 (da)
AU (1) AU646108B2 (da)
CA (1) CA2056102C (da)
DE (1) DE69126281T2 (da)
DK (1) DK0488470T3 (da)
ES (1) ES2103770T3 (da)
GR (1) GR3024487T3 (da)
NZ (1) NZ240748A (da)
ZA (1) ZA919299B (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474755A (en) * 1984-01-31 1995-12-12 Akzo Nobel N.V. Tumor associated monoclonal antibodies
EP0650735A3 (en) * 1993-07-09 1999-04-14 Akzo Nobel N.V. Kit and method for pretargeting
WO1995021244A1 (en) * 1994-02-04 1995-08-10 Akzo Nobel N.V. Monoclonal antibody 88bv59, subclones and method of making
ZA9710391B (en) * 1996-12-06 1998-06-23 Akzo Nobel Nv Method of preparing a monoclonal antibody, monoclonal antibody, a pharmaceutical composition and a diagnostic reagent.
IL122233A (en) * 1996-12-06 2001-04-30 Akzo Nobel Nv Method of generating monoclonal antibodies to cell wall and pharmaceutical preparations and diagnostic agents containing them
US7037663B2 (en) 1998-02-19 2006-05-02 Eastern Virginia Medical School Human zona pellucida protein 3 and uses thereof
WO1999042581A1 (en) 1998-02-19 1999-08-26 Eastern Virginia Medical School RECOMBINANT ACTIVE HUMAN ZONA PELLUCIDA PROTEIN 3 (hZP3)
US6541225B1 (en) * 2000-01-26 2003-04-01 Raven Biotechnologies, Inc. Methods and compositions for generating human monoclonal antibodies
SE0002835D0 (sv) * 2000-08-07 2000-08-07 Karolinska Innovations Ab Method and kit for production of monoclonal antibodies
DE60129572T2 (de) 2000-08-14 2008-04-17 N.V. Organon Verwendung von antikörpern gegen spezifische mhc-peptidkomplexe
EP1421104A4 (en) 2001-08-02 2005-08-24 Trinity Biomedical Technology HUMANE ZONA PELLUCIDA PROTEINS AND METHOD FOR THEIR USE IN THE DIAGNOSIS OF MALE INFERENCE
EP1614749A4 (en) * 2003-03-28 2006-10-25 Toyama New Industry Organizaio METHOD OF CONSTRUCTING A HYBRIDOMA CELL PRODUCING AN ANTIGEN-SPECIFIC ANTIBODY USING A SINGLE ANTIGEN-SPECIFIC B-LYMPHOCYTE AND METHOD FOR THE PRODUCTION OF A MONOCLONAL ANTIBODY
GB0312481D0 (en) * 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
US7771969B2 (en) * 2003-08-20 2010-08-10 Celltech R&D Limited Methods for obtaining antibodies
ATE505535T1 (de) 2005-08-23 2011-04-15 Iq Corp Verfahren zur herstellung stabiler b-lymphozyten
MX2008014692A (es) * 2006-05-19 2009-08-18 Alder Biopharmaceuticals Inc Metodo de cultivo para obtener una poblacion clonal de celulas b especificas de antigeno.
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
HUE043782T2 (hu) 2007-05-21 2019-09-30 Alderbio Holdings Llc IL-6 elleni antitestek és alkalmazásuk
US9056905B2 (en) 2007-05-21 2015-06-16 Alderbio Holdings Llc Antibodies to TNF-α and use thereof
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
WO2011066374A2 (en) 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antagonists of il-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
ES2847891T3 (es) 2010-11-23 2021-08-04 Vitaeris Inc Anticuerpos anti-IL-6 para el tratamiento de la mucositis oral
EP4350345A2 (en) 2011-06-23 2024-04-10 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
US20180009888A9 (en) 2011-06-23 2018-01-11 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
EP2944654A1 (en) 2011-06-23 2015-11-18 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobin single variable domains
WO2014067642A1 (en) 2012-11-05 2014-05-08 Mab Discovery Gmbh Method for the production of multispecific antibodies
EP2727943A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Trispecific antibodies against human EGFR, HER2 and HER3
EP2727942A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Bispecific antibodies against human EGFR, HER2, and HER3
EP2727941A1 (en) 2012-11-05 2014-05-07 MAB Discovery GmbH Method for the production of multispecific antibodies
WO2014146074A2 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens
CN108026172B (zh) 2015-06-26 2022-04-29 赛诺菲生物技术公司 单克隆抗il-1racp抗体
JP7026634B2 (ja) * 2016-03-30 2022-02-28 エフ．ホフマン－ラ ロシュ アーゲー Ｂ細胞培養法
EP3241845A1 (en) 2016-05-06 2017-11-08 MAB Discovery GmbH Humanized anti-il-1r3 antibodies
EP3562936A1 (en) 2017-01-02 2019-11-06 H. Hoffnabb-La Roche Ag B-cell cultivation method
EP3401332A1 (en) 2017-05-08 2018-11-14 MAB Discovery GmbH Anti-il-1r3 antibodies for use in inflammatory conditions
WO2018210896A1 (en) 2017-05-19 2018-11-22 F. Hoffmann-La Roche Ag Method for the production of thymocyte supernatant
WO2019105864A1 (en) 2017-11-30 2019-06-06 F. Hoffmann-La Roche Ag B-cell cultivation method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6054687A (ja) * 1983-07-19 1985-03-29 スロ−ン−ケツタリング　インステイテユ−ト　フオ−　キヤンサ−　リサ−チ ヒト　モノクロ−ン抗体の製法
US4797473A (en) * 1986-06-25 1989-01-10 Regents Of The University Of Minnesota Monoclonal antibodies to unreduced, nonenzymatically-glycated proteins
DE4107765A1 (de) * 1990-07-28 1992-01-30 Schebo Tech Medizinisch Biolog Pankreas-elastase-1-spezifischer antikoerper, ein verfahren zu seiner gewinnung und ein testkit der solche antikoerper enthaelt

Also Published As

Publication number Publication date
KR100223381B1 (ko) 1999-10-15
EP0488470B1 (en) 1997-05-28
ATE153695T1 (de) 1997-06-15
KR920009987A (ko) 1992-06-26
GR3024487T3 (en) 1997-11-28
CA2056102C (en) 2003-03-25
ES2103770T3 (es) 1997-10-01
JPH0576383A (ja) 1993-03-30
CA2056102A1 (en) 1992-05-27
JP3392883B2 (ja) 2003-03-31
DE69126281T2 (de) 1997-10-16
AU8817391A (en) 1992-08-20
ZA919299B (en) 1992-08-26
AU646108B2 (en) 1994-02-10
NZ240748A (en) 1996-12-20
EP0488470A1 (en) 1992-06-03
DE69126281D1 (de) 1997-07-03

Similar Documents

Publication Publication Date Title
DK0488470T3 (da) Fremgangsmåde til fremstilling af antistoffer
DK0906426T3 (da) Antistoffer mod ED-B-domænet af fibronektin, deres konstruktion og anvendelser
ATE208820T1 (de) Humanisierte antikoerper
DE122004000017I1 (de) Monoklonaler Antik¦rper gegen ein Cytotoxin, denselben erzeugendes Hybridoma und Verfahren f}r die Herstellung des gereinigten Cytotoxin.
ES2103751T3 (es) Procedimiento para la obtencion de oxetanonas.
EP0134552A3 (en) Monoclonal antibody with a high affinity for digoxin
DK0380068T3 (da) Ekspressionssystem til fremstilling af kimære monoklonale antistoffer
DK0538754T3 (da) Anvendelse af antistofholdige præparater til immunundertrykkelse
FI873410A (fi) Kahden uuden hybridooman tuottamia apolipoproteiini-B-spesifisiä monoklonaalisia vasta-aineita
DK0840620T3 (da) IL-8-antagonister til behandling af astma
ES2114547T3 (es) Anticuerpos monoclonales contra el virus de la hepatitis c.
ES2115022T3 (es) Inmunoensayo de isotiazolonas.
NO962125D0 (no) Anti-idiotypiske antistoffer som induserer en immunrespons mot epidermal vekstfaktorreseptor
DE59309133D1 (de) Granulozytenbindende Antikörperkonstrukte, ihre Herstellung und Verwendung
DK0459450T3 (da) Monoklonalt antistof, som genkender membran-phospholipase A2 og immunobestemmelse af membran-phospho liphase A2
DK0491240T3 (da) Fremgangsmåde til fremstilling af vandopløselige sulfonerede diphosphaner
ES2059726T3 (es) Anticuerpos monoclonales que reconocen el itsp humano, hibridomas que producen los mismos, y su preparacion y uso.
EA200000705A1 (ru) Промежуточные соединения и способ синтеза 17-замещенных 16.бета.-арилокси 4-азастероидов
TW245721B (en) Monoclonal antibody specific to organophosphate pesticide monocrotophos
IT1267669B1 (it) Metodo per la produzione di anticorpi monoclonali specifici per le chemochine
KR960023044A (ko) 재조합 인간 에리스로포이에틴에 대한 단일클론항체 및 이를 생산하는 신규의 융합세포주