DE869486C - Process for the production of ferrocalcium citrate - Google Patents

Process for the production of ferrocalcium citrate

Info

Publication number
DE869486C
DE869486C DEO1297A DEO0001297A DE869486C DE 869486 C DE869486 C DE 869486C DE O1297 A DEO1297 A DE O1297A DE O0001297 A DEO0001297 A DE O0001297A DE 869486 C DE869486 C DE 869486C
Authority
DE
Germany
Prior art keywords
citrate
ferrocalcium
production
calcium
citric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEO1297A
Other languages
German (de)
Inventor
Adolf Dipl-Chem Opfermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johann G W Opfermann & Sohn
Original Assignee
Johann G W Opfermann & Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johann G W Opfermann & Sohn filed Critical Johann G W Opfermann & Sohn
Priority to DEO1297A priority Critical patent/DE869486C/en
Application granted granted Critical
Publication of DE869486C publication Critical patent/DE869486C/en
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/418—Preparation of metal complexes containing carboxylic acid moieties

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von Ferrocalciumcitrat In der Patentschrift 857 363 ist ein Verfahren zur Herstellung eines für therapeutische Zwecke bestimmten Ferrocalciumcitrats der Formel Ca Fe. (C, H;, 0-,), durch Umsetzung von vorzugsweise stöchiometrischen Mengen Citronensäure, Ferrum reductum, Calciumcarbonat oder Calciumcitrat in Anwesenheit eines Schutzgases und Abtreibung des Wassers nach erfolgter Umsetzung vorzugsweise ebenfalls in Gegenwart eines Schutzgases beschrieben.Process for the preparation of ferrocalcium citrate In the patent specification 857 363 there is a process for the preparation of a ferrocalcium citrate of the formula Ca Fe intended for therapeutic purposes. (C, H ;, 0-,), by reacting preferably stoichiometric amounts of citric acid, Ferrum reductum, calcium carbonate or calcium citrate in the presence of a protective gas and aborting the water after the reaction, preferably also in the presence of a protective gas.

Es wurde nun gefunden, daß man das gleiche Diferromonocalciumcitrat auch durch Umsetzung von Citronensäure und Calciumcarbonat oder Calciumcitrat mit Ferrohydroxyd oder Ferrosalzen flüchtiger Säuren, insbesondere Ferrocarbonat, herstellen kann. Als weitere geeignete Eisensalze kommen Ferroformiat, -acetat und -lactat in Frage. Diese Eisenverbindungen sind im allgemeinen leichter herstellbar als das Ferrum reductum, außerdem verläuft die Reaktion sehr viel leichter und schneller.It has now been found that one can use the same Diferromonocalciumcitrat also by reacting citric acid and calcium carbonate or calcium citrate with Ferrohydroxyd or ferrous salts of volatile acids, especially ferrocarbonate, produce can. Other suitable iron salts are ferroformate, acetate and lactate in question. These iron compounds are generally easier to make than that Ferrum reductum, in addition, the reaction is much easier and faster.

Beispiel Eine Lösung von 2 Mol Citronensäure in destilliertem Wasser wird nach Vertreiben der gelösten Luft durch Auskochen und Durchleiten von Stickstoff mit 2 Mol Eisenhydroxyd versetzt. Hierauf wird i Mol Cälciumcarbonat zugesetzt, wobei unter Kohlensäureentwicklung das Calciumferrocitrat gebildet wird. Während beider-Umsetzungen- wird weiterhin- Stickstoff durchgeleitet. Hierauf- wird das Wasser durch. Erhitzen bis auf 2oo° unter weiterem Durchleiten des Schutzgases abgetrieben. -Die--Analyse-des erhaltenen gelblichen Kristallpulvers ergäb` fölgeride Daten gefunden: 25,8 % C, 2,io % H, 2i,i % Fell-; berechnet: 27,i 0% C, 1,890/, H, 2i,io % Fea. EXAMPLE A solution of 2 moles of citric acid in distilled water is mixed with 2 moles of iron hydroxide after the dissolved air has been expelled by boiling out and nitrogen passed through. One mole of calcium carbonate is then added, with the formation of calcium ferrocitrate with evolution of carbonic acid. During both reactions, nitrogen is still passed through. Then the water gets through. Heating up to 2oo ° driven off with further passage of the protective gas. The analysis of the yellowish crystal powder obtained yielded additional data found: 25.8% C, 2, io% H, 2i, i% fur-; calculated: 27, i 0% C, 1.890 /, H, 2i, io% Fea.

Claims (1)

PATENTANSPRUCH: Abänderung des Verfahrens zur Herstellung von Ferrocalciumcitrat der Formel Ca Fee (C0 H;, O7)2 nach Patent 857 363, dadurch gekennzeichnet, daB die Umsetzung statt mit Ferrum reductum mit Ferrohydroxyd oder Ferrosalzen flüchtiger Säuren, insbesondere Ferrocarbonat, erfolgt. PATENT CLAIM: Modification of the process for the production of ferrocalcium citrate of the formula Ca Fee (C0 H ;, O7) 2 according to Patent 857 363, characterized in that the reaction takes place with ferrohydroxide or ferrous salts of volatile acids, in particular ferrocarbonate, instead of Ferrum reductum.
DEO1297A 1950-11-22 1950-11-22 Process for the production of ferrocalcium citrate Expired DE869486C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEO1297A DE869486C (en) 1950-11-22 1950-11-22 Process for the production of ferrocalcium citrate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEO1297A DE869486C (en) 1950-11-22 1950-11-22 Process for the production of ferrocalcium citrate

Publications (1)

Publication Number Publication Date
DE869486C true DE869486C (en) 1953-03-05

Family

ID=7349495

Family Applications (1)

Application Number Title Priority Date Filing Date
DEO1297A Expired DE869486C (en) 1950-11-22 1950-11-22 Process for the production of ferrocalcium citrate

Country Status (1)

Country Link
DE (1) DE869486C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1270540B (en) * 1959-08-10 1968-06-20 Beecham Group Ltd Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1270540B (en) * 1959-08-10 1968-06-20 Beecham Group Ltd Process for the preparation of water-soluble complex compounds of aliphatic oxycarboxylic acids

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