DK0413487T3 - Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidin - Google Patents
Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidinInfo
- Publication number
- DK0413487T3 DK0413487T3 DK90308637.9T DK90308637T DK0413487T3 DK 0413487 T3 DK0413487 T3 DK 0413487T3 DK 90308637 T DK90308637 T DK 90308637T DK 0413487 T3 DK0413487 T3 DK 0413487T3
- Authority
- DK
- Denmark
- Prior art keywords
- dexmedetomidine
- transdermal administration
- adhesive layer
- therapeutic system
- administering
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/395,717 US5124157A (en) | 1989-08-18 | 1989-08-18 | Method and device for administering dexmedetomidine transdermally |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0413487T3 true DK0413487T3 (da) | 1995-07-17 |
Family
ID=23564195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90308637.9T DK0413487T3 (da) | 1989-08-18 | 1990-08-06 | Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidin |
Country Status (25)
Country | Link |
---|---|
US (1) | US5124157A (da) |
EP (1) | EP0413487B1 (da) |
JP (1) | JP3043064B2 (da) |
CN (1) | CN1035922C (da) |
AT (1) | ATE122899T1 (da) |
AU (1) | AU639015B2 (da) |
BG (1) | BG95935A (da) |
CA (1) | CA2064687C (da) |
DD (1) | DD297066A5 (da) |
DE (1) | DE69019628T2 (da) |
DK (1) | DK0413487T3 (da) |
ES (1) | ES2072397T3 (da) |
FI (1) | FI100857B (da) |
HU (1) | HUT64223A (da) |
IE (1) | IE67127B1 (da) |
LT (1) | LT3753B (da) |
LV (1) | LV10685B (da) |
NO (1) | NO300408B1 (da) |
NZ (1) | NZ234749A (da) |
PL (1) | PL165023B1 (da) |
PT (1) | PT95002B (da) |
RU (1) | RU2098083C1 (da) |
UA (1) | UA26988C2 (da) |
WO (1) | WO1991002505A1 (da) |
ZA (1) | ZA906539B (da) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217718A (en) * | 1989-08-18 | 1993-06-08 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
GB2256135B (en) * | 1991-05-31 | 1995-01-18 | Orion Yhtymae Oy | Transdermal administration of 4-substituted imidazoles |
WO1993007842A1 (en) * | 1991-10-15 | 1993-04-29 | Cygnus Therapeutic Systems | Thermal enhancement of transdermal drug administration |
US5883115A (en) * | 1992-11-09 | 1999-03-16 | Pharmetrix Division Technical Chemicals & Products, Inc. | Transdermal delivery of the eutomer of a chiral drug |
US5591767A (en) * | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
WO1994022432A1 (en) * | 1993-04-07 | 1994-10-13 | Rexham Industries Corp. | Method of coating microporous membranes and resulting products |
US5536263A (en) * | 1994-03-30 | 1996-07-16 | Lectec Corporation | Non-occulusive adhesive patch for applying medication to the skin |
US5635203A (en) * | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
GB9521680D0 (en) * | 1995-10-23 | 1996-01-03 | Orion Yhtymo Oy | New use of imidazole derivatives |
US5730721A (en) * | 1996-01-25 | 1998-03-24 | Vesture Corporation | Medical applicator and method |
GB9614098D0 (en) | 1996-07-05 | 1996-09-04 | Orion Yhtymae Oy | Transdermal delivery of levosimendan |
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
AR015744A1 (es) * | 1998-04-01 | 2001-05-16 | Orion Corp | Uso de dexmedetomidina para sedacion en terapia intensiva |
US6716867B1 (en) | 1998-04-01 | 2004-04-06 | Orion Corporation | Use of dexmedetomidine for ICU sedation |
DE19925338A1 (de) * | 1999-06-02 | 2000-12-07 | Lohmann Therapie Syst Lts | Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung |
WO2001030347A1 (en) | 1999-10-29 | 2001-05-03 | Orion Corporation | Treatment or prevention of hypotension and shock |
WO2001041745A1 (en) | 1999-12-10 | 2001-06-14 | Lectec Corporation | Anti pruritic patch |
EP1566136B1 (en) | 2000-07-10 | 2008-03-05 | Uni-Charm Corporation | Cleaning article |
DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
JP4358978B2 (ja) * | 2000-09-05 | 2009-11-04 | 日東電工株式会社 | 経皮吸収製剤 |
US20020198215A1 (en) * | 2000-10-23 | 2002-12-26 | Lino Tavares | Terazosin transdermal device and methods |
US20030195272A1 (en) * | 2001-02-01 | 2003-10-16 | Michael Harwell | Scented hot melt adhesives |
US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
US8133505B2 (en) | 2002-10-31 | 2012-03-13 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
US7662404B2 (en) | 2002-10-31 | 2010-02-16 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides |
IL152574A (en) | 2002-10-31 | 2009-09-22 | Transpharma Medical Ltd | A system for passing through the skin of dry items or dried medicines |
US7383084B2 (en) | 2002-10-31 | 2008-06-03 | Transpharma Medical Ltd. | Transdermal delivery system for dried particulate or lyophilized medications |
DE60204229T2 (de) * | 2002-12-02 | 2006-02-02 | Schwarz Pharma Ag | Verabreichung von Rotigotine zur Behandlung der Parkinson'schen Krankheit durch Iontophorese |
DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE102006054733A1 (de) * | 2006-11-21 | 2008-05-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit |
US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
US7795263B2 (en) * | 2008-07-08 | 2010-09-14 | Wildlife Laboratories, Inc. | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals |
KR101859486B1 (ko) * | 2009-05-15 | 2018-06-28 | 레크로파마, 인코포레이티드 | 설하용 덱스메데토미딘 조성물과 그의 사용 방법 |
JP2013516482A (ja) * | 2010-01-08 | 2013-05-13 | レクロ・ファーマ,インコーポレーテッド | 局所経皮用デクスメデトミジン組成物およびそれらの使用方法 |
US20130096170A1 (en) | 2011-10-14 | 2013-04-18 | Hospira, Inc. | Methods of treating pediatric patients using dexmedetomidine |
AU2012352528B9 (en) | 2011-12-11 | 2017-11-02 | Baudax Bio, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
US8242158B1 (en) | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
WO2013173317A1 (en) * | 2012-05-14 | 2013-11-21 | Prospire, Llc | TREATMENT OF OBSTRUCTIVE SLEEP APNEA WITH α2-ADRENERGIC RECEPTOR AGONISTS |
RU2648817C2 (ru) * | 2013-10-07 | 2018-03-28 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Способы и композиции для лечения абстинентных синдромов с использованием неседативных трансдермальных композиций на основе дексмедетомидина |
TWI709417B (zh) * | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
EP3054930B1 (en) | 2013-10-07 | 2020-12-02 | Teikoku Pharma USA, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
CA2924188C (en) | 2013-10-07 | 2018-12-18 | Teikoku Pharma Usa, Inc. | Methods and compositions for managing pain comprising dexmedetomidine transdermal compositions |
US10772871B2 (en) | 2013-10-07 | 2020-09-15 | Teikoku Pharma Usa, Inc. | Dexmedetomidine transdermal delivery devices and methods for using the same |
US9974754B2 (en) | 2013-12-18 | 2018-05-22 | Maruishi Pharmaceutical Co., Ltd. | Hydrous adhesive patch |
US9717796B1 (en) | 2016-04-20 | 2017-08-01 | Slypharma, Llc | Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container |
CN109862885A (zh) * | 2016-10-18 | 2019-06-07 | Lts勒曼治疗***股份公司 | 双层局部治疗*** |
CN110022865A (zh) * | 2016-10-31 | 2019-07-16 | 帝国制药美国公司 | 使用右美托咪定经皮递送装置管理疼痛的方法 |
ES2895764T3 (es) * | 2016-12-26 | 2022-02-22 | Hisamitsu Pharmaceutical Co | Dispositivo de microagujas |
US11160791B2 (en) | 2018-11-01 | 2021-11-02 | Medefil, Inc. | Dexmedetomidine injection premix formulation in ready to use (RTU) bags |
CN111346072B (zh) * | 2018-12-21 | 2022-05-27 | 宜昌人福药业有限责任公司 | 一种透皮给药的药物组合物及其制备方法 |
BR112021001304A2 (pt) * | 2019-04-24 | 2021-11-16 | Medrx Co Ltd | Preparação de emplastro, e, método para fabricar a preparação de emplastro |
TWI772807B (zh) * | 2019-05-27 | 2022-08-01 | 日商救急藥品工業股份有限公司 | 外用製劑 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3731683A (en) * | 1971-06-04 | 1973-05-08 | Alza Corp | Bandage for the controlled metering of topical drugs to the skin |
US3731583A (en) | 1971-07-30 | 1973-05-08 | Automated Building Components | Connector plate |
US3923939A (en) * | 1974-06-07 | 1975-12-02 | Alza Corp | Process for improving release kinetics of a monolithic drug delivery device |
US3926188A (en) * | 1974-11-14 | 1975-12-16 | Alza Corp | Laminated drug dispenser |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
FI844786A0 (fi) * | 1984-12-04 | 1984-12-04 | Farmos Oy | Terapeutiskt utnyttjbar foerening. |
US4717568A (en) * | 1985-08-09 | 1988-01-05 | Alza Corporation | Laminar arrangement for increasing delivery of beneficial agent from dispenser |
US4826686A (en) * | 1985-12-14 | 1989-05-02 | Boehringer Ingelheim Kg | Therapeutic system |
FI864570A0 (fi) * | 1986-11-11 | 1986-11-11 | Farmos Oy | Terapeutiskt anvaendbar foerening. |
AU607172B2 (en) * | 1986-12-22 | 1991-02-28 | Cygnus, Inc. | Diffusion matrix for transdermal drug administration |
AU601528B2 (en) * | 1986-12-22 | 1990-09-13 | Ortho-Mcneil Pharmaceutical, Inc. | Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers |
US4906463A (en) * | 1986-12-22 | 1990-03-06 | Cygnus Research Corporation | Transdermal drug-delivery composition |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
US4915950A (en) * | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
-
1989
- 1989-08-18 US US07/395,717 patent/US5124157A/en not_active Expired - Fee Related
-
1990
- 1990-08-01 NZ NZ234749A patent/NZ234749A/en unknown
- 1990-08-06 ES ES90308637T patent/ES2072397T3/es not_active Expired - Lifetime
- 1990-08-06 DK DK90308637.9T patent/DK0413487T3/da active
- 1990-08-06 DE DE69019628T patent/DE69019628T2/de not_active Expired - Fee Related
- 1990-08-06 AT AT90308637T patent/ATE122899T1/de not_active IP Right Cessation
- 1990-08-06 EP EP90308637A patent/EP0413487B1/en not_active Expired - Lifetime
- 1990-08-08 DD DD90343324A patent/DD297066A5/de not_active IP Right Cessation
- 1990-08-14 UA UA93004242A patent/UA26988C2/uk unknown
- 1990-08-14 CA CA002064687A patent/CA2064687C/en not_active Expired - Fee Related
- 1990-08-14 HU HU9200517A patent/HUT64223A/hu unknown
- 1990-08-14 PT PT95002A patent/PT95002B/pt active IP Right Grant
- 1990-08-14 WO PCT/US1990/004575 patent/WO1991002505A1/en active IP Right Grant
- 1990-08-14 JP JP2511906A patent/JP3043064B2/ja not_active Expired - Lifetime
- 1990-08-14 RU SU925011651A patent/RU2098083C1/ru active
- 1990-08-14 AU AU61834/90A patent/AU639015B2/en not_active Expired
- 1990-08-17 CN CN90107099A patent/CN1035922C/zh not_active Expired - Lifetime
- 1990-08-17 IE IE299390A patent/IE67127B1/en not_active IP Right Cessation
- 1990-08-17 ZA ZA906539A patent/ZA906539B/xx unknown
- 1990-08-17 PL PL90286525A patent/PL165023B1/pl unknown
-
1992
- 1992-02-10 NO NO920521A patent/NO300408B1/no unknown
- 1992-02-11 FI FI920576A patent/FI100857B/fi active
- 1992-02-17 BG BG095935A patent/BG95935A/bg unknown
-
1993
- 1993-09-22 LV LVP-93-1079A patent/LV10685B/lv unknown
-
1994
- 1994-01-13 LT LTIP1773A patent/LT3753B/lt not_active IP Right Cessation
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