DK0413487T3 - Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidin - Google Patents

Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidin

Info

Publication number
DK0413487T3
DK0413487T3 DK90308637.9T DK90308637T DK0413487T3 DK 0413487 T3 DK0413487 T3 DK 0413487T3 DK 90308637 T DK90308637 T DK 90308637T DK 0413487 T3 DK0413487 T3 DK 0413487T3
Authority
DK
Denmark
Prior art keywords
dexmedetomidine
transdermal administration
adhesive layer
therapeutic system
administering
Prior art date
Application number
DK90308637.9T
Other languages
English (en)
Inventor
Gary W Cleary
Kenneth J Colley
Donald R Wilson
Risto Lammintausta
Harry Jalonen
Original Assignee
Orion Yhtymae Oy
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy, Cygnus Therapeutic Systems filed Critical Orion Yhtymae Oy
Application granted granted Critical
Publication of DK0413487T3 publication Critical patent/DK0413487T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DK90308637.9T 1989-08-18 1990-08-06 Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidin DK0413487T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/395,717 US5124157A (en) 1989-08-18 1989-08-18 Method and device for administering dexmedetomidine transdermally

Publications (1)

Publication Number Publication Date
DK0413487T3 true DK0413487T3 (da) 1995-07-17

Family

ID=23564195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90308637.9T DK0413487T3 (da) 1989-08-18 1990-08-06 Fremgangsmåde og indretning til transdermal indgivelse af dexmedetomidin

Country Status (25)

Country Link
US (1) US5124157A (da)
EP (1) EP0413487B1 (da)
JP (1) JP3043064B2 (da)
CN (1) CN1035922C (da)
AT (1) ATE122899T1 (da)
AU (1) AU639015B2 (da)
BG (1) BG95935A (da)
CA (1) CA2064687C (da)
DD (1) DD297066A5 (da)
DE (1) DE69019628T2 (da)
DK (1) DK0413487T3 (da)
ES (1) ES2072397T3 (da)
FI (1) FI100857B (da)
HU (1) HUT64223A (da)
IE (1) IE67127B1 (da)
LT (1) LT3753B (da)
LV (1) LV10685B (da)
NO (1) NO300408B1 (da)
NZ (1) NZ234749A (da)
PL (1) PL165023B1 (da)
PT (1) PT95002B (da)
RU (1) RU2098083C1 (da)
UA (1) UA26988C2 (da)
WO (1) WO1991002505A1 (da)
ZA (1) ZA906539B (da)

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US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
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GB2256135B (en) * 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
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DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
AR015744A1 (es) * 1998-04-01 2001-05-16 Orion Corp Uso de dexmedetomidina para sedacion en terapia intensiva
US6716867B1 (en) 1998-04-01 2004-04-06 Orion Corporation Use of dexmedetomidine for ICU sedation
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US20020198215A1 (en) * 2000-10-23 2002-12-26 Lino Tavares Terazosin transdermal device and methods
US20030195272A1 (en) * 2001-02-01 2003-10-16 Michael Harwell Scented hot melt adhesives
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
US8211462B2 (en) * 2002-07-30 2012-07-03 Ucb Pharma Gmbh Hot-melt TTS for administering rotigotine
US8246979B2 (en) 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine
US8133505B2 (en) 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
US7662404B2 (en) 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
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DE60204229T2 (de) * 2002-12-02 2006-02-02 Schwarz Pharma Ag Verabreichung von Rotigotine zur Behandlung der Parkinson'schen Krankheit durch Iontophorese
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE102006054733A1 (de) * 2006-11-21 2008-05-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches Systems mit hoher Wirkstoffausnutzungsrate und Dosiergenauigkeit
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US7795263B2 (en) * 2008-07-08 2010-09-14 Wildlife Laboratories, Inc. Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals
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JP2013516482A (ja) * 2010-01-08 2013-05-13 レクロ・ファーマ，インコーポレーテッド 局所経皮用デクスメデトミジン組成物およびそれらの使用方法
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RU2648817C2 (ru) * 2013-10-07 2018-03-28 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Способы и композиции для лечения абстинентных синдромов с использованием неседативных трансдермальных композиций на основе дексмедетомидина
TWI709417B (zh) * 2013-10-07 2020-11-11 美商帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
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CA2924188C (en) 2013-10-07 2018-12-18 Teikoku Pharma Usa, Inc. Methods and compositions for managing pain comprising dexmedetomidine transdermal compositions
US10772871B2 (en) 2013-10-07 2020-09-15 Teikoku Pharma Usa, Inc. Dexmedetomidine transdermal delivery devices and methods for using the same
US9974754B2 (en) 2013-12-18 2018-05-22 Maruishi Pharmaceutical Co., Ltd. Hydrous adhesive patch
US9717796B1 (en) 2016-04-20 2017-08-01 Slypharma, Llc Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
CN109862885A (zh) * 2016-10-18 2019-06-07 Lts勒曼治疗***股份公司 双层局部治疗***
CN110022865A (zh) * 2016-10-31 2019-07-16 帝国制药美国公司 使用右美托咪定经皮递送装置管理疼痛的方法
ES2895764T3 (es) * 2016-12-26 2022-02-22 Hisamitsu Pharmaceutical Co Dispositivo de microagujas
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Also Published As

Publication number Publication date
DD297066A5 (de) 1992-01-02
US5124157A (en) 1992-06-23
HU9200517D0 (en) 1992-05-28
JPH05503916A (ja) 1993-06-24
CA2064687C (en) 1998-04-21
CN1035922C (zh) 1997-09-24
IE67127B1 (en) 1996-03-06
NO300408B1 (no) 1997-05-26
PL286525A1 (en) 1991-05-20
HUT64223A (en) 1993-12-28
AU6183490A (en) 1991-04-03
NZ234749A (en) 1992-03-26
FI100857B (fi) 1998-03-13
PT95002B (pt) 1997-10-31
DE69019628D1 (de) 1995-06-29
EP0413487B1 (en) 1995-05-24
AU639015B2 (en) 1993-07-15
CN1049450A (zh) 1991-02-27
NO920521L (no) 1992-02-10
DE69019628T2 (de) 1995-09-28
LV10685A (lv) 1995-06-20
EP0413487A1 (en) 1991-02-20
NO920521D0 (no) 1992-02-10
LV10685B (en) 1995-12-20
RU2098083C1 (ru) 1997-12-10
PT95002A (pt) 1992-02-28
LT3753B (en) 1996-03-25
BG95935A (bg) 1993-12-24
ZA906539B (en) 1991-06-26
WO1991002505A1 (en) 1991-03-07
UA26988C2 (uk) 2000-02-28
IE902993A1 (en) 1991-02-27
LTIP1773A (en) 1995-07-25
PL165023B1 (pl) 1994-11-30
ATE122899T1 (de) 1995-06-15
ES2072397T3 (es) 1995-07-16
JP3043064B2 (ja) 2000-05-22
FI920576A0 (fi) 1992-02-11
CA2064687A1 (en) 1991-02-19

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