DK0477819T3 - Benzimidazolderivater, fremstilling og anvendelse heraf - Google Patents
Benzimidazolderivater, fremstilling og anvendelse herafInfo
- Publication number
- DK0477819T3 DK0477819T3 DK91116148.7T DK91116148T DK0477819T3 DK 0477819 T3 DK0477819 T3 DK 0477819T3 DK 91116148 T DK91116148 T DK 91116148T DK 0477819 T3 DK0477819 T3 DK 0477819T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- halogen
- alkyl
- independently
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Graft Or Block Polymers (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58690090A | 1990-09-24 | 1990-09-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0477819T3 true DK0477819T3 (da) | 1995-07-17 |
Family
ID=24347548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91116148.7T DK0477819T3 (da) | 1990-09-24 | 1991-09-23 | Benzimidazolderivater, fremstilling og anvendelse heraf |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0477819B1 (da) |
JP (1) | JP3203017B2 (da) |
KR (1) | KR100195770B1 (da) |
AT (1) | ATE119887T1 (da) |
AU (1) | AU635440B2 (da) |
CA (1) | CA2052041C (da) |
DE (1) | DE69108156T2 (da) |
DK (1) | DK0477819T3 (da) |
ES (1) | ES2072504T3 (da) |
FI (1) | FI103408B (da) |
IE (1) | IE67133B1 (da) |
NO (1) | NO180795C (da) |
NZ (1) | NZ239540A (da) |
PT (1) | PT99032B (da) |
ZA (1) | ZA916805B (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69224448T2 (de) * | 1991-06-24 | 1998-06-10 | Neurosearch As | Imidazol-Verbindungen, Verfahren zu ihrer Herstellung und ihre Anwendung |
US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
US5232899A (en) * | 1992-06-08 | 1993-08-03 | Imperial Chemical Industries Plc | Benzoxazolinones and their use as herbicides |
AU5433594A (en) * | 1992-11-19 | 1994-06-08 | Dainippon Pharmaceutical Co. Ltd. | 3,4-dihydro-1-(2-hydroxyphenyl)-2(1h)-quinoxalinone derivative and related compound |
DK154092D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
DK28893D0 (da) * | 1993-03-15 | 1993-03-15 | Neurosearch As | Benzimidazole derivater, deres fremstilling og anvendelse |
DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
US5637470A (en) * | 1994-05-13 | 1997-06-10 | Merck & Co., Inc. | Screening array using cells expressing recombinant α and β subunits of the mammalian large-conductance (maxi-K) potassium channel |
FR2722190B1 (fr) * | 1994-07-05 | 1996-10-04 | Sanofi Sa | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant |
US5565483A (en) * | 1995-06-07 | 1996-10-15 | Bristol-Myers Squibb Company | 3-substituted oxindole derivatives as potassium channel modulators |
TW504504B (en) * | 1996-11-26 | 2002-10-01 | Bristol Myers Squibb Co | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators |
US5893085A (en) * | 1997-06-10 | 1999-04-06 | Phillips; Ronald W. | Dynamic fuzzy logic process for identifying objects in three-dimensional data |
EP1011677A4 (en) * | 1997-08-28 | 2002-03-20 | Bristol Myers Squibb Co | 4-ARYL-3-AMINOQUINOLEIN-2-ONE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS |
EP1144387A1 (en) | 1998-12-04 | 2001-10-17 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
JP2002531549A (ja) * | 1998-12-04 | 2002-09-24 | ブリストル−マイヤーズ スクイブ カンパニー | カリウムチャネル・モジュレーターとしての3−置換−4−アリールキノリン−2−オン誘導体 |
JP2005533814A (ja) * | 2002-06-26 | 2005-11-10 | ポセイドン・ファーマスーティカルス・アクティーゼルスカブ | 新規ベンズイミダゾール−2−オン誘導体及びその使用方法 |
WO2004064835A1 (en) * | 2003-01-17 | 2004-08-05 | Neurosearch A/S | Use of ion channel modulating agents for treating pain |
ES2222831B2 (es) * | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+. |
PE20060572A1 (es) * | 2004-07-27 | 2006-06-27 | Novartis Ag | Compuestos de benzoimidazolona como inhibidores de hsp90 |
CA2680769C (en) | 2007-04-18 | 2015-10-13 | Kissei Pharmaceutical Co., Ltd. | Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH460028A (de) * | 1965-01-22 | 1968-07-31 | Wander Ag Dr A | Verfahren zur Herstellung von Benzimidazolonderivaten |
FR1561830A (da) * | 1968-05-08 | 1969-03-28 | ||
GB1408408A (en) * | 1971-11-24 | 1975-10-01 | Beecham Group Ltd | Benzimidazole derivatives |
GB1476949A (en) * | 1974-11-20 | 1977-06-16 | Wyeth John & Brother Ltd | Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions |
CH622009A5 (da) * | 1976-06-11 | 1981-03-13 | Ciba Geigy Ag | |
DE3042481A1 (de) * | 1980-11-11 | 1982-06-16 | A. Nattermann & Cie GmbH, 5000 Köln | (omega)-(2-oxo-benzazolinyl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3781173T2 (de) * | 1986-02-03 | 1992-12-17 | Janssen Pharmaceutica Nv | N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen. |
-
1991
- 1991-08-26 NZ NZ239540A patent/NZ239540A/en not_active IP Right Cessation
- 1991-08-28 ZA ZA916805A patent/ZA916805B/xx unknown
- 1991-08-28 AU AU82767/91A patent/AU635440B2/en not_active Ceased
- 1991-09-11 IE IE319791A patent/IE67133B1/en not_active IP Right Cessation
- 1991-09-11 FI FI914275A patent/FI103408B/fi not_active IP Right Cessation
- 1991-09-20 JP JP24194691A patent/JP3203017B2/ja not_active Expired - Fee Related
- 1991-09-20 KR KR1019910016522A patent/KR100195770B1/ko not_active IP Right Cessation
- 1991-09-23 EP EP91116148A patent/EP0477819B1/en not_active Expired - Lifetime
- 1991-09-23 AT AT91116148T patent/ATE119887T1/de not_active IP Right Cessation
- 1991-09-23 NO NO913728A patent/NO180795C/no unknown
- 1991-09-23 ES ES91116148T patent/ES2072504T3/es not_active Expired - Lifetime
- 1991-09-23 DK DK91116148.7T patent/DK0477819T3/da active
- 1991-09-23 CA CA002052041A patent/CA2052041C/en not_active Expired - Fee Related
- 1991-09-23 DE DE69108156T patent/DE69108156T2/de not_active Expired - Fee Related
- 1991-09-24 PT PT99032A patent/PT99032B/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI103408B1 (fi) | 1999-06-30 |
NO180795C (no) | 1997-06-25 |
EP0477819B1 (en) | 1995-03-15 |
CA2052041A1 (en) | 1992-03-25 |
ES2072504T3 (es) | 1995-07-16 |
KR100195770B1 (ko) | 1999-06-15 |
JP3203017B2 (ja) | 2001-08-27 |
NZ239540A (en) | 1993-11-25 |
FI914275A0 (fi) | 1991-09-11 |
AU635440B2 (en) | 1993-03-18 |
NO913728D0 (no) | 1991-09-23 |
DE69108156T2 (de) | 1995-07-06 |
DE69108156D1 (de) | 1995-04-20 |
CA2052041C (en) | 2002-08-20 |
JPH04305568A (ja) | 1992-10-28 |
KR920006327A (ko) | 1992-04-27 |
NO180795B (no) | 1997-03-17 |
ZA916805B (en) | 1992-05-27 |
AU8276791A (en) | 1992-03-26 |
ATE119887T1 (de) | 1995-04-15 |
IE67133B1 (en) | 1996-03-06 |
PT99032B (pt) | 1999-02-26 |
IE913197A1 (en) | 1992-02-25 |
FI103408B (fi) | 1999-06-30 |
NO913728L (no) | 1992-03-25 |
EP0477819A2 (en) | 1992-04-01 |
EP0477819A3 (en) | 1992-05-20 |
PT99032A (pt) | 1993-11-30 |
FI914275A (fi) | 1992-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0477819T3 (da) | Benzimidazolderivater, fremstilling og anvendelse heraf | |
DE68920654D1 (de) | 4-Oxochinolin-3-carbonsäure-Derivate, ihre Herstellung und ihre Verwendung. | |
ATE18355T1 (de) | Verwendung von adenosinderivaten zur herstellung eines psychopharmakons. | |
FI884955A (fi) | Konserverade haor- och hudrengoeringsmedel och anvaendning av en konserveringsmedelkombination. | |
DE59001281D1 (de) | Oxidierte diphenylheteroalkane, ihre herstellung und verwendung. | |
DK0399358T3 (da) | Butensyrederivater | |
FI941214A0 (fi) | Bentsimidatsolin johdannaisia, niiden valmistus ja käyttö | |
PT78155B (de) | N-(3-trifluormethylphenyl)-n'-propargylpiperazin seine herstellung und verwendung | |
ATE198750T1 (de) | Isatinoxim-derivate, ihre herstellung und verwendung | |
ATE17485T1 (de) | 3,7a-diazacyclohepta(j,k)fluorenderivate, ihre herstellung und ihre therapeutische verwendung. | |
SE7910612L (sv) | Metod att kontrollera hypertension och intestinala sjukdomar samt kompositioner | |
ATE114307T1 (de) | Phenylglycidamide, verwendbar in der herstellung von alpha-hydroxy-beta-sulfido-arylpropionsäure- derivaten. | |
DE69116187D1 (de) | Verwendung eines Dihydropyridins zur Verbesserung der Blutzirkulation des inneren Ohres | |
JPS53119825A (en) | 1,3-dithioallophanate derivatives, their preparation, insecticides, acaricides, and bactericides for agricultural and horticultural uses |