DE935246C - Solubilizer for salicylic acid - Google Patents
Solubilizer for salicylic acidInfo
- Publication number
- DE935246C DE935246C DED4328D DED0004328D DE935246C DE 935246 C DE935246 C DE 935246C DE D4328 D DED4328 D DE D4328D DE D0004328 D DED0004328 D DE D0004328D DE 935246 C DE935246 C DE 935246C
- Authority
- DE
- Germany
- Prior art keywords
- salicylic acid
- weight
- solubilizer
- parts
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Description
Lösungsvermittler für Salicylsäure Zusatz zum Patent 754124 Wie aus dem Patent 754 I24 hervorgeht, lassen sich mit Hilfe der in Wasser löslichen alkoholischen Hydrierungsprodukte des Furfurols und seiner Homologen bzw. der Ester oder Äther derselben hochprozentige Lösungen der Salicylsäure herstellen.Solubilizer for salicylic acid. Addition to patent 754124 How out the patent 754 I24 reveals, can be with the help of the water-soluble alcoholic Hydrogenation products of furfural and its homologues or of the esters or ethers the same to produce high-percentage solutions of salicylic acid.
Diese vermögen noch 20 bis 25 0/, Wasser aufzunehmen.These are still able to absorb 20 to 25% of water.
Es wurde nun gefunden, daß das Aufnahmevermögen von Salicylsäurelösungen, insbesondere für Wasser, noch gesteigert werden kann, wenn man als Lösungsvermittler gleichzeitig kalk- und säurebeständige kapillaraktive Mittel mitverwendet. Solche Lösungsvermittler sind beispielsweise hochsulfuriertes Rizinusöl, Kondensationsprodukte aus Fettsäuren mit Eiweißabbauprodukten, Sulfurierungsprodukte von höhermolekularen Olefinen, Fettalkoholen, Monoglyceriden der Fettsäuren, ferner alkylierte aromatische Sulfonsäuren u. a. Hierzu gehören auch die quaternären Ammoniumverbindungen, von denen beispielsweise Triäthylcetylammoniumbromid und Dodecylpyndiniumsulfat genannt sein mögen. It has now been found that the absorption capacity of salicylic acid solutions, especially for water, can be increased if you act as a solubilizer lime- and acid-resistant capillary-active agents are used at the same time. Such Solubilizers are, for example, highly sulphurised castor oil and condensation products from fatty acids with protein breakdown products, sulfurization products from higher molecular weight Olefins, fatty alcohols, monoglycerides of fatty acids, also alkylated aromatic Sulfonic acids and others This also includes the quaternary ammonium compounds, of those named, for example, triethylcetylammonium bromide and dodecylpyndinium sulfate like to be.
Die Mitverwendung dieser kalk- und säurebeständigen kapillaraktiven Mittel bei der Herstellung von Salicylsäurelösungen mit Hilfe der in Wasser löslichen alkoholischen Hydrierungsprodukte des Furfurols und seiner Homologen bzw. deren Derivaten hat - den Vorteil, daß einerseits stark wasserhaltige Zubereitungen von Salicylsäure erhältlich sind, die pharmazeutisch und kosmetisch vielfach größere Wirksamkeit haben und bei Bedarf zudem noch mit fetten Ölen oder flüssigen Wachsen klar mischbar sind, andererseits aus den klaren Stammlösungen leicht mit größeren Mengen Wasser Emulsionen von salbenartiger Beschaffenheit erhalten werden können, aus denen die Salicylsäure nicht auskristallisiert. The use of this lime- and acid-resistant capillary-active Means in the preparation of salicylic acid solutions with the help of those soluble in water alcoholic hydrogenation products of furfural and its homologues or their Derivatives - has the advantage that, on the one hand, it is highly water-containing Preparations of salicylic acid are available that are pharmaceutical and cosmetic are often more effective and if necessary also with fatty oils or liquid waxes are clearly miscible, on the other hand from the clear stock solutions easily obtained with large amounts of water emulsions of an ointment-like consistency from which the salicylic acid does not crystallize.
Beispiel I Eine I5°/Oige Salicylsäurelösung erhält man aus I5 Gewichtsteilen Salicylsäure, 20 Gewichtsteilen Türkischrotöl mit hohem Sulfurierungsgrad, 35 Gewichtsteilen Tetrahydrofurfurylalkohol und 30 Gewichtsteilen Wasser. Diese Lösung nimmt 20 bis 30 Gewichtsteile fettes Ö1, flüssiges Wachs, Paraffinöl od. dgl. auf, ohne Trübungen oder Ausscheidungen von Salicylsäure zu ergeben. Example I A 15% salicylic acid solution is obtained from 15 parts by weight Salicylic acid, 20 parts by weight of Turkish red oil with a high degree of sulfurization, 35 parts by weight Tetrahydrofurfuryl alcohol and 30 parts by weight of water. This solution takes 20 to 30 parts by weight of fatty oil, liquid wax, paraffin oil or the like, without cloudiness or to give excretions of salicylic acid.
Beispiel 2 Eine 350/0 Wasser enthaltende Salicylsalbe wird durch Zusammenschmelzen von 25 Gewichtsteilen hochsulfuriertem Türkischrotöl, I8 Gewichtsteilen technischem Cetylalkohol, 2 Gewichtsteilen Cetylalkoholsulfonat und 5 Gewichtsteilen Tetrahydrofurfurylalkohol, Einrühren von 15 Gewichtsteilen Salicylsäure und Zugabe von 35 Gewichtsteilen warmem Wasser erhalten. Example 2 A salicylic ointment containing 350/0 water is made through Melting together 25 parts by weight of highly sulphurized Turkish red oil, 18 parts by weight technical grade cetyl alcohol, 2 parts by weight of cetyl alcohol sulfonate and 5 parts by weight Tetrahydrofurfuryl alcohol, stirring in 15 parts by weight of salicylic acid and adding obtained from 35 parts by weight of warm water.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED4328D DE935246C (en) | 1942-08-06 | 1942-08-06 | Solubilizer for salicylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DED4328D DE935246C (en) | 1942-08-06 | 1942-08-06 | Solubilizer for salicylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE935246C true DE935246C (en) | 1955-11-17 |
Family
ID=7030952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DED4328D Expired DE935246C (en) | 1942-08-06 | 1942-08-06 | Solubilizer for salicylic acid |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE935246C (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE438061C (en) * | 1923-05-31 | 1930-05-28 | J D Riedel Akt Ges | Cleaning and emulsifying agents |
| DE605973C (en) * | 1930-11-30 | 1934-11-22 | I G Farbenindustrie Akt Ges | Process for the production of ethers from hydroxyl-containing organic compounds and ethylene oxide |
| DE647988C (en) * | 1933-01-15 | 1937-07-19 | I G Farbenindustrie Akt Ges | Process for the preparation of condensation products containing sulfuric acid residues |
-
1942
- 1942-08-06 DE DED4328D patent/DE935246C/en not_active Expired
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE438061C (en) * | 1923-05-31 | 1930-05-28 | J D Riedel Akt Ges | Cleaning and emulsifying agents |
| DE605973C (en) * | 1930-11-30 | 1934-11-22 | I G Farbenindustrie Akt Ges | Process for the production of ethers from hydroxyl-containing organic compounds and ethylene oxide |
| DE647988C (en) * | 1933-01-15 | 1937-07-19 | I G Farbenindustrie Akt Ges | Process for the preparation of condensation products containing sulfuric acid residues |
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