DK0432677T3 - N-(Pyrrolo(2,3-d)pyrimidin-3-ylacyl-glutaminsyrederivater - Google Patents

N-(Pyrrolo(2,3-d)pyrimidin-3-ylacyl-glutaminsyrederivater

Info

Publication number: DK0432677T3
Authority: DK; Denmark
Prior art keywords: ylacyl; pyrrolo; pyrimidine; glutamic acid; acid derivatives
Prior art date: 1989-12-11

Application number

DK90123671.1T

Other languages

English (en)

Inventor

Chuan Shih

Edward C Taylor

Dietmar G Kuhnt

Gerald B Grindey

Original Assignee

Univ Princeton

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-11

Filing date

1990-12-10

Publication date

1996-04-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27503964&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0432677(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-05-24 Priority claimed from US07/528,155 external-priority patent/US5028608A/en

1990-12-10 Application filed by Univ Princeton, Lilly Co Eli filed Critical Univ Princeton

1996-04-09 Application granted granted Critical

1996-04-09 Publication of DK0432677T3 publication Critical patent/DK0432677T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DK90123671.1T 1989-12-11 1990-12-10 N-(Pyrrolo(2,3-d)pyrimidin-3-ylacyl-glutaminsyrederivater DK0432677T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US44874289A	1989-12-11	1989-12-11
US47965590A	1990-02-08	1990-02-08
US07/528,155 US5028608A (en)	1989-12-11	1990-05-24	N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
US07/528,805 US4996206A (en)	1989-12-11	1990-05-24	N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

Publications (1)

Publication Number	Publication Date
DK0432677T3 true DK0432677T3 (da)	1996-04-09

Family

ID=27503964

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90123671.1T DK0432677T3 (da)	1989-12-11	1990-12-10	N-(Pyrrolo(2,3-d)pyrimidin-3-ylacyl-glutaminsyrederivater

Country Status (22)

Country	Link
EP (1)	EP0432677B1 (da)
JP (1)	JP3016876B2 (da)
CN (1)	CN1030608C (da)
AR (1)	AR245129A1 (da)
AT (1)	ATE135007T1 (da)
AU (1)	AU640182B2 (da)
CA (1)	CA2031890C (da)
CY (1)	CY2076B1 (da)
DE (2)	DE69025723T2 (da)
DK (1)	DK0432677T3 (da)
ES (1)	ES2084639T4 (da)
GR (1)	GR3019784T3 (da)
HK (1)	HK1000920A1 (da)
HU (1)	HU218483B (da)
IE (1)	IE904445A1 (da)
IL (1)	IL96531A (da)
LU (1)	LU91147I2 (da)
NL (1)	NL300181I2 (da)
NZ (1)	NZ236385A (da)
PT (1)	PT96140B (da)
RU (1)	RU2057131C9 (da)
SG (1)	SG48098A1 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5254687A (en)	1991-12-04	1993-10-19	The Trustees Of Princeton University	Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5235053A (en) *	1992-06-22	1993-08-10	Eli Lilly And Company	Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
EP2316468A1 (en)	2002-02-22	2011-05-04	Shire LLC	Delivery system and methods for protecting and administering dextroamphetamine
CN100344615C (zh) *	2004-11-25	2007-10-24	重庆医药工业研究院有限责任公司	制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
US20080161251A1 (en)	2005-01-21	2008-07-03	Astex Therapeutics Limited	Pharmaceutical Compounds
KR101101443B1 (ko)	2006-08-14	2012-01-03	시코르, 인크.	페메트렉세드의 중간체의 제조 방법
EP1934226A2 (en)	2006-08-14	2008-06-25	Sicor, Inc.	Highly pure pemetrexed diacid and processes for the preparation thereof
DE602007010894D1 (de)	2006-08-14	2011-01-13	Sicor Inc	Tellungsverfahren dafür
EP1943252B1 (en)	2006-08-14	2010-12-22	Sicor, Inc.	Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
EP2073803B1 (en)	2006-10-12	2018-09-19	Astex Therapeutics Limited	Pharmaceutical combinations
WO2008044045A1 (en)	2006-10-12	2008-04-17	Astex Therapeutics Limited	Pharmaceutical combinations
CN101417998B (zh)	2007-10-24	2012-10-24	重庆医药工业研究院有限责任公司	一种培美曲塞盐的纯化方法
ME02273B (me) *	2008-06-06	2016-02-20	Boehringer Ingelheim Int	Farmaceutska kombinacija
AU2015210337B2 (en) *	2008-06-06	2017-02-02	Boehringer Ingelheim International Gmbh	Pharmaceutical combination
CN101684121B (zh) *	2008-09-22	2013-04-03	重庆医药工业研究院有限责任公司	培美曲塞二酸的新晶型及其制备方法
US9174991B2 (en)	2009-11-24	2015-11-03	Azad Pharmaceutical Ingredients Ag	Crystalline form of pemetrexed disodium
EP2854768B1 (en)	2012-05-30	2017-03-22	Fresenius Kabi Oncology Limited	Pharmaceutical compositions of pemetrexed
ITRM20120398A1 (it)	2012-08-08	2014-02-09	Berlin Chemie Ag	Procedimento di sintesi pemetrexed e suo sale di lisina.
US20160051679A1 (en)	2013-04-12	2016-02-25	Actavis Group Ptc Ehf.	Pemetrexed Formulation
WO2014185797A1 (en)	2013-05-17	2014-11-20	Instytut Farmaceutyczny	Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d] pyrimidin-5-yl)ethyl] benzoyl]-l-glutamic acid
US20160145260A1 (en)	2013-06-14	2016-05-26	Synthon B.V.	Stable pemetrexed arginine salt and compositions comprising it
WO2015008221A1 (en)	2013-07-16	2015-01-22	Dr. Reddy’S Laboratories Limited	Novel crystalline forms of pemetrexed tromethamine salts
NZ630292A (en)	2013-11-25	2015-02-27	Shilpa Medicare Ltd	Process for crystalline pemetrexed dipotassium salt
SI3206666T1 (sl)	2014-10-16	2020-04-30	Synthon B.V.	Tekoč farmacevtski sestavek, ki obsega pemetreksed
CN104672241B (zh) *	2015-01-29	2018-04-24	王磊	吡咯并[2,3-d]嘧啶类化合物及其用途
FR3037956B1 (fr) *	2015-06-23	2017-08-04	Servier Lab	Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR112018068565A2 (pt)	2016-03-15	2019-02-12	Oryzon Genomics, S.A.	combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos
EP3675864A4 (en) *	2017-08-31	2022-02-16	Duquesne University of The Holy Spirit	FIRST REPRESENTATIVES OF SHMT2 AND MTHFD2 INHIBITORS AS ANTITUMORS
CN110305135B (zh) *	2018-03-20	2022-02-22	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305137A (zh) *	2018-03-20	2019-10-08	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305136A (zh) *	2018-03-20	2019-10-08	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法
CN110305134B (zh) *	2018-03-20	2022-02-22	鲁南制药集团股份有限公司	一种培美曲塞二钠中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4818819A (en) *	1986-10-20	1989-04-04	The Trustees Of Princeton University	Process for the preparation of fused pyridine compounds
NO169490C (no) *	1988-03-24	1992-07-01	Takeda Chemical Industries Ltd	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK172753B1 (da) *	1988-05-25	1999-06-28	Lilly Co Eli	N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US4883799A (en) *	1988-06-29	1989-11-28	The Trustees Of Princeton University	N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives

1990
- 1990-12-04 IL IL9653190A patent/IL96531A/en active Protection Beyond IP Right Term
- 1990-12-05 AU AU67791/90A patent/AU640182B2/en not_active Expired
- 1990-12-07 NZ NZ236385A patent/NZ236385A/en unknown
- 1990-12-10 IE IE444590A patent/IE904445A1/en not_active IP Right Cessation
- 1990-12-10 ES ES90123671T patent/ES2084639T4/es not_active Expired - Lifetime
- 1990-12-10 DE DE69025723T patent/DE69025723T2/de not_active Expired - Lifetime
- 1990-12-10 SG SG1996007025A patent/SG48098A1/en unknown
- 1990-12-10 PT PT96140A patent/PT96140B/pt not_active IP Right Cessation
- 1990-12-10 HU HU147/90A patent/HU218483B/hu unknown
- 1990-12-10 CA CA002031890A patent/CA2031890C/en not_active Expired - Lifetime
- 1990-12-10 DK DK90123671.1T patent/DK0432677T3/da active
- 1990-12-10 EP EP90123671A patent/EP0432677B1/en not_active Expired - Lifetime
- 1990-12-10 AT AT90123671T patent/ATE135007T1/de active
- 1990-12-10 DE DE200512000012 patent/DE122005000012I2/de active Active
- 1990-12-10 AR AR90318580A patent/AR245129A1/es active
- 1990-12-11 CN CN90110125A patent/CN1030608C/zh not_active Ceased
- 1990-12-11 JP JP2409992A patent/JP3016876B2/ja not_active Expired - Lifetime
1991
- 1991-02-07 RU SU4894454/04A patent/RU2057131C9/ru active Protection Beyond IP Right Term
1996
- 1996-04-29 GR GR960401164T patent/GR3019784T3/el unknown
1997
- 1997-12-22 HK HK97102541A patent/HK1000920A1/xx not_active IP Right Cessation
1998
- 1998-09-11 CY CY9802076A patent/CY2076B1/xx unknown
2005
- 2005-03-14 LU LU91147C patent/LU91147I2/fr unknown
- 2005-03-16 NL NL300181C patent/NL300181I2/nl unknown

Also Published As

Publication number	Publication date
RU2057131C1 (ru)	1996-03-27
AU640182B2 (en)	1993-08-19
PT96140A (pt)	1991-09-30
EP0432677B1 (en)	1996-03-06
NL300181I1 (nl)	2005-05-02
LU91147I2 (fr)	2005-05-17
CA2031890A1 (en)	1991-06-12
ES2084639T4 (es)	2013-06-11
HU218483B (hu)	2000-09-28
JP3016876B2 (ja)	2000-03-06
PT96140B (pt)	1997-06-30
HU908147D0 (en)	1991-06-28
HUT58335A (en)	1992-02-28
ES2084639T3 (es)	1996-05-16
DE122005000012I1 (de)	2005-06-23
CN1055182A (zh)	1991-10-09
RU2057131C9 (ru)	2006-04-10
SG48098A1 (en)	1998-04-17
EP0432677A1 (en)	1991-06-19
IE904445A1 (en)	1991-06-19
AR245129A1 (es)	1993-12-30
NZ236385A (en)	1992-05-26
JPH083166A (ja)	1996-01-09
DE122005000012I2 (de)	2006-02-09
NL300181I2 (nl)	2005-06-01
IL96531A (en)	1995-08-31
GR3019784T3 (en)	1996-07-31
AU6779190A (en)	1991-06-13
ATE135007T1 (de)	1996-03-15
HK1000920A1 (en)	1998-05-08
DE69025723T2 (de)	1996-10-31
CA2031890C (en)	2000-07-25
CN1030608C (zh)	1996-01-03
CY2076B1 (en)	1998-09-11
DE69025723D1 (de)	1996-04-11
IL96531A0 (en)	1991-09-16

Publication	Publication Date	Title
DK0432677T3 (da)	1996-04-09	N-(Pyrrolo(2,3-d)pyrimidin-3-ylacyl-glutaminsyrederivater
ZA909631B (en)	1991-10-30	N-(pyrrolo(2,3,-d)pyrimidin-3-ylacyl)-glutamic acid derivatives
DE59008394D1 (de)	1995-03-16	Aminosäureamid-Derivate.
DK0394026T3 (da)	1993-11-08	Formulering
NO901399L (no)	1990-10-01	Aminosyrederivater.
DE68915207D1 (de)	1994-06-16	Aminosäure-Derivate.
NO903832L (no)	1991-03-05	Aminosyrederivater.
NO901033L (no)	1990-09-07	Aminosyrederivater.
DK0384522T3 (da)	1993-04-19	Antivirale tetrahydroimidazo(1,4)benzodiazepin-2-thioner
ZA893714B (en)	1990-02-28	N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)glutamic acid derivatives
NO901533L (no)	1990-10-08	Aminosyrederivater.
DK232387A (da)	1987-12-07	Diastereoisomere tetrahydropyrido (2,3-d) pyrimi- din derivativer
DK382788D0 (da)	1988-07-08	4-amino-substituerede 1,2-dihydroxy-naphthalen-derivater
DK10190D0 (da)	1990-01-12	1,1-dioxo-cephem-4-carbothiolsyrederivater
DK360888A (da)	1989-01-02	3',4'-dinitrogen-substituerede epipodophyllotoxinglucosidderivater
DE69122555D1 (de)	1996-11-14	2,4-Dihydroxyadipinsäurederivate
DE3682244D1 (de)	1991-12-05	Substituierte dihydroimidazo(1,2-a)chinoxalinderivate.
NO892728L (no)	1990-01-02	Aminoalkyl-aminokarbonyl-aminodiolaminosyre derivater somanti-hypertensive midler.
BR9003294A (pt)	1991-08-27	Micropulverizador
ATE163641T1 (de)	1998-03-15	Carbamoylderivate
DE69018816D1 (de)	1995-05-24	Aminosäurederivate.
DE59002430D1 (de)	1993-09-30	Cyclopropanoylaminosäureamid-Derivate.
NO901519L (no)	1990-10-05	Aminosyrederivater.
DK9588A (da)	1988-07-13	2,1-benzothiazepin-2,2-dioxid-5-carboxylsyrederivater
FI931574A0 (fi)	1993-04-07	4-substituerade pyrazolo/3,4-d/pyrimidinderivat