DK0384122T3 - Mutanter af humant antithrombin III - Google Patents

Mutanter af humant antithrombin III

Info

Publication number: DK0384122T3
Authority: DK; Denmark
Prior art keywords: mutants; antithrombin iii; human antithrombin; iii; human
Prior art date: 1989-01-24

Application number

DK90101045T

Other languages

English (en)

Inventor

Gerd Dr Zettlmeissl

Hermann Erich Dr Karges

Achim Becker

Original Assignee

Aventis Behring Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-24

Filing date

1990-01-19

Publication date

2000-03-27

1990-01-19 Application filed by Aventis Behring Gmbh filed Critical Aventis Behring Gmbh

2000-03-27 Application granted granted Critical

2000-03-27 Publication of DK0384122T3 publication Critical patent/DK0384122T3/da

Links

101000757319 Homo sapiens Antithrombin-III Proteins 0.000 title 1
102000052834 human SERPINC1 Human genes 0.000 title 1
229960004336 human antithrombin iii Drugs 0.000 title 1
230000013595 glycosylation Effects 0.000 abstract 1
238000006206 glycosylation reaction Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8128—Antithrombin III
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physics & Mathematics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK90101045T 1989-01-24 1990-01-19 Mutanter af humant antithrombin III DK0384122T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3901917A DE3901917A1 (de)	1989-01-24	1989-01-24	Mutanten von humanem antithrombin iii

Publications (1)

Publication Number	Publication Date
DK0384122T3 true DK0384122T3 (da)	2000-03-27

Family

ID=6372631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90101045T DK0384122T3 (da)	1989-01-24	1990-01-19	Mutanter af humant antithrombin III

Country Status (13)

Country	Link
US (2)	US5618713A (da)
EP (1)	EP0384122B1 (da)
JP (1)	JP3226215B2 (da)
KR (1)	KR0171197B1 (da)
AT (1)	ATE184913T1 (da)
AU (1)	AU625667B2 (da)
CA (1)	CA2008390C (da)
DE (2)	DE3901917A1 (da)
DK (1)	DK0384122T3 (da)
ES (1)	ES2137918T3 (da)
GR (1)	GR3031991T3 (da)
IE (1)	IE900251L (da)
PT (1)	PT92928B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3479539B2 (ja) *	1992-04-10	2003-12-15	エーザイ株式会社	ヒトアンチトロンビンｉｉｉ変異体
CA2328397A1 (en) *	1998-05-12	1999-11-18	Temple University - Of The Commonwealth System Of Higher Education	Human antithrombin iiis and methods related thereto
DE19839337A1 (de) *	1998-08-28	2000-03-02	Centeon Pharma Gmbh	Antithrombin III-beta enthaltende Arzneimittelzubereitung
DE69911629D1 (de)	1998-10-08	2003-10-30	Childrens Hospital Boston	Zusammensetzungen und deren verwendung zur hemmung von angiogenese
AUPP971299A0 (en) *	1999-04-12	1999-05-06	South Eastern Sydney Area Health Service	Procoagulant assay
CA2368608A1 (en) *	1999-05-13	2000-11-23	Genzyme Transgenics Corp.	Transgenically produced antithrombin iii and mutants thereof
JP4339962B2 (ja)	1999-06-23	2009-10-07	武比古小出	ヒトアンチトロンビン変異体
DE19932782A1 (de) *	1999-07-14	2001-01-18	Biotest Pharma Gmbh	Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
ATE522601T1 (de) *	2002-05-31	2011-09-15	Univ Utah Res Found	Varianten von antithrombin iii
US20070259809A1 (en) *	2004-01-09	2007-11-08	Bock Susan C	Methods of Using High Affinity Atiii Variants
CA2694047C (en) *	2007-07-20	2018-01-30	Universite Paris-Sud Xi	Use of mutated antithrombins for treating or preventing coagulation disorders
CA2749772C (en) *	2009-01-16	2018-02-20	Assistance Publique-Hopitaux De Paris	Mutated antithrombins, a process for preparing the same and their use as drugs
WO2011056793A2 (en)	2009-11-03	2011-05-12	Talecris Biotherapeutics, Inc.	Composition, method, and kit for alpha-1 proteinase inhibitor
NZ600271A (en)	2009-11-24	2013-09-27	Grifols Therapeutics Inc	Lyophilization methods, compositions, and kits

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3381783D1 (de) *	1982-03-03	1990-09-13	Genentech Inc	Menschliches antithrombin iii, dns sequenzen dafuer, expressions- und klonierungsvektoren die solche sequenzen enthalten und damit transformierte zellkulturen, verfahren zur expression von menschlichem antithrombin iii und diese enthaltende pharmazeutische zusammensetzungen.
US4746306A (en) *	1982-03-26	1988-05-24	General Motors Corporation	Electrical connector lock with gauge pin
US4632981A (en) *	1982-07-30	1986-12-30	Genentech, Inc.	Human antithrombin III
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
DE3624453A1 (de) *	1986-07-19	1988-01-28	Behringwerke Ag	Verfahren zur herstellung von humanem antithrombin iii (atiii), dafuer geeignete vektoren und wirtszellen, so erhaltenes, biologisch aktives atiii und dieses enthaltende arzneimittel
GB8621118D0 (en) *	1986-09-01	1986-10-08	Whitbread & Co Plc	Stabilised polypeptides
IE902276A1 (en) *	1989-06-26	1991-01-16	Akzo Nv	Serpin variants

1989
- 1989-01-24 DE DE3901917A patent/DE3901917A1/de not_active Withdrawn
1990
- 1990-01-19 EP EP90101045A patent/EP0384122B1/de not_active Expired - Lifetime
- 1990-01-19 DE DE59010884T patent/DE59010884D1/de not_active Expired - Fee Related
- 1990-01-19 DK DK90101045T patent/DK0384122T3/da active
- 1990-01-19 AT AT90101045T patent/ATE184913T1/de not_active IP Right Cessation
- 1990-01-19 ES ES90101045T patent/ES2137918T3/es not_active Expired - Lifetime
- 1990-01-23 KR KR1019900000748A patent/KR0171197B1/ko not_active IP Right Cessation
- 1990-01-23 CA CA002008390A patent/CA2008390C/en not_active Expired - Fee Related
- 1990-01-23 IE IE900251A patent/IE900251L/xx not_active IP Right Cessation
- 1990-01-23 AU AU48639/90A patent/AU625667B2/en not_active Ceased
- 1990-01-23 PT PT92928A patent/PT92928B/pt not_active IP Right Cessation
- 1990-01-24 JP JP01471290A patent/JP3226215B2/ja not_active Expired - Fee Related
1992
- 1992-12-18 US US07/993,910 patent/US5618713A/en not_active Expired - Fee Related
1995
- 1995-05-30 US US08/452,836 patent/US5700663A/en not_active Expired - Fee Related
1999
- 1999-11-30 GR GR990403084T patent/GR3031991T3/el unknown

Also Published As

Publication number	Publication date
IE900251L (en)	1990-07-24
KR0171197B1 (ko)	1999-02-01
CA2008390C (en)	2002-03-19
PT92928B (pt)	1995-12-29
EP0384122A2 (de)	1990-08-29
EP0384122B1 (de)	1999-09-22
DE59010884D1 (de)	1999-10-28
EP0384122A3 (de)	1991-07-03
US5700663A (en)	1997-12-23
US5618713A (en)	1997-04-08
AU4863990A (en)	1990-09-13
GR3031991T3 (en)	2000-03-31
DE3901917A1 (de)	1990-07-26
CA2008390A1 (en)	1990-07-24
KR900011896A (ko)	1990-08-02
ATE184913T1 (de)	1999-10-15
AU625667B2 (en)	1992-07-16
PT92928A (pt)	1990-07-31
JP3226215B2 (ja)	2001-11-05
ES2137918T3 (es)	2000-01-01
JPH02262598A (ja)	1990-10-25

Publication	Publication Date	Title
FI20050238A (fi)	2005-03-04	Markfortiini- ja paraherkvamidiyhdisteet
FI913284A (fi)	1992-01-07	Deformerbar kirurgisk anordning.
DE69114287D1 (de)	1995-12-07	Sichernde Schraube.
ES1020240Y (es)	1993-01-01	Grapa de fijacion.
FI912409A (fi)	1991-11-20	Bicykliska 1-aza-cykloalkaner.
FI904851A0 (fi)	1990-10-02	Radiomaerkta antikoagulantpeptider.
DK0384122T3 (da)	2000-03-27	Mutanter af humant antithrombin III
DE69300694D1 (de)	1995-11-30	Desinfizierende Zusammensetzungen.
ITMI912655A1 (it)	1993-04-07	Combinazione di estrusore-calandra.
NO912598D0 (no)	1991-07-02	Hypokalori-matsammensetning.
DE69003075D1 (de)	1993-10-07	Stabilisierungszusammensetzungen.
DE59002341D1 (de)	1993-09-16	Praezisions-referenzspannungsquelle.
FR2696483B3 (fr)	1994-08-19	Charrue à ballast.
PT99900A (pt)	1994-01-31	Conjunto de dobradica desmontavel
DE69203968D1 (de)	1995-09-14	Fräsvorsatz.
DE59008462D1 (de)	1995-03-23	Stabilisatordispersionen.
FI914156A (fi)	1992-03-05	Kompositioner.
FI913494A (fi)	1992-01-24	Haol- och provtagande instrument.
NO923514L (no)	1993-03-15	Bjelke
FR2670332B1 (fr)	1993-01-15	Reglette de raccordement precablable.
BR7102072U (pt)	1993-04-06	Montagem de pecas de adorno
IT9018128A0 (it)	1990-11-28	Piano di cottura sdoppiabile
ATE57976T1 (de)	1990-11-15	Verbindungsprofil oder -balken.
FR2694948B1 (fr)	1994-10-28	Charrue à ballast.
ES1012166Y (es)	1991-02-01	Protector-embellecedor de peldanos de escalera.