DE873701C - Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine - Google Patents

Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine

Info

Publication number
DE873701C
DE873701C DEB9096D DEB0009096D DE873701C DE 873701 C DE873701 C DE 873701C DE B9096 D DEB9096 D DE B9096D DE B0009096 D DEB0009096 D DE B0009096D DE 873701 C DE873701 C DE 873701C
Authority
DE
Germany
Prior art keywords
dioxypyrimidine
amino
methyl
nitroso
formylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB9096D
Other languages
German (de)
Inventor
Hans Dr-Ing Langner
Viktor Dipl-Chem Lebedew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Priority to DEB9096D priority Critical patent/DE873701C/en
Application granted granted Critical
Publication of DE873701C publication Critical patent/DE873701C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Verfahren zur Herstellung von 3-Methyl-4-amino-5-formylamno-2, 6-dioxypyrimidin aus der 3-Methylverbindung des 4-Amino-5-nitroso-2, 6-dioxypyrimidins Gegenstand des Patents 859 311 ist ein Verfahren zur Darstellung von i, 3-Dimethyl-4.-amino-5-formylamino=2, 6-dioxypyrimidin aus I, 3-Dimethyl-q.-amino-5-nitroso-2, 6-dioxypyrimidin durch Reduktion mittels Zinkstaub und Ameisensäure. In weiterer Ausbildung dieser Erfindung zeigte es sich nun, daß auch das 3-Methyl-4-amino-5-formylamino-z, 6-dioxypyrimidin auf diese Weise dargestellt werden kann, und zwar aus dem 3-Methyl-4-amino-5-nitroso-2, 6-dioxypyrimidin. Ausführungsbeispiel io Teile 3-Methyl-4-amino-5-nitroso-2, 6-dioxypyrimidin werden mit Zoo Teilen 8o°/Qiger Ameisensäure und io Teilen Zinkstaub bei etwa 4.o° behandelt. Am Ende der Reduktion kristallisieren größere Mengen der Formylaminoverbindung aus. Da das 3-Methylg-amino-5-formylamino-2, 6-dioxypyrimidin in konzentrierter Ameisensäure leichter löslich und in Wasser schwerer löslich ist als Zinkformiat, sind beide Ver- Bindungen verhältnismäßig leicht voneinander -zu . trennen. Ausbeute 9o °/o der Theorie.Process for the preparation of 3-methyl-4-amino-5-formylamno-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2, 6-dioxypyrimidine subject of patent 859 311 is a method for the preparation of i, 3-dimethyl-4.-amino-5-formylamino = 2, 6-dioxypyrimidine from 1,3-dimethyl-q.-amino-5-nitroso-2,6-dioxypyrimidine Reduction using zinc dust and formic acid. In a further development of this invention it was now found that 3-methyl-4-amino-5-formylamino-z, 6-dioxypyrimidine can be represented in this way, namely from the 3-methyl-4-amino-5-nitroso-2, 6-dioxypyrimidine. Exemplary embodiment 10 parts of 3-methyl-4-amino-5-nitroso-2,6-dioxypyrimidine zoo parts 8o ° / qiger formic acid and 10 parts zinc dust at about 4o ° treated. At the end of the reduction, larger amounts of the formylamino compound crystallize the end. Since the 3-methylg-amino-5-formylamino-2, 6-dioxypyrimidine in concentrated Formic acid is more soluble and less soluble in water than zinc formate, are both Ties relatively easy to one another . separate. Yield 90% of theory.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von "3-ilIethyl-q.-ami- no-5-formylamino-2, 6-dioxypyrimidin aus der
3-Methylverbindnng des q.-Amino-5-nitroso-2, 6-dioxypyrimidins, dadurch gekennzeichnet, daB in weiterer Ausbildung des Verfahrens des Patents $59 311 das 3-Methylderivat des 4.-Amino-5-nitroso-2, 6-dioxypyrimidins der Behandlung mit Zinkstaub und Ameisensäure unterworfen wird. PATENT CLAIM: Process for the preparation of "3-ilIethyl-q.-ami- no-5-formylamino-2,6-dioxypyrimidine from the
3-methyl compound of q-amino-5-nitroso-2, 6-dioxypyrimidine, characterized in that in a further development of the process of patent $ 59 311 the 3-methyl derivative of 4-amino-5-nitroso-2, 6- dioxypyrimidines is subjected to treatment with zinc dust and formic acid.
DEB9096D 1943-08-26 1943-08-26 Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine Expired DE873701C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB9096D DE873701C (en) 1943-08-26 1943-08-26 Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB9096D DE873701C (en) 1943-08-26 1943-08-26 Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine

Publications (1)

Publication Number Publication Date
DE873701C true DE873701C (en) 1953-04-16

Family

ID=6956133

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB9096D Expired DE873701C (en) 1943-08-26 1943-08-26 Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine

Country Status (1)

Country Link
DE (1) DE873701C (en)

Similar Documents

Publication Publication Date Title
DE873701C (en) Process for the preparation of 3-methyl-4-amino-5-formylamino-2,6-dioxypyrimidine from the 3-methyl compound of 4-amino-5-nitroso-2,6-dioxypyrimidine
DE857116C (en) Process for improving the binder properties of sulphite waste liquor when used in foundries
DE585519C (en) Process for the preparation of organic bismuth compounds
DE551805C (en) Process to accelerate the vulcanization of natural and synthetic rubbers
DE337939C (en) Process for the production of a betaine of hexamethylenetetramine
DE378065C (en) Method for increasing the sticking point of waste naphthylamine pitch
DE843415C (en) Process for the preparation of a guaiacol derivative
DE614337C (en) Process for the preparation of a calcium salt solution suitable for injection
DE542801C (en) Process for the production of real Kuepen dyes
AT129939B (en) Process for the production of a wound ointment.
DE736885C (en) Process for processing residues from glycerine distillation
DE487199C (en) Process for the preparation of purified tuberculin preparations
DE346947C (en) Method for the representation of Santonin
DE494691C (en) Procedure for purifying extraction oil
DE415319C (en) Process for the preparation of derivatives of 4-arylimino-1-naphthoquinone
DE552447C (en) Process for the preparation of lipoid-soluble antimony compounds
DE816696C (en) Process for the preparation of the dibasic calcium salt of acetylglutamic acid
DE401407C (en) Process for the manufacture of a sugar substitute
AT132707B (en) Process for the preparation of organic bromine derivatives.
AT122298B (en) Process for the preparation of cholesterol-free or low-cholesterol solutions of the active substance from glands with internal secretion.
DE499150C (en) Process for the preparation of a physiologically active substance from testicles
DE503920C (en) Process for the preparation of aminopyridines iodinated in the 5-position from the chloroiodine compounds of 2-aminopyridine and its derivatives
DE712257C (en) Process for the separation of mixtures of hexamethylene diamine and hexamethylene imine
DE367560C (en) Process for plasticizing cellulose derivatives
DE327310C (en) Seed dressing